CO6251245A2 - Compuestos de prolina modificados con propiedades inhibitorias del virus de la hepatitis c - Google Patents

Compuestos de prolina modificados con propiedades inhibitorias del virus de la hepatitis c

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Publication number
CO6251245A2
CO6251245A2 CO09145305A CO09145305A CO6251245A2 CO 6251245 A2 CO6251245 A2 CO 6251245A2 CO 09145305 A CO09145305 A CO 09145305A CO 09145305 A CO09145305 A CO 09145305A CO 6251245 A2 CO6251245 A2 CO 6251245A2
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CO
Colombia
Prior art keywords
alkyl
alkoxy
alkenyl
optionally substituted
2nrsrt
Prior art date
Application number
CO09145305A
Other languages
English (en)
Inventor
Aesop Cho
Michael Clarke
Hanrahan Oneil
Choung Kim
Hyung-Jung Pyun
Xiaoning Sheng
Qiaoyin Wu
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of CO6251245A2 publication Critical patent/CO6251245A2/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0819—Tripeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

1.- Un compuesto de formula I:o una sal farmacéuticamente aceptable, o profármaco del mismo, en donde:Y1 es O, S, o NR3; Y2 es O, S, o NR3; Z es O, S, o NR3;Z1 se selecciona de las siguientes estructuras:cada Ra es alquilo(C1-10), en donde uno o más átomos de carbono de dicho alquilo (C1-10) es opcionalmente reemplazado por O y cuyo alquilo(C1-10) está opcionalmente sustituido con uno o más heterociclilo y cuyo heterociclilo está opcionalmente sustituido con uno o más A3; cada Rb es R1, H, F, CI, Br, I, CF3, alquilo(C1-10), o XR3; cada Rc es R1, H, ciano, F, CI, Br, I, -C(=O)NRdRe, C(=O)NRsRt, NRsRt, S(=O)2NRsRt, alquilo(C1-10), alquenilo(C2-10), alquinilo(C2-10), alcoxi(C1-10), cicloalquilo, ORr, SRr, S(O)Rr, S(O)2Rr, arilo, o heteroarilo, cuyo alquilo(C1-10), alcoxi(C1-10), cícloalquilo, arilo o heteroarilo está opcionalmente sustituido con uno o más grupos seleccionados independientemente de halo, hidroxi, alquilo(C1-10), alquenilo(C2-10), alquinilo(C2-10), alcanoilo(C1-10), alcoxi(C1-10), alcanoiloxi(C1-10), alcoxi(C1-10)carbonilo, NRnRp; SRr, S(O)Rn o S(O)2Rr; Rd y Re son cada uno independientemente H o alquilo(C1-10); cada Rf es H, hidroxi, carboxi, ciano, alquilo(C1-10), alquenilo(C2-10), alquinilo(C2-10), alcanoilo(C1-10), alcoxi(C1-10), alcanoiloxi(C1-10), alcoxicarbonilo(C1-10), NRnRp, SRr, S(O)Rr, o S(O)2Rr; cada Rh es H, A3, C(=O)2NRsRt, o S(=O)2NRsRt; cada Rm es H, ciano, F, CI, Br, I, -C(=O)NRdRe, alcoxi(C1-10), cicloalquilo, o fenilo que está opcionalmente sustituido con uno o más F, CI, Br, I, alquilo(C1-10), o alcoxi(C1-10);cada L es independientemente CH o N; uno de E o D es O, S, o NRf t el otro E o D es CRh o N; Z2a es H, alquilo(C1-10), alquenilo(C2-10), ...
CO09145305A 2007-06-29 2009-12-18 Compuestos de prolina modificados con propiedades inhibitorias del virus de la hepatitis c CO6251245A2 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US93775207P 2007-06-29 2007-06-29
US95977107P 2007-07-16 2007-07-16
US3798808P 2008-03-19 2008-03-19

Publications (1)

Publication Number Publication Date
CO6251245A2 true CO6251245A2 (es) 2011-02-21

Family

ID=40121200

Family Applications (1)

Application Number Title Priority Date Filing Date
CO09145305A CO6251245A2 (es) 2007-06-29 2009-12-18 Compuestos de prolina modificados con propiedades inhibitorias del virus de la hepatitis c

Country Status (19)

Country Link
US (5) US8178491B2 (es)
EP (1) EP2162431B1 (es)
JP (3) JP5465666B2 (es)
KR (2) KR20150006905A (es)
CN (1) CN101790524B (es)
AP (1) AP2874A (es)
AR (1) AR067442A1 (es)
AU (1) AU2008271116B2 (es)
BR (1) BRPI0813500A2 (es)
CA (1) CA2691442C (es)
CO (1) CO6251245A2 (es)
EA (2) EA019749B1 (es)
EC (1) ECSP109904A (es)
IL (2) IL202764A (es)
MX (1) MX2009013827A (es)
NZ (1) NZ582096A (es)
TW (1) TWI395746B (es)
UA (1) UA98494C2 (es)
WO (1) WO2009005676A2 (es)

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US8178491B2 (en) 2012-05-15
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