UY28525A1 - Péptidos macrociclicos activos contra en virus de la hepatitis c - Google Patents
Péptidos macrociclicos activos contra en virus de la hepatitis cInfo
- Publication number
- UY28525A1 UY28525A1 UY28525A UY28525A UY28525A1 UY 28525 A1 UY28525 A1 UY 28525A1 UY 28525 A UY28525 A UY 28525A UY 28525 A UY28525 A UY 28525A UY 28525 A1 UY28525 A1 UY 28525A1
- Authority
- UY
- Uruguay
- Prior art keywords
- macrociclic
- viruses
- active
- against hepatitis
- peptides against
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
Compuestos de la fórmula I: en la que se definen D, R4, R3, L0. L1, L2 y Rc; o una de sus sales o ésteres farmacéuticamente aceptables, útiles como inhibidores de la proteasa NS3 del VHC.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50483903P | 2003-09-22 | 2003-09-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY28525A1 true UY28525A1 (es) | 2005-04-29 |
Family
ID=34375541
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY28525A UY28525A1 (es) | 2003-09-22 | 2004-09-20 | Péptidos macrociclicos activos contra en virus de la hepatitis c |
Country Status (22)
Country | Link |
---|---|
US (2) | US7642235B2 (es) |
EP (1) | EP1673385B1 (es) |
JP (2) | JP4704342B2 (es) |
KR (1) | KR20060094083A (es) |
CN (1) | CN1856502A (es) |
AR (1) | AR045938A1 (es) |
AT (1) | ATE500264T1 (es) |
AU (1) | AU2004274051A1 (es) |
BR (1) | BRPI0414571A (es) |
CA (1) | CA2536182C (es) |
DE (1) | DE602004031645D1 (es) |
EA (1) | EA200600498A1 (es) |
EC (1) | ECSP066448A (es) |
ES (1) | ES2361997T3 (es) |
IL (1) | IL174403A0 (es) |
MX (1) | MXPA06003141A (es) |
NO (1) | NO20061767L (es) |
PE (1) | PE20050431A1 (es) |
RS (1) | RS20060197A (es) |
TW (1) | TW200521144A (es) |
UY (1) | UY28525A1 (es) |
WO (1) | WO2005028501A1 (es) |
Families Citing this family (125)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2268391A1 (en) | 1996-10-18 | 1998-04-30 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease |
SV2003000617A (es) * | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
US7119072B2 (en) * | 2002-01-30 | 2006-10-10 | Boehringer Ingelheim (Canada) Ltd. | Macrocyclic peptides active against the hepatitis C virus |
MY140680A (en) | 2002-05-20 | 2010-01-15 | Bristol Myers Squibb Co | Hepatitis c virus inhibitors |
US20050075279A1 (en) * | 2002-10-25 | 2005-04-07 | Boehringer Ingelheim International Gmbh | Macrocyclic peptides active against the hepatitis C virus |
CN100363055C (zh) * | 2003-04-02 | 2008-01-23 | 贝林格尔·英格海姆国际有限公司 | 用作c型肝炎病毒蛋白酶抑制剂的药物组合物 |
CA2522205A1 (en) * | 2003-04-10 | 2004-10-28 | Boehringer Ingelheim International Gmbh | Process for preparing macrocyclic compounds |
US7176208B2 (en) * | 2003-04-18 | 2007-02-13 | Enanta Pharmaceuticals, Inc. | Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors |
AU2004240704B9 (en) | 2003-05-21 | 2009-10-22 | Boehringer Ingelheim International Gmbh | Hepatitis C inhibitor compounds |
MY148123A (en) | 2003-09-05 | 2013-02-28 | Vertex Pharma | Inhibitors of serine proteases, particularly hcv ns3-ns4a protease |
US7642235B2 (en) * | 2003-09-22 | 2010-01-05 | Boehringer Ingelheim International Gmbh | Macrocyclic peptides active against the hepatitis C virus |
US7491794B2 (en) * | 2003-10-14 | 2009-02-17 | Intermune, Inc. | Macrocyclic compounds as inhibitors of viral replication |
US7132504B2 (en) * | 2003-11-12 | 2006-11-07 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
DE602004019973D1 (de) * | 2003-12-08 | 2009-04-23 | Boehringer Ingelheim Int | Abtrennung von ruthenium-nebenprodukten durch behandlung mit überkritischen flüssigkeiten |
EP1730167B1 (en) * | 2004-01-21 | 2011-01-12 | Boehringer Ingelheim International GmbH | Macrocyclic peptides active against the hepatitis c virus |
ATE459638T1 (de) * | 2004-03-15 | 2010-03-15 | Boehringer Ingelheim Int | Verfahren zur herstellung makrocyclischer dipeptide, die sich für die behandlung von hepatitis-c-virusinfektionen eignen |
EP1753775B1 (en) | 2004-05-25 | 2012-12-26 | Boehringer Ingelheim International GmbH | Process for preparing acyclic hcv protease inhibitors |
UY29016A1 (es) | 2004-07-20 | 2006-02-24 | Boehringer Ingelheim Int | Analogos de dipeptidos inhibidores de la hepatitis c |
ES2366478T3 (es) | 2004-07-20 | 2011-10-20 | Boehringer Ingelheim International Gmbh | Análogos peptídicos inhibidores de la hepatitis c. |
CA2578428A1 (en) * | 2004-09-17 | 2006-03-30 | Boehringer Ingelheim International Gmbh | Ring-closing metathesis process in supercritical fluid |
EP1794178A1 (en) | 2004-09-17 | 2007-06-13 | Boehringer Ingelheim International Gmbh | Process for preparing macrocyclic hcv protease inhibitors |
RU2007116265A (ru) | 2004-10-01 | 2008-11-10 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Ингибирование протеазы ns3-ns4a вируса hcv |
TW201424733A (zh) | 2004-10-29 | 2014-07-01 | Vertex Pharma | 劑量型式 |
DE102005002336A1 (de) | 2005-01-17 | 2006-07-20 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Durchführung von kontinuierlichen Olefin-Ringschluss-Metathesen in komprimiertem Kohlendioxid |
US7323447B2 (en) | 2005-02-08 | 2008-01-29 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
EP1863833B1 (en) | 2005-03-08 | 2013-09-18 | Boehringer Ingelheim International GmbH | Process for preparing macrocyclic compounds |
US7592336B2 (en) | 2005-05-10 | 2009-09-22 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7608592B2 (en) | 2005-06-30 | 2009-10-27 | Virobay, Inc. | HCV inhibitors |
US7601686B2 (en) | 2005-07-11 | 2009-10-13 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
EP2305697A3 (en) * | 2005-07-25 | 2011-07-27 | Intermune, Inc. | Macrocyclic inhibitors of Hepatitis C virus replication |
PL1919898T3 (pl) * | 2005-07-29 | 2011-06-30 | Tibotec Pharm Ltd | Makrocykliczne inhibitory wirusa zapalenia wątroby typu C |
BRPI0614637A2 (pt) * | 2005-07-29 | 2011-04-12 | Tibotec Pharm Ltd | inibidores macrocìclicos do vìrus da hepatite c |
CN101273038A (zh) * | 2005-07-29 | 2008-09-24 | 美迪维尔公司 | 丙型肝炎病毒的大环化合物抑制剂 |
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PE20070211A1 (es) * | 2005-07-29 | 2007-05-12 | Medivir Ab | Compuestos macrociclicos como inhibidores del virus de hepatitis c |
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CN101233131B (zh) * | 2005-07-29 | 2011-06-08 | 泰博特克药品有限公司 | 丙型肝炎病毒的大环抑制剂 |
EP1919899B1 (en) * | 2005-07-29 | 2011-01-19 | Tibotec Pharmaceuticals | Macrocyclic inhibitors of hepatitis c virus |
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MX2008001528A (es) * | 2005-08-02 | 2008-04-04 | Vertex Pharma | Inhibidores de serina proteasas. |
CA2618682C (en) | 2005-08-12 | 2011-06-21 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
US7964624B1 (en) * | 2005-08-26 | 2011-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
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CA2621360C (en) | 2005-09-09 | 2013-12-24 | Boehringer Ingelheim International Gmbh | Ring-closing metathesis process for the preparation of macrocyclic peptides |
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- 2004-09-20 KR KR1020067007658A patent/KR20060094083A/ko not_active Application Discontinuation
- 2004-09-20 RS YUP-2006/0197A patent/RS20060197A/sr unknown
- 2004-09-20 ES ES04761821T patent/ES2361997T3/es active Active
- 2004-09-20 AT AT04761821T patent/ATE500264T1/de active
- 2004-09-20 WO PCT/CA2004/001658 patent/WO2005028501A1/en active Application Filing
- 2004-09-20 DE DE602004031645T patent/DE602004031645D1/de active Active
- 2004-09-20 BR BRPI0414571-2A patent/BRPI0414571A/pt not_active IP Right Cessation
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EP1673385B1 (en) | 2011-03-02 |
KR20060094083A (ko) | 2006-08-28 |
IL174403A0 (en) | 2006-08-01 |
BRPI0414571A (pt) | 2006-11-07 |
ES2361997T3 (es) | 2011-06-27 |
ECSP066448A (es) | 2006-09-18 |
EP1673385A4 (en) | 2006-10-04 |
AU2004274051A1 (en) | 2005-03-31 |
TW200521144A (en) | 2005-07-01 |
US20100028300A1 (en) | 2010-02-04 |
PE20050431A1 (es) | 2005-07-19 |
CN1856502A (zh) | 2006-11-01 |
US7642235B2 (en) | 2010-01-05 |
US20050080005A1 (en) | 2005-04-14 |
EA200600498A1 (ru) | 2006-10-27 |
EP1673385A1 (en) | 2006-06-28 |
JP2011006420A (ja) | 2011-01-13 |
AR045938A1 (es) | 2005-11-16 |
MXPA06003141A (es) | 2006-06-05 |
WO2005028501A1 (en) | 2005-03-31 |
JP2007529411A (ja) | 2007-10-25 |
RS20060197A (en) | 2008-09-29 |
CA2536182C (en) | 2012-07-24 |
JP4704342B2 (ja) | 2011-06-15 |
ATE500264T1 (de) | 2011-03-15 |
CA2536182A1 (en) | 2005-03-31 |
NO20061767L (no) | 2006-06-16 |
DE602004031645D1 (de) | 2011-04-14 |
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