ES2653265T3 - Morfinanos sustituidos y el uso de éstos - Google Patents
Morfinanos sustituidos y el uso de éstos Download PDFInfo
- Publication number
- ES2653265T3 ES2653265T3 ES13823996T ES13823996T ES2653265T3 ES 2653265 T3 ES2653265 T3 ES 2653265T3 ES 13823996 T ES13823996 T ES 13823996T ES 13823996 T ES13823996 T ES 13823996T ES 2653265 T3 ES2653265 T3 ES 2653265T3
- Authority
- ES
- Spain
- Prior art keywords
- cycloalkyl
- cycloalkenyl
- heterocycle
- alkyl
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un compuesto que tiene la Fórmula I-A: **(Ver fórmula)** o una sal o solvato farmacéuticamente aceptable de éste, en el que: R1 es hidrógeno, OH, halo, ciano, carboxi, o aminocarbonilo; o alquilo, alquenilo, alquinilo, alcoxi, alqueniloxi, o alquiniloxi, cualquiera de los cuales está sustituido opcionalmente con 1, 2, ó 3 sustituyentes, cada uno seleccionado independientemente del grupo que consiste en hidroxi, halo, haloalquilo, amino, alquilamino, dialquilamino, carboxi, alcoxi, alcoxicarbonilo, arilo, heteroarilo, heterociclo, cicloalquilo, y cicloalquenilo, en el que el arilo, heteroarilo, heterociclo, cicloalquilo, y cicloalquenilo están sustituidos opcionalmente con 1, 2, ó 3 grupos R11a seleccionados independientemente; R2 es: (a) hidrógeno o carboxamido; o (b) alquilo, alquenilo, alquinilo, cicloalquilo, cicloalquenilo, heterociclo, arilo, heteroarilo, (cicloalquil)alquilo, (cicloalquenil)alquilo, (heterociclo)alquilo, arilalquilo, heteroarilalquilo, alquilcarbonilo, alcoxicarbonilo, (arilalcoxi)carbonilo, o (heteroarilalcoxi)carbonilo, cualquiera de los cuales está sustituido opcionalmente con 1, 2, ó 3 sustituyentes, cada uno seleccionado independientemente del grupo que consiste en hidroxi, alquilo, halo, haloalquilo, amino, alquilamino, dialquilamino, carboxi, alcoxi, alcoxicarbonilo, arilo, heteroarilo, heterociclo, cicloalquilo, y cicloalquenilo, en el que el arilo, heteroarilo, heterociclo, cicloalquilo, y cicloalquenilo están sustituidos opcionalmente con 1, 2, ó 3 grupos R11a seleccionados independientemente; R3 es hidrógeno, OH, o halo; o alcoxi, alquilamino, o dialquilamino, cualquiera de los cuales está sustituido opcionalmente con 1, 2, ó 3 sustituyentes, cada uno seleccionado independientemente del grupo que consiste en hidroxilo, halo, haloalquilo, amino, alquilamino, dialquilamino, carboxi, alcoxi, alcoxicarbonilo, arilo, heteroarilo, heterociclo, cicloalquilo, y cicloalquenilo, en el que el arilo, heteroarilo, heterociclo, cicloalquilo, y cicloalquenilo están sustituidos opcionalmente con 1, 2, ó 3 grupos R11a seleccionados independientemente; R4a1 se selecciona del grupo que consiste en alquilo C3-C6, arilalquilo, (cicloalquil)alquilo, alcoxi C3-C6, aralquiloxi, -N(H)COR4c, -CH2C(>=O)NR4dR4e, -N(H)SO2R4f, **(Ver fórmula)** ...
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261746878P | 2012-12-28 | 2012-12-28 | |
PCT/IB2013/002883 WO2014102593A1 (en) | 2012-12-28 | 2013-12-23 | Substituted morphinans and the use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2653265T3 true ES2653265T3 (es) | 2018-02-06 |
Family
ID=50000021
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES13823996T Active ES2653265T3 (es) | 2012-12-28 | 2013-12-23 | Morfinanos sustituidos y el uso de éstos |
Country Status (9)
Country | Link |
---|---|
US (2) | US8946255B2 (es) |
EP (1) | EP2941431B1 (es) |
JP (1) | JP6159417B2 (es) |
AR (1) | AR094646A1 (es) |
CA (1) | CA2896202A1 (es) |
ES (1) | ES2653265T3 (es) |
IL (1) | IL239643A0 (es) |
TW (1) | TW201441199A (es) |
WO (1) | WO2014102593A1 (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ME02367B (me) | 2010-09-21 | 2016-06-20 | Purdue Pharma Lp | Analozi buprenorfina kao agonisti i/ili antagonisti opioidnog receptora |
EP2917182B1 (en) | 2012-11-09 | 2018-01-03 | Purdue Pharma LP | Benzomorphan analogs and the use thereof |
WO2014087226A1 (en) | 2012-12-07 | 2014-06-12 | Purdue Pharma L.P. | Buprenorphine analogs as opiod receptor modulators |
US8987287B2 (en) | 2012-12-14 | 2015-03-24 | Purdue Pharma L.P. | Spirocyclic morphinans and their use |
ES2631197T3 (es) | 2012-12-14 | 2017-08-29 | Purdue Pharma Lp | Análogos de piridonamorfinano y actividad biológica sobre los receptores opiodes |
EP2951160B1 (en) | 2013-01-31 | 2019-04-24 | Purdue Pharma LP | Benzomorphan analogs and the use thereof |
US8969358B2 (en) | 2013-03-15 | 2015-03-03 | Purdue Pharma L.P. | Buprenorphine analogs |
US9994571B2 (en) | 2013-12-26 | 2018-06-12 | Purdue Pharma L.P. | 10-substituted morphinan hydantoins |
WO2015097548A1 (en) | 2013-12-26 | 2015-07-02 | Purdue Pharma L.P. | 7-beta-alkyl analogs of orvinols |
JP6353543B2 (ja) | 2013-12-26 | 2018-07-04 | パーデュー、ファーマ、リミテッド、パートナーシップ | 環縮小モルフィナン及びその使用 |
WO2015097546A1 (en) | 2013-12-26 | 2015-07-02 | Purdue Pharma L.P. | Propellane-based compounds and their use as opioid receptor modulators |
WO2015097545A1 (en) | 2013-12-26 | 2015-07-02 | Purdue Pharma L.P. | Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans |
US10550088B2 (en) | 2013-12-27 | 2020-02-04 | Purdue Pharma L.P. | 6-substituted and 7-substituted morphinan analogs and the use thereof |
CA2950567A1 (en) | 2014-05-27 | 2015-12-03 | Purdue Pharma L.P. | Spirocyclic morphinans and use thereof |
US10202382B2 (en) | 2014-06-13 | 2019-02-12 | Purdue Pharma L.P. | Azamorphinan derivatives and use thereof |
MA41125A (fr) | 2014-12-05 | 2017-10-10 | Purdue Pharma Lp | Dérivés de 6.7-cyclomorphinane et leur utilisation |
US10246436B2 (en) * | 2015-09-02 | 2019-04-02 | Trevena, Inc. | 6-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same |
US10745402B2 (en) | 2017-01-02 | 2020-08-18 | Purdue Pharma L.P. | Morphinan derivatives and use thereof |
GB201719667D0 (en) * | 2017-11-27 | 2018-01-10 | Johnson Matthey Plc | Process |
WO2021015109A1 (ja) | 2019-07-19 | 2021-01-28 | 日本ケミファ株式会社 | フェノール誘導体の製造方法 |
CN117062815A (zh) | 2021-03-22 | 2023-11-14 | 纽罗克里生物科学有限公司 | Vmat2抑制剂及使用方法 |
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-
2013
- 2013-12-23 EP EP13823996.7A patent/EP2941431B1/en active Active
- 2013-12-23 US US14/138,691 patent/US8946255B2/en active Active - Reinstated
- 2013-12-23 CA CA2896202A patent/CA2896202A1/en not_active Abandoned
- 2013-12-23 ES ES13823996T patent/ES2653265T3/es active Active
- 2013-12-23 WO PCT/IB2013/002883 patent/WO2014102593A1/en active Application Filing
- 2013-12-23 TW TW102147764A patent/TW201441199A/zh unknown
- 2013-12-23 JP JP2015550154A patent/JP6159417B2/ja not_active Expired - Fee Related
- 2013-12-27 AR ARP130105048A patent/AR094646A1/es unknown
-
2014
- 2014-12-19 US US14/576,718 patent/US9388162B2/en active Active
-
2015
- 2015-06-25 IL IL239643A patent/IL239643A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
US20140187573A1 (en) | 2014-07-03 |
US8946255B2 (en) | 2015-02-03 |
JP6159417B2 (ja) | 2017-07-05 |
US20150175571A1 (en) | 2015-06-25 |
IL239643A0 (en) | 2015-08-31 |
EP2941431B1 (en) | 2017-10-25 |
CA2896202A1 (en) | 2014-07-03 |
WO2014102593A1 (en) | 2014-07-03 |
AR094646A1 (es) | 2015-08-19 |
US9388162B2 (en) | 2016-07-12 |
JP2016509588A (ja) | 2016-03-31 |
TW201441199A (zh) | 2014-11-01 |
EP2941431A1 (en) | 2015-11-11 |
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