PE20090630A1 - Derivados de indol 2-carboxi sustituidos y metodos para su utilizacion - Google Patents

Derivados de indol 2-carboxi sustituidos y metodos para su utilizacion

Info

Publication number
PE20090630A1
PE20090630A1 PE2008001453A PE2008001453A PE20090630A1 PE 20090630 A1 PE20090630 A1 PE 20090630A1 PE 2008001453 A PE2008001453 A PE 2008001453A PE 2008001453 A PE2008001453 A PE 2008001453A PE 20090630 A1 PE20090630 A1 PE 20090630A1
Authority
PE
Peru
Prior art keywords
carboxi
indeol
substitute
derivatives
methods
Prior art date
Application number
PE2008001453A
Other languages
English (en)
Inventor
Kevin X Chen
Srikanth Venkatraman
George F Njoroge
Stuart B Rosenblum
Charles A Lesburg
Jose S Duca
Neng-Yang Shih
Francisco Velazquez
Gopinadhan N Anilkumar
Qingbei Zei
Joseph A Kozlowski
Frank Bennett
Tin-Yau Chan
Mousumi Sannigrahi
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39968138&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20090630(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of PE20090630A1 publication Critical patent/PE20090630A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE INDOL 2-CARBOXI SUSTITUIDOS DE FORMULA (I) DONDE R1 ES -[C(R12)2]r-, -[C(R12)2]r-O-[C(R12)2]q-, -[C(R12)2]r-N(R9)-[C(R12)2]q-, ENTRE OTROS; R2 ES -C(O)R9, -C(O)OR9, -C(O)OCH2OR9, ENTRE OTROS, EN DONDE R12 ES H, HALO, -N(R9)2, ENTRE OTROS; R9 ES H, ALQUILO, ALQUENILO, ALQUINILO, ENTRE OTROS; q ES DE 0 A 4; r ES DE 1 A 4; R4, R5, R6 Y R7 SON CADA UNO H, ALQUILO, ALQUENILO, ARILO, ENTRE OTROS; R10 ES H, CICLOALQUILO, ARILO, HETEROARILO, ENTRE OTROS; R3 ES UN COMPUESTO DE FORMULA (i) O (ii), DONDE R30 ES H, ALQUILO, ARILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS LOS DE FORMULA (a), (b), ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON UTILES PARA EL TRATAMIENTO DE UNA INFECCION VIRAL POR EL VIRUS DE LA HEPATITIS C (VHC)
PE2008001453A 2007-08-29 2008-08-27 Derivados de indol 2-carboxi sustituidos y metodos para su utilizacion PE20090630A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US96869807P 2007-08-29 2007-08-29

Publications (1)

Publication Number Publication Date
PE20090630A1 true PE20090630A1 (es) 2009-05-16

Family

ID=39968138

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008001453A PE20090630A1 (es) 2007-08-29 2008-08-27 Derivados de indol 2-carboxi sustituidos y metodos para su utilizacion

Country Status (17)

Country Link
US (1) US8614229B2 (es)
EP (1) EP2408761B1 (es)
JP (2) JP5272008B2 (es)
KR (1) KR20100067652A (es)
CN (1) CN101821252A (es)
AR (1) AR068106A1 (es)
AU (1) AU2008295484B2 (es)
BR (1) BRPI0815811A2 (es)
CA (1) CA2697454C (es)
CL (1) CL2008002539A1 (es)
EC (1) ECSP10010004A (es)
ES (1) ES2447543T3 (es)
MX (1) MX2010002317A (es)
PE (1) PE20090630A1 (es)
RU (1) RU2010111551A (es)
TW (1) TW200924780A (es)
WO (1) WO2009032124A1 (es)

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Also Published As

Publication number Publication date
ES2447543T3 (es) 2014-03-12
WO2009032124A1 (en) 2009-03-12
JP5272008B2 (ja) 2013-08-28
TW200924780A (en) 2009-06-16
CA2697454A1 (en) 2009-03-12
AR068106A1 (es) 2009-11-04
JP2013100375A (ja) 2013-05-23
AU2008295484A1 (en) 2009-03-12
US8614229B2 (en) 2013-12-24
RU2010111551A (ru) 2011-10-10
EP2408761A1 (en) 2012-01-25
ECSP10010004A (es) 2010-03-31
EP2408761B1 (en) 2014-01-01
JP2010537981A (ja) 2010-12-09
CL2008002539A1 (es) 2009-07-17
MX2010002317A (es) 2010-03-22
CN101821252A (zh) 2010-09-01
US20110104110A1 (en) 2011-05-05
KR20100067652A (ko) 2010-06-21
AU2008295484B2 (en) 2013-09-26
CA2697454C (en) 2015-11-03
BRPI0815811A2 (pt) 2015-02-18

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