DE69533112T2 - Verwendung von flavolignanen zur herstellung von medikamenten mit antiproliferativer aktivität in gebärmutter,brust,eierstöcken - Google Patents
Verwendung von flavolignanen zur herstellung von medikamenten mit antiproliferativer aktivität in gebärmutter,brust,eierstöcken Download PDFInfo
- Publication number
- DE69533112T2 DE69533112T2 DE69533112T DE69533112T DE69533112T2 DE 69533112 T2 DE69533112 T2 DE 69533112T2 DE 69533112 T DE69533112 T DE 69533112T DE 69533112 T DE69533112 T DE 69533112T DE 69533112 T2 DE69533112 T2 DE 69533112T2
- Authority
- DE
- Germany
- Prior art keywords
- silicristin
- silidianin
- mixtures
- effective amount
- therapeutically effective
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI951047A IT1274549B (it) | 1995-05-23 | 1995-05-23 | Uso di flavanolignani per la preparazione di medicamenti ad attivita' antiproliferativa nei tumori dell'utero,dell'ovaio e del seno |
PCT/EP1995/003993 WO1996037209A1 (en) | 1995-05-23 | 1995-10-10 | Use of flavanolignanes for the preparation of medicaments with antiproliferative activity in uterus, ovary and breast |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69533112D1 DE69533112D1 (de) | 2004-07-08 |
DE69533112T2 true DE69533112T2 (de) | 2004-10-21 |
Family
ID=11371650
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69533112T Expired - Lifetime DE69533112T2 (de) | 1995-05-23 | 1995-10-10 | Verwendung von flavolignanen zur herstellung von medikamenten mit antiproliferativer aktivität in gebärmutter,brust,eierstöcken |
Country Status (21)
Country | Link |
---|---|
US (2) | US5912265A (de) |
EP (1) | EP0828500B1 (de) |
JP (1) | JP3178844B2 (de) |
KR (1) | KR100290030B1 (de) |
CN (1) | CN1148181C (de) |
AT (1) | ATE268183T1 (de) |
AU (1) | AU709802B2 (de) |
CA (1) | CA2221753C (de) |
DE (1) | DE69533112T2 (de) |
DK (1) | DK0828500T3 (de) |
ES (1) | ES2222466T3 (de) |
FI (1) | FI119100B (de) |
HK (1) | HK1006222A1 (de) |
HU (1) | HU220627B1 (de) |
IT (1) | IT1274549B (de) |
NO (1) | NO317153B1 (de) |
PL (1) | PL182064B1 (de) |
PT (1) | PT828500E (de) |
RU (1) | RU2161488C2 (de) |
SI (1) | SI0828500T1 (de) |
WO (1) | WO1996037209A1 (de) |
Families Citing this family (66)
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FR2432560A1 (fr) | 1978-08-02 | 1980-02-29 | Texas Instruments Inc | Procede de decapage de metaux, en particulier d'aluminium, au plasma de tetrachlorure de silicium |
US6379714B1 (en) | 1995-04-14 | 2002-04-30 | Pharmaprint, Inc. | Pharmaceutical grade botanical drugs |
CN1263731C (zh) * | 1996-08-12 | 2006-07-12 | 赛尔金有限公司 | 新的治疗免疫剂及其在降低细胞因子水平中的应用 |
US6239114B1 (en) * | 1997-09-26 | 2001-05-29 | Kgk Synergize | Compositions and methods for treatment of neoplastic diseases with combinations of limonoids, flavonoids and tocotrienols |
US6486193B2 (en) | 1998-12-31 | 2002-11-26 | Aventis Pharmaceuticals Inc. | 3-substituted pyrrolidines useful as inhibitors of matrix metalloproteinases |
FR2792846B1 (fr) | 1999-04-30 | 2001-07-27 | Salomon Sa | Patin a roues en ligne du type a platine superieure articulee |
WO2000066232A2 (fr) | 1999-04-30 | 2000-11-09 | Salomon S.A. | Chassis articule |
KR100342942B1 (ko) * | 1999-07-05 | 2002-07-02 | 민경윤 | 카르두스 마리아누스 추출물 또는 이로부터 정제된 실리빈을함유하는 경구용 마이크로에멀젼 조성물 |
US20010025027A1 (en) * | 2000-03-07 | 2001-09-27 | Sonis Stephen T. | Inhibition of ceramide for the prevention and treatment of oral mucositis induced by antineoplastic drugs or radiation |
WO2002083124A1 (en) * | 2000-10-06 | 2002-10-24 | Probiochem, Llc | A composition and method of sustaining chemotherapeutic effect while reducing dose of chemotherapeutic agent using cox-2 inhibitor and statin |
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WO2002064083A2 (en) * | 2000-11-30 | 2002-08-22 | The Children's Medical Center Corporation | Synthesis of 3-amino-thalidomide and its enantiomers |
US20040092565A1 (en) * | 2001-07-25 | 2004-05-13 | George Kindness | Composition and method of sustaining chemotherapeutic effect while reducing dose of chemotherapeutic agent using cox-2 inhibitor and statin |
EP1314438A1 (de) * | 2001-11-23 | 2003-05-28 | Nutricia N.V. | Antiproliferative Zusammensetzung |
KR20050056247A (ko) * | 2002-10-15 | 2005-06-14 | 셀진 코포레이션 | 골수형성이상증후군의 치료 및 관리를 위한 선택적인사이토킨 저해 약물의 사용 방법 및 이를 포함하는 조성물 |
EP1562597A4 (de) * | 2002-10-31 | 2008-05-14 | Celgene Corp | Anwendungsverfahren für und zusammensetzungen mit immunomodulatorischen verbindungen zur behandlung und versorgung von makuladegeneration |
US20040091455A1 (en) * | 2002-10-31 | 2004-05-13 | Zeldis Jerome B. | Methods of using and compositions comprising immunomodulatory compounds for treatment and management of macular degeneration |
US7776907B2 (en) * | 2002-10-31 | 2010-08-17 | Celgene Corporation | Methods for the treatment and management of macular degeneration using cyclopropyl-N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-3-oxoisoindoline-4-yl}carboxamide |
JP2006507324A (ja) * | 2002-11-06 | 2006-03-02 | セルジーン・コーポレーション | 骨髄増殖性疾患を治療および管理するための選択的サイトカイン阻害薬を含む組成物およびその使用法 |
NZ540547A (en) * | 2002-11-18 | 2008-03-28 | Celgene Corp | Use of compositions comprising (+)-3-(3,4-dimethoxy-phenyl)-3-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionamide for inhibiting TNF-alpha production |
WO2004054501A2 (en) * | 2002-11-18 | 2004-07-01 | Celgene Corporation | Methods of usig and compositions comprising (-)-3-(3,4-dimethoxy-phenyl)-3-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionamide |
CN100402023C (zh) * | 2003-06-21 | 2008-07-16 | 山东绿叶天然药物研究开发有限公司 | 一种水飞蓟素软胶囊及其制备方法 |
US20080027113A1 (en) * | 2003-09-23 | 2008-01-31 | Zeldis Jerome B | Methods of Using and Compositions Comprising Immunomodulatory Compounds for Treatment and Management of Macular Degeneration |
KR100577514B1 (ko) * | 2003-10-21 | 2006-05-10 | 한미약품 주식회사 | 비페닐디메틸디카복실레이트, 및 카르두스 마리아누스추출물 또는 이로부터 정제된 실리빈을 함유하는 경구용마이크로에멀젼 조성물 |
US20050142104A1 (en) * | 2003-11-06 | 2005-06-30 | Zeldis Jerome B. | Methods of using and compositions comprising PDE4 modulators for the treatment and management of asbestos-related diseases and disorders |
US20060084704A1 (en) * | 2004-01-28 | 2006-04-20 | Charles Shih | Methods and compositions for enhancing degradation of nuclear receptor transcription factors and uses thereof |
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US8877780B2 (en) | 2006-08-30 | 2014-11-04 | Celgene Corporation | 5-substituted isoindoline compounds |
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CN101573360A (zh) | 2006-10-19 | 2009-11-04 | 西格诺药品有限公司 | 杂芳基化合物、其组合物以及它们作为蛋白激酶抑制剂的用途 |
AU2008205312B2 (en) | 2007-01-08 | 2013-11-21 | Annji Pharmaceutical Co., Ltd. | Compounds with (substituted phenyl)-propenal moiety, their derivatives, biological activity, and uses thereof |
US8710272B2 (en) | 2007-01-08 | 2014-04-29 | Androscience Corporation | Compounds with (1 E, 6E)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstituted-hepta-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof |
US9000222B2 (en) | 2007-01-08 | 2015-04-07 | Androscience Corporation | Compounds with (1E, 6E)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstituted-hepta-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof |
US7907654B2 (en) * | 2007-04-27 | 2011-03-15 | Hewlett-Packard Development Company, L.P. | Laser diode with a grating layer |
MX2010001125A (es) | 2007-07-31 | 2010-09-30 | Androscience Corp | Composiciones incluyendo receptor androgeno de degradacion (ard) ponteciadores y metodos de tratamiento profilactico o terapeutico de trastornos de la piel y la caida de cabello. |
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US20090298882A1 (en) * | 2008-05-13 | 2009-12-03 | Muller George W | Thioxoisoindoline compounds and compositions comprising and methods of using the same |
CZ2008407A3 (cs) * | 2008-06-26 | 2009-08-26 | Agra Group, A. S. | Vodorozpustný prípravek na bázi flavanonol lignanu a zpusob jeho prípravy |
US8110578B2 (en) | 2008-10-27 | 2012-02-07 | Signal Pharmaceuticals, Llc | Pyrazino[2,3-b]pyrazine mTOR kinase inhibitors for oncology indications and diseases associated with the mTOR/PI3K/Akt pathway |
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US8603527B2 (en) | 2010-10-25 | 2013-12-10 | Signal Pharmaceuticals, Llc | Pharmaceutical formulations of a substituted diaminopurine |
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US20140221427A1 (en) | 2011-06-22 | 2014-08-07 | Celgene Corporation | Isotopologues of pomalidomide |
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EP3524598B1 (de) | 2012-08-09 | 2021-07-07 | Celgene Corporation | Eine feste form des (s)3-(4-((4-morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidin-2,6-dion hydrochlorids |
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US9132117B2 (en) | 2013-06-17 | 2015-09-15 | Kgk Synergize, Inc | Compositions and methods for glycemic control of subjects with impaired fasting glucose |
UA117141C2 (uk) | 2013-10-08 | 2018-06-25 | Селджин Корпорейшн | Склади (s)-3-(4-((4-(морфолінометил)бензил)оксі)-1-оксоізоіндолін-2-іл)піперидин-2,6-діону |
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TW201540323A (zh) | 2014-01-15 | 2015-11-01 | Celgene Corp | 3-(5-胺基-2-甲基-4-側氧基-4h-喹唑啉-3-基)-哌啶-2,6-二酮之調配物 |
US20170172921A1 (en) * | 2016-12-14 | 2017-06-22 | Mahmoud Reza Jaafari | Polyphenolic compounds encapsualated in long circulating liposomes and use thereof |
CN110183431B (zh) * | 2018-06-09 | 2023-04-11 | 江苏新元素医药科技有限公司 | 一类用于肝病治疗或预防的化合物 |
CN109432084A (zh) * | 2018-12-26 | 2019-03-08 | 温州医科大学 | 一种抗癌组合物及其在药物制备中的应用 |
CN112494479B (zh) * | 2020-12-28 | 2022-06-21 | 华中科技大学同济医学院附属同济医院 | 茶黄素在制备卵巢功能保护药物方面的应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2261434A (en) * | 1991-11-15 | 1993-05-19 | Inverni Della Beffa Spa | New radical scavenging and antipoperoxidant flavanolignans their preparation and formulations for therapeutic use |
CN1047944C (zh) * | 1993-06-26 | 2000-01-05 | 曾庆通 | 一种治疗慢性肝炎的中药胶囊 |
-
1995
- 1995-05-23 IT ITMI951047A patent/IT1274549B/it active IP Right Grant
- 1995-10-10 CA CA002221753A patent/CA2221753C/en not_active Expired - Fee Related
- 1995-10-10 KR KR1019970708287A patent/KR100290030B1/ko not_active IP Right Cessation
- 1995-10-10 DE DE69533112T patent/DE69533112T2/de not_active Expired - Lifetime
- 1995-10-10 WO PCT/EP1995/003993 patent/WO1996037209A1/en active IP Right Grant
- 1995-10-10 JP JP53528596A patent/JP3178844B2/ja not_active Expired - Fee Related
- 1995-10-10 AT AT95935927T patent/ATE268183T1/de active
- 1995-10-10 HU HU9801682A patent/HU220627B1/hu not_active IP Right Cessation
- 1995-10-10 ES ES95935927T patent/ES2222466T3/es not_active Expired - Lifetime
- 1995-10-10 CN CNB951978616A patent/CN1148181C/zh not_active Expired - Fee Related
- 1995-10-10 PL PL95323450A patent/PL182064B1/pl not_active IP Right Cessation
- 1995-10-10 SI SI9530704T patent/SI0828500T1/xx unknown
- 1995-10-10 DK DK95935927T patent/DK0828500T3/da active
- 1995-10-10 AU AU38051/95A patent/AU709802B2/en not_active Ceased
- 1995-10-10 RU RU97121286/14A patent/RU2161488C2/ru not_active IP Right Cessation
- 1995-10-10 US US08/952,415 patent/US5912265A/en not_active Expired - Lifetime
- 1995-10-10 EP EP95935927A patent/EP0828500B1/de not_active Expired - Lifetime
- 1995-10-10 PT PT95935927T patent/PT828500E/pt unknown
-
1997
- 1997-11-18 FI FI974268A patent/FI119100B/fi not_active IP Right Cessation
- 1997-11-20 NO NO19975334A patent/NO317153B1/no not_active IP Right Cessation
-
1998
- 1998-06-03 HK HK98104797A patent/HK1006222A1/xx not_active IP Right Cessation
-
1999
- 1999-04-07 US US09/287,103 patent/US6218369B1/en not_active Expired - Fee Related
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