AR067442A1 - Compuestos antivirales - Google Patents

Compuestos antivirales

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Publication number
AR067442A1
AR067442A1 ARP080102757A ARP080102757A AR067442A1 AR 067442 A1 AR067442 A1 AR 067442A1 AR P080102757 A ARP080102757 A AR P080102757A AR P080102757 A ARP080102757 A AR P080102757A AR 067442 A1 AR067442 A1 AR 067442A1
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Argentina
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alkyl
alkoxy
alkynyl
alkenyl
optionally substituted
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ARP080102757A
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English (en)
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Gilead Sciences Inc
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Publication of AR067442A1 publication Critical patent/AR067442A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0819—Tripeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente se refiere a compuestos antivirales y composiciones que contienen tales compuestos. También se refiere a procesos e intermediarios para preparar tales compuestos. Reivindicacion 1: Un compuesto de formula (1) o su sal o profármaco aceptable para uso farmacéutico, donde Y1 es O, S, o NR3; Y2 es O, S, o NR3; Z es O, S, o NR3; Z1 se selecciona de las estructuras del grupo de formulas (2); cada Ra es R1, H, trifluorometoxi, NRsRt, C(=O)NRsRt, S(=O)2NRsRt o alquilo C1-10, donde uno o más átomos de carbono de dicho alquilo C1-10 es opcionalmente reemplazado por O, S, S(=O), S(=O)2 o NRg y dicho alquilo C1-10 está opcionalmente sustituido con uno o más hidroxi, halo, ciano, NRnRp, C(=O)NRnRp, alcoxi C1-10, carboxi, alcoxi C1-10carbonilo, arilo, heteroarilo, o heterociclilo y dicho heterociclilo está opcionalmente sustituido con uno o más A3; o Ra y Rb tomados juntos con los átomos a los cuales están unidos forman un anillo heterocíclico de 5 o 6 miembros que contienen uno o más O, S, o NRg; cada Rb es R1, H, F, CI, Br, I, CF3, alquilo C1-10, o XR3; cada Rc es R1, H, ciano, F, CI, Br, I, -C(=O)NRdRe, -C(=O)NRsRt, NRsRt, S(=O)2NRsRt, alquilo C1-10, alquenilo C2-10, alquinilo C2-10, alcoxi C1-10, cicloalquilo, ORr, SRr, S(O)Rr, S(O)2Rr, arilo, o heteroarilo, dicho alquilo C1-10, alcoxi C1-10, cicloalquilo, arilo a heteroarilo está opcionalmente sustituido con uno o más independientemente seleccionados de halo, hidroxi, alquilo C1-10, alquenilo C2-10, alquinilo C2-10, alcanoílo C1-10, alcoxi C1-10, alcanoiloxi C1-10, alcoxi C1-10carbonilo, NRnRp, SRr, S(O)Rr, o S(O)2Rr; Rd y Re son cada uno de ellos independientemente H a alquilo C1-10; cada Rf es H, hidroxi, carboxi, ciano, alquilo C1-10, alquenilo C2-10, alquinilo C2-10, alcanoílo C1-10, alcoxi C1-10, alcanoiloxi C1-10, alcoxi C1-10carbonilo, NRnRp, SRr, S(O)Rr, o S(O)2Rr; cada Rg es H, NRsRt, C(=O)NRsRt, S(=O)2NRsRt, A2, hidroxi, carboxi, ciano, alquilo C1-10, alquenilo C2-10, alquinilo C2-10, alcanoilo C1-10, alcoxi C1-10, alcanoiloxi C1-10, alcoxi C1-10carbonilo, NRnRp, SRr, S(O)Rr, o S(O)2Rr; cada Rh es H, A3, C(=O)NRsRt, o S(=O)2NRsRt; cada Rm es H, ciano, F, CI, Br, I, -C(=O)NRdRe, alcoxi C1-10, cicloalquilo, o fenilo que está opcionalmente sustituido con uno o más F, CI, Br, I, alquilo C1-10, o alcoxi C1-10; cada L es independientemente CH o N; uno de E o D es O, S, o NRf y el otro E o D es CRh o N; Z2a es H, alquilo C1-10, alquenilo C2-10, alquinilo C2-10, haloalquilo , alquilo C1-10, -S(=O)2-alquilo C1-10, o cicloalquilo, donde cualquier átomo de carbono de Z2a puede estar opcionalmente reemplazado con un heteroátomo seleccionado de O, S o NRg y donde cualquier cicloalquilo está opcionalmente sustituido con uno o más alquilo C1-10, alquenilo C2-10, alquinilo C2-10, F, CI, Br, o I; o Z2a opcionalmente forma un heterociclo con Q1; Z2b es H, alquilo C1-10, alquenilo C2-10, alquinilo C2-10; Q1 es alquilo C1-10, alquenilo C2-10, o alquinilo C2-10 dicho Q1 está opcionalmente sustituido con R1 o Rc; o Q1 y Z2a tomados juntos con los átomos a los cuales están unidos forman un heterociclo, dicho heterociclo puede estar opcionalmente sustituido con uno o más oxo (=O), R1, o A3; cada X es independientemente un enlace, O, S, o NR3; Y es un policarbociclo o un poliheterociclo, dicho policarbociclo o poliheterociclo está opcionalmente sustituido con uno o más R1, halo, carboxi, hidroxi, alquilo C1-10, alquenilo C2-10, alquinilo C2-10, alcanoílo C1-10, alcoxi C1-10, alcanoiloxi C1-10, alcoxi C1-10carbonilo, NRnRp, SRr, S(O)Rr, o S(O)2Rr; cada R1 es independientemente -P(Y3)(OA2)(OA2), -P(Y3)(OA2)(N(A2)2), -P(Y3)(A2)(OA2), -P(Y3)(A2)(N(A2)2) o P(Y3)(N(A2)2)(N(A2)2); cada A2 es independientemente H, alquilo C1-10, alquenilo C2-10, alquinilo C2-10, haloalquilo C1-10, cicloalquilo C3-10, arilo, o heteroarilo; cada Y3 es independientemente O, S, o NR3; cada Rn y Rp es independientemente H, alquilo C1-10, alquenilo C2-10, alquinilo C2-10, alcanoilo C1-10, alcoxi C1-10, alcanoiloxi C1-10, o alcoxi C1-10carbonilo, dicho alquilo C1-10, alquenilo C2-10, alquinilo C2-10, alcanoílo C1-10, alcoxi C1-10, alcanoiloxi C1-10, o alcoxi C1-10carbonilo, está opcionalmente sustituido con uno o más R1, halo, hidroxi, carboxi, ciano, o alcoxi C1-10; o Rn y Rp junto con el nitrogeno al cual están unidos forman un anillo de pirrolidina, piperidina, piperazina, morfolino, o tiomorfolino; dicho anillo está opcionalmente sustituido con uno o más alquilo C1-10 o alcoxi C1-10, y dicho alquilo C1-10 o alcoxi C1-10 está opcionalmente sustituido con uno o más halo; cada Rr es independientemente H, alquilo C1-10, cicloalquilo, alquenilo C2-10, alquinilo C2-10, alcanoilo C1-10, arilo, heteroarilo, o alcoxi C1-10carbonilo; cada Rs y Rt es independientemente H, alquilo C1-10, cicloalquilo, alquenilo C2-10, alquinilo C2-10, alcanoílo C1-10, S(=O)2A2, alcoxi C1-10, alcanoiloxi C1-10, o alcoxi C1-10carbonilo, dicho alquilo C1-10, cicloalquilo, alquenilo C2-10, alquinilo C2-10, alcanoilo C1-10, alcoxi C1-10, alcanoiloxi C1-10, o alcoxi C1-10carbonilo, está opcionalmente sustituido con uno o más R1, halo, hidroxi, carboxi, ciano, o alcoxi C1-10; o Rs y Rt junto con el nitrogeno al cual están unidos forman un anillo de pirrolidina, piperidina, piperazina, morfolino, o tiomorfolino donde uno o más átomos de carbono de dicho anillo de pirrolidina, piperidina, piperazina, morfolino, o tiomorfolino es opcionalmente reemplazado por S(=O), S(=O)2, o C(=O); cada A3 es independientemente seleccionado de halo, hidroxi, carboxi, ciano, alquilo C1-10, alquenilo C2-10, alquinilo C2-10, alcanoilo C1-10, alcoxi C1-10, alcanoiloxi C1-10, alcoxi C1-10carbonilo, NRnRp, SRr, S(O)Rr, o S(O)2Rr; y R3 es H o alquilo C1-10.
ARP080102757A 2007-06-29 2008-06-26 Compuestos antivirales AR067442A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US93775207P 2007-06-29 2007-06-29
US95977107P 2007-07-16 2007-07-16
US3798808P 2008-03-19 2008-03-19

Publications (1)

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AR067442A1 true AR067442A1 (es) 2009-10-14

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US (5) US8178491B2 (es)
EP (1) EP2162431B1 (es)
JP (3) JP5465666B2 (es)
KR (2) KR101596524B1 (es)
CN (1) CN101790524B (es)
AP (1) AP2874A (es)
AR (1) AR067442A1 (es)
AU (1) AU2008271116B2 (es)
BR (1) BRPI0813500A2 (es)
CA (1) CA2691442C (es)
CO (1) CO6251245A2 (es)
EA (2) EA019749B1 (es)
EC (1) ECSP109904A (es)
IL (2) IL202764A (es)
MX (1) MX2009013827A (es)
NZ (1) NZ582096A (es)
TW (1) TWI395746B (es)
UA (1) UA98494C2 (es)
WO (1) WO2009005676A2 (es)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY140680A (en) 2002-05-20 2010-01-15 Bristol Myers Squibb Co Hepatitis c virus inhibitors
RU2008152171A (ru) 2006-07-05 2010-08-10 Интермьюн, Инк. (Us) Новые ингибиторы вирусной репликации гепатита с
AP2874A (en) * 2007-06-29 2014-03-31 Gilead Sciences Inc Antiviral compounds
CA2712971A1 (en) * 2008-02-04 2009-08-13 Idenix Pharamaceuticals, Inc. Macrocyclic serine protease inhibitors
UY32099A (es) 2008-09-11 2010-04-30 Enanta Pharm Inc Inhibidores macrocíclicos de serina proteasas de hepatitis c
NZ591030A (en) 2008-09-17 2012-10-26 Boehringer Ingelheim Int Combination of hcv ns3 protease inhibitor with interferon and ribavirin
WO2010034105A1 (en) * 2008-09-23 2010-04-01 Boehringer Ingelheim International Gmbh Hepatitis c inhibitor compounds
JP2012520891A (ja) * 2009-03-19 2012-09-10 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング スルホニルキノリンの製造方法
TW201040181A (en) 2009-04-08 2010-11-16 Idenix Pharmaceuticals Inc Macrocyclic serine protease inhibitors
WO2010129451A1 (en) * 2009-05-05 2010-11-11 Boehringer Ingelheim International Gmbh Process for preparing bromo-substituted quinolines
US8232246B2 (en) 2009-06-30 2012-07-31 Abbott Laboratories Anti-viral compounds
US9284307B2 (en) 2009-08-05 2016-03-15 Idenix Pharmaceuticals Llc Macrocyclic serine protease inhibitors
NZ598465A (en) 2009-10-30 2013-10-25 Boehringer Ingelheim Int Dosage regimens for hcv combination therapy comprising bi201335, interferon alpha and ribavirin
US8476225B2 (en) 2009-12-04 2013-07-02 Gilead Sciences, Inc. Antiviral compounds
AR082453A1 (es) 2010-04-21 2012-12-12 Novartis Ag Compuestos de furopiridina, composiciones farmaceuticas que los contienen y usos de los mismos
WO2012047764A1 (en) * 2010-10-04 2012-04-12 Intermune, Inc. Therapeutic antiviral peptides
WO2012087596A1 (en) 2010-12-20 2012-06-28 Gilead Sciences, Inc. Combinations for treating hcv
CN103534256B (zh) 2010-12-30 2016-08-10 益安药业 大环丙型肝炎丝氨酸蛋白酶抑制剂
KR20140003521A (ko) 2010-12-30 2014-01-09 이난타 파마슈티칼스, 인코포레이티드 페난트리딘 매크로사이클릭 ｃ형 간염 세린 프로테아제 억제제
TW201309690A (zh) 2011-02-10 2013-03-01 Idenix Pharmaceuticals Inc 巨環絲胺酸蛋白酶抑制劑，其醫藥組合物及其於治療ｈｃｖ感染之用途
US8957203B2 (en) 2011-05-05 2015-02-17 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US10201584B1 (en) 2011-05-17 2019-02-12 Abbvie Inc. Compositions and methods for treating HCV
CN106166160A (zh) 2011-09-16 2016-11-30 吉利德制药有限责任公司 用于治疗hcv的组合物
US8492386B2 (en) 2011-10-21 2013-07-23 Abbvie Inc. Methods for treating HCV
US8466159B2 (en) 2011-10-21 2013-06-18 Abbvie Inc. Methods for treating HCV
BR112014005617A2 (pt) 2011-10-21 2017-06-13 Abbvie Inc tratamento de combinação (por exemplo, com abt-072 ou abt -333) de daas para uso no tratamento de hcv
ES2572329B1 (es) 2011-10-21 2017-08-24 Abbvie Inc. Combinación de al menos dos agentes antivirales de acción directa y ribavirina pero no interferón, para uso en el tratamientodel vhc
EP3750544A3 (en) 2011-11-30 2021-03-24 Emory University Jak inhibitors for use in the prevention or treatment of viral infection
KR102051693B1 (ko) * 2012-05-29 2019-12-03 가부시키가이샤 미토콘도리아 겐큐쇼 디히드로오로토산 탈수소효소 억제제
UA119315C2 (uk) 2012-07-03 2019-06-10 Гіліад Фармассет Елелсі Інгібітори вірусу гепатиту с
EP2903988A1 (en) 2012-10-08 2015-08-12 AbbVie Inc. Compounds useful for making hcv protease inhibitors
JP6154474B2 (ja) 2012-10-19 2017-06-28 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｃ型肝炎ウイルス阻害剤
US9643999B2 (en) 2012-11-02 2017-05-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US9334279B2 (en) 2012-11-02 2016-05-10 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US9598433B2 (en) 2012-11-02 2017-03-21 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
EP2914614B1 (en) 2012-11-05 2017-08-16 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
US20140212491A1 (en) 2013-01-31 2014-07-31 Gilead Pharmasset Llc Combination formulation of two antiviral compounds
EP2964664B1 (en) 2013-03-07 2017-01-11 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
CA2902569A1 (en) * 2013-03-15 2014-09-18 Gilead Sciences, Inc. Inhibitors of hepatitis c virus
US11814664B2 (en) 2013-05-24 2023-11-14 Genomatica, Inc. Microorganisms and methods for producing (3R)-hydroxybutyl (3R)-hydroxybutyrate
EP4005560A1 (en) 2013-08-27 2022-06-01 Gilead Pharmasset LLC Combination formulation of two antiviral compounds
WO2015103490A1 (en) 2014-01-03 2015-07-09 Abbvie, Inc. Solid antiviral dosage forms
CN103965286B (zh) * 2014-04-22 2017-11-03 南京安赛莱医药科技有限公司 丙型肝炎病毒（hcv）ns3蛋白酶抑制剂
BR112017013858A2 (pt) 2014-12-26 2018-02-27 Univ Emory n4-hidroxicitidina e derivados e usos antivirais relacionados aos mesmos
CN105646208B (zh) * 2016-02-24 2018-10-16 潍坊晶润化工股份有限公司 丙酮酸甲酯的制备方法
WO2017189978A1 (en) 2016-04-28 2017-11-02 Emory University Alkyne containing nucleotide and nucleoside therapeutic compositions and uses related thereto
WO2017197036A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. Spirocyclic degronimers for target protein degradation
EP3455218A4 (en) 2016-05-10 2019-12-18 C4 Therapeutics, Inc. C3 CARBON-BASED GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN REDUCTION
EP3454856A4 (en) 2016-05-10 2019-12-25 C4 Therapeutics, Inc. HETEROCYCLIC DEGRONIMERS FOR TARGET PROTEIN REDUCTION
CN118178444A (zh) 2016-05-27 2024-06-14 吉利德科学公司 使用ns5a、ns5b或ns3抑制剂治疗乙型肝炎病毒感染的方法
BR102017011025A2 (pt) 2016-06-02 2017-12-19 Gilead Pharmasset Llc Formulation of combination of three antiviral compounds
KR102626210B1 (ko) 2017-12-07 2024-01-18 에모리 유니버시티 N4-하이드록시사이티딘 및 유도체 및 이와 관련된 항-바이러스 용도
CN109796736B (zh) * 2018-12-25 2021-05-18 金发科技股份有限公司 一种聚碳酸酯组合物及其制备方法和应用

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1230595B (it) * 1988-10-24 1991-10-28 Ausimont Srl Perossiacidi immido derivati
US5610054A (en) * 1992-05-14 1997-03-11 Ribozyme Pharmaceuticals, Inc. Enzymatic RNA molecule targeted against Hepatitis C virus
US5500208A (en) 1994-06-07 1996-03-19 The Procter & Gamble Company Oral compositions comprising a novel tripeptide
MY147327A (en) * 1995-06-29 2012-11-30 Novartis Ag Somatostatin peptides
GB9517022D0 (en) 1995-08-19 1995-10-25 Glaxo Group Ltd Medicaments
US5658940A (en) * 1995-10-06 1997-08-19 Celgene Corporation Succinimide and maleimide cytokine inhibitors
US5633388A (en) * 1996-03-29 1997-05-27 Viropharma Incorporated Compounds, compositions and methods for treatment of hepatitis C
EP0907659A1 (en) 1996-05-10 1999-04-14 Schering Corporation Synthetic inhibitors of hepatitis c virus ns3 protease
ZA979327B (en) * 1996-10-18 1998-05-11 Vertex Pharma Inhibitors of serine proteases, particularly hepatitis C virus NS3 protease.
GB9623908D0 (en) * 1996-11-18 1997-01-08 Hoffmann La Roche Amino acid derivatives
WO1998046597A1 (en) 1997-04-14 1998-10-22 Emory University Serine protease inhibitors
GB9707659D0 (en) 1997-04-16 1997-06-04 Peptide Therapeutics Ltd Hepatitis C NS3 Protease inhibitors
CA2294562C (en) 1997-08-11 2005-07-26 Boehringer Ingelheim (Canada) Ltd. Hepatitis c inhibitor peptide analogues
ATE291032T1 (de) 1997-08-11 2005-04-15 Boehringer Ingelheim Ca Ltd Hepatitis c inhibitor peptide
IT1299134B1 (it) 1998-02-02 2000-02-29 Angeletti P Ist Richerche Bio Procedimento per la produzione di peptidi con proprieta' inibitrici della proteasi ns3 del virus hcv, peptidi cosi' ottenibili e peptidi
AU3376699A (en) 1998-03-31 1999-10-18 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease
GB9812523D0 (en) 1998-06-10 1998-08-05 Angeletti P Ist Richerche Bio Peptide inhibitors of hepatitis c virus ns3 protease
ATE298317T1 (de) 1998-07-27 2005-07-15 Angeletti P Ist Richerche Bio Diketosäure-derivate als hemmstoffe von polymerasen
AR022061A1 (es) 1998-08-10 2002-09-04 Boehringer Ingelheim Ca Ltd Peptidos inhibidores de la hepatitis c, una composicion farmaceutica que los contiene, el uso de los mismos para preparar una composicion farmaceutica, el uso de un producto intermedio para la preparacion de estos peptidos y un procedimiento para la preparacion de un peptido analogo de los mismos.
US6323180B1 (en) * 1998-08-10 2001-11-27 Boehringer Ingelheim (Canada) Ltd Hepatitis C inhibitor tri-peptides
WO2000010573A1 (en) 1998-08-21 2000-03-02 Viropharma Incorporated Compounds, compositions and methods for treating or preventing viral infections and associated diseases
CN1324250A (zh) 1998-09-04 2001-11-28 维洛药品公司 治疗或预防病毒感染及其所致疾病的方法
JP2002525295A (ja) 1998-09-25 2002-08-13 バイロファーマ・インコーポレイテッド ウイルス感染および関連疾患の治療または予防法
UA74546C2 (en) 1999-04-06 2006-01-16 Boehringer Ingelheim Ca Ltd Macrocyclic peptides having activity relative to hepatitis c virus, a pharmaceutical composition and use of the pharmaceutical composition
US6608027B1 (en) * 1999-04-06 2003-08-19 Boehringer Ingelheim (Canada) Ltd Macrocyclic peptides active against the hepatitis C virus
AU1262001A (en) 1999-11-04 2001-05-14 Biochem Pharma Inc. Method for the treatment or prevention of flaviviridae viral infection using nucleoside analogues
ID30204A (id) 1999-12-27 2001-11-15 Japan Tobacco Inc Senyawa-senyawa cincin terfusi dan penggunaannya sebagai obat
JP2004509066A (ja) 2000-05-10 2004-03-25 スミスクライン・ビーチャム・コーポレイション 新規抗感染症薬
US6448281B1 (en) 2000-07-06 2002-09-10 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
GB0017676D0 (en) 2000-07-19 2000-09-06 Angeletti P Ist Richerche Bio Inhibitors of viral polymerase
DE60119968T2 (de) * 2000-11-20 2007-01-18 Bristol-Myers Squibb Co. Hepatitis c tripeptid inhibitoren
US6867185B2 (en) * 2001-12-20 2005-03-15 Bristol-Myers Squibb Company Inhibitors of hepatitis C virus
CA2369711A1 (en) 2002-01-30 2003-07-30 Boehringer Ingelheim (Canada) Ltd. Macrocyclic peptides active against the hepatitis c virus
CA2370396A1 (en) 2002-02-01 2003-08-01 Boehringer Ingelheim (Canada) Ltd. Hepatitis c inhibitor tri-peptides
US6642204B2 (en) * 2002-02-01 2003-11-04 Boehringer Ingelheim International Gmbh Hepatitis C inhibitor tri-peptides
CA2369970A1 (en) * 2002-02-01 2003-08-01 Boehringer Ingelheim (Canada) Ltd. Hepatitis c inhibitor tri-peptides
US6828301B2 (en) 2002-02-07 2004-12-07 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for hepatitis C viral protease inhibitors
US6878722B2 (en) * 2002-05-20 2005-04-12 Bristol-Myers Squibb Company Substituted cycloalkyl P1′ hepatitis C virus inhibitors
AU2003248535A1 (en) * 2002-05-20 2003-12-12 Bristol-Myers Squibb Company Heterocyclicsulfonamide hepatitis c virus inhibitors
AU2003299519A1 (en) * 2002-05-20 2004-05-04 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
MY140680A (en) 2002-05-20 2010-01-15 Bristol Myers Squibb Co Hepatitis c virus inhibitors
JP2007524576A (ja) 2003-02-07 2007-08-30 エナンタ ファーマシューティカルズ インコーポレイテッド 大環状のｃ型肝炎セリンプロテアーゼ阻害剤
JP4550824B2 (ja) * 2003-03-05 2010-09-22 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃ型肝炎抑制化合物
CA2516018C (en) * 2003-03-05 2011-08-23 Boehringer Ingelheim International Gmbh Hepatitis c inhibitor peptide analogs
US7148347B2 (en) * 2003-04-10 2006-12-12 Boehringer Ingelheim International Gmbh Process for preparing macrocyclic compounds
ES2386161T3 (es) * 2003-04-16 2012-08-10 Bristol-Myers Squibb Company Proceso para separar una mezcla de enantiómeros de éster alquílico usando una enzima
CN1788006A (zh) * 2003-04-18 2006-06-14 安南塔制药公司 喹喔啉基大环丙型肝炎丝氨酸蛋白酶抑制剂
BRPI0410456B8 (pt) 2003-05-21 2021-05-25 Boehringer Ingelheim Int compostos inibidores de hepatite c, composição farmacêutica, uso dos mesmos, bem como artigo de fabricação
WO2004113365A2 (en) 2003-06-05 2004-12-29 Enanta Pharmaceuticals, Inc. Hepatitis c serine protease tri-peptide inhibitors
US7125845B2 (en) 2003-07-03 2006-10-24 Enanta Pharmaceuticals, Inc. Aza-peptide macrocyclic hepatitis C serine protease inhibitors
CN102020697B (zh) * 2003-10-14 2014-10-29 F·霍夫曼-罗须公司 作为hcv复制抑制剂的巨环羧酸和酰基磺酰胺
US7132504B2 (en) 2003-11-12 2006-11-07 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
CA2549851C (en) * 2004-01-21 2012-09-11 Boehringer Ingelheim International Gmbh Macrocyclic peptides active against the hepatitis c virus
WO2005095403A2 (en) 2004-03-30 2005-10-13 Intermune, Inc. Macrocyclic compounds as inhibitors of viral replication
JP5676839B2 (ja) * 2004-07-16 2015-02-25 ギリアード サイエンシーズ， インコーポレイテッド 抗ウイルス化合物
CA2573346C (en) 2004-07-20 2011-09-20 Boehringer Ingelheim International Gmbh Hepatitis c inhibitor peptide analogs
UY29016A1 (es) 2004-07-20 2006-02-24 Boehringer Ingelheim Int Analogos de dipeptidos inhibidores de la hepatitis c
WO2007001406A2 (en) * 2004-10-05 2007-01-04 Chiron Corporation Aryl-containing macrocyclic compounds
US7323447B2 (en) 2005-02-08 2008-01-29 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7592336B2 (en) 2005-05-10 2009-09-22 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7601686B2 (en) * 2005-07-11 2009-10-13 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
TWI389908B (zh) 2005-07-14 2013-03-21 Gilead Sciences Inc 抗病毒化合物類
TW200738742A (en) 2005-07-14 2007-10-16 Gilead Sciences Inc Antiviral compounds
KR101294467B1 (ko) * 2005-07-25 2013-09-09 인터뮨, 인크. Ｃ형 간염 바이러스 복제의 신규 거대고리형 억제제
US7772183B2 (en) 2005-10-12 2010-08-10 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
AP2874A (en) * 2007-06-29 2014-03-31 Gilead Sciences Inc Antiviral compounds

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