PL2364309T3 - Nowe peptydy 4-amino-4-oksobutanoilowe jako inhibitory wirusowej replikacji - Google Patents
Nowe peptydy 4-amino-4-oksobutanoilowe jako inhibitory wirusowej replikacjiInfo
- Publication number
- PL2364309T3 PL2364309T3 PL09832541T PL09832541T PL2364309T3 PL 2364309 T3 PL2364309 T3 PL 2364309T3 PL 09832541 T PL09832541 T PL 09832541T PL 09832541 T PL09832541 T PL 09832541T PL 2364309 T3 PL2364309 T3 PL 2364309T3
- Authority
- PL
- Poland
- Prior art keywords
- inhibitors
- amino
- new
- viral replication
- oxobutanoyl peptides
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12137808P | 2008-12-10 | 2008-12-10 | |
US22631709P | 2009-07-17 | 2009-07-17 | |
PCT/US2009/067506 WO2010068760A2 (en) | 2008-12-10 | 2009-12-10 | New 4-amino-4-oxobutanoyl peptides as inhibitors of viral replication |
EP20090832541 EP2364309B1 (en) | 2008-12-10 | 2009-12-10 | New 4-amino-4-oxobutanoyl peptides as inhibitors of viral replication |
Publications (1)
Publication Number | Publication Date |
---|---|
PL2364309T3 true PL2364309T3 (pl) | 2015-03-31 |
Family
ID=42243312
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL09832541T PL2364309T3 (pl) | 2008-12-10 | 2009-12-10 | Nowe peptydy 4-amino-4-oksobutanoilowe jako inhibitory wirusowej replikacji |
Country Status (20)
Country | Link |
---|---|
US (2) | US8614180B2 (pl) |
EP (1) | EP2364309B1 (pl) |
JP (1) | JP5723783B2 (pl) |
KR (1) | KR101762842B1 (pl) |
CN (1) | CN102245599B (pl) |
AU (1) | AU2009324643B2 (pl) |
BR (1) | BRPI0922912A8 (pl) |
CA (1) | CA2746264C (pl) |
CY (1) | CY1116254T1 (pl) |
DK (1) | DK2364309T3 (pl) |
EA (1) | EA022134B1 (pl) |
ES (1) | ES2527166T3 (pl) |
HK (1) | HK1156623A1 (pl) |
IL (1) | IL212786A (pl) |
MX (1) | MX2011006244A (pl) |
NZ (1) | NZ592668A (pl) |
PL (1) | PL2364309T3 (pl) |
PT (1) | PT2364309E (pl) |
SI (1) | SI2364309T1 (pl) |
WO (1) | WO2010068760A2 (pl) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
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PL2041156T3 (pl) * | 2006-07-13 | 2014-05-30 | Achillion Pharmaceuticals Inc | Peptydy 4-amino-4-oksobutanoilowe jako inhibitory replikacji wirusowej |
EP2125113A2 (en) * | 2007-02-26 | 2009-12-02 | Achillion Pharmaceuticals, Inc. | Tertiary amine substituted peptides useful as inhibitors of hcv replication |
CN102245599B (zh) | 2008-12-10 | 2014-05-14 | 艾其林医药公司 | 作为病毒复制抑制剂的新的4-氨基-4-氧代丁酰基肽 |
US20100152103A1 (en) * | 2008-12-10 | 2010-06-17 | Achillion Pharmaceuticals, Inc. | 4-amino-4-oxobutanoyl peptide cyclic analogues, inhibitors of viral replication |
US8957203B2 (en) | 2011-05-05 | 2015-02-17 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
AP2013007263A0 (en) | 2011-05-27 | 2013-11-30 | Achillion Pharmaceuticals Inc | Substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenesuseful for treating HCV infections |
US8492386B2 (en) | 2011-10-21 | 2013-07-23 | Abbvie Inc. | Methods for treating HCV |
SE1450130A1 (sv) | 2011-10-21 | 2014-05-07 | Abbvie Inc | Förfaranden för att behandla hcv innefattande minst två direktverkande antivirala agenser, ribavirin men inte interferon |
US8466159B2 (en) | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
AU2013201532B2 (en) | 2011-10-21 | 2014-10-02 | Abbvie Ireland Unlimited Company | Methods for treating HCV |
MA37992B1 (fr) | 2012-10-19 | 2018-09-28 | Bristol Myers Squibb Co | Composes inhibiteurs de protéase ns3 pour une utilisation dans le traitement de l’infection par le virus de l'hépatite c. |
WO2014071007A1 (en) | 2012-11-02 | 2014-05-08 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
US9598433B2 (en) | 2012-11-02 | 2017-03-21 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US9643999B2 (en) | 2012-11-02 | 2017-05-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
EP2914614B1 (en) | 2012-11-05 | 2017-08-16 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
TW201428002A (zh) * | 2012-11-09 | 2014-07-16 | 必治妥美雅史谷比公司 | 用於抑制細胞凋亡抑制劑之巨環化合物 |
WO2014137869A1 (en) | 2013-03-07 | 2014-09-12 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
EA201591722A1 (ru) | 2013-03-14 | 2016-02-29 | Ачиллион Фармасьютикалз, Инк. | Новые способы получения совапревира |
US9006423B2 (en) | 2013-03-15 | 2015-04-14 | Achillion Pharmaceuticals Inc. | Process for making a 4-amino-4-oxobutanoyl peptide cyclic analogue, an inhibitor of viral replication, and intermediates thereof |
US9085607B2 (en) | 2013-03-15 | 2015-07-21 | Achillion Pharmaceuticals, Inc. | ACH-0142684 sodium salt polymorph, composition including the same, and method of manufacture thereof |
WO2014144087A1 (en) | 2013-03-15 | 2014-09-18 | Achillion Pharmaceuticals, Inc. | Sovaprevir polymorphs and methods of manufacture thereof |
KR20160003700A (ko) | 2013-04-12 | 2016-01-11 | 아칠리온 파르마세우티칼스 인코포레이티드 | C형간염 바이러스의 치료를 위한 고활성 뉴클레오시드 유도체 |
CN103396351B (zh) * | 2013-08-09 | 2015-10-21 | 山东大学 | 吡咯烷类Bcl-2蛋白小分子抑制剂化合物及其制备、药物组合物与制药用途 |
CA3022119A1 (en) | 2016-04-28 | 2017-11-02 | Emory University | Alkyne containing nucleotide and nucleoside therapeutic compositions and uses related thereto |
WO2017197055A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Heterocyclic degronimers for target protein degradation |
CN109641874A (zh) | 2016-05-10 | 2019-04-16 | C4医药公司 | 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体 |
CN109562113A (zh) | 2016-05-10 | 2019-04-02 | C4医药公司 | 用于靶蛋白降解的螺环降解决定子体 |
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JP5190364B2 (ja) | 2005-09-09 | 2013-04-24 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 大環状ペプチドの調製の為の閉環メタセシス工程 |
ATE493409T1 (de) | 2005-10-11 | 2011-01-15 | Intermune Inc | Verbindungen und verfahren zur inhibierung der replikation des hepatitis-c-virus |
US7772183B2 (en) * | 2005-10-12 | 2010-08-10 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7741281B2 (en) * | 2005-11-03 | 2010-06-22 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
PL2041156T3 (pl) * | 2006-07-13 | 2014-05-30 | Achillion Pharmaceuticals Inc | Peptydy 4-amino-4-oksobutanoilowe jako inhibitory replikacji wirusowej |
EP1881002A1 (en) | 2006-07-20 | 2008-01-23 | Tibotec Pharmaceuticals Ltd. | HCV NS-3 serine protease inhibitors |
KR20090101372A (ko) | 2007-01-08 | 2009-09-25 | 페노믹스 코포레이션 | 매크로시클릭 c형 간염 프로테아제 억제제 |
US20080207528A1 (en) | 2007-02-01 | 2008-08-28 | Syaulan Yang | Hcv protease inhibitors |
CN102245599B (zh) | 2008-12-10 | 2014-05-14 | 艾其林医药公司 | 作为病毒复制抑制剂的新的4-氨基-4-氧代丁酰基肽 |
-
2009
- 2009-12-10 CN CN200980149528.2A patent/CN102245599B/zh not_active Expired - Fee Related
- 2009-12-10 EP EP20090832541 patent/EP2364309B1/en not_active Not-in-force
- 2009-12-10 NZ NZ59266809A patent/NZ592668A/en not_active IP Right Cessation
- 2009-12-10 MX MX2011006244A patent/MX2011006244A/es active IP Right Grant
- 2009-12-10 KR KR1020117015962A patent/KR101762842B1/ko active IP Right Grant
- 2009-12-10 DK DK09832541T patent/DK2364309T3/en active
- 2009-12-10 US US12/635,270 patent/US8614180B2/en active Active
- 2009-12-10 JP JP2011540889A patent/JP5723783B2/ja not_active Expired - Fee Related
- 2009-12-10 WO PCT/US2009/067506 patent/WO2010068760A2/en active Application Filing
- 2009-12-10 SI SI200931098T patent/SI2364309T1/sl unknown
- 2009-12-10 EA EA201100928A patent/EA022134B1/ru not_active IP Right Cessation
- 2009-12-10 CA CA2746264A patent/CA2746264C/en not_active Expired - Fee Related
- 2009-12-10 BR BRPI0922912A patent/BRPI0922912A8/pt not_active Application Discontinuation
- 2009-12-10 PT PT98325418T patent/PT2364309E/pt unknown
- 2009-12-10 AU AU2009324643A patent/AU2009324643B2/en not_active Ceased
- 2009-12-10 PL PL09832541T patent/PL2364309T3/pl unknown
- 2009-12-10 ES ES09832541.8T patent/ES2527166T3/es active Active
-
2011
- 2011-05-09 IL IL21278611A patent/IL212786A/en not_active IP Right Cessation
- 2011-10-17 HK HK11111013.7A patent/HK1156623A1/xx not_active IP Right Cessation
-
2013
- 2013-12-23 US US14/139,196 patent/US9133115B2/en not_active Expired - Fee Related
-
2014
- 2014-12-22 CY CY20141101077T patent/CY1116254T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
BRPI0922912A2 (pt) | 2016-01-26 |
SI2364309T1 (sl) | 2015-03-31 |
US20100216725A1 (en) | 2010-08-26 |
WO2010068760A3 (en) | 2010-10-14 |
US20140113890A1 (en) | 2014-04-24 |
CA2746264A1 (en) | 2010-06-17 |
JP5723783B2 (ja) | 2015-05-27 |
US8614180B2 (en) | 2013-12-24 |
EP2364309B1 (en) | 2014-10-01 |
IL212786A0 (en) | 2011-07-31 |
JP2012511587A (ja) | 2012-05-24 |
DK2364309T3 (en) | 2015-01-12 |
EA201100928A1 (ru) | 2011-12-30 |
CA2746264C (en) | 2017-11-14 |
US9133115B2 (en) | 2015-09-15 |
EP2364309A2 (en) | 2011-09-14 |
CN102245599A (zh) | 2011-11-16 |
EA022134B1 (ru) | 2015-11-30 |
CY1116254T1 (el) | 2017-02-08 |
MX2011006244A (es) | 2011-06-27 |
PT2364309E (pt) | 2015-01-14 |
AU2009324643A1 (en) | 2010-06-17 |
AU2009324643B2 (en) | 2014-08-28 |
BRPI0922912A8 (pt) | 2018-01-02 |
CN102245599B (zh) | 2014-05-14 |
ES2527166T3 (es) | 2015-01-21 |
WO2010068760A2 (en) | 2010-06-17 |
HK1156623A1 (en) | 2012-06-15 |
EP2364309A4 (en) | 2012-08-29 |
KR101762842B1 (ko) | 2017-08-04 |
IL212786A (en) | 2014-11-30 |
KR20110114566A (ko) | 2011-10-19 |
NZ592668A (en) | 2013-12-20 |
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