DK2528930T3 - 4'-azido-nukleosider som anti-hcv-forbindelser - Google Patents
4'-azido-nukleosider som anti-hcv-forbindelserInfo
- Publication number
- DK2528930T3 DK2528930T3 DK11701107.2T DK11701107T DK2528930T3 DK 2528930 T3 DK2528930 T3 DK 2528930T3 DK 11701107 T DK11701107 T DK 11701107T DK 2528930 T3 DK2528930 T3 DK 2528930T3
- Authority
- DK
- Denmark
- Prior art keywords
- hcv compounds
- azido nucleosides
- nucleosides
- azido
- hcv
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29922910P | 2010-01-28 | 2010-01-28 | |
| PCT/EP2011/050971 WO2011092158A1 (en) | 2010-01-28 | 2011-01-25 | 4 ' - azido - nucleosides as anti - hcv compunds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2528930T3 true DK2528930T3 (da) | 2013-11-11 |
Family
ID=43587111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK11701107.2T DK2528930T3 (da) | 2010-01-28 | 2011-01-25 | 4'-azido-nukleosider som anti-hcv-forbindelser |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8236779B2 (da) |
| EP (1) | EP2528930B1 (da) |
| JP (1) | JP5675849B2 (da) |
| KR (1) | KR101384389B1 (da) |
| CN (1) | CN102725303B (da) |
| BR (1) | BR112012015951A2 (da) |
| CA (1) | CA2784330C (da) |
| DK (1) | DK2528930T3 (da) |
| ES (1) | ES2437933T3 (da) |
| HK (1) | HK1176938A1 (da) |
| MX (1) | MX337050B (da) |
| PL (1) | PL2528930T3 (da) |
| PT (1) | PT2528930E (da) |
| RU (1) | RU2556991C2 (da) |
| TW (1) | TW201141488A (da) |
| WO (1) | WO2011092158A1 (da) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2701020T3 (es) * | 2010-09-22 | 2019-02-20 | Alios Biopharma Inc | Nucleósidos azido y análogos nucleotídicos |
| CA2843324A1 (en) | 2011-03-31 | 2012-11-15 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of viral infections |
| EP2755983B1 (en) | 2011-09-12 | 2017-03-15 | Idenix Pharmaceuticals LLC. | Substituted carbonyloxymethylphosphoramidate compounds and pharmaceutical compositions for the treatment of viral infections |
| US8507460B2 (en) | 2011-10-14 | 2013-08-13 | Idenix Pharmaceuticals, Inc. | Substituted 3′,5′-cyclic phosphates of purine nucleotide compounds and pharmaceutical compositions for the treatment of viral infections |
| WO2013177195A1 (en) | 2012-05-22 | 2013-11-28 | Idenix Pharmaceuticals, Inc. | 3',5'-cyclic phosphate prodrugs for hcv infection |
| US9109001B2 (en) | 2012-05-22 | 2015-08-18 | Idenix Pharmaceuticals, Inc. | 3′,5′-cyclic phosphoramidate prodrugs for HCV infection |
| MX355708B (es) | 2012-05-22 | 2018-04-27 | Idenix Pharmaceuticals Llc | Compuestos de d-aminoacidos para enfermedades del higado. |
| EP2861611B1 (en) | 2012-05-25 | 2016-07-13 | Janssen Sciences Ireland UC | Uracyl spirooxetane nucleosides |
| WO2014052638A1 (en) | 2012-09-27 | 2014-04-03 | Idenix Pharmaceuticals, Inc. | Esters and malonates of sate prodrugs |
| CA2887578A1 (en) | 2012-10-08 | 2014-04-17 | Idenix Pharamaceuticals, Inc. | 2'-chloro nucleoside analogs for hcv infection |
| US10723754B2 (en) | 2012-10-22 | 2020-07-28 | Idenix Pharmaceuticals Llc | 2′,4′-bridged nucleosides for HCV infection |
| EP2935304A1 (en) | 2012-12-19 | 2015-10-28 | IDENIX Pharmaceuticals, Inc. | 4'-fluoro nucleosides for the treatment of hcv |
| US9309275B2 (en) | 2013-03-04 | 2016-04-12 | Idenix Pharmaceuticals Llc | 3′-deoxy nucleosides for the treatment of HCV |
| US9339541B2 (en) | 2013-03-04 | 2016-05-17 | Merck Sharp & Dohme Corp. | Thiophosphate nucleosides for the treatment of HCV |
| EP2970357A1 (en) | 2013-03-13 | 2016-01-20 | IDENIX Pharmaceuticals, Inc. | Amino acid phosphoramidate pronucleotides of 2'-cyano, azido and amino nucleosides for the treatment of hcv |
| WO2014165542A1 (en) | 2013-04-01 | 2014-10-09 | Idenix Pharmaceuticals, Inc. | 2',4'-fluoro nucleosides for the treatment of hcv |
| EP3004130B1 (en) | 2013-06-05 | 2019-08-07 | Idenix Pharmaceuticals LLC. | 1',4'-thio nucleosides for the treatment of hcv |
| US20150037282A1 (en) | 2013-08-01 | 2015-02-05 | Idenix Pharmaceuticals, Inc. | D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease |
| EP3131914B1 (en) | 2014-04-16 | 2023-05-10 | Idenix Pharmaceuticals LLC | 3'-substituted methyl or alkynyl nucleosides for the treatment of hcv |
| SI3845221T1 (sl) * | 2014-06-13 | 2024-03-29 | Ratiopharm Gmbh | Trdne oblike sofosbuvirja |
| RS62434B1 (sr) | 2014-12-26 | 2021-11-30 | Univ Emory | Antivirusni n4-hidroksicitidin derivati |
| US10448015B2 (en) * | 2015-06-16 | 2019-10-15 | Lg Electronics Inc. | Method and device for performing adaptive filtering according to block boundary |
| KR102626210B1 (ko) | 2017-12-07 | 2024-01-18 | 에모리 유니버시티 | N4-하이드록시사이티딘 및 유도체 및 이와 관련된 항-바이러스 용도 |
| CN113880903B (zh) * | 2021-09-23 | 2024-07-02 | 厦门蔚嘉制药有限公司 | 莫那比拉韦的制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001259068A1 (en) * | 2000-04-13 | 2001-10-30 | Pharmasset, Ltd. | 3'-or 2'-hydroxymethyl substituted nucleoside derivatives for treatment of hepatitis virus infections |
| KR101195019B1 (ko) * | 2000-10-18 | 2012-10-29 | 파마셋 인코포레이티드 | 바이러스 감염 및 비정상적인 세포 증식의 치료를 위한 변형된 뉴클레오시드 |
| EP2399588B1 (en) * | 2001-01-22 | 2020-04-29 | Merck Sharp & Dohme Corp. | Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase |
| GB0114286D0 (en) * | 2001-06-12 | 2001-08-01 | Hoffmann La Roche | Nucleoside Derivatives |
| AU2003232071A1 (en) * | 2002-05-06 | 2003-11-17 | Genelabs Technologies, Inc. | Nucleoside derivatives for treating hepatitis c virus infection |
| TWI332507B (en) | 2002-11-19 | 2010-11-01 | Hoffmann La Roche | Antiviral nucleoside derivatives |
| CN100351264C (zh) * | 2002-11-19 | 2007-11-28 | 霍夫曼-拉罗奇有限公司 | 抗病毒核苷衍生物 |
| WO2007068615A2 (en) * | 2005-12-14 | 2007-06-21 | F. Hoffmann-La Roche Ag | Hcv prodrug formulation |
| US20090318380A1 (en) * | 2007-11-20 | 2009-12-24 | Pharmasset, Inc. | 2',4'-substituted nucleosides as antiviral agents |
| TW200936146A (en) | 2007-11-29 | 2009-09-01 | Metabasis Therapeutics Inc | Antiviral nucleoside compounds |
-
2011
- 2011-01-25 BR BR112012015951A patent/BR112012015951A2/pt active Search and Examination
- 2011-01-25 KR KR1020127022217A patent/KR101384389B1/ko not_active IP Right Cessation
- 2011-01-25 MX MX2012008443A patent/MX337050B/es active IP Right Grant
- 2011-01-25 CA CA2784330A patent/CA2784330C/en not_active Expired - Fee Related
- 2011-01-25 CN CN201180007367.0A patent/CN102725303B/zh not_active Expired - Fee Related
- 2011-01-25 PL PL11701107T patent/PL2528930T3/pl unknown
- 2011-01-25 PT PT117011072T patent/PT2528930E/pt unknown
- 2011-01-25 WO PCT/EP2011/050971 patent/WO2011092158A1/en active Application Filing
- 2011-01-25 DK DK11701107.2T patent/DK2528930T3/da active
- 2011-01-25 JP JP2012550415A patent/JP5675849B2/ja not_active Expired - Fee Related
- 2011-01-25 EP EP11701107.2A patent/EP2528930B1/en not_active Not-in-force
- 2011-01-25 RU RU2012136379/04A patent/RU2556991C2/ru not_active IP Right Cessation
- 2011-01-25 ES ES11701107.2T patent/ES2437933T3/es active Active
- 2011-01-25 TW TW100102705A patent/TW201141488A/zh unknown
- 2011-01-26 US US13/014,022 patent/US8236779B2/en not_active Expired - Fee Related
-
2013
- 2013-04-09 HK HK13104289.7A patent/HK1176938A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP2528930B1 (en) | 2013-10-30 |
| KR20120110177A (ko) | 2012-10-09 |
| BR112012015951A2 (pt) | 2018-10-16 |
| ES2437933T3 (es) | 2014-01-15 |
| RU2556991C2 (ru) | 2015-07-20 |
| CA2784330A1 (en) | 2011-08-04 |
| JP5675849B2 (ja) | 2015-02-25 |
| EP2528930A1 (en) | 2012-12-05 |
| RU2012136379A (ru) | 2014-03-10 |
| PT2528930E (pt) | 2013-11-26 |
| CN102725303A (zh) | 2012-10-10 |
| KR101384389B1 (ko) | 2014-04-10 |
| US20110150829A1 (en) | 2011-06-23 |
| MX337050B (es) | 2016-02-10 |
| MX2012008443A (es) | 2012-08-15 |
| TW201141488A (en) | 2011-12-01 |
| CA2784330C (en) | 2018-02-13 |
| US8236779B2 (en) | 2012-08-07 |
| JP2013518076A (ja) | 2013-05-20 |
| HK1176938A1 (en) | 2013-08-09 |
| PL2528930T3 (pl) | 2014-03-31 |
| CN102725303B (zh) | 2015-05-27 |
| WO2011092158A1 (en) | 2011-08-04 |
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