MX2012006513A - Compuestos heterociclicos antivirales. - Google Patents

Compuestos heterociclicos antivirales.

Info

Publication number
MX2012006513A
MX2012006513A MX2012006513A MX2012006513A MX2012006513A MX 2012006513 A MX2012006513 A MX 2012006513A MX 2012006513 A MX2012006513 A MX 2012006513A MX 2012006513 A MX2012006513 A MX 2012006513A MX 2012006513 A MX2012006513 A MX 2012006513A
Authority
MX
Mexico
Prior art keywords
antiviral compounds
heterocyclic antiviral
heterocyclic
compounds
rdand
Prior art date
Application number
MX2012006513A
Other languages
English (en)
Inventor
Francisco Xavier Talamas
Ryan Craig Schoenfeld
Leanna Renee Staben
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2012006513A publication Critical patent/MX2012006513A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Los compuestos que tienen la fórmula I, en la que R1, R2, R3, R4, R5, Ra, Rb, Rc, Rd y n tienen los significados aquí definidos son inhibidores de la polimerasa NS5b del virus de la hepatitis C. Se describen también composiciones y métodos para tratar una infección del HCV y para inhibir la replicación del HCV. (ver fórmula (I)).
MX2012006513A 2009-12-14 2010-12-13 Compuestos heterociclicos antivirales. MX2012006513A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28613609P 2009-12-14 2009-12-14
PCT/EP2010/069442 WO2011073114A1 (en) 2009-12-14 2010-12-13 Heterocyclic antiviral compounds

Publications (1)

Publication Number Publication Date
MX2012006513A true MX2012006513A (es) 2012-07-17

Family

ID=43446588

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012006513A MX2012006513A (es) 2009-12-14 2010-12-13 Compuestos heterociclicos antivirales.

Country Status (12)

Country Link
US (1) US20110123490A1 (es)
EP (1) EP2513092A1 (es)
JP (1) JP2013513584A (es)
KR (1) KR20120104343A (es)
CN (1) CN102652134A (es)
AR (1) AR079440A1 (es)
BR (1) BR112012014299A2 (es)
CA (1) CA2780526A1 (es)
MX (1) MX2012006513A (es)
RU (1) RU2012129657A (es)
TW (1) TW201144298A (es)
WO (1) WO2011073114A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102256968A (zh) * 2008-12-22 2011-11-23 弗·哈夫曼-拉罗切有限公司 杂环抗病毒化合物
BR112012015868A2 (pt) 2009-12-11 2017-06-20 Autifony Therapeutics Ltd derivados de imidazolidinadiona
SG190203A1 (en) 2010-12-06 2013-06-28 Autifony Therapeutics Ltd Hydantoin derivatives useful as kv3 inhibitors
CN103596943B (zh) 2011-06-07 2016-10-12 奥蒂福尼疗法有限公司 用作kv3抑制剂的乙内酰脲衍生物
PL2788339T3 (pl) * 2011-12-06 2016-09-30 Pochodne hydantoiny przydatne jako inhibitory KV3
EP2852588B8 (en) 2012-05-22 2018-01-10 Autifony Therapeutics Limited Hydantoin derivatives as kv3 inhibitors
US9422252B2 (en) 2012-05-22 2016-08-23 Autifony Therapeutics Limited Triazoles as Kv3 inhibitors
WO2015197028A1 (en) * 2014-06-28 2015-12-30 Sunshine Lake Pharma Co., Ltd. Compounds as hepatitis c virus (hcv) inhibitors and uses thereof in medicine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ600371A (en) * 2007-09-17 2014-07-25 Abbvie Bahamas Ltd Uracil or thymine derivative for treating hepatitis c
SI2203431T1 (sl) * 2007-09-17 2011-12-30 Abbott Lab Antiinfekcijski pririmidini in njihove uporabe
RU2552533C2 (ru) * 2009-03-25 2015-06-10 Эббви Инк. Противовирусные соединения и их применения

Also Published As

Publication number Publication date
AR079440A1 (es) 2012-01-25
CA2780526A1 (en) 2011-06-23
CN102652134A (zh) 2012-08-29
WO2011073114A1 (en) 2011-06-23
RU2012129657A (ru) 2014-01-27
EP2513092A1 (en) 2012-10-24
JP2013513584A (ja) 2013-04-22
KR20120104343A (ko) 2012-09-20
TW201144298A (en) 2011-12-16
BR112012014299A2 (pt) 2016-07-05
US20110123490A1 (en) 2011-05-26

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