ES2322602T3 - Compuestos heterotetraciclicos condensados y su uso como inhibidor de polimerasa del vhc. - Google Patents
Compuestos heterotetraciclicos condensados y su uso como inhibidor de polimerasa del vhc. Download PDFInfo
- Publication number
- ES2322602T3 ES2322602T3 ES05710778T ES05710778T ES2322602T3 ES 2322602 T3 ES2322602 T3 ES 2322602T3 ES 05710778 T ES05710778 T ES 05710778T ES 05710778 T ES05710778 T ES 05710778T ES 2322602 T3 ES2322602 T3 ES 2322602T3
- Authority
- ES
- Spain
- Prior art keywords
- polymerase inhibitor
- heterotethyclic
- condensed
- compounds
- hcv
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Abstract
Un compuesto representado por la siguiente fórmula [I] o una de sus sales farmacéuticamente aceptables: **(Ver fórmula)** en donde **(Ver fórmula)** es C=C-N o N-C=C, G 3 , G 4 y G 5 son cada uno de modo independiente un átomo de carbono o un átomo de nitrógeno, cuando al menos uno de G 3 , G 4 y G 5 es un átomo de carbono, dicho átomo de carbono está opcionalmente sustituido con R3 , Q es (1) -(CH2)b- o (2) -(CH2)c-Q1 -(CH2)d- (en donde b es un número entero de 1 a 4, c y d son cada uno de modo independiente 0 o un número entero de 1 a 4, Q 1 es (1'') -O-, (2'') -NH-, (3'') -S-, (4'') -OCO-, (5'') -OCONH-( 6'') -CO-, (7'') -SO-, (8'') -SO2-, (9'') -NHCO-, (10'') -NHSO2-, (11'') -NHCOO-, (12'') -COO-, ...
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2004-48815 | 2004-02-24 | ||
JP2004048815 | 2004-02-24 | ||
JP2004169190 | 2004-06-07 | ||
JP2004-169190 | 2004-06-07 | ||
JP2004296390 | 2004-10-08 | ||
JP2004-296390 | 2004-10-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2322602T3 true ES2322602T3 (es) | 2009-06-23 |
Family
ID=34890893
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES05710778T Active ES2322602T3 (es) | 2004-02-24 | 2005-02-24 | Compuestos heterotetraciclicos condensados y su uso como inhibidor de polimerasa del vhc. |
Country Status (13)
Country | Link |
---|---|
EP (2) | EP1719773B1 (es) |
JP (2) | JP4143669B2 (es) |
AT (1) | ATE428714T1 (es) |
CY (1) | CY1109183T1 (es) |
DE (1) | DE602005013922D1 (es) |
DK (1) | DK1719773T3 (es) |
ES (1) | ES2322602T3 (es) |
HR (1) | HRP20090250T1 (es) |
PL (1) | PL1719773T3 (es) |
PT (1) | PT1719773E (es) |
RS (1) | RS50815B (es) |
SI (1) | SI1719773T1 (es) |
WO (1) | WO2005080399A1 (es) |
Families Citing this family (73)
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US20070049593A1 (en) | 2004-02-24 | 2007-03-01 | Japan Tobacco Inc. | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor |
PL1719773T3 (pl) * | 2004-02-24 | 2009-08-31 | Japan Tobacco Inc | Skondensowane związki heterotetracykliczne i ich zastosowanie jako inhibitora polimerazy HCV |
US7153848B2 (en) | 2004-08-09 | 2006-12-26 | Bristol-Myers Squibb Company | Inhibitors of HCV replication |
CA2585113A1 (en) * | 2004-10-26 | 2006-05-04 | Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa | Tetracyclic indole derivatives as antiviral agents |
US7795247B2 (en) | 2004-10-26 | 2010-09-14 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa | Tetracyclic indole derivatives as antiviral agents |
US7659263B2 (en) | 2004-11-12 | 2010-02-09 | Japan Tobacco Inc. | Thienopyrrole compound and use thereof as HCV polymerase inhibitor |
CA2606195C (en) | 2005-05-02 | 2015-03-31 | Merck And Co., Inc. | Hcv ns3 protease inhibitors |
BRPI0614205A2 (pt) | 2005-08-01 | 2016-11-22 | Merck & Co Inc | composto, composição farmacêutica, e, uso de composto |
GB0518390D0 (en) * | 2005-09-09 | 2005-10-19 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
US7399758B2 (en) | 2005-09-12 | 2008-07-15 | Meanwell Nicholas A | Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors |
US7473688B2 (en) * | 2005-09-13 | 2009-01-06 | Bristol-Myers Squibb Company | Indolobenzazepine HCV NS5B inhibitors |
GB0522881D0 (en) * | 2005-11-10 | 2005-12-21 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
WO2007092000A1 (en) * | 2006-02-06 | 2007-08-16 | Bristol-Myers Squibb Company | Inhibitors of hcv replication |
US7456165B2 (en) | 2006-02-08 | 2008-11-25 | Bristol-Myers Squibb Company | HCV NS5B inhibitors |
GB0608928D0 (en) * | 2006-05-08 | 2006-06-14 | Angeletti P Ist Richerche Bio | Therapeutic agents |
GB0609492D0 (en) | 2006-05-15 | 2006-06-21 | Angeletti P Ist Richerche Bio | Therapeutic agents |
US7521443B2 (en) | 2006-05-17 | 2009-04-21 | Bristol-Myers Squibb Company | Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors |
US7456166B2 (en) | 2006-05-17 | 2008-11-25 | Bristol-Myers Squibb Company | Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors |
US7521441B2 (en) | 2006-05-22 | 2009-04-21 | Bristol-Myers Squibb Company | Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors |
EP2029606B1 (en) * | 2006-05-25 | 2010-05-26 | Brystol-Myers Squibb Company | Cyclopropyl fused indolobenzazepine hcv ns5b inhibitors |
US7521442B2 (en) | 2006-05-25 | 2009-04-21 | Bristol-Myers Squibb Company | Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors |
US7452876B2 (en) | 2006-06-08 | 2008-11-18 | Bristol-Myers Squibb Company | Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors |
GB0612423D0 (en) | 2006-06-23 | 2006-08-02 | Angeletti P Ist Richerche Bio | Therapeutic agents |
CN101528741A (zh) * | 2006-07-20 | 2009-09-09 | 健亚生物科技公司 | 多环病毒抑制剂 |
CN101583372A (zh) | 2006-10-24 | 2009-11-18 | 默克公司 | Hcv ns3蛋白酶抑制剂 |
EP2076278B1 (en) | 2006-10-24 | 2015-05-06 | Merck Sharp & Dohme Corp. | Macrocyclic HCV NS3 protease inhibitors |
JP5345541B2 (ja) | 2006-10-24 | 2013-11-20 | メルク・シャープ・アンド・ドーム・コーポレーション | Hcvns3プロテアーゼ阻害剤 |
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-
2005
- 2005-02-24 PL PL05710778T patent/PL1719773T3/pl unknown
- 2005-02-24 JP JP2006510349A patent/JP4143669B2/ja not_active Expired - Fee Related
- 2005-02-24 ES ES05710778T patent/ES2322602T3/es active Active
- 2005-02-24 AT AT05710778T patent/ATE428714T1/de active
- 2005-02-24 EP EP05710778A patent/EP1719773B1/en active Active
- 2005-02-24 DE DE602005013922T patent/DE602005013922D1/de active Active
- 2005-02-24 SI SI200530714T patent/SI1719773T1/sl unknown
- 2005-02-24 EP EP09157033A patent/EP2206715A1/en not_active Withdrawn
- 2005-02-24 RS RSP-2009/0284A patent/RS50815B/sr unknown
- 2005-02-24 WO PCT/JP2005/003555 patent/WO2005080399A1/ja active Application Filing
- 2005-02-24 PT PT05710778T patent/PT1719773E/pt unknown
- 2005-02-24 DK DK05710778T patent/DK1719773T3/da active
-
2008
- 2008-05-09 JP JP2008124017A patent/JP2008208139A/ja not_active Ceased
-
2009
- 2009-04-29 HR HR20090250T patent/HRP20090250T1/xx unknown
- 2009-06-15 CY CY20091100633T patent/CY1109183T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP1719773A4 (en) | 2008-05-07 |
HRP20090250T1 (en) | 2009-06-30 |
WO2005080399A1 (ja) | 2005-09-01 |
SI1719773T1 (sl) | 2009-08-31 |
JPWO2005080399A1 (ja) | 2008-01-10 |
PT1719773E (pt) | 2009-06-03 |
CY1109183T1 (el) | 2014-07-02 |
EP1719773B1 (en) | 2009-04-15 |
EP2206715A1 (en) | 2010-07-14 |
JP2008208139A (ja) | 2008-09-11 |
DE602005013922D1 (de) | 2009-05-28 |
EP1719773A1 (en) | 2006-11-08 |
JP4143669B2 (ja) | 2008-09-03 |
RS50815B (sr) | 2010-08-31 |
DK1719773T3 (da) | 2009-06-29 |
ATE428714T1 (de) | 2009-05-15 |
PL1719773T3 (pl) | 2009-08-31 |
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