PE20090995A1 - Derivados indolicos 2,3-sustituidos como inhibidores del virus de la hepatitis c (vhc) - Google Patents
Derivados indolicos 2,3-sustituidos como inhibidores del virus de la hepatitis c (vhc)Info
- Publication number
- PE20090995A1 PE20090995A1 PE2008001454A PE2008001454A PE20090995A1 PE 20090995 A1 PE20090995 A1 PE 20090995A1 PE 2008001454 A PE2008001454 A PE 2008001454A PE 2008001454 A PE2008001454 A PE 2008001454A PE 20090995 A1 PE20090995 A1 PE 20090995A1
- Authority
- PE
- Peru
- Prior art keywords
- hcv
- inhibitors
- substituted
- hepatitis
- virus
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
REFERIDA A COMPUESTOS DERIVADOS INDOLICOS 2,3 SUSTITUIDOS DE FORMULA I, DONDE R1 ES UN ENLACE, -[C(R12)2]r-, -[C(R12)2]r-O-[C(R12)2]q-, ENTRE OTROS; R12 ES H, HALO, -N(R9)2, OR9, ENTRE OTROS; R9 ES H, ALQUILO, ALQUENILO, ALQUINILO, ENTRE OTROS; R2 ES -[C(R12)2]q-C(O)N(R9)SOR11, -[C(R12)2]q-C(O)N(R9)SO2R11, -[C(R12)2]q-C(O)N(R9)SO2N(R9)2, ENTRE OTROS; R3 ES (x) O (y); R30 ES H, ALQUILO, ARILO, ENTRE OTROS; R4, R5, R6 Y R7 SON CADA UNO H, ALQUILO, ARILO. ENTRE OTROS; R10 ES H, CICLOALQUILO, CICLOALQUENILO, HETEROCICLOALQUILO, ENTRE OTROS; q ES UN ENTERO DE 0 A 4; r ES UN ENTERO DE 1 A 4. SON COMPUESTOS SELECCIONADOS: (a), (b), ENTRE OTROS. SE REFIERE TAMBIEN A SU PROCEDIMIENTO DE PREPARACION Y A COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN. DICHOS COMPUESTOS SON INHIBIDORES DE LA REPLICACION DEL VHC, SIENDO UTILES PARA EL TRATAMIENTO DE CIRROSIS, ICTERICIA, ENCEFALOPATIA HEPATICA, ENTRE OTROS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US96874507P | 2007-08-29 | 2007-08-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20090995A1 true PE20090995A1 (es) | 2009-08-03 |
Family
ID=40220015
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2008001454A PE20090995A1 (es) | 2007-08-29 | 2008-08-27 | Derivados indolicos 2,3-sustituidos como inhibidores del virus de la hepatitis c (vhc) |
Country Status (18)
Country | Link |
---|---|
US (1) | US8143305B2 (es) |
EP (1) | EP2197842B1 (es) |
JP (1) | JP5272007B2 (es) |
KR (1) | KR20100049667A (es) |
CN (1) | CN101842353A (es) |
AR (1) | AR068107A1 (es) |
AU (1) | AU2008295476B2 (es) |
BR (1) | BRPI0816116A2 (es) |
CA (1) | CA2697375A1 (es) |
CL (1) | CL2008002538A1 (es) |
CO (1) | CO6321236A2 (es) |
EC (1) | ECSP10010002A (es) |
MX (1) | MX2010002319A (es) |
PE (1) | PE20090995A1 (es) |
RU (1) | RU2010111550A (es) |
TW (1) | TW200924751A (es) |
WO (1) | WO2009032116A1 (es) |
ZA (1) | ZA201001335B (es) |
Families Citing this family (59)
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EP1604988A1 (en) | 2004-05-18 | 2005-12-14 | Sanofi-Aventis Deutschland GmbH | Pyridazinone derivatives, methods for producing them and their use as pharmaceuticals |
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-
2008
- 2008-08-27 PE PE2008001454A patent/PE20090995A1/es not_active Application Discontinuation
- 2008-08-27 WO PCT/US2008/010130 patent/WO2009032116A1/en active Application Filing
- 2008-08-27 CN CN200880114487A patent/CN101842353A/zh active Pending
- 2008-08-27 BR BRPI0816116-0A2A patent/BRPI0816116A2/pt not_active IP Right Cessation
- 2008-08-27 KR KR1020107006703A patent/KR20100049667A/ko not_active Application Discontinuation
- 2008-08-27 TW TW097132720A patent/TW200924751A/zh unknown
- 2008-08-27 US US12/675,897 patent/US8143305B2/en not_active Expired - Fee Related
- 2008-08-27 CA CA2697375A patent/CA2697375A1/en not_active Abandoned
- 2008-08-27 RU RU2010111550/04A patent/RU2010111550A/ru not_active Application Discontinuation
- 2008-08-27 JP JP2010522925A patent/JP5272007B2/ja not_active Expired - Fee Related
- 2008-08-27 AR ARP080103716A patent/AR068107A1/es unknown
- 2008-08-27 EP EP08795611A patent/EP2197842B1/en active Active
- 2008-08-27 AU AU2008295476A patent/AU2008295476B2/en not_active Ceased
- 2008-08-27 MX MX2010002319A patent/MX2010002319A/es active IP Right Grant
- 2008-08-28 CL CL2008002538A patent/CL2008002538A1/es unknown
-
2010
- 2010-02-24 ZA ZA2010/01335A patent/ZA201001335B/en unknown
- 2010-02-26 EC EC2010010002A patent/ECSP10010002A/es unknown
- 2010-03-25 CO CO10035485A patent/CO6321236A2/es not_active Application Discontinuation
Also Published As
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EP2197842B1 (en) | 2012-05-23 |
WO2009032116A1 (en) | 2009-03-12 |
TW200924751A (en) | 2009-06-16 |
RU2010111550A (ru) | 2011-10-10 |
BRPI0816116A2 (pt) | 2015-03-03 |
CN101842353A (zh) | 2010-09-22 |
JP5272007B2 (ja) | 2013-08-28 |
CO6321236A2 (es) | 2011-09-20 |
CA2697375A1 (en) | 2009-03-12 |
KR20100049667A (ko) | 2010-05-12 |
AU2008295476B2 (en) | 2013-08-01 |
US8143305B2 (en) | 2012-03-27 |
JP2010537979A (ja) | 2010-12-09 |
ECSP10010002A (es) | 2010-03-31 |
AU2008295476A1 (en) | 2009-03-12 |
CL2008002538A1 (es) | 2009-07-17 |
ZA201001335B (en) | 2010-12-29 |
MX2010002319A (es) | 2010-03-22 |
EP2197842A1 (en) | 2010-06-23 |
AR068107A1 (es) | 2009-11-04 |
US20110033417A1 (en) | 2011-02-10 |
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