BRPI0414814A - inibidores macrocìclicos de protease de serina ns3 de vìrus de hepatite c - Google Patents
inibidores macrocìclicos de protease de serina ns3 de vìrus de hepatite cInfo
- Publication number
- BRPI0414814A BRPI0414814A BRPI0414814-2A BRPI0414814A BRPI0414814A BR PI0414814 A BRPI0414814 A BR PI0414814A BR PI0414814 A BRPI0414814 A BR PI0414814A BR PI0414814 A BRPI0414814 A BR PI0414814A
- Authority
- BR
- Brazil
- Prior art keywords
- protease inhibitors
- virus serine
- virus
- macrocyclic hepatitis
- macrocyclic
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
- C07D245/04—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
- C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
- C04B35/632—Organic additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0217—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -C(=O)-C-N-C(=O)-N-C-C(=O)-
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
Abstract
"INIBIDORES MACROCìCLICOS DE PROTEASE DE SERINA NS3 DE VìRUS DE HEPATITE C". A presente invenção descreve novos compostos que podem ter atividade inibitória de protese de HCV bem como composições farmacêuticas compreendendo tais compostos e métodos de usar eles para tratar distúrbios associados à protease HCV. Os novos compostos tipicamente incluem uma macrociclo de 15-20 membros e têm a fórmula geral (1): em que que Z<39>, L<39>, M<39>, R~ 1~, X e D são definidos aqui.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50663703P | 2003-09-26 | 2003-09-26 | |
PCT/US2004/031136 WO2005030796A1 (en) | 2003-09-26 | 2004-09-23 | Macrocyclic inhibitors of hepatitis c virus ns3 serine protease |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0414814A true BRPI0414814A (pt) | 2006-11-14 |
Family
ID=34393181
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0414814-2A BRPI0414814A (pt) | 2003-09-26 | 2004-09-23 | inibidores macrocìclicos de protease de serina ns3 de vìrus de hepatite c |
Country Status (21)
Country | Link |
---|---|
US (1) | US7592419B2 (pt) |
EP (1) | EP1664092B1 (pt) |
JP (2) | JP4525982B2 (pt) |
KR (1) | KR20060085248A (pt) |
CN (1) | CN1894274A (pt) |
AR (1) | AR046166A1 (pt) |
AT (1) | ATE497505T1 (pt) |
AU (1) | AU2004276281A1 (pt) |
BR (1) | BRPI0414814A (pt) |
CA (1) | CA2540031A1 (pt) |
CO (1) | CO5680449A2 (pt) |
DE (1) | DE602004031298D1 (pt) |
EC (1) | ECSP066456A (pt) |
IL (1) | IL174459A0 (pt) |
MX (1) | MXPA06003455A (pt) |
NO (1) | NO20061822L (pt) |
PE (1) | PE20050953A1 (pt) |
RU (1) | RU2006113880A (pt) |
TW (1) | TWI280964B (pt) |
WO (1) | WO2005030796A1 (pt) |
ZA (1) | ZA200602447B (pt) |
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US7244721B2 (en) * | 2000-07-21 | 2007-07-17 | Schering Corporation | Peptides as NS3-serine protease inhibitors of hepatitis C virus |
WO2002048172A2 (en) * | 2000-12-12 | 2002-06-20 | Schering Corporation | Diaryl peptides as ns3-serine protease inhibitors of hepatits c virus |
MXPA04007163A (es) * | 2002-01-23 | 2004-10-29 | Schering Corp | Compuestos de prolina como inhibidores de la proteasa serina ns3 para utilizarse en el tratamiento de la infeccion por el virus de la hepatitis c. |
CN1771050A (zh) | 2003-02-07 | 2006-05-10 | 益安药业 | 丙型肝炎丝氨酸蛋白酶的大环抑制剂 |
JP4778893B2 (ja) | 2003-04-18 | 2011-09-21 | エナンタ ファーマシューティカルズ インコーポレイテッド | キノキサリニル大環状のc型肝炎セリンプロテアーゼ阻害剤 |
-
2004
- 2004-09-23 JP JP2006528146A patent/JP4525982B2/ja not_active Expired - Fee Related
- 2004-09-23 AR ARP040103438A patent/AR046166A1/es unknown
- 2004-09-23 AT AT04784827T patent/ATE497505T1/de not_active IP Right Cessation
- 2004-09-23 CN CNA2004800349233A patent/CN1894274A/zh active Pending
- 2004-09-23 BR BRPI0414814-2A patent/BRPI0414814A/pt not_active IP Right Cessation
- 2004-09-23 PE PE2004000928A patent/PE20050953A1/es not_active Application Discontinuation
- 2004-09-23 AU AU2004276281A patent/AU2004276281A1/en not_active Abandoned
- 2004-09-23 KR KR1020067005941A patent/KR20060085248A/ko not_active Application Discontinuation
- 2004-09-23 RU RU2006113880/04A patent/RU2006113880A/ru not_active Application Discontinuation
- 2004-09-23 TW TW093128803A patent/TWI280964B/zh not_active IP Right Cessation
- 2004-09-23 WO PCT/US2004/031136 patent/WO2005030796A1/en active Application Filing
- 2004-09-23 US US10/948,367 patent/US7592419B2/en not_active Expired - Fee Related
- 2004-09-23 EP EP04784827A patent/EP1664092B1/en active Active
- 2004-09-23 MX MXPA06003455A patent/MXPA06003455A/es unknown
- 2004-09-23 CA CA002540031A patent/CA2540031A1/en not_active Abandoned
- 2004-09-23 DE DE602004031298T patent/DE602004031298D1/de active Active
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2006
- 2006-03-21 IL IL174459A patent/IL174459A0/en unknown
- 2006-03-24 CO CO06029608A patent/CO5680449A2/es not_active Application Discontinuation
- 2006-03-24 ZA ZA200602447A patent/ZA200602447B/en unknown
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- 2006-04-25 NO NO20061822A patent/NO20061822L/no not_active Application Discontinuation
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2009
- 2009-07-03 JP JP2009159346A patent/JP2009275048A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP1664092A1 (en) | 2006-06-07 |
CA2540031A1 (en) | 2005-04-07 |
PE20050953A1 (es) | 2005-11-19 |
RU2006113880A (ru) | 2007-11-20 |
US20050119168A1 (en) | 2005-06-02 |
CO5680449A2 (es) | 2006-09-29 |
JP4525982B2 (ja) | 2010-08-18 |
EP1664092B1 (en) | 2011-02-02 |
US7592419B2 (en) | 2009-09-22 |
ECSP066456A (es) | 2006-09-18 |
TWI280964B (en) | 2007-05-11 |
AU2004276281A1 (en) | 2005-04-07 |
NO20061822L (no) | 2006-06-22 |
CN1894274A (zh) | 2007-01-10 |
ATE497505T1 (de) | 2011-02-15 |
DE602004031298D1 (de) | 2011-03-17 |
TW200526687A (en) | 2005-08-16 |
IL174459A0 (en) | 2006-08-01 |
AR046166A1 (es) | 2005-11-30 |
KR20060085248A (ko) | 2006-07-26 |
ZA200602447B (en) | 2007-09-26 |
MXPA06003455A (es) | 2006-05-31 |
JP2007534627A (ja) | 2007-11-29 |
JP2009275048A (ja) | 2009-11-26 |
WO2005030796A1 (en) | 2005-04-07 |
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