UY30437A1 - Quinoxalinil macroceclicos inhibidores de serina proteasa del virus de la hepatitis c - Google Patents

Quinoxalinil macroceclicos inhibidores de serina proteasa del virus de la hepatitis c

Info

Publication number
UY30437A1
UY30437A1 UY30437A UY30437A UY30437A1 UY 30437 A1 UY30437 A1 UY 30437A1 UY 30437 A UY30437 A UY 30437A UY 30437 A UY30437 A UY 30437A UY 30437 A1 UY30437 A1 UY 30437A1
Authority
UY
Uruguay
Prior art keywords
hepatitis
virus
serine protease
quinoxalinil
macroceclic
Prior art date
Application number
UY30437A
Other languages
English (en)
Inventor
Zhe Wang
Datong Tang
Yonghua Gai
Ying Sun
Guoyou Xu
Joel D Moore
Dong Liu
Deqiang Niu
Yat Sun Or
Original Assignee
Enanta Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enanta Pharm Inc filed Critical Enanta Pharm Inc
Publication of UY30437A1 publication Critical patent/UY30437A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
    • C07D245/04—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/215—IFN-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Compuestos de formula I, o una sal, éstrer o prodroga aceptable para uso farmacéutico de los mismos: que inhiben la actividad de serina proteasea, particularmente la propiedad de la proteasa NS3-NS4A del virus de la hepatitis C (HCV). En consecuencia, los mismos interfieren con el ciclo de vida del virus de la hepatitis C y tambicn son utiles como agentes antivirales. Composiciones farmacéuticas que comprenden los compuestos anteriormente mencionados para administrar a un sujeto que sufre de una infeccinn por HCV, y métodos de tratar una infeccion por HCV en un sujeto administrando una composicion farmacéutica que comprende los compuestos de la presente invencion.
UY30437A 2006-06-26 2007-06-25 Quinoxalinil macroceclicos inhibidores de serina proteasa del virus de la hepatitis c UY30437A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87244206P 2006-06-26 2006-06-26

Publications (1)

Publication Number Publication Date
UY30437A1 true UY30437A1 (es) 2008-01-31

Family

ID=38846474

Family Applications (1)

Application Number Title Priority Date Filing Date
UY30437A UY30437A1 (es) 2006-06-26 2007-06-25 Quinoxalinil macroceclicos inhibidores de serina proteasa del virus de la hepatitis c

Country Status (18)

Country Link
US (2) US8501681B2 (es)
EP (1) EP2066326A4 (es)
JP (1) JP5520046B2 (es)
KR (1) KR101505056B1 (es)
CN (1) CN101478970B (es)
AR (1) AR061629A1 (es)
AU (1) AU2007265157B2 (es)
BR (1) BRPI0714074A2 (es)
CA (1) CA2654945C (es)
IL (1) IL195512A (es)
MX (1) MX2008016528A (es)
NZ (1) NZ573275A (es)
PE (1) PE20080992A1 (es)
RU (1) RU2475494C2 (es)
TW (1) TWI454264B (es)
UY (1) UY30437A1 (es)
WO (1) WO2008002924A2 (es)
ZA (1) ZA200810519B (es)

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Also Published As

Publication number Publication date
US8501681B2 (en) 2013-08-06
JP2009541491A (ja) 2009-11-26
WO2008002924A3 (en) 2008-04-03
EP2066326A2 (en) 2009-06-10
TWI454264B (zh) 2014-10-01
PE20080992A1 (es) 2008-08-06
TW200810777A (en) 2008-03-01
JP5520046B2 (ja) 2014-06-11
US8809264B2 (en) 2014-08-19
IL195512A0 (en) 2009-09-01
ZA200810519B (en) 2009-08-26
MX2008016528A (es) 2009-03-31
AU2007265157B2 (en) 2013-06-27
CN101478970B (zh) 2014-07-02
KR101505056B1 (ko) 2015-03-23
BRPI0714074A2 (pt) 2012-12-18
NZ573275A (en) 2011-12-22
CA2654945A1 (en) 2008-01-03
EP2066326A4 (en) 2010-09-29
AU2007265157A1 (en) 2008-01-03
AR061629A1 (es) 2008-09-10
US20080008681A1 (en) 2008-01-10
CN101478970A (zh) 2009-07-08
RU2475494C2 (ru) 2013-02-20
KR20090023732A (ko) 2009-03-05
US20070299078A1 (en) 2007-12-27
CA2654945C (en) 2013-08-06
WO2008002924A2 (en) 2008-01-03
IL195512A (en) 2014-05-28
RU2009102252A (ru) 2010-08-10

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