PE20060381A1 - Analogos de dipeptidos inhibidores de la hepatitis c - Google Patents
Analogos de dipeptidos inhibidores de la hepatitis cInfo
- Publication number
- PE20060381A1 PE20060381A1 PE2005000824A PE2005000824A PE20060381A1 PE 20060381 A1 PE20060381 A1 PE 20060381A1 PE 2005000824 A PE2005000824 A PE 2005000824A PE 2005000824 A PE2005000824 A PE 2005000824A PE 20060381 A1 PE20060381 A1 PE 20060381A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- hepatitis
- dimetoxy
- quinoline
- refers
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE m Y n SON 1-2; R1 ES ALQUILO C1-C6, ALQUENILO C2-C6, ALQUINILO C2-C6, LOS QUE ESTAN SUSTITUIDOS O NO CON 1-3 ATOMOS DE HALOGENO; R2 ES DE PREFERENCIA 2-ETOXI-4,7-DIMETOXI-8-BROMO-QUINOLINA, 4,7-DIMETOXI-8-METIL-QUINOLINA, ENTRE OTROS; R3 ES -COO(ALQUILO C1-C6), 3,3-DIMETIL-1-IL-BUTANONA; 3,3,3-TRIFLUORO-1-BUTANOIL, ENTRE OTROS; R4 ES DE PREFERENCIA PROPIL, FENILO, 3-CLOROFENIL, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DE PROTEASA NS3 UTILES EN EL TRATAMIENTO DE INFECCION POR EL VIRUS DE LA HAPATITIS C (VHC)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58943504P | 2004-07-20 | 2004-07-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20060381A1 true PE20060381A1 (es) | 2006-06-01 |
Family
ID=35784836
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2005000824A PE20060381A1 (es) | 2004-07-20 | 2005-07-18 | Analogos de dipeptidos inhibidores de la hepatitis c |
Country Status (9)
Country | Link |
---|---|
US (2) | US7511157B2 (es) |
EP (1) | EP1771453B1 (es) |
JP (1) | JP4914354B2 (es) |
AR (1) | AR050430A1 (es) |
CA (1) | CA2573219C (es) |
PE (1) | PE20060381A1 (es) |
TW (1) | TW200615275A (es) |
UY (1) | UY29016A1 (es) |
WO (1) | WO2006007700A1 (es) |
Families Citing this family (88)
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US7491794B2 (en) * | 2003-10-14 | 2009-02-17 | Intermune, Inc. | Macrocyclic compounds as inhibitors of viral replication |
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CA2573346C (en) * | 2004-07-20 | 2011-09-20 | Boehringer Ingelheim International Gmbh | Hepatitis c inhibitor peptide analogs |
US7323447B2 (en) * | 2005-02-08 | 2008-01-29 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
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US7592336B2 (en) | 2005-05-10 | 2009-09-22 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
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-
2005
- 2005-07-14 UY UY29016A patent/UY29016A1/es not_active Application Discontinuation
- 2005-07-15 EP EP05763539A patent/EP1771453B1/en not_active Not-in-force
- 2005-07-15 JP JP2007521757A patent/JP4914354B2/ja not_active Expired - Fee Related
- 2005-07-15 WO PCT/CA2005/001115 patent/WO2006007700A1/en active Application Filing
- 2005-07-15 CA CA2573219A patent/CA2573219C/en not_active Expired - Fee Related
- 2005-07-18 PE PE2005000824A patent/PE20060381A1/es not_active Application Discontinuation
- 2005-07-19 US US11/185,671 patent/US7511157B2/en active Active
- 2005-07-19 TW TW094124344A patent/TW200615275A/zh unknown
- 2005-07-20 AR ARP050102985A patent/AR050430A1/es unknown
-
2009
- 2009-02-10 US US12/368,321 patent/US7767818B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US7511157B2 (en) | 2009-03-31 |
JP2008506719A (ja) | 2008-03-06 |
JP4914354B2 (ja) | 2012-04-11 |
US20060046965A1 (en) | 2006-03-02 |
WO2006007700A1 (en) | 2006-01-26 |
CA2573219A1 (en) | 2006-01-26 |
CA2573219C (en) | 2011-01-18 |
AR050430A1 (es) | 2006-10-25 |
TW200615275A (en) | 2006-05-16 |
US20090156822A1 (en) | 2009-06-18 |
UY29016A1 (es) | 2006-02-24 |
US7767818B2 (en) | 2010-08-03 |
EP1771453B1 (en) | 2012-05-30 |
EP1771453A1 (en) | 2007-04-11 |
EP1771453A4 (en) | 2009-03-18 |
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