DK1934243T3 - Cykliserende metathesefremgangsmåde til fremstilling af makrocykliske peptider - Google Patents
Cykliserende metathesefremgangsmåde til fremstilling af makrocykliske peptiderInfo
- Publication number
- DK1934243T3 DK1934243T3 DK06803140.0T DK06803140T DK1934243T3 DK 1934243 T3 DK1934243 T3 DK 1934243T3 DK 06803140 T DK06803140 T DK 06803140T DK 1934243 T3 DK1934243 T3 DK 1934243T3
- Authority
- DK
- Denmark
- Prior art keywords
- formula
- compound
- cyclizing
- macrocyclic peptides
- metathesis method
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71553405P | 2005-09-09 | 2005-09-09 | |
PCT/US2006/034921 WO2007030656A1 (en) | 2005-09-09 | 2006-09-08 | Ring-closing metathesis process for the preparation of macrocyclic peptides |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1934243T3 true DK1934243T3 (da) | 2011-09-05 |
Family
ID=37549189
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK06803140.0T DK1934243T3 (da) | 2005-09-09 | 2006-09-08 | Cykliserende metathesefremgangsmåde til fremstilling af makrocykliske peptider |
Country Status (9)
Country | Link |
---|---|
US (1) | US7951773B2 (da) |
EP (1) | EP1934243B1 (da) |
JP (1) | JP5190364B2 (da) |
AT (1) | ATE510846T1 (da) |
CA (1) | CA2621360C (da) |
DK (1) | DK1934243T3 (da) |
ES (1) | ES2364426T3 (da) |
PL (1) | PL1934243T3 (da) |
WO (1) | WO2007030656A1 (da) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0100623D0 (en) * | 2001-01-10 | 2001-02-21 | Vernalis Res Ltd | Chemical compounds IV |
JP5517614B2 (ja) | 2006-07-13 | 2014-06-11 | アキリオン ファーマシューティカルズ,インコーポレーテッド | ウイルス複製阻害剤としての4−アミノ−4−オキソブタノイルペプチド類 |
WO2008106130A2 (en) | 2007-02-26 | 2008-09-04 | Achillion Pharmaceuticals, Inc. | Tertiary amine substituted peptides useful as inhibitors of hcv replication |
US8193346B2 (en) * | 2007-12-06 | 2012-06-05 | Enanta Pharmaceuticals, Inc. | Process for making macrocyclic oximyl hepatitis C protease inhibitors |
NZ587133A (en) | 2008-02-04 | 2012-10-26 | Idenix Pharmaceuticals Inc | Macrocyclic serine protease inhibitor compounds for treating an HCV infection |
CA2722867A1 (en) * | 2008-05-09 | 2009-11-12 | Boehringer Ingelheim International Gmbh | A method for preparing macrocycles |
MX2011000789A (es) * | 2008-08-07 | 2011-02-24 | Hoffmann La Roche | Proceso para la preparacion de un macrociclo. |
UY32099A (es) | 2008-09-11 | 2010-04-30 | Enanta Pharm Inc | Inhibidores macrocíclicos de serina proteasas de hepatitis c |
ES2527166T3 (es) | 2008-12-10 | 2015-01-21 | Achillion Pharmaceuticals, Inc. | Nuevos péptidos de 4-amino-4-oxobutanoílo como inhibidores de la replicación viral |
CA2758072A1 (en) | 2009-04-08 | 2010-10-14 | Idenix Pharmaceuticals, Inc. | Macrocyclic serine protease inhibitors |
US8232246B2 (en) * | 2009-06-30 | 2012-07-31 | Abbott Laboratories | Anti-viral compounds |
WO2011017389A1 (en) | 2009-08-05 | 2011-02-10 | Idenix Pharmaceuticals, Inc. | Macrocyclic serine protease inhibitors useful against viral infections, particularly hcv |
US8937041B2 (en) | 2010-12-30 | 2015-01-20 | Abbvie, Inc. | Macrocyclic hepatitis C serine protease inhibitors |
EP2658858A4 (en) | 2010-12-30 | 2014-06-25 | Enanta Pharm Inc | MACROCYCLIC INHIBITORS OF HEPATITIS C SERINE PROTEASE PHENANTHRIDINE |
US9353100B2 (en) | 2011-02-10 | 2016-05-31 | Idenix Pharmaceuticals Llc | Macrocyclic serine protease inhibitors, pharmaceutical compositions thereof, and their use for treating HCV infections |
US8957203B2 (en) | 2011-05-05 | 2015-02-17 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
WO2013061285A1 (en) | 2011-10-28 | 2013-05-02 | Janssen Pharmaceuticals, Inc | Improved process for preparing an intermediate of the macrocyclic protease inhibitor tmc 435 |
BR112015007887A2 (pt) | 2012-10-08 | 2017-07-04 | Abbvie Inc | compostos úteis para produzir inibidores hcv protease |
SI2909205T1 (sl) | 2012-10-19 | 2017-02-28 | Bristol-Myers Squibb Company | 9-metil substituiran heksadekahidrociklopropa(e)pirolo(1,2-A)(1,4)diazaciklopentadecinil karbamat derivati kot nestrukturalni 3 (NS3) proteazni inhibitorji za zdravljenje hepatitis C virusnih infekcij |
WO2014071007A1 (en) | 2012-11-02 | 2014-05-08 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
WO2014070964A1 (en) | 2012-11-02 | 2014-05-08 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
US9643999B2 (en) | 2012-11-02 | 2017-05-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
EP2914614B1 (en) | 2012-11-05 | 2017-08-16 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
WO2014137869A1 (en) | 2013-03-07 | 2014-09-12 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
EP2970195B1 (en) | 2013-03-14 | 2017-08-02 | Achillion Pharmaceuticals, Inc. | Processes for producing sovaprevir |
WO2014145507A1 (en) | 2013-03-15 | 2014-09-18 | Achillion Pharmaceuticals, Inc. | A process for making a 4-amino-4-oxobutanoyl peptide cyclic analogue, an inhibitor of viral replication, and intermediates thereof |
KR20160005686A (ko) | 2013-03-15 | 2016-01-15 | 아칠리온 파르마세우티칼스 인코포레이티드 | 소바프레비르 다형체들 및 이의 제조 방법 |
US9085607B2 (en) | 2013-03-15 | 2015-07-21 | Achillion Pharmaceuticals, Inc. | ACH-0142684 sodium salt polymorph, composition including the same, and method of manufacture thereof |
EP3089757A1 (en) | 2014-01-03 | 2016-11-09 | AbbVie Inc. | Solid antiviral dosage forms |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5811515A (en) | 1995-06-12 | 1998-09-22 | California Institute Of Technology | Synthesis of conformationally restricted amino acids, peptides, and peptidomimetics by catalytic ring closing metathesis |
US6306987B1 (en) | 1997-06-27 | 2001-10-23 | Ciba Specialty Chemicals Corporation | Ruthenium and osmium catalysts |
US6323180B1 (en) | 1998-08-10 | 2001-11-27 | Boehringer Ingelheim (Canada) Ltd | Hepatitis C inhibitor tri-peptides |
AR022061A1 (es) | 1998-08-10 | 2002-09-04 | Boehringer Ingelheim Ca Ltd | Peptidos inhibidores de la hepatitis c, una composicion farmaceutica que los contiene, el uso de los mismos para preparar una composicion farmaceutica, el uso de un producto intermedio para la preparacion de estos peptidos y un procedimiento para la preparacion de un peptido analogo de los mismos. |
US6608027B1 (en) * | 1999-04-06 | 2003-08-19 | Boehringer Ingelheim (Canada) Ltd | Macrocyclic peptides active against the hepatitis C virus |
US7119072B2 (en) | 2002-01-30 | 2006-10-10 | Boehringer Ingelheim (Canada) Ltd. | Macrocyclic peptides active against the hepatitis C virus |
US20050075279A1 (en) * | 2002-10-25 | 2005-04-07 | Boehringer Ingelheim International Gmbh | Macrocyclic peptides active against the hepatitis C virus |
KR20060008877A (ko) * | 2003-04-10 | 2006-01-27 | 베링거 인겔하임 인터내셔날 게엠베하 | 루테늄 착물 촉매 존재하의 복분해 반응에 의한거대사이클릭 화합물의 제조방법 |
US7148347B2 (en) * | 2003-04-10 | 2006-12-12 | Boehringer Ingelheim International Gmbh | Process for preparing macrocyclic compounds |
ATE500264T1 (de) | 2003-09-22 | 2011-03-15 | Boehringer Ingelheim Int | Makrozyklische peptide mit wirkung gegen das hepatitis-c-virus |
-
2006
- 2006-09-08 EP EP06803140A patent/EP1934243B1/en active Active
- 2006-09-08 WO PCT/US2006/034921 patent/WO2007030656A1/en active Application Filing
- 2006-09-08 US US12/065,927 patent/US7951773B2/en active Active
- 2006-09-08 JP JP2008530207A patent/JP5190364B2/ja active Active
- 2006-09-08 AT AT06803140T patent/ATE510846T1/de active
- 2006-09-08 CA CA2621360A patent/CA2621360C/en active Active
- 2006-09-08 ES ES06803140T patent/ES2364426T3/es active Active
- 2006-09-08 PL PL06803140T patent/PL1934243T3/pl unknown
- 2006-09-08 DK DK06803140.0T patent/DK1934243T3/da active
Also Published As
Publication number | Publication date |
---|---|
PL1934243T3 (pl) | 2011-10-31 |
US20080242835A1 (en) | 2008-10-02 |
WO2007030656A8 (en) | 2007-07-05 |
ATE510846T1 (de) | 2011-06-15 |
JP2009509933A (ja) | 2009-03-12 |
JP5190364B2 (ja) | 2013-04-24 |
CA2621360C (en) | 2013-12-24 |
EP1934243A1 (en) | 2008-06-25 |
US7951773B2 (en) | 2011-05-31 |
EP1934243B1 (en) | 2011-05-25 |
ES2364426T3 (es) | 2011-09-02 |
CA2621360A1 (en) | 2007-03-15 |
WO2007030656A1 (en) | 2007-03-15 |
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