DE602005025855D1 - Makrocyclische peptide mit wirkung gegen das hepatitis-c-virus - Google Patents
Makrocyclische peptide mit wirkung gegen das hepatitis-c-virusInfo
- Publication number
- DE602005025855D1 DE602005025855D1 DE602005025855T DE602005025855T DE602005025855D1 DE 602005025855 D1 DE602005025855 D1 DE 602005025855D1 DE 602005025855 T DE602005025855 T DE 602005025855T DE 602005025855 T DE602005025855 T DE 602005025855T DE 602005025855 D1 DE602005025855 D1 DE 602005025855D1
- Authority
- DE
- Germany
- Prior art keywords
- hepatitis
- virus
- effect
- macrocyclic peptides
- macrocyclic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US53786304P | 2004-01-21 | 2004-01-21 | |
PCT/CA2005/000055 WO2005070955A1 (en) | 2004-01-21 | 2005-01-18 | Macrocyclic peptides active against the hepatitis c virus |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602005025855D1 true DE602005025855D1 (de) | 2011-02-24 |
Family
ID=34807139
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602005025855T Active DE602005025855D1 (de) | 2004-01-21 | 2005-01-18 | Makrocyclische peptide mit wirkung gegen das hepatitis-c-virus |
Country Status (12)
Country | Link |
---|---|
US (2) | US7749961B2 (de) |
EP (1) | EP1730167B1 (de) |
JP (1) | JP4682155B2 (de) |
AR (1) | AR047444A1 (de) |
AT (1) | ATE495185T1 (de) |
CA (1) | CA2549851C (de) |
DE (1) | DE602005025855D1 (de) |
ES (1) | ES2358333T3 (de) |
PE (1) | PE20050764A1 (de) |
TW (1) | TW200528094A (de) |
UY (1) | UY28722A1 (de) |
WO (1) | WO2005070955A1 (de) |
Families Citing this family (115)
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MY140680A (en) | 2002-05-20 | 2010-01-15 | Bristol Myers Squibb Co | Hepatitis c virus inhibitors |
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AR045596A1 (es) | 2003-09-05 | 2005-11-02 | Vertex Pharma | Inhibidores de proteasas de serina en particular proteasa ns3-ns4a del vhc |
UY28525A1 (es) * | 2003-09-22 | 2005-04-29 | Boehringer Ingelheim Int | Péptidos macrociclicos activos contra en virus de la hepatitis c |
US7491794B2 (en) * | 2003-10-14 | 2009-02-17 | Intermune, Inc. | Macrocyclic compounds as inhibitors of viral replication |
EP1730167B1 (de) | 2004-01-21 | 2011-01-12 | Boehringer Ingelheim International GmbH | Makrocyclische peptide mit wirkung gegen das hepatitis-c-virus |
KR20130083938A (ko) * | 2004-10-01 | 2013-07-23 | 버텍스 파마슈티칼스 인코포레이티드 | Hcv ns3-ns4a 프로테아제 저해 |
MX2007004783A (es) * | 2004-10-21 | 2007-05-11 | Pfizer | Inhibidores de la proteasa del virus de la hepatitis c, y composiciones y tratamientos que los usan. |
TW201424733A (zh) | 2004-10-29 | 2014-07-01 | Vertex Pharma | 劑量型式 |
US7323447B2 (en) | 2005-02-08 | 2008-01-29 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
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US7592336B2 (en) | 2005-05-10 | 2009-09-22 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
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EA019888B1 (ru) * | 2005-07-25 | 2014-07-30 | Интермьюн, Инк. | Промежуточное соединение для получения макроциклических ингибиторов репликации вируса гепатита с и способ его синтеза |
EP1913016B1 (de) | 2005-08-01 | 2013-01-16 | Merck Sharp & Dohme Corp. | Makrocyclische peptide als hcv-ns3 -proteasehemmer |
US8076365B2 (en) | 2005-08-12 | 2011-12-13 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
AR055395A1 (es) | 2005-08-26 | 2007-08-22 | Vertex Pharma | Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c |
US7964624B1 (en) | 2005-08-26 | 2011-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
DK1999129T3 (da) * | 2005-10-11 | 2011-02-07 | Intermune Inc | Forbindelser og fremgangsmåder til inhibering af replikationen af hepatitis C-virus |
US7772183B2 (en) | 2005-10-12 | 2010-08-10 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7741281B2 (en) | 2005-11-03 | 2010-06-22 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7816348B2 (en) | 2006-02-03 | 2010-10-19 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
CA2643688A1 (en) | 2006-02-27 | 2007-08-30 | Vertex Pharmaceuticals Incorporated | Co-crystals and pharmaceutical compositions comprising the same |
EP1993994A2 (de) | 2006-03-16 | 2008-11-26 | Vertex Pharmceuticals Incorporated | Deuterierte hepatitis-c-protease-hemmer |
GB0609492D0 (en) | 2006-05-15 | 2006-06-21 | Angeletti P Ist Richerche Bio | Therapeutic agents |
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US7935670B2 (en) | 2006-07-11 | 2011-05-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
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-
2005
- 2005-01-18 EP EP05706397A patent/EP1730167B1/de not_active Not-in-force
- 2005-01-18 JP JP2006549804A patent/JP4682155B2/ja not_active Expired - Fee Related
- 2005-01-18 WO PCT/CA2005/000055 patent/WO2005070955A1/en active Application Filing
- 2005-01-18 AT AT05706397T patent/ATE495185T1/de active
- 2005-01-18 ES ES05706397T patent/ES2358333T3/es active Active
- 2005-01-18 DE DE602005025855T patent/DE602005025855D1/de active Active
- 2005-01-18 CA CA2549851A patent/CA2549851C/en not_active Expired - Fee Related
- 2005-01-19 PE PE2005000074A patent/PE20050764A1/es not_active Application Discontinuation
- 2005-01-19 UY UY28722A patent/UY28722A1/es not_active Application Discontinuation
- 2005-01-19 US US11/039,698 patent/US7749961B2/en active Active
- 2005-01-20 TW TW094101708A patent/TW200528094A/zh unknown
- 2005-01-21 AR ARP050100220A patent/AR047444A1/es unknown
-
2009
- 2009-06-29 US US12/493,681 patent/US20090264346A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2549851C (en) | 2012-09-11 |
PE20050764A1 (es) | 2005-11-24 |
WO2005070955A1 (en) | 2005-08-04 |
US20090264346A1 (en) | 2009-10-22 |
US20050192212A1 (en) | 2005-09-01 |
EP1730167B1 (de) | 2011-01-12 |
CA2549851A1 (en) | 2005-08-04 |
UY28722A1 (es) | 2005-08-31 |
EP1730167A1 (de) | 2006-12-13 |
JP4682155B2 (ja) | 2011-05-11 |
ES2358333T3 (es) | 2011-05-09 |
JP2007534662A (ja) | 2007-11-29 |
US7749961B2 (en) | 2010-07-06 |
EP1730167A4 (de) | 2008-04-09 |
AR047444A1 (es) | 2006-01-18 |
ATE495185T1 (de) | 2011-01-15 |
TW200528094A (en) | 2005-09-01 |
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