AR106945A2 - Compuestos de isoindolina y composiciones farmacéuticas de los mismos - Google Patents

Compuestos de isoindolina y composiciones farmacéuticas de los mismos

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Publication number
AR106945A2
AR106945A2 ARP160103716A ARP160103716A AR106945A2 AR 106945 A2 AR106945 A2 AR 106945A2 AR P160103716 A ARP160103716 A AR P160103716A AR P160103716 A ARP160103716 A AR P160103716A AR 106945 A2 AR106945 A2 AR 106945A2
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AR
Argentina
Prior art keywords
alkyl
optionally substituted
heterocyclyl
aryl
same
Prior art date
Application number
ARP160103716A
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English (en)
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Celgene Corp
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Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of AR106945A2 publication Critical patent/AR106945A2/es

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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Anesthesiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Un compuesto que tiene la fórmula (3), o una sal, solvato, prodroga o estereoisómero farmacéuticamente aceptable del mismo, en donde: X es C(=O) o CH₂; m es un entero de 0, 1, 2, ó 3; R⁵ y R⁶ son cada uno, de manera independiente: hidrógeno, halo, C₁₋₆ alquilo, oxo, -NO₂, C₁₋₆ alcoxi, -Z-C₁₋₆ alquilo, C₀₋₆ alquil-(heteroarilo de 5 a 10 miembros), C₀₋₆ alquil-(heterociclilo de 5 a 6 miembros), C₀₋₆ alquil-OH, C₀₋₄ alquil-NH₂, -NHCO-C₁₋₆ alquilo, -OR²¹, o -(CH₂-Y)₀₋₂-(heteroarilo de 5 a 10 miembros), en donde Z es S o SO₂; Y es CH₂, NH, u O; en donde R²¹ es C₆₋₁₀ arilo, heteroarilo de 5 a 10 miembros, heterociclilo de 5 a 6 miembros, o -CO(CH₂)₀₋₂R²², en donde el arilo, heteroarilo, y heterociclilo están cada uno opcionalmente sustituido con uno o más C₁₋₆ alquilo; R²² es -NH₂ o heterociclilo de 5 a 6 miembros; en donde cada heteroarilo y heterociclilo anterior está opcionalmente sustituido con uno o más C₁₋₆ alquilo; y en donde el alquilo o alcoxi anterior puede estar opcionalmente sustituido con uno o más entre: halógeno; ciano; nitro; amino; C₁₋₆ alquilidendioxi; C₁₋₆ alcoxi, el mismo opcionalmente sustituido con uno o más halógenos; o C₁₋₆ alquiltio, el mismo opcionalmente sustituido con uno o más halógenos; R⁷ es -COR⁷¹ o -PO(OR⁷²)(OR⁷³); R⁷¹ es C₁₋₁₀ alquilo, C₆₋₁₀ arilo, o heterociclilo de 5 a 6 miembros; en donde el alquilo, arilo, heterociclilo pueden estar opcionalmente sustituidos con uno o más de amino, C₁₋₆ alquilamino, di(C₁₋₆ alquil)amino, o -COOR⁷⁴; y R⁷², R⁷³, y R⁷⁴ son cada uno, de manera independiente, hidrógeno o C₁₋₁₀ alquilo.
ARP160103716A 2008-10-29 2016-12-02 Compuestos de isoindolina y composiciones farmacéuticas de los mismos AR106945A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10947508P 2008-10-29 2008-10-29

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AR106945A2 true AR106945A2 (es) 2018-03-07

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Family Applications (6)

Application Number Title Priority Date Filing Date
ARP090104177 AR074001A1 (es) 2008-10-29 2009-10-29 Compuestos de isoindolina y composiciones farmaceuticas y uso para tratamiento de cancer
ARP160103712A AR106942A2 (es) 2008-10-29 2016-12-02 Compuestos de isoindolina y composiciones farmacéuticas de los mismos
ARP160103715A AR106944A2 (es) 2008-10-29 2016-12-02 Compuestos de isoindolina y composiciones farmacéuticas de los mismos
ARP160103713A AR106943A2 (es) 2008-10-29 2016-12-02 Compuestos de isoindolina y composiciones farmacéuticas de los mismos
ARP160103716A AR106945A2 (es) 2008-10-29 2016-12-02 Compuestos de isoindolina y composiciones farmacéuticas de los mismos
ARP160103802A AR106963A2 (es) 2008-10-29 2016-12-12 Compuestos de isoindolina y composiciones farmacéuticas de los mismos

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ARP090104177 AR074001A1 (es) 2008-10-29 2009-10-29 Compuestos de isoindolina y composiciones farmaceuticas y uso para tratamiento de cancer
ARP160103712A AR106942A2 (es) 2008-10-29 2016-12-02 Compuestos de isoindolina y composiciones farmacéuticas de los mismos
ARP160103715A AR106944A2 (es) 2008-10-29 2016-12-02 Compuestos de isoindolina y composiciones farmacéuticas de los mismos
ARP160103713A AR106943A2 (es) 2008-10-29 2016-12-02 Compuestos de isoindolina y composiciones farmacéuticas de los mismos

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US (6) US8129375B2 (es)
EP (3) EP3354646A1 (es)
JP (3) JP5603876B2 (es)
KR (3) KR20180000750A (es)
CN (2) CN102264720B (es)
AR (6) AR074001A1 (es)
AU (1) AU2009311477B2 (es)
BR (1) BRPI0919942B1 (es)
CA (2) CA2741299C (es)
CL (1) CL2011000957A1 (es)
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DK (1) DK2358697T3 (es)
ES (2) ES2662407T3 (es)
HR (1) HRP20151366T1 (es)
HU (1) HUE026105T2 (es)
IL (9) IL212435A (es)
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NI (1) NI201100082A (es)
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PE (2) PE20140963A1 (es)
PL (1) PL2358697T3 (es)
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RU (1) RU2527952C2 (es)
SG (2) SG195613A1 (es)
SI (1) SI2358697T1 (es)
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UA (1) UA107783C2 (es)
WO (1) WO2010053732A1 (es)
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US9540340B2 (en) 2013-01-14 2017-01-10 Deuterx, Llc 3-(5-substituted-4-oxoquinazolin-3(4H)-yl)-3-deutero-piperidine-2,6-dione derivatives and compositions comprising and methods of using the same
US9290475B2 (en) 2013-03-14 2016-03-22 Deuterx, Llc 3-(substituted-4-oxoquinazolin-3(4H)-yl)-3-deutero-piperidine-2,6-dione derivatives and compositions comprising and methods of using the same
AU2014254056B2 (en) 2013-04-17 2019-06-06 Signal Pharmaceuticals, Llc Combination therapy comprising a TOR kinase inhibitor and an IMiD compound for treating cancer
BR112016012795A2 (pt) 2013-12-06 2017-08-08 Celgene Corp Métodos para a determinação da eficácia do fármaco para o tratamento de linfoma difuso de grandes células b, mieloma múltiplo e cânceres mieloides
JP6778114B2 (ja) * 2014-04-14 2020-10-28 アルビナス・オペレーションズ・インコーポレイテッドＡｒｖｉｎａｓ Ｏｐｅｒａｔｉｏｎｓ， Ｉｎｃ． イミド系タンパク質分解モジュレーター及び関連する使用方法
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