MX2011012541A - Compuestos heterociclicos antivirales. - Google Patents
Compuestos heterociclicos antivirales.Info
- Publication number
- MX2011012541A MX2011012541A MX2011012541A MX2011012541A MX2011012541A MX 2011012541 A MX2011012541 A MX 2011012541A MX 2011012541 A MX2011012541 A MX 2011012541A MX 2011012541 A MX2011012541 A MX 2011012541A MX 2011012541 A MX2011012541 A MX 2011012541A
- Authority
- MX
- Mexico
- Prior art keywords
- antiviral compound
- heterocyclic antiviral
- heterocyclic
- hepatitis
- compositions
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 230000000840 anti-viral effect Effects 0.000 title 1
- 125000000623 heterocyclic group Chemical group 0.000 title 1
- 108700008776 hepatitis C virus NS-5 Proteins 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000010076 replication Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/10—Oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
- C07D233/34—Ethylene-urea
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
- C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/18—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/15—Six-membered rings
- C07D285/16—Thiadiazines; Hydrogenated thiadiazines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Los compuestos que tienen la fórmula I, en la que R1, R2, R3, R4, y R5 tienen los significados aquí definidos, son inhibidores de la polimerasa NS5B del virus de la hepatitis C. Se describen también composiciones y métodos para tratar una infección del HCV y para inhibir la replicación del HCV.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21997709P | 2009-06-24 | 2009-06-24 | |
PCT/EP2010/058681 WO2010149598A2 (en) | 2009-06-24 | 2010-06-21 | Heterocyclic antiviral compound |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2011012541A true MX2011012541A (es) | 2012-08-03 |
Family
ID=42942262
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2011012541A MX2011012541A (es) | 2009-06-24 | 2010-06-21 | Compuestos heterociclicos antivirales. |
Country Status (13)
Country | Link |
---|---|
US (1) | US8158631B2 (es) |
EP (1) | EP2445875A2 (es) |
JP (1) | JP2012530751A (es) |
CN (1) | CN102803212A (es) |
AR (1) | AR077173A1 (es) |
AU (1) | AU2010264802A1 (es) |
BR (1) | BRPI1011744A2 (es) |
CA (1) | CA2762675A1 (es) |
IL (1) | IL216338A0 (es) |
MX (1) | MX2011012541A (es) |
SG (1) | SG176976A1 (es) |
TW (1) | TW201103545A (es) |
WO (1) | WO2010149598A2 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8178547B2 (en) * | 2008-12-22 | 2012-05-15 | Roche Palo Alto Llc | Heterocyclic antiviral compounds |
EP2411352B1 (en) * | 2009-03-25 | 2017-01-18 | AbbVie Inc. | Antiviral compounds and uses thereof |
US8975443B2 (en) | 2010-07-16 | 2015-03-10 | Abbvie Inc. | Phosphine ligands for catalytic reactions |
JP6030057B2 (ja) | 2010-07-16 | 2016-11-24 | アッヴィ・バハマズ・リミテッド | 触媒反応用ホスフィンリガンド |
US9255074B2 (en) | 2010-07-16 | 2016-02-09 | Abbvie Inc. | Process for preparing antiviral compounds |
KR101893751B1 (ko) | 2010-07-16 | 2018-09-03 | 애브비 아일랜드 언리미티드 컴퍼니 | 항바이러스성 화합물의 제조 방법 |
CA2882624A1 (en) * | 2012-08-21 | 2014-02-27 | Shashank Shekhar | Process for preparing antiviral compounds |
CN110483496B (zh) * | 2019-07-17 | 2021-05-04 | 杭州市西溪医院 | 一类具有尿嘧啶-苯并噻唑结构衍生物、其制备方法及抗hcv药物的应用 |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU1407899A (en) * | 1997-12-01 | 1999-06-16 | E.I. Du Pont De Nemours And Company | Fungicidal cyclic amides |
US6323180B1 (en) | 1998-08-10 | 2001-11-27 | Boehringer Ingelheim (Canada) Ltd | Hepatitis C inhibitor tri-peptides |
DE19932813A1 (de) * | 1999-07-14 | 2001-01-18 | Bayer Ag | Substituierte Phenyluracile |
DE60034027T2 (de) | 1999-12-24 | 2007-12-13 | Asahi Glass Co., Ltd. | Siliziumnitridfilter und verfahren zu dessen herstellung |
JP2004509066A (ja) | 2000-05-10 | 2004-03-25 | スミスクライン・ビーチャム・コーポレイション | 新規抗感染症薬 |
US6448281B1 (en) | 2000-07-06 | 2002-09-10 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
AR036081A1 (es) | 2001-06-07 | 2004-08-11 | Smithkline Beecham Corp | Compuesto de 1,2-dihidroquinolina, su uso para preparar una composicion farmaceutica, metodos para prepararlo y compuestos del acido 2-aminobenzoico n-alquilado de utilidad como intermediarios en dichos metodos |
AR035543A1 (es) | 2001-06-26 | 2004-06-16 | Japan Tobacco Inc | Agente terapeutico para la hepatitis c que comprende un compuesto de anillo condensado, compuesto de anillo condensado, composicion farmaceutica que lo comprende, compuestos de benzimidazol, tiazol y bifenilo utiles como intermediarios para producir dichos compuestos, uso del compuesto de anillo con |
JP4558314B2 (ja) | 2001-07-20 | 2010-10-06 | ベーリンガー インゲルハイム (カナダ) リミテッド | ウイルスポリメラーゼインヒビター |
US6899700B2 (en) | 2001-08-29 | 2005-05-31 | Kimberly-Clark Worldwide, Inc. | Therapeutic agent delivery tampon |
AU2002359320A1 (en) | 2001-10-29 | 2003-05-12 | Smithkline Beecham Corporation | Novel anit-infectives |
WO2003059356A2 (en) | 2001-10-30 | 2003-07-24 | Smithkline Beecham Corporation | Novel anti-infectives |
AU2003248566A1 (en) | 2002-05-24 | 2003-12-12 | Smithkline Beecham Corporation | Novel anti-infectives |
MXPA05004670A (es) | 2002-11-01 | 2005-08-18 | Abbott Lab | Agentes anti-infecciones. |
GB0225986D0 (en) * | 2002-11-07 | 2002-12-11 | Astrazeneca Ab | Chemical compounds |
TWI332507B (en) | 2002-11-19 | 2010-11-01 | Hoffmann La Roche | Antiviral nucleoside derivatives |
GB0228410D0 (en) * | 2002-12-05 | 2003-01-08 | Glaxo Group Ltd | Novel Compounds |
AU2003300956A1 (en) | 2002-12-11 | 2004-06-30 | Smithkline Beecham Corporation | Anti-infectives |
AU2003300957A1 (en) | 2002-12-11 | 2004-06-30 | Smithkline Beecham Corporation | Anti-infectives |
WO2004058150A2 (en) | 2002-12-17 | 2004-07-15 | Smithkline Beecham Corporation | Anti-infectives |
WO2005019191A2 (en) | 2003-08-25 | 2005-03-03 | Abbott Laboratories | 1, 1-dioxido-4h-1,2,4-benzothiadiazine derivate und verwandte verbindungen als inhibitoren der hcv polymerase zur behandlung von hepatitis c |
EP1786807B1 (en) | 2004-08-23 | 2009-07-29 | F.Hoffmann-La Roche Ag | Heterocyclic antiviral compounds |
CA2607089A1 (en) | 2005-05-04 | 2006-11-09 | F. Hoffmann-La Roche Ag | Heterocyclic antiviral compounds |
JP5258889B2 (ja) | 2007-08-29 | 2013-08-07 | メルク・シャープ・アンド・ドーム・コーポレーション | ウイルス感染症の治療のための2,3−置換アザインドール誘導体 |
TW200924751A (en) | 2007-08-29 | 2009-06-16 | Schering Corp | 2,3-substituted indole derivatives and methods of use thereof |
AU2008295483B2 (en) | 2007-08-29 | 2013-11-21 | Merck Sharp & Dohme Corp. | Tetracyclic indole derivatives and their use for treating or preventing viral infections |
PA8796201A1 (es) * | 2007-09-17 | 2009-04-23 | Abbott Lab | Agentes anti-infecciosos y su uso |
JP5726527B2 (ja) * | 2007-09-17 | 2015-06-03 | アッヴィ・バハマズ・リミテッド | C型肝炎ウイルス(hcv)阻害薬として有用なn−フェニル−ジオキソ−ヒドロピリミジン |
EP2368882B1 (en) | 2007-09-17 | 2014-08-13 | AbbVie Bahamas Ltd. | Anti-infective pyrimidines and uses thereof |
CA2705586A1 (en) | 2007-11-16 | 2009-05-22 | Schering Corporation | 3-heterocyclic substituted indole derivatives and methods of use thereof |
CN102317285A (zh) | 2007-11-16 | 2012-01-11 | 先灵公司 | 3-氨基磺酰基取代的吲哚衍生物及其使用方法 |
EP2411352B1 (en) | 2009-03-25 | 2017-01-18 | AbbVie Inc. | Antiviral compounds and uses thereof |
MX2011010047A (es) | 2009-03-25 | 2011-10-11 | Abbott Lab | Compuestos antivirales y usos de los mismos. |
-
2010
- 2010-06-21 SG SG2011095742A patent/SG176976A1/en unknown
- 2010-06-21 WO PCT/EP2010/058681 patent/WO2010149598A2/en active Application Filing
- 2010-06-21 CN CN2010800278002A patent/CN102803212A/zh active Pending
- 2010-06-21 JP JP2012516672A patent/JP2012530751A/ja active Pending
- 2010-06-21 EP EP10726075A patent/EP2445875A2/en not_active Withdrawn
- 2010-06-21 CA CA2762675A patent/CA2762675A1/en not_active Abandoned
- 2010-06-21 TW TW099120135A patent/TW201103545A/zh unknown
- 2010-06-21 BR BRPI1011744A patent/BRPI1011744A2/pt not_active Application Discontinuation
- 2010-06-21 MX MX2011012541A patent/MX2011012541A/es not_active Application Discontinuation
- 2010-06-21 AU AU2010264802A patent/AU2010264802A1/en not_active Abandoned
- 2010-06-22 AR ARP100102180A patent/AR077173A1/es unknown
- 2010-06-24 US US12/822,630 patent/US8158631B2/en not_active Expired - Fee Related
-
2011
- 2011-11-14 IL IL216338A patent/IL216338A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
JP2012530751A (ja) | 2012-12-06 |
BRPI1011744A2 (pt) | 2016-03-22 |
TW201103545A (en) | 2011-02-01 |
AR077173A1 (es) | 2011-08-10 |
IL216338A0 (en) | 2012-01-31 |
US20100330032A1 (en) | 2010-12-30 |
EP2445875A2 (en) | 2012-05-02 |
WO2010149598A3 (en) | 2011-05-19 |
WO2010149598A2 (en) | 2010-12-29 |
CN102803212A (zh) | 2012-11-28 |
CA2762675A1 (en) | 2010-12-29 |
SG176976A1 (en) | 2012-02-28 |
AU2010264802A1 (en) | 2012-01-19 |
US8158631B2 (en) | 2012-04-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |