AR045938A1 - Peptidos macrociclicos activos contra el virus de la hepatitis c - Google Patents
Peptidos macrociclicos activos contra el virus de la hepatitis cInfo
- Publication number
- AR045938A1 AR045938A1 ARP040103399A ARP040103399A AR045938A1 AR 045938 A1 AR045938 A1 AR 045938A1 AR P040103399 A ARP040103399 A AR P040103399A AR P040103399 A ARP040103399 A AR P040103399A AR 045938 A1 AR045938 A1 AR 045938A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- cycloalkyl
- aryl
- substituted
- independently selected
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
Compuestos de la fórmula (1) en la que W es CH o N; L0 es H, -OH, -O-alquilo (C1-4), -NH2, -NHalquilo (C1-4) o -N(alquilo (C1-4))2; L1, L2 son cada uno independientemente halógeno, alquilo (C1-4), alquinilo (C2-4), -O-alquilo (C1-4), -S-alquilo (C1- 4), -SO-alquilo (C1-4) o -SO2-alquilo (C1-4), y ya sea L1 o L2 (pero no ambos simultáneamente) también puede ser H, o L0 y L1 o L0 y L2 pueden estar covalentemente unidos para formar, junto con los átomos de C a los que están unidos, un anillo carbocíclico de 4, 5 o 6 miembros, en los que un grupo -CH2 y, en el caso de un anillo de 5 o 6 miembros, uno o dos grupos -CH2 que no están directamente unidos entre sí, pueden estar reemplazados cada uno independientemente con -O- o NRa para formar un anillo heterocíclico en el que Ra es H o alquilo (C1-4) y en el que dicho anillo carbo o heterocíclico está opcionalmente mono o di-sustituido con alquilo (C1-4); R2 es arilo (C6-10) o Het, en el que Het es un heterociclo saturado o insaturado (incluyendo aromático) de 5, 6 o 7 miembros, que contiene entre 1 y 4 heteroátomos, cada uno independientemente seleccionado entre N, O y S, estando dicho arilo o Het sustituido con R24, en el que R24 es H, halo, alcoxi (C1-6), cicloalcoxi (C3-6) o NO2, o R24 es R20, -NHCOR20, -NHCOOR20, -NHR21 o -NHCONR21R22, en los que R20 se selecciona entre alquilo (C1-8), cicloalquilo (C3-7) y alquilo (C1-4)-cicloalquilo (C3-7), en el que dichos cicloalquilo y alquil-cicloalquilo pueden estar mono, di, o tri-sustituidos con alquilo (C1-3); R21 es H o 20 tal como se definió anteriormente; y R22 es H o metilo; R3 es hidroxi, NH2 o un grupo de la fórmula -NH-R31, en la que R31 es arilo (C6-10), heteroarilo, -C(O)-B, -C(O)-OB o - C(O)-NH-B, en el que B es alquilo (C1-10), cicloalquilo (C3-7) o alquilo (C1-4)-cicloalquilo (C3-7), a) en el que dichos alquilo, cicloalquilo y alquil-cicloalquilo pueden estar mono, di o tri-sustituidos con alquilo (C1-3), y b) en el que dichos alquilo, cicloalquilo y alquil-cicloalquilo pueden estar mono, di o tri-sustituidos con sustituyentes, seleccionados cada uno independientemente entre hidroxi y O-alquilo (C1-69, y c) en el que dichos grupos alquilo pueden estar mono, di o tri- sustituidos con halógeno; y d) en el que en cada uno de dichos grupos cicloalquilo de 5, 6 o 7 miembros, uno o dos grupos -CH2 que no están directamente unidos entre sí pueden estar reemplazados con -O-; D es una cadena de alquileno saturada o insaturada de 5 a 10 átomos que opcionalmente contiene 1 a 3 heteroátomos, cada uno independientemente seleccionado entre O, S y N-R41, en el que R41 es h, alquilo (C1-6), cicloalquilo (C3-6)o -C(O)-R42, en el que R42 es alquilo (C1-6), cicloalquilo (C3-6) o arilo (C6-10); R4 es H o entre 1 y 3 sustituyentes en cualquier átomo de C de dicha cadena D, estando cada uno de dichos sustituyentes independientemente seleccionado entre el grupo que consiste en. alquilo (C1-6), haloalquilo (C1-6), alcoxi (C1-6), hidroxi, halo, amino, oxo, tio y alquiltio (C1-6); y Rc es hidroxi o -NHSO2Rs, en el que Rs es alquilo (C1-6), alquenilo (C2-6), cicloalquilo (C3-7), alquilo (C1-6)-cicloalquilo (C3-7), fenilo, naftilo, piridinilo, alquilo (C1-4)- fenilo, alquilo (C1-4)naftilo o alquilo (C1-4)-piridinilo; estando cada uno opcionalmente sustituido con nitro; y estando cada uno opcionalmente mono, di o tri-sustituido con sustituyentes seleccionados cada uno independientemente entre halógeno, hidroxi, ciano, alquilo (C1-6), alquenilo (C2-6), -O-alquilo (C1-4, -CO-NH2, -CO-NHalquilo (C1-4), -CO-N(alquilo (C1-4))2, -NH2, -NHalquilo (C1-4) y -N(alquilo (C1-4)2, en el que alquilo (c1-4) y O-alquilo (C1-6) están opcionalmente sustituidos con uno a tres átomos de halógeno; o Rs es -N(RN2)(RN1), en el que RN1 y RN2 se seleccionan cada uno independientemente entre H, alquilo (C1-6), cicloalquilo (C3-7), alquilo (C1-6)-cicloalquilo (C3-7), arilo y alquilo (C1-6)-arilo; en el que dichos alquilo (C1-6), cicloalquilo (C3-7), alquilo (C1-6)-cicloalquilo (C3-7), arilo y alquilo (C1-6)-arilo están cada uno opcionalmente sustituidos con 1 o más sustituyentes, seleccionados cada uno independientemente entre halógeno, alquilo (C1-69, hidroxi, ciano, O-alquilo (C1-6), -NH2, -NHalquilo (C1-4), N(alquilo (C1-4))2, -CO-NH2, -CO-NHalquilo (C1-4), -CO-N(alquilo C1-4))2, -COOH y -COOalquilo (C1-6), o RN2 y RN1 están unidos, junto con el N al cual están unidos, para formar un heterociclo saturado o insaturado monocíclico de 3 a 7 miembros o un heterociclo saturado o insaturado bicíclico de 9 o 10 miembros, cada uno de los cuales contiene opcionalmente entre 1 y 3 heteroátomos adicionales, cada uno independientemente seleccionado entre N, S y O, y cada uno de los cuales está opcionalmente sustituido con uno o más sustituyentes, seleccionados cada uno independientemente entre halógeno, alquilo (C1-6), hidroxi, ciano, O-alquilo (C1-6), -NH2 -NHalquilo (C1-4), - N(alquilo (C1-4))2, -CO-NH2, -CO-NHalquilo (C1-4), -CO-N(alquilo (C1-4))2, -COOH y -COOalquilo (C1-6); o una de sus sales o ésteres farmacéuticamente aceptables, siempre que cuando W es N; y L0 es H, uno de L1 o L2 es H y el otro L2 o L1 es halo o - O-alquilo (C1-4), y R2 es arilo (C6 o 10) o Het, en el que het es un heterociclo saturado o insaturado (incluyendo aromático) de 5, 6 o 7 miembros, que contiene entre 1 y 4 heteroátomos, cada uno independientemente seleccionado entre N, O y S, estando dicho arilo o Het sustituido con R24; en el que R24 selecciona entre H, halo, alquilo (C1-6), -NH2, -NHalquilo (C1-6), -NHcicloaqluilo (C3-6), -NHCOOalquilo (C1-6), -NHCOOcicloalquilo (C3-6), -NHCOalquilo (C1-6), -NHCOcicloalquilo (C3-6) y - NHCONR21R22, en el que R21 se selecciona entre H, alquilo (C1-6) y cicloalquilo (C3-6) y R22 se selecciona entre H y metilo; y R3 es NH2, o un grupo de la fórmula -NH-R31, en la que R31 es -C(O)-B, -C(O)-OB, o -C(O)-NH-B, en la que B es alquilo (C1- 6) opcionalmente sustituido con halo, o B es -(CH2)p-cicloalquilo (C3-7), en el que p es 0-4 o B es un anillo de tetrahidrofurano unido a través de la posición C3 o C4 del anillo; y D es una cadena de alquileno saturada o insaturada de 5 a 9 átomos que opcionalmente contiene entre 1 y 3 heteroátomos, cada uno independientemente seleccionado entre O y S; y R4 es H; entonces Rc no es -NHSO2Rs, en el que Rs es alquilo (C1-6) o cicloalquilo (C3-7) no sustituido, o una de sus sales o ésteres farmacéuticamente aceptables, útiles como inhibidores de la proteasa NS3 del VHC. Reivindicación 32: Una composición farmacéutica que comprende una cantidad viralmente eficaz anti-hepatitis C de un compuesto de acuerdo con una o más de las reivindicaciones 1 a 31, incluyendo una de sus sales o ésteres farmacéuticamente aceptables, en mezcla con un vehículo o agente auxiliar farmacéuticamente aceptable.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50483903P | 2003-09-22 | 2003-09-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR045938A1 true AR045938A1 (es) | 2005-11-16 |
Family
ID=34375541
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP040103399A AR045938A1 (es) | 2003-09-22 | 2004-09-22 | Peptidos macrociclicos activos contra el virus de la hepatitis c |
Country Status (22)
Country | Link |
---|---|
US (2) | US7642235B2 (es) |
EP (1) | EP1673385B1 (es) |
JP (2) | JP4704342B2 (es) |
KR (1) | KR20060094083A (es) |
CN (1) | CN1856502A (es) |
AR (1) | AR045938A1 (es) |
AT (1) | ATE500264T1 (es) |
AU (1) | AU2004274051A1 (es) |
BR (1) | BRPI0414571A (es) |
CA (1) | CA2536182C (es) |
DE (1) | DE602004031645D1 (es) |
EA (1) | EA200600498A1 (es) |
EC (1) | ECSP066448A (es) |
ES (1) | ES2361997T3 (es) |
IL (1) | IL174403A0 (es) |
MX (1) | MXPA06003141A (es) |
NO (1) | NO20061767L (es) |
PE (1) | PE20050431A1 (es) |
RS (1) | RS20060197A (es) |
TW (1) | TW200521144A (es) |
UY (1) | UY28525A1 (es) |
WO (1) | WO2005028501A1 (es) |
Families Citing this family (126)
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US7148347B2 (en) * | 2003-04-10 | 2006-12-12 | Boehringer Ingelheim International Gmbh | Process for preparing macrocyclic compounds |
US7176208B2 (en) | 2003-04-18 | 2007-02-13 | Enanta Pharmaceuticals, Inc. | Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors |
KR101115294B1 (ko) | 2003-05-21 | 2012-04-12 | 베링거 인겔하임 인터내셔날 게엠베하 | C형 간염 억제제 화합물 |
TW201127828A (en) | 2003-09-05 | 2011-08-16 | Vertex Pharma | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease |
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US7491794B2 (en) * | 2003-10-14 | 2009-02-17 | Intermune, Inc. | Macrocyclic compounds as inhibitors of viral replication |
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2006
- 2006-03-20 IL IL174403A patent/IL174403A0/en unknown
- 2006-03-22 EC EC2006006448A patent/ECSP066448A/es unknown
- 2006-04-21 NO NO20061767A patent/NO20061767L/no not_active Application Discontinuation
-
2009
- 2009-09-28 US US12/567,861 patent/US20100028300A1/en not_active Abandoned
-
2010
- 2010-07-08 JP JP2010156015A patent/JP2011006420A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
EP1673385A4 (en) | 2006-10-04 |
KR20060094083A (ko) | 2006-08-28 |
CA2536182C (en) | 2012-07-24 |
ATE500264T1 (de) | 2011-03-15 |
EA200600498A1 (ru) | 2006-10-27 |
MXPA06003141A (es) | 2006-06-05 |
WO2005028501A1 (en) | 2005-03-31 |
JP4704342B2 (ja) | 2011-06-15 |
JP2007529411A (ja) | 2007-10-25 |
TW200521144A (en) | 2005-07-01 |
DE602004031645D1 (de) | 2011-04-14 |
ES2361997T3 (es) | 2011-06-27 |
RS20060197A (en) | 2008-09-29 |
PE20050431A1 (es) | 2005-07-19 |
US7642235B2 (en) | 2010-01-05 |
AU2004274051A1 (en) | 2005-03-31 |
EP1673385A1 (en) | 2006-06-28 |
CA2536182A1 (en) | 2005-03-31 |
EP1673385B1 (en) | 2011-03-02 |
IL174403A0 (en) | 2006-08-01 |
UY28525A1 (es) | 2005-04-29 |
JP2011006420A (ja) | 2011-01-13 |
NO20061767L (no) | 2006-06-16 |
ECSP066448A (es) | 2006-09-18 |
US20050080005A1 (en) | 2005-04-14 |
CN1856502A (zh) | 2006-11-01 |
BRPI0414571A (pt) | 2006-11-07 |
US20100028300A1 (en) | 2010-02-04 |
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