ES2527544T1 - Tratamiento mono (PSI-7977) o de combinación con AAD para su uso en el tratamiento del VHC - Google Patents

Tratamiento mono (PSI-7977) o de combinación con AAD para su uso en el tratamiento del VHC Download PDF

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Publication number
ES2527544T1
ES2527544T1 ES12189195.6T ES12189195T ES2527544T1 ES 2527544 T1 ES2527544 T1 ES 2527544T1 ES 12189195 T ES12189195 T ES 12189195T ES 2527544 T1 ES2527544 T1 ES 2527544T1
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Prior art keywords
treatment
combination
psi
infected
compound
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ES12189195.6T
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Inventor
Barry M. Bernstein
Rajeev M. Menon
Amit Khatri
Sven MENSING
Sandeep Dutta
Daniel E. Cohen
Thomas Podsadecki
Scott C. Brun
Walid M. Awni
Emily O. Dumas
Cheri E. Klein
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AbbVie Inc
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AbbVie Inc
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Application filed by AbbVie Inc filed Critical AbbVie Inc
Publication of ES2527544T1 publication Critical patent/ES2527544T1/es
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
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  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Prostheses (AREA)

Abstract

Una combinación de al menos dos agentes antivirales de acción directa (AAD) para su uso en el tratamiento del VHC, donde dicho tratamiento no incluye la administración de interferón o ribavirina y dicho tratamiento dura 8, 9, 10, 11 o 12 semanas.

Claims (15)

  1. imagen1
  2. 3.
    La combinación de la reivindicación 2, donde dichos al menos dos AAD comprenden BMS-790052 y BMS-650032. 10
  3. 4. La combinación de la reivindicación 3, donde dicho tratamiento es para un paciente no tratado previamente que está infectado con el genotipo 1 del VHC.
  4. 5.
    La combinación de la reivindicación 2, donde dichos al menos dos AAD comprenden PSI-7977 y TMC-435. 15
  5. 6. La combinación de la reivindicación 5, donde dicho tratamiento es para un paciente no tratado previamente que está infectado con el genotipo 1 del VHC.
  6. 7.
    La combinación de la reivindicación 2, donde dichos al menos dos AAD comprenden PSI-7977 y daclatasvir. 20
  7. 8. La combinación de la reivindicación 7, donde dicho tratamiento es para un paciente no tratado previamente que está infectado por el genotipo 1 del VHC.
  8. 9.
    La combinación de la reivindicación 2, donde dichos al menos dos AAD comprenden PSI-7977 y GS-5885. 25
  9. 10.
    La combinación de la reivindicación 9, donde dicho tratamiento es para un paciente no tratado previamente que está infectado por el genotipo 1 del VHC.
  10. 11.
    La combinación de la reivindicación 2, donde dichos al menos dos AAD comprenden:
    30 el compuesto 1 o una sal farmacéuticamente aceptable del mismo, y el compuesto 4 o una sal farmacéuticamente aceptable del mismo,
    donde el Compuesto 1 o la sal del mismo se coadministra con ritonavir. 35
  11. 12.
    La combinación de la reivindicación 11, donde dicho tratamiento es para un paciente no tratado previamente que está infectado por el genotipo 1 del VHC.
  12. 13.
    La combinación de la reivindicación 2, donde dichos al menos dos AAD comprenden:
    40 el compuesto 1 o una sal farmacéuticamente aceptable del mismo, el compuesto 2 o una sal farmacéuticamente aceptable del mismo, y el compuesto 4 o una sal farmacéuticamente aceptable del mismo,
    45 donde el Compuesto 1 o la sal del mismo se coadministra con ritonavir.
  13. 14. La combinación de la reivindicación 13, donde dicho tratamiento es para un paciente no tratado previamente que está infectado por el genotipo 1 del VHC.
    50 15. La combinación de la reivindicación 13, donde dicho tratamiento es para un no respondedor al interferón que está infectado por el genotipo 1 del VHC.
  14. 16. PSI-7977 para su uso en el tratamiento del VHC, donde dicho tratamiento no incluye la administración de
    interferón o ribavirina y dicho tratamiento dura 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23 o 24 55 semanas.
  15. 17. PSI-799 de la reivindicación 16, donde dicho tratamiento dura 12 semanas.
    2
ES12189195.6T 2011-10-21 2012-10-19 Tratamiento mono (PSI-7977) o de combinación con AAD para su uso en el tratamiento del VHC Pending ES2527544T1 (es)

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US201161550360P 2011-10-21 2011-10-21
US201161550360P 2011-10-21
US201161562176P 2011-11-21 2011-11-21
US201161562176P 2011-11-21
US201261587197P 2012-01-17 2012-01-17
US201261587197P 2012-01-17
US201261600468P 2012-02-17 2012-02-17
US201261600468P 2012-02-17
US201261619883P 2012-04-03 2012-04-03
US201261619883P 2012-04-03
US201261656253P 2012-06-06 2012-06-06
US201261656253P 2012-06-06
US201261711793P 2012-10-10 2012-10-10
US201261711793P 2012-10-10

Publications (1)

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ES2527544T1 true ES2527544T1 (es) 2015-01-26

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ES12189195.6T Pending ES2527544T1 (es) 2011-10-21 2012-10-19 Tratamiento mono (PSI-7977) o de combinación con AAD para su uso en el tratamiento del VHC

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US (2) US8809265B2 (es)
EP (1) EP2583680A3 (es)
JP (2) JP5677646B2 (es)
CN (2) CN104436197A (es)
AR (1) AR088408A1 (es)
AU (1) AU2013201532B2 (es)
BR (1) BR112014005617A2 (es)
CA (1) CA2811250C (es)
CH (1) CH707030B1 (es)
CL (2) CL2014000778A1 (es)
DE (6) DE202012013117U1 (es)
DK (1) DK2583680T1 (es)
DO (1) DOP2014000067A (es)
EA (1) EA201490836A1 (es)
ES (1) ES2527544T1 (es)
GB (4) GB2515942A (es)
HK (2) HK1199817A1 (es)
IL (1) IL230862A0 (es)
MX (1) MX2014004729A (es)
PH (1) PH12014502847A1 (es)
PT (2) PT107924A (es)
SE (2) SE1450020A1 (es)
SG (1) SG2014011670A (es)
TW (2) TWI532485B (es)
UY (1) UY34401A (es)
WO (1) WO2013059638A1 (es)
ZA (1) ZA201406352B (es)

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Publication number Priority date Publication date Assignee Title
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