BR0112666A - Peptìdeos como inibidores de ns3-serina protease de vìrus da hepatite c - Google Patents
Peptìdeos como inibidores de ns3-serina protease de vìrus da hepatite cInfo
- Publication number
- BR0112666A BR0112666A BR0112666-0A BR0112666A BR0112666A BR 0112666 A BR0112666 A BR 0112666A BR 0112666 A BR0112666 A BR 0112666A BR 0112666 A BR0112666 A BR 0112666A
- Authority
- BR
- Brazil
- Prior art keywords
- peptides
- virus
- inhibitors
- serine protease
- hepatitis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/50—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
- C07C205/51—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
Abstract
"PEPTìDEOS COMO INIBIDORES DE NS3-SERINA PROTEASE DE VìRUS DA HEPATITE C". A presente invenção refere-se compostos de peptídeo que têm atividade de inibição de protease de HCV bem como métodos para a preparação de tais compostos. Em uma outra modalidade, a invenção descreve composições farmacêuticas compreendendo tais compostos bem como métodos de uso delas para tratar distúrbios associados à protease de HCV.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22010700P | 2000-07-21 | 2000-07-21 | |
PCT/US2001/022813 WO2002008187A1 (en) | 2000-07-21 | 2001-07-19 | Novel peptides as ns3-serine protease inhibitors of hepatitis c virus |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0112666A true BR0112666A (pt) | 2003-06-10 |
Family
ID=22822091
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0112666-0A BR0112666A (pt) | 2000-07-21 | 2001-07-19 | Peptìdeos como inibidores de ns3-serina protease de vìrus da hepatite c |
Country Status (22)
Country | Link |
---|---|
US (2) | US7169760B2 (pt) |
EP (1) | EP1303487A4 (pt) |
JP (2) | JP4452441B2 (pt) |
KR (1) | KR20030081297A (pt) |
CN (1) | CN1446201A (pt) |
AR (1) | AR030249A1 (pt) |
AU (1) | AU8063701A (pt) |
BR (1) | BR0112666A (pt) |
CA (1) | CA2410682A1 (pt) |
CZ (1) | CZ2003195A3 (pt) |
EC (1) | ECSP034439A (pt) |
HU (1) | HUP0303358A3 (pt) |
IL (1) | IL153669A0 (pt) |
MX (1) | MXPA03000626A (pt) |
NO (1) | NO20030271L (pt) |
NZ (1) | NZ523781A (pt) |
PE (1) | PE20020266A1 (pt) |
PL (1) | PL365695A1 (pt) |
RU (1) | RU2003105221A (pt) |
SK (1) | SK742003A3 (pt) |
WO (1) | WO2002008187A1 (pt) |
ZA (1) | ZA200210311B (pt) |
Families Citing this family (169)
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2001
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- 2001-07-19 SK SK74-2003A patent/SK742003A3/sk unknown
- 2001-07-19 CN CN01813921A patent/CN1446201A/zh active Pending
- 2001-07-19 CZ CZ2003195A patent/CZ2003195A3/cs unknown
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- 2001-07-19 EP EP01959041A patent/EP1303487A4/en not_active Withdrawn
- 2001-07-19 US US09/909,012 patent/US7169760B2/en not_active Expired - Lifetime
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- 2001-07-19 RU RU2003105221/04A patent/RU2003105221A/ru not_active Application Discontinuation
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SK742003A3 (en) | 2003-06-03 |
PL365695A1 (en) | 2005-01-10 |
MXPA03000626A (es) | 2004-07-30 |
JP4452441B2 (ja) | 2010-04-21 |
JP2009292832A (ja) | 2009-12-17 |
HUP0303358A3 (en) | 2005-10-28 |
HUP0303358A2 (hu) | 2004-01-28 |
EP1303487A4 (en) | 2005-11-23 |
US20050176648A1 (en) | 2005-08-11 |
RU2003105221A (ru) | 2004-09-20 |
IL153669A0 (en) | 2003-07-06 |
KR20030081297A (ko) | 2003-10-17 |
ECSP034439A (es) | 2003-03-10 |
JP2004513881A (ja) | 2004-05-13 |
EP1303487A1 (en) | 2003-04-23 |
NO20030271L (no) | 2003-03-18 |
US7595299B2 (en) | 2009-09-29 |
NO20030271D0 (no) | 2003-01-20 |
ZA200210311B (en) | 2004-03-19 |
CZ2003195A3 (cs) | 2003-04-16 |
US7169760B2 (en) | 2007-01-30 |
WO2002008187A1 (en) | 2002-01-31 |
AR030249A1 (es) | 2003-08-13 |
CA2410682A1 (en) | 2002-01-31 |
PE20020266A1 (es) | 2002-05-11 |
AU8063701A (en) | 2002-02-05 |
CN1446201A (zh) | 2003-10-01 |
WO2002008187A9 (en) | 2003-01-03 |
US20020160962A1 (en) | 2002-10-31 |
NZ523781A (en) | 2004-10-29 |
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