EA201390988A1 - Фенантридиновые макроциклические ингибиторы сериновой протеазы вируса гепатита c - Google Patents

Фенантридиновые макроциклические ингибиторы сериновой протеазы вируса гепатита c

Info

Publication number
EA201390988A1
EA201390988A1 EA201390988A EA201390988A EA201390988A1 EA 201390988 A1 EA201390988 A1 EA 201390988A1 EA 201390988 A EA201390988 A EA 201390988A EA 201390988 A EA201390988 A EA 201390988A EA 201390988 A1 EA201390988 A1 EA 201390988A1
Authority
EA
Eurasian Patent Office
Prior art keywords
hypatitis
phenantridine
virus
macrocyclic inhibitors
serin protease
Prior art date
Application number
EA201390988A
Other languages
English (en)
Inventor
Кит Ф. Макдэниел
Хой-Цзюй Чэнь
Джейсон П. Шэнли
Дэвид Дж. Грамповник
Брайан Грин
Тимоти Миддлтон
Тодд Хопкинс
Ят Сунь Ор
Original Assignee
Энанта Фармасьютикалз, Инк.
Эббви Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46383854&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201390988(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Энанта Фармасьютикалз, Инк., Эббви Инк. filed Critical Энанта Фармасьютикалз, Инк.
Publication of EA201390988A1 publication Critical patent/EA201390988A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Abstract

Изобретение относится к новым макроциклическим соединениям и способам лечения инфекционного гепатита С у субъекта, которому необходимо такое лечение, с применением указанных макроциклических соединений. Кроме того, настоящее изобретение относится к фармацевтическим композициям, включающим соединения по настоящему изобретению, или их фармацевтически приемлемые соли, сложные эфиры или пролекарства, в комбинации с фармацевтически приемлемым носителем или эксципиентом.
EA201390988A 2010-12-30 2011-12-29 Фенантридиновые макроциклические ингибиторы сериновой протеазы вируса гепатита c EA201390988A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201061428488P 2010-12-30 2010-12-30
US201161449331P 2011-03-04 2011-03-04
PCT/US2011/067701 WO2012092411A2 (en) 2010-12-30 2011-12-29 Phenanthridine macrocyclic hepatitis c serine protease inhibitors

Publications (1)

Publication Number Publication Date
EA201390988A1 true EA201390988A1 (ru) 2014-04-30

Family

ID=46383854

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201390988A EA201390988A1 (ru) 2010-12-30 2011-12-29 Фенантридиновые макроциклические ингибиторы сериновой протеазы вируса гепатита c

Country Status (18)

Country Link
US (1) US8951964B2 (ru)
EP (1) EP2658858A4 (ru)
JP (1) JP2014506255A (ru)
KR (1) KR20140003521A (ru)
CN (1) CN103380132B (ru)
AU (1) AU2011352145A1 (ru)
BR (1) BR112013016480A2 (ru)
CA (1) CA2821340A1 (ru)
CO (1) CO6771427A2 (ru)
CR (1) CR20130341A (ru)
EA (1) EA201390988A1 (ru)
EC (1) ECSP13012791A (ru)
GT (1) GT201300172A (ru)
MX (1) MX2013007698A (ru)
PE (1) PE20140039A1 (ru)
SG (1) SG191759A1 (ru)
WO (1) WO2012092411A2 (ru)
ZA (1) ZA201304579B (ru)

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