AR088441A1 - Compuestos de carboniloximetilfosforamidato sustituido y composiciones farmaceuticas para el tratamiento de infecciones virales - Google Patents

Compuestos de carboniloximetilfosforamidato sustituido y composiciones farmaceuticas para el tratamiento de infecciones virales

Info

Publication number
AR088441A1
AR088441A1 ARP120103338A ARP120103338A AR088441A1 AR 088441 A1 AR088441 A1 AR 088441A1 AR P120103338 A ARP120103338 A AR P120103338A AR P120103338 A ARP120103338 A AR P120103338A AR 088441 A1 AR088441 A1 AR 088441A1
Authority
AR
Argentina
Prior art keywords
alkyl
cycloalkyl
substituted
independently hydrogen
cycloalkenyl
Prior art date
Application number
ARP120103338A
Other languages
English (en)
Original Assignee
Idenix Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idenix Pharmaceuticals Inc filed Critical Idenix Pharmaceuticals Inc
Publication of AR088441A1 publication Critical patent/AR088441A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Composiciones y métodos para el tratamiento de trastornos del hígado, que incluyen infecciones por HCV. Se revelan composiciones de derivados de nucleósidos, que se pueden administrar ya sea solos o en combinación con otros agentes antivirales. Reivindicación 1: Un compuesto de la fórmula (1) o una sal, solvato aceptable para uso farmacéutico, forma estereoisomérica, tautomérica o polimórfica del mismo, donde R es un resto derivable por medio de la eliminación de un radical hidrógeno de un grupo hidroxi de un fármaco antiviral; Q es -N(RY)-, -O-, -S- o -C(RY)₂-; X es O ó S; cada RY es en forma independiente hidrógeno o alquilo; cada R³ y R³ es en forma independiente hidrógeno o alquilo; o R³ y R³ junto con el átomo de carbono al cual están unidos forman un anillo de 3 a 7 miembros; R¹ y R² se seleccionan de acuerdo con lo presentado a continuación: i) R¹ y R² son cada uno en forma independiente hidrógeno, alquilo, alquenilo, alquinilo, arilo, aralquilo, cicloalquilo, cicloalquenilo, alquilheterociclilo o alquilheteroarilo; ii) R¹ y R² junto con el átomo de nitrógeno en el cual están sustituidos forman un anillo heterocíclico o de heteroarilo de 3 a 7 miembros, donde el anillo no está sustituido o está sustituido por C(O)Q¹; o iii) R¹ es hidrógeno, alquilo o cicloalquilo, y R² es -(G)ₘC(O)Q¹; Q¹ es OR⁴, SR⁴ o NR⁵R⁶; cada G es en forma independiente CR⁷R⁸; y cada m es 1 ó 2; R⁴ es alquilo, alquenilo, alquinilo, arilo, aralquilo, cicloalquilo o cicloalquenilo; R⁵ y R⁶ se seleccionan de acuerdo con lo presentado a continuación: i) R⁵ y R⁶ son cada uno en forma independiente hidrógeno, alquilo, alquenilo, alquinilo, arilo, aralquilo, cicloalquilo o cicloalquenilo; o ii) R⁵ y R⁶ junto con el átomo de nitrógeno en el cual están sustituidos forman un anillo heterocíclico o de heteroarilo de 3 a 7 miembros; y R⁷ y R⁸ se seleccionan de acuerdo con lo presentado a continuación: i) R⁷ y R⁸ son cada uno en forma independiente hidrógeno, alquilo, heteroalquilo, alquenilo, heteroalquenilo, alquinilo, heteroalquinilo, arilo, aralquilo, heteroarilo, heteroaralquilo, cicloalquilo, cicloalquenilo, alquilheterociclilo o alquilheteroarilo, donde alquilo está sustituido en forma opcional por alcoxi; o ii) R⁷ y R⁸ junto con el átomo de carbono al cual están unidos forman un anillo de cicloalquilo de 3 a 7 miembros.
ARP120103338A 2011-09-12 2012-09-11 Compuestos de carboniloximetilfosforamidato sustituido y composiciones farmaceuticas para el tratamiento de infecciones virales AR088441A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161533649P 2011-09-12 2011-09-12

Publications (1)

Publication Number Publication Date
AR088441A1 true AR088441A1 (es) 2014-06-11

Family

ID=46940603

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP120103338A AR088441A1 (es) 2011-09-12 2012-09-11 Compuestos de carboniloximetilfosforamidato sustituido y composiciones farmaceuticas para el tratamiento de infecciones virales

Country Status (5)

Country Link
US (1) US9403863B2 (es)
EP (1) EP2755983B1 (es)
AR (1) AR088441A1 (es)
TW (1) TW201329096A (es)
WO (1) WO2013039920A1 (es)

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