MX337050B - Compuestos 4'-azido-nucleósidos como anti-vhc. - Google Patents

Compuestos 4'-azido-nucleósidos como anti-vhc.

Info

Publication number
MX337050B
MX337050B MX2012008443A MX2012008443A MX337050B MX 337050 B MX337050 B MX 337050B MX 2012008443 A MX2012008443 A MX 2012008443A MX 2012008443 A MX2012008443 A MX 2012008443A MX 337050 B MX337050 B MX 337050B
Authority
MX
Mexico
Prior art keywords
hcv
compunds
nucleosides
azido
hepatitis
Prior art date
Application number
MX2012008443A
Other languages
English (en)
Other versions
MX2012008443A (es
Inventor
David Bernard Smith
Keshab Sarma
Han Ma
Original Assignee
Riboscience Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Riboscience Llc filed Critical Riboscience Llc
Publication of MX2012008443A publication Critical patent/MX2012008443A/es
Publication of MX337050B publication Critical patent/MX337050B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Abstract

Compuestos que presentan la fórmula I, en la que R1, R2 y R3 son tal como se define en la presente memoria, inhibidores de la polimerasa NS5b del virus de la hepatitis C. También se dan a conocer composiciones y métodos para el tratamiento de una infección por VHC y para inhibir la replicación del VHC (Ver Formula).
MX2012008443A 2010-01-28 2011-01-25 Compuestos 4'-azido-nucleósidos como anti-vhc. MX337050B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29922910P 2010-01-28 2010-01-28
PCT/EP2011/050971 WO2011092158A1 (en) 2010-01-28 2011-01-25 4 ' - azido - nucleosides as anti - hcv compunds

Publications (2)

Publication Number Publication Date
MX2012008443A MX2012008443A (es) 2012-08-15
MX337050B true MX337050B (es) 2016-02-10

Family

ID=43587111

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012008443A MX337050B (es) 2010-01-28 2011-01-25 Compuestos 4'-azido-nucleósidos como anti-vhc.

Country Status (16)

Country Link
US (1) US8236779B2 (es)
EP (1) EP2528930B1 (es)
JP (1) JP5675849B2 (es)
KR (1) KR101384389B1 (es)
CN (1) CN102725303B (es)
BR (1) BR112012015951A2 (es)
CA (1) CA2784330C (es)
DK (1) DK2528930T3 (es)
ES (1) ES2437933T3 (es)
HK (1) HK1176938A1 (es)
MX (1) MX337050B (es)
PL (1) PL2528930T3 (es)
PT (1) PT2528930E (es)
RU (1) RU2556991C2 (es)
TW (1) TW201141488A (es)
WO (1) WO2011092158A1 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2812962C (en) * 2010-09-22 2020-03-31 Alios Biopharma, Inc. Azido nucleosides and nucleotide analogs
CA2843324A1 (en) 2011-03-31 2012-11-15 Idenix Pharmaceuticals, Inc. Compounds and pharmaceutical compositions for the treatment of viral infections
AR088441A1 (es) 2011-09-12 2014-06-11 Idenix Pharmaceuticals Inc Compuestos de carboniloximetilfosforamidato sustituido y composiciones farmaceuticas para el tratamiento de infecciones virales
AR089650A1 (es) 2011-10-14 2014-09-10 Idenix Pharmaceuticals Inc Fosfatos 3,5-ciclicos sustituidos de compuestos de nucleotido de purina y composiciones farmaceuticas para el tratamiento de infecciones virales
WO2013177188A1 (en) 2012-05-22 2013-11-28 Idenix Pharmaceuticals, Inc. 3',5'-cyclic phosphoramidate prodrugs for hcv infection
PE20150132A1 (es) 2012-05-22 2015-02-14 Idenix Pharmaceuticals Inc Compuestos d-aminoacidos para enfermedad hepatica
US9296778B2 (en) 2012-05-22 2016-03-29 Idenix Pharmaceuticals, Inc. 3′,5′-cyclic phosphate prodrugs for HCV infection
CA2871547C (en) 2012-05-25 2021-05-25 Janssen R&D Ireland Uracyl spirooxetane nucleosides
WO2014052638A1 (en) 2012-09-27 2014-04-03 Idenix Pharmaceuticals, Inc. Esters and malonates of sate prodrugs
AP2015008384A0 (en) 2012-10-08 2015-04-30 Univ Montpellier Ct Nat De La Rech Scient 2'-Chloro nucleoside analogs for hcv infection
WO2014066239A1 (en) 2012-10-22 2014-05-01 Idenix Pharmaceuticals, Inc. 2',4'-bridged nucleosides for hcv infection
US9211300B2 (en) 2012-12-19 2015-12-15 Idenix Pharmaceuticals Llc 4′-fluoro nucleosides for the treatment of HCV
WO2014137930A1 (en) 2013-03-04 2014-09-12 Idenix Pharmaceuticals, Inc. Thiophosphate nucleosides for the treatment of hcv
US9309275B2 (en) 2013-03-04 2016-04-12 Idenix Pharmaceuticals Llc 3′-deoxy nucleosides for the treatment of HCV
WO2014160484A1 (en) 2013-03-13 2014-10-02 Idenix Pharmaceuticals, Inc. Amino acid phosphoramidate pronucleotides of 2'-cyano, azido and amino nucleosides for the treatment of hcv
WO2014165542A1 (en) 2013-04-01 2014-10-09 Idenix Pharmaceuticals, Inc. 2',4'-fluoro nucleosides for the treatment of hcv
EP3004130B1 (en) 2013-06-05 2019-08-07 Idenix Pharmaceuticals LLC. 1',4'-thio nucleosides for the treatment of hcv
WO2015017713A1 (en) 2013-08-01 2015-02-05 Idenix Pharmaceuticals, Inc. D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease
WO2015161137A1 (en) 2014-04-16 2015-10-22 Idenix Pharmaceuticals, Inc. 3'-substituted methyl or alkynyl nucleosides for the treatment of hcv
EP3845221B1 (en) * 2014-06-13 2023-12-13 Ratiopharm GmbH Solid state forms of sofosbuvir
HRP20211456T1 (hr) 2014-12-26 2021-12-24 Emory University Protuvirusni derivati n4-hidroksicitidina
WO2016204531A1 (ko) * 2015-06-16 2016-12-22 엘지전자(주) 블록 경계에 따라 적응적으로 필터링을 수행하는 방법 및 장치
US11331331B2 (en) 2017-12-07 2022-05-17 Emory University N4-hydroxycytidine and derivatives and anti-viral uses related thereto
CN113880903A (zh) * 2021-09-23 2022-01-04 厦门蔚嘉制药有限公司 莫那比拉韦的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7094770B2 (en) * 2000-04-13 2006-08-22 Pharmasset, Ltd. 3′-or 2′-hydroxymethyl substituted nucleoside derivatives for treatment of hepatitis virus infections
CN1646141B (zh) * 2000-10-18 2014-06-25 吉利德制药有限责任公司 用于治疗病毒感染和异常细胞增殖的修饰核苷类化合物
EP1707571B1 (en) * 2001-01-22 2011-09-28 Merck Sharp & Dohme Corp. Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase
GB0114286D0 (en) * 2001-06-12 2001-08-01 Hoffmann La Roche Nucleoside Derivatives
AU2003232071A1 (en) * 2002-05-06 2003-11-17 Genelabs Technologies, Inc. Nucleoside derivatives for treating hepatitis c virus infection
TWI332507B (en) 2002-11-19 2010-11-01 Hoffmann La Roche Antiviral nucleoside derivatives
CN100351264C (zh) * 2002-11-19 2007-11-28 霍夫曼-拉罗奇有限公司 抗病毒核苷衍生物
ATE482690T1 (de) * 2005-12-14 2010-10-15 Hoffmann La Roche Hcv-prodrug-formulierung
US20090318380A1 (en) * 2007-11-20 2009-12-24 Pharmasset, Inc. 2',4'-substituted nucleosides as antiviral agents
CL2008003511A1 (es) * 2007-11-29 2010-02-19 Metabasis Therapeutics Inc Compuestos derivados nucleotidicos, inhibidores de polimerasa ns5b del virus de la hepatitis c; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de la hepatitis c.

Also Published As

Publication number Publication date
CN102725303B (zh) 2015-05-27
JP5675849B2 (ja) 2015-02-25
RU2012136379A (ru) 2014-03-10
EP2528930A1 (en) 2012-12-05
BR112012015951A2 (pt) 2018-10-16
MX2012008443A (es) 2012-08-15
KR20120110177A (ko) 2012-10-09
US20110150829A1 (en) 2011-06-23
RU2556991C2 (ru) 2015-07-20
TW201141488A (en) 2011-12-01
US8236779B2 (en) 2012-08-07
KR101384389B1 (ko) 2014-04-10
DK2528930T3 (da) 2013-11-11
CN102725303A (zh) 2012-10-10
CA2784330A1 (en) 2011-08-04
WO2011092158A1 (en) 2011-08-04
PL2528930T3 (pl) 2014-03-31
HK1176938A1 (en) 2013-08-09
JP2013518076A (ja) 2013-05-20
EP2528930B1 (en) 2013-10-30
PT2528930E (pt) 2013-11-26
CA2784330C (en) 2018-02-13
ES2437933T3 (es) 2014-01-15

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Legal Events

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Owner name: RIBOSCIENCE LLC

FG Grant or registration