IT1274549B - Uso di flavanolignani per la preparazione di medicamenti ad attivita' antiproliferativa nei tumori dell'utero,dell'ovaio e del seno - Google Patents

Uso di flavanolignani per la preparazione di medicamenti ad attivita' antiproliferativa nei tumori dell'utero,dell'ovaio e del seno

Info

Publication number
IT1274549B
IT1274549B ITMI951047A ITMI951047A IT1274549B IT 1274549 B IT1274549 B IT 1274549B IT MI951047 A ITMI951047 A IT MI951047A IT MI951047 A ITMI951047 A IT MI951047A IT 1274549 B IT1274549 B IT 1274549B
Authority
IT
Italy
Prior art keywords
silicristin
silidianin
mixtures
effective amount
therapeutically effective
Prior art date
Application number
ITMI951047A
Other languages
English (en)
Inventor
Ezio Bombardelli
Paolo Morazzoni
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena Spa filed Critical Indena Spa
Publication of ITMI951047A0 publication Critical patent/ITMI951047A0/it
Priority to ITMI951047A priority Critical patent/IT1274549B/it
Priority to AU38051/95A priority patent/AU709802B2/en
Priority to KR1019970708287A priority patent/KR100290030B1/ko
Priority to RU97121286/14A priority patent/RU2161488C2/ru
Priority to AT95935927T priority patent/ATE268183T1/de
Priority to DK95935927T priority patent/DK0828500T3/da
Priority to EP95935927A priority patent/EP0828500B1/en
Priority to US08/952,415 priority patent/US5912265A/en
Priority to HK98104797.0A priority patent/HK1006222B/en
Priority to JP53528596A priority patent/JP3178844B2/ja
Priority to CNB951978616A priority patent/CN1148181C/zh
Priority to PT95935927T priority patent/PT828500E/pt
Priority to ES95935927T priority patent/ES2222466T3/es
Priority to HU9801682A priority patent/HU220627B1/hu
Priority to CA002221753A priority patent/CA2221753C/en
Priority to DE69533112T priority patent/DE69533112T2/de
Priority to SI9530704T priority patent/SI0828500T1/xx
Priority to PCT/EP1995/003993 priority patent/WO1996037209A1/en
Priority to PL95323450A priority patent/PL182064B1/pl
Publication of ITMI951047A1 publication Critical patent/ITMI951047A1/it
Application granted granted Critical
Publication of IT1274549B publication Critical patent/IT1274549B/it
Priority to FI974268A priority patent/FI119100B/fi
Priority to NO19975334A priority patent/NO317153B1/no
Priority to US09/287,103 priority patent/US6218369B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ITMI951047A 1995-05-23 1995-05-23 Uso di flavanolignani per la preparazione di medicamenti ad attivita' antiproliferativa nei tumori dell'utero,dell'ovaio e del seno IT1274549B (it)

Priority Applications (22)

Application Number Priority Date Filing Date Title
ITMI951047A IT1274549B (it) 1995-05-23 1995-05-23 Uso di flavanolignani per la preparazione di medicamenti ad attivita' antiproliferativa nei tumori dell'utero,dell'ovaio e del seno
CNB951978616A CN1148181C (zh) 1995-05-23 1995-10-10 黄酮木酯素在制备对子宫、卵巢和乳腺具有抗增殖活性的药物中的应用
ES95935927T ES2222466T3 (es) 1995-05-23 1995-10-10 Uso de flavanolignanos para la preparacion de medicamentos con actividad antiproliferativa en utero, ovario y mama.
RU97121286/14A RU2161488C2 (ru) 1995-05-23 1995-10-10 Применение флаванолигнанов в качестве лекарственных средств, обладающих антипролиферативной активностью в отношении опухолей матки, яичника и молочной железы
AT95935927T ATE268183T1 (de) 1995-05-23 1995-10-10 Verwendung von flavolignanen zur herstellung von medikamenten mit antiproliferativer aktivität in gebärmutter,brust,eierstöcken
DK95935927T DK0828500T3 (da) 1995-05-23 1995-10-10 Anvendelse af flavanyllignaner til fremstilling af lægemidler med proliferativ aktivitet i uturus, ovarie og bryst
EP95935927A EP0828500B1 (en) 1995-05-23 1995-10-10 Use of flavanolignanes for the preparation of medicaments with antiproliferative activity in uterus, ovary and breast
US08/952,415 US5912265A (en) 1995-05-23 1995-10-10 Pharmaceutical compositions containing flavanolignanes and methods for using same as an antiproliferative
HK98104797.0A HK1006222B (en) 1995-05-23 1995-10-10 Use of flavanolignanes for the preparation of medicaments with antiproliferative activity in uterus, ovary and breast
JP53528596A JP3178844B2 (ja) 1995-05-23 1995-10-10 子宮、卵巣及び乳房における抗増殖活性を有する薬剤の製造のためのフラバノリグナンの利用
AU38051/95A AU709802B2 (en) 1995-05-23 1995-10-10 Use of flavanolignanes for the preparation of medicaments with antiproliferative activity in uterus, ovary and breast
PT95935927T PT828500E (pt) 1995-05-23 1995-10-10 Utilizacao de flavanolignanos para a preparacao de medicamentos com actividade antiproliferativa no utero ovarios e mama
KR1019970708287A KR100290030B1 (ko) 1995-05-23 1995-10-10 자궁, 난소 및 유방암의 항증식작용을 갖는 약제제조시의 후라바노리그난류의 용도
HU9801682A HU220627B1 (hu) 1995-05-23 1995-10-10 Flavanolignánok alkalmazása II. típusú ösztrogénreceptor antagonista és antiproliferatív hatású gyógyszerkészítmények előállítására
CA002221753A CA2221753C (en) 1995-05-23 1995-10-10 Use of flavanolignanes for the preparation of medicaments with antiproliferative activity in uterus, ovary and breast
DE69533112T DE69533112T2 (de) 1995-05-23 1995-10-10 Verwendung von flavolignanen zur herstellung von medikamenten mit antiproliferativer aktivität in gebärmutter,brust,eierstöcken
SI9530704T SI0828500T1 (en) 1995-05-23 1995-10-10 Use of flavanolignanes for the preparation of medicaments with antiproliferative activity in uterus, ovary and breast
PCT/EP1995/003993 WO1996037209A1 (en) 1995-05-23 1995-10-10 Use of flavanolignanes for the preparation of medicaments with antiproliferative activity in uterus, ovary and breast
PL95323450A PL182064B1 (pl) 1995-05-23 1995-10-10 Srodek farmaceutyczny wykazujacy dzialanie antagonistyczne na receptory estrogenowe typu II i dzialanie antyproliferacyjne PL
FI974268A FI119100B (fi) 1995-05-23 1997-11-18 Flavanolignaanien käyttö valmistettaessa lääkkeitä, joilla on antiproliferatiivista vaikutusta kohdussa, munasarjoissa ja rintarauhasessa
NO19975334A NO317153B1 (no) 1995-05-23 1997-11-20 Anvendelse av flavanolignaner for fremstilling av medikamenter med antiproliferativ aktivitet i uterus, ovarium og bryst
US09/287,103 US6218369B1 (en) 1995-05-23 1999-04-07 Pharmaceutical compositions containing flavanolignanes and methods for using same as an antiproliferative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI951047A IT1274549B (it) 1995-05-23 1995-05-23 Uso di flavanolignani per la preparazione di medicamenti ad attivita' antiproliferativa nei tumori dell'utero,dell'ovaio e del seno

Publications (3)

Publication Number Publication Date
ITMI951047A0 ITMI951047A0 (it) 1995-05-23
ITMI951047A1 ITMI951047A1 (it) 1996-11-23
IT1274549B true IT1274549B (it) 1997-07-17

Family

ID=11371650

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI951047A IT1274549B (it) 1995-05-23 1995-05-23 Uso di flavanolignani per la preparazione di medicamenti ad attivita' antiproliferativa nei tumori dell'utero,dell'ovaio e del seno

Country Status (20)

Country Link
US (2) US5912265A (it)
EP (1) EP0828500B1 (it)
JP (1) JP3178844B2 (it)
KR (1) KR100290030B1 (it)
CN (1) CN1148181C (it)
AT (1) ATE268183T1 (it)
AU (1) AU709802B2 (it)
CA (1) CA2221753C (it)
DE (1) DE69533112T2 (it)
DK (1) DK0828500T3 (it)
ES (1) ES2222466T3 (it)
FI (1) FI119100B (it)
HU (1) HU220627B1 (it)
IT (1) IT1274549B (it)
NO (1) NO317153B1 (it)
PL (1) PL182064B1 (it)
PT (1) PT828500E (it)
RU (1) RU2161488C2 (it)
SI (1) SI0828500T1 (it)
WO (1) WO1996037209A1 (it)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2432560A1 (fr) 1978-08-02 1980-02-29 Texas Instruments Inc Procede de decapage de metaux, en particulier d'aluminium, au plasma de tetrachlorure de silicium
US6379714B1 (en) 1995-04-14 2002-04-30 Pharmaprint, Inc. Pharmaceutical grade botanical drugs
ES2315435T3 (es) * 1996-08-12 2009-04-01 Celgene Corporation Nuevos agentes inmunoterapeuticos y su uso para la reduccion de los niveles de citoquinas.
US6239114B1 (en) * 1997-09-26 2001-05-29 Kgk Synergize Compositions and methods for treatment of neoplastic diseases with combinations of limonoids, flavonoids and tocotrienols
US6486193B2 (en) 1998-12-31 2002-11-26 Aventis Pharmaceuticals Inc. 3-substituted pyrrolidines useful as inhibitors of matrix metalloproteinases
FR2792846B1 (fr) 1999-04-30 2001-07-27 Salomon Sa Patin a roues en ligne du type a platine superieure articulee
WO2000066232A2 (fr) 1999-04-30 2000-11-09 Salomon S.A. Chassis articule
KR100342942B1 (ko) * 1999-07-05 2002-07-02 민경윤 카르두스 마리아누스 추출물 또는 이로부터 정제된 실리빈을함유하는 경구용 마이크로에멀젼 조성물
US20010025027A1 (en) * 2000-03-07 2001-09-27 Sonis Stephen T. Inhibition of ceramide for the prevention and treatment of oral mucositis induced by antineoplastic drugs or radiation
WO2002083124A1 (en) * 2000-10-06 2002-10-24 Probiochem, Llc A composition and method of sustaining chemotherapeutic effect while reducing dose of chemotherapeutic agent using cox-2 inhibitor and statin
WO2002067853A2 (en) * 2000-10-06 2002-09-06 Probiochem, Llc A combination and method of treatment of hiv and viral diseases, vascular disease and cancer utilizing a cox-2 inhibitor and cystine
CA2430669C (en) * 2000-11-30 2011-06-14 The Children's Medical Center Corporation Synthesis of 3-amino-thalidomide and its enantiomers
US20040092565A1 (en) * 2001-07-25 2004-05-13 George Kindness Composition and method of sustaining chemotherapeutic effect while reducing dose of chemotherapeutic agent using cox-2 inhibitor and statin
EP1314438A1 (en) * 2001-11-23 2003-05-28 Nutricia N.V. Anti-proliferative composition
US7842691B2 (en) * 2002-10-15 2010-11-30 Celgene Corporation Method for the treatment of myelodysplastic syndromes using cyclopropanecarboxylic acid {2-[1-(3-ethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethyl]-3-OXO-2,3-dihydro-1 H-isoindol-4-yl}-amide
US7776907B2 (en) * 2002-10-31 2010-08-17 Celgene Corporation Methods for the treatment and management of macular degeneration using cyclopropyl-N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-3-oxoisoindoline-4-yl}carboxamide
US20040091455A1 (en) * 2002-10-31 2004-05-13 Zeldis Jerome B. Methods of using and compositions comprising immunomodulatory compounds for treatment and management of macular degeneration
EP1562597A4 (en) * 2002-10-31 2008-05-14 Celgene Corp COMPOSITIONS COMPRISING IMMUNOMODULATORY COMPOUNDS FOR THE TREATMENT AND MANAGEMENT OF MACULAR DEGENERATION AND METHODS OF USE THEREOF
BR0316002A (pt) * 2002-11-06 2005-09-13 Celgene Corp Métodos de tratar ou prevenir e controlar uma doença mieloproliferativa, de reduzir ou evitar de um efeito adverso associado com a administração de um segundo agente ativo em um paciente sofrendo de uma doença mieloproliferativa e de aumentar a eficácia terapêutica de um tratamento de doença mieloproliferativa, composição farmacêutica e kit
BR0316256A (pt) * 2002-11-18 2005-10-04 Celgene Corp Métodos de inibir a produção de tnf-alfa e a atividade de pde4, de tratar ou prevenir uma doença ou um distúrbio, de controlar os nìveis de camp em uma célula e de produzir um composto, composição farmacêutica e composto
WO2004045597A1 (en) * 2002-11-18 2004-06-03 Celgene Corporation Methods of using and compositions comprising (+)-3-(3,4-dimethoxy-phenyl)-3-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionamide
CN100402023C (zh) * 2003-06-21 2008-07-16 山东绿叶天然药物研究开发有限公司 一种水飞蓟素软胶囊及其制备方法
US20080027113A1 (en) * 2003-09-23 2008-01-31 Zeldis Jerome B Methods of Using and Compositions Comprising Immunomodulatory Compounds for Treatment and Management of Macular Degeneration
KR100577514B1 (ko) * 2003-10-21 2006-05-10 한미약품 주식회사 비페닐디메틸디카복실레이트, 및 카르두스 마리아누스추출물 또는 이로부터 정제된 실리빈을 함유하는 경구용마이크로에멀젼 조성물
US20050142104A1 (en) * 2003-11-06 2005-06-30 Zeldis Jerome B. Methods of using and compositions comprising PDE4 modulators for the treatment and management of asbestos-related diseases and disorders
US20060084704A1 (en) * 2004-01-28 2006-04-20 Charles Shih Methods and compositions for enhancing degradation of nuclear receptor transcription factors and uses thereof
EP1765346A4 (en) * 2004-01-28 2008-10-15 Androscience Corp IMPROVEMENT OF ANTI-ORGANIC ACTIVITY BY A COMBINATION OF INHIBITORS OBTAINED TO DIFFERENT STEPS OF A STEROID-DEPENDENT GENEACTIVATION PATH AND USES THEREOF
CA2563207A1 (en) * 2004-04-14 2005-11-24 Celgene Corporation Use of selective cytokine inhibitory drugs in myelodysplastic syndromes
BRPI0510166A (pt) * 2004-04-23 2007-10-02 Celgene Corp método para tratar, prevenir ou controlar hipertensão pulmonar, e, composição farmacêutica
RU2283658C1 (ru) * 2005-03-29 2006-09-20 Автономная некоммерческая организация Научно-технический центр "Фармбиопресс" Средство и способ лечения и профилактики онкологических заболеваний
RU2292898C1 (ru) * 2005-08-02 2007-02-10 Автономная некоммерческая организация Научно-технический центр "Фармбиопресс" Противоопухолевый липосомный препарат направленного действия
BRPI0614995A2 (pt) 2005-08-31 2010-01-12 Celgene Corp composto ou um sal, solvato ou estereoisemero farmaceuticamente aceitável do mesmo, composição farmacêutica, uso de uma quantidade terapêutica ou profilaticamente eficaz de um composto ou um sal, solvato ou estereoisemero farmaceuticamente aceitável do mesmo, e, forma de dosagem unitária única
RU2306945C1 (ru) * 2006-02-15 2007-09-27 Автономная некоммерческая организация Научно-технический центр "Фармбиопресс" Профилактическая композиция на основе веществ фенольной природы и фосфолипидов
RU2310453C1 (ru) * 2006-02-28 2007-11-20 Автономная некоммерческая организация Научно-технический центр "Фармбиопресс" Способ получения гидрофильного комплекса на основе флавонолигнанов и фосфолипидов
US8877780B2 (en) 2006-08-30 2014-11-04 Celgene Corporation 5-substituted isoindoline compounds
LT2420498T (lt) 2006-09-26 2017-10-25 Celgene Corporation 5-pakeistieji chinazolinono dariniai, kaip priešvėžiniai agentai
NZ576278A (en) 2006-10-19 2011-12-22 Signal Pharm Llc Heteroaryl compounds, compositions thereof, and their use as protein kinase inhibitors
US9000222B2 (en) 2007-01-08 2015-04-07 Androscience Corporation Compounds with (1E, 6E)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstituted-hepta-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof
NZ578914A (en) 2007-01-08 2012-11-30 Andhoscience Corp Compounds with (substituted phenyl)-propenal moiety, their derivatives, biological activity, and uses thereof
US8710272B2 (en) 2007-01-08 2014-04-29 Androscience Corporation Compounds with (1 E, 6E)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstituted-hepta-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof
US7907654B2 (en) * 2007-04-27 2011-03-15 Hewlett-Packard Development Company, L.P. Laser diode with a grating layer
MX2010001125A (es) 2007-07-31 2010-09-30 Androscience Corp Composiciones incluyendo receptor androgeno de degradacion (ard) ponteciadores y metodos de tratamiento profilactico o terapeutico de trastornos de la piel y la caida de cabello.
JP5637852B2 (ja) 2007-09-26 2014-12-10 セルジーン コーポレイション ６、７又は８置換キナゾリノン誘導体並びにそれらを含有する組成物及びそれらを使用する方法
WO2009139880A1 (en) * 2008-05-13 2009-11-19 Celgene Corporation Thioxoisoindoline compounds and compositions and methods of using the same
CZ2008407A3 (cs) * 2008-06-26 2009-08-26 Agra Group, A. S. Vodorozpustný prípravek na bázi flavanonol lignanu a zpusob jeho prípravy
US8110578B2 (en) 2008-10-27 2012-02-07 Signal Pharmaceuticals, Llc Pyrazino[2,3-b]pyrazine mTOR kinase inhibitors for oncology indications and diseases associated with the mTOR/PI3K/Akt pathway
MX361467B (es) 2008-10-29 2018-12-06 Celgene Corp Compuestos de isoindolina para uso en el tratamiento de cancer.
RU2379046C1 (ru) * 2008-11-18 2010-01-20 Сергей Викторович Луценко Композиция для терапии патологий печени и онкологических заболеваний
WO2010093434A1 (en) 2009-02-11 2010-08-19 Celgene Corporation Isotopologues of lenalidomide
EP3199149A1 (en) 2009-05-19 2017-08-02 Celgene Corporation Formulations of 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione
AU2010333767A1 (en) 2009-12-22 2012-07-05 Celgene Corporation (Methylsulfonyl) ethyl benzene isoindoline derivatives and their therapeutical uses
PL2536706T3 (pl) 2010-02-11 2017-10-31 Celgene Corp Pochodne arylometoksyizoindoliny i zawierające je kompozycje oraz sposoby ich zastosowania
US8603527B2 (en) 2010-10-25 2013-12-10 Signal Pharmaceuticals, Llc Pharmaceutical formulations of a substituted diaminopurine
MX347928B (es) 2011-01-10 2017-05-19 Celgene Corp Derivados de fenetilsulfona isoindolina y su uso.
WO2012097116A2 (en) 2011-01-14 2012-07-19 Celgene Corporation Isotopologues of isoindole derivatives
EA026100B1 (ru) 2011-03-11 2017-03-31 Селджин Корпорейшн Твердые формы 3-(5-амино-2-метил-4-оксо-4н-хиназолин-3-ил)пиперидин-2,6-диона и их фармацевтические композиции и применение
US20140221427A1 (en) 2011-06-22 2014-08-07 Celgene Corporation Isotopologues of pomalidomide
JP2014526508A (ja) 2011-09-14 2014-10-06 セルジーン コーポレイション シクロプロパンカルボン酸｛２−［（１ｓ）−１−（３−エトキシ−４−メトキシ−フェニル）−２−メタンスルホニル−エチル］−３−オキソ−２，３−ジヒドロ−１ｈ−イソインドール−４−イル｝−アミドの製剤
BR112014015923B1 (pt) 2011-12-27 2022-02-01 Amgen (Europe) GmbH Comprimidos revestidos de (+)-2-[1-(3-etoxi-4-metoxi-fenil)-2-metano-sulfoniletil]-4 - acetilaminoisoindolina-1,3-diona
RS58548B1 (sr) 2012-08-09 2019-05-31 Celgene Corp Čvrsta forma (s)-3-(4-((4-(morfolinometil)benzil)oksi)-1-oksoizoindolin-2-il)piperidin-2,6-dion hidrohlorida
EP2752201A1 (en) * 2013-01-04 2014-07-09 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. C-terminal HSP90 inhibitors to treat pituitary adenomas
US9540340B2 (en) 2013-01-14 2017-01-10 Deuterx, Llc 3-(5-substituted-4-oxoquinazolin-3(4H)-yl)-3-deutero-piperidine-2,6-dione derivatives and compositions comprising and methods of using the same
EP2764866A1 (en) 2013-02-07 2014-08-13 IP Gesellschaft für Management mbH Inhibitors of nedd8-activating enzyme
US9132117B2 (en) 2013-06-17 2015-09-15 Kgk Synergize, Inc Compositions and methods for glycemic control of subjects with impaired fasting glucose
UA117141C2 (uk) 2013-10-08 2018-06-25 Селджин Корпорейшн Склади (s)-3-(4-((4-(морфолінометил)бензил)оксі)-1-оксоізоіндолін-2-іл)піперидин-2,6-діону
TWI546722B (zh) * 2013-12-11 2016-08-21 新益先創科技股份有限公司 控制點感測面板及控制點感測面板設計方法
US20150196562A1 (en) 2014-01-15 2015-07-16 Celgene Corporation Formulations of 3-(5-amino-2-methyl-4-oxo-4h-quinazolin-3-yl)-piperidine-2,6-dione
US20170172921A1 (en) * 2016-12-14 2017-06-22 Mahmoud Reza Jaafari Polyphenolic compounds encapsualated in long circulating liposomes and use thereof
EP3805216A4 (en) * 2018-06-09 2022-08-03 Jiangsu Atom Bioscience and Pharmaceutical Co., Ltd. COMPOUNDS TO TREAT OR PREVENT LIVER DISEASES
CN109432084A (zh) * 2018-12-26 2019-03-08 温州医科大学 一种抗癌组合物及其在药物制备中的应用
KR102682905B1 (ko) * 2020-10-22 2024-07-08 경희대학교 산학협력단 실리마린 매개된 셀레늄 나노입자 및 이의 용도
CN112494479B (zh) * 2020-12-28 2022-06-21 华中科技大学同济医学院附属同济医院 茶黄素在制备卵巢功能保护药物方面的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1215291B (it) * 1985-07-17 1990-01-31 Inverni Della Beffa Spa Complessi di flavanolignani con fosfolipidi, loro preparazione e relative composizioni farmaceutiche.
GB2261434A (en) * 1991-11-15 1993-05-19 Inverni Della Beffa Spa New radical scavenging and antipoperoxidant flavanolignans their preparation and formulations for therapeutic use
CN1047944C (zh) * 1993-06-26 2000-01-05 曾庆通 一种治疗慢性肝炎的中药胶囊

Also Published As

Publication number Publication date
ITMI951047A0 (it) 1995-05-23
FI974268L (fi) 1997-12-02
AU3805195A (en) 1996-12-11
DE69533112D1 (de) 2004-07-08
ITMI951047A1 (it) 1996-11-23
US5912265A (en) 1999-06-15
ES2222466T3 (es) 2005-02-01
HK1006222A1 (en) 1999-02-19
US6218369B1 (en) 2001-04-17
PL182064B1 (pl) 2001-10-31
PL323450A1 (en) 1998-03-30
WO1996037209A1 (en) 1996-11-28
CN1148181C (zh) 2004-05-05
AU709802B2 (en) 1999-09-09
HUT77966A (hu) 1998-12-28
DE69533112T2 (de) 2004-10-21
EP0828500A1 (en) 1998-03-18
NO975334L (no) 1997-11-20
CA2221753A1 (en) 1996-11-28
CA2221753C (en) 2001-07-24
JPH10511685A (ja) 1998-11-10
NO975334D0 (no) 1997-11-20
KR19990014941A (ko) 1999-02-25
KR100290030B1 (ko) 2001-05-15
RU2161488C2 (ru) 2001-01-10
DK0828500T3 (da) 2004-08-16
CN1185112A (zh) 1998-06-17
SI0828500T1 (en) 2004-10-31
JP3178844B2 (ja) 2001-06-25
PT828500E (pt) 2004-08-31
ATE268183T1 (de) 2004-06-15
EP0828500B1 (en) 2004-06-02
FI119100B (fi) 2008-07-31
FI974268A0 (fi) 1997-11-18
NO317153B1 (no) 2004-08-30
HU220627B1 (hu) 2002-03-28

Similar Documents

Publication Publication Date Title
IT1274549B (it) Uso di flavanolignani per la preparazione di medicamenti ad attivita' antiproliferativa nei tumori dell'utero,dell'ovaio e del seno
BR0209147A (pt) Terapia combinada que usa anticorpos anti-egfr e agentes anti-hormonais
DK1169059T3 (da) Docetaxel i kombination med rhuMAb HER2 til behandling af cancere
NZ592039A (en) Combination therapy for the treatment of ocular neovascular disorders
BR0115109A (pt) Agentes terapêuticos e métodos de uso dos mesmos para a modulação da angiogênese
GR3034535T3 (en) Antisense oligonucleotides against the alpha regulatory subunit of the cAMP dependent-protein kinase for treatment of cancer
MY127082A (en) Synergistic methods and compositions for treating cancer
NZ527113A (en) Rapid-onset medicament for the treatment of sexual dysfunction
IL121160A0 (en) Method compositions and kits for increasing the oral bioavailability of pharmaceutical agents
YU176191A (sh) Derivati hinazolina za pojačavanje antitumorne aktivnosti
ATE258444T1 (de) Therapeutische chemokine rezeptor antagonisten
KR960700063A (ko) 사람 종양 세포내에서의 테모졸로마이드의 강화방법(Potentiation of temozolomide in human tumour cells)
ATE361746T1 (de) Botanischer extrakt mit antikrebs-aktivität enthaltend isoliquiritigenin
KR960700734A (ko) 사람 암에 대한 시스플래틴/타목시펜 배합 치료(Combination cisplatin/tamoxifen therapy for human cancers)
BR9808060A (pt) Composição farmacêutica, processos para tratamento de infecções virais pela administração de uma quantidade farmaceuticamente segura e eficaz de uma composição farmacêutica, uso da lamivudina ou um seu derivado farmaceuticamente aceitável, e, processo para a preparação de uma composição farmacêutica.
ATE13488T1 (de) Gallium-chlorid, ein neues antikrebsmittel.
KR927002224A (ko) 항종양효과증강제 및 항종양제
TR200401810T4 (tr) Kısırlık tedavisinde fsh'ın kullanılması
BRPI0416316A (pt) combinação de um inibidor da farnesil transferase com um agente anti-hormonal para o tratamento de cáncer de mama
ATE274523T1 (de) Tetrapeptid, das prostatafunktionen reguliert sowie seine zusammensetzungen und verwendungen
MX2025011751A (es) Conjugados anticuerpo-farmaco de derivados de camptotecina y usos de estos
BRPI0409870A (pt) uso de irinotecano para tratamento de cáncer de mama resistente
TW200500073A (en) Pharmaceutical composition comprising an indolopyrrolocarbazole derivative and use thereof
ATE280584T1 (de) Verwendung von beta interferon zur herstellung eines arzneimittels zur behandlung von ewings sarkom und eoe
RU2002129097A (ru) Комбинированные терапии с использованием активности, повреждающей сосуды

Legal Events

Date Code Title Description
0001 Granted