DE69533112T2 - Verwendung von flavolignanen zur herstellung von medikamenten mit antiproliferativer aktivität in gebärmutter,brust,eierstöcken - Google Patents

Verwendung von flavolignanen zur herstellung von medikamenten mit antiproliferativer aktivität in gebärmutter,brust,eierstöcken Download PDF

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Publication number
DE69533112T2
DE69533112T2 DE69533112T DE69533112T DE69533112T2 DE 69533112 T2 DE69533112 T2 DE 69533112T2 DE 69533112 T DE69533112 T DE 69533112T DE 69533112 T DE69533112 T DE 69533112T DE 69533112 T2 DE69533112 T2 DE 69533112T2
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DE
Germany
Prior art keywords
silicristin
silidianin
mixtures
effective amount
therapeutically effective
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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DE69533112T
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English (en)
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DE69533112D1 (de
Inventor
Ezio Bombardelli
Paolo Morazzoni
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Indena SpA
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Indena SpA
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Publication of DE69533112D1 publication Critical patent/DE69533112D1/de
Application granted granted Critical
Publication of DE69533112T2 publication Critical patent/DE69533112T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/582Recycling of unreacted starting or intermediate materials
DE69533112T 1995-05-23 1995-10-10 Verwendung von flavolignanen zur herstellung von medikamenten mit antiproliferativer aktivität in gebärmutter,brust,eierstöcken Expired - Lifetime DE69533112T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI951047A IT1274549B (it) 1995-05-23 1995-05-23 Uso di flavanolignani per la preparazione di medicamenti ad attivita' antiproliferativa nei tumori dell'utero,dell'ovaio e del seno
PCT/EP1995/003993 WO1996037209A1 (en) 1995-05-23 1995-10-10 Use of flavanolignanes for the preparation of medicaments with antiproliferative activity in uterus, ovary and breast

Publications (2)

Publication Number Publication Date
DE69533112D1 DE69533112D1 (de) 2004-07-08
DE69533112T2 true DE69533112T2 (de) 2004-10-21

Family

ID=11371650

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69533112T Expired - Lifetime DE69533112T2 (de) 1995-05-23 1995-10-10 Verwendung von flavolignanen zur herstellung von medikamenten mit antiproliferativer aktivität in gebärmutter,brust,eierstöcken

Country Status (21)

Country Link
US (2) US5912265A (de)
EP (1) EP0828500B1 (de)
JP (1) JP3178844B2 (de)
KR (1) KR100290030B1 (de)
CN (1) CN1148181C (de)
AT (1) ATE268183T1 (de)
AU (1) AU709802B2 (de)
CA (1) CA2221753C (de)
DE (1) DE69533112T2 (de)
DK (1) DK0828500T3 (de)
ES (1) ES2222466T3 (de)
FI (1) FI119100B (de)
HK (1) HK1006222A1 (de)
HU (1) HU220627B1 (de)
IT (1) IT1274549B (de)
NO (1) NO317153B1 (de)
PL (1) PL182064B1 (de)
PT (1) PT828500E (de)
RU (1) RU2161488C2 (de)
SI (1) SI0828500T1 (de)
WO (1) WO1996037209A1 (de)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2432560A1 (fr) 1978-08-02 1980-02-29 Texas Instruments Inc Procede de decapage de metaux, en particulier d'aluminium, au plasma de tetrachlorure de silicium
US6379714B1 (en) 1995-04-14 2002-04-30 Pharmaprint, Inc. Pharmaceutical grade botanical drugs
CN1263731C (zh) * 1996-08-12 2006-07-12 赛尔金有限公司 新的治疗免疫剂及其在降低细胞因子水平中的应用
US6239114B1 (en) * 1997-09-26 2001-05-29 Kgk Synergize Compositions and methods for treatment of neoplastic diseases with combinations of limonoids, flavonoids and tocotrienols
US6486193B2 (en) 1998-12-31 2002-11-26 Aventis Pharmaceuticals Inc. 3-substituted pyrrolidines useful as inhibitors of matrix metalloproteinases
FR2792846B1 (fr) 1999-04-30 2001-07-27 Salomon Sa Patin a roues en ligne du type a platine superieure articulee
WO2000066232A2 (fr) 1999-04-30 2000-11-09 Salomon S.A. Chassis articule
KR100342942B1 (ko) * 1999-07-05 2002-07-02 민경윤 카르두스 마리아누스 추출물 또는 이로부터 정제된 실리빈을함유하는 경구용 마이크로에멀젼 조성물
US20010025027A1 (en) * 2000-03-07 2001-09-27 Sonis Stephen T. Inhibition of ceramide for the prevention and treatment of oral mucositis induced by antineoplastic drugs or radiation
WO2002083124A1 (en) * 2000-10-06 2002-10-24 Probiochem, Llc A composition and method of sustaining chemotherapeutic effect while reducing dose of chemotherapeutic agent using cox-2 inhibitor and statin
WO2002067853A2 (en) * 2000-10-06 2002-09-06 Probiochem, Llc A combination and method of treatment of hiv and viral diseases, vascular disease and cancer utilizing a cox-2 inhibitor and cystine
WO2002064083A2 (en) * 2000-11-30 2002-08-22 The Children's Medical Center Corporation Synthesis of 3-amino-thalidomide and its enantiomers
US20040092565A1 (en) * 2001-07-25 2004-05-13 George Kindness Composition and method of sustaining chemotherapeutic effect while reducing dose of chemotherapeutic agent using cox-2 inhibitor and statin
EP1314438A1 (de) * 2001-11-23 2003-05-28 Nutricia N.V. Antiproliferative Zusammensetzung
KR20050056247A (ko) * 2002-10-15 2005-06-14 셀진 코포레이션 골수형성이상증후군의 치료 및 관리를 위한 선택적인사이토킨 저해 약물의 사용 방법 및 이를 포함하는 조성물
EP1562597A4 (de) * 2002-10-31 2008-05-14 Celgene Corp Anwendungsverfahren für und zusammensetzungen mit immunomodulatorischen verbindungen zur behandlung und versorgung von makuladegeneration
US20040091455A1 (en) * 2002-10-31 2004-05-13 Zeldis Jerome B. Methods of using and compositions comprising immunomodulatory compounds for treatment and management of macular degeneration
US7776907B2 (en) * 2002-10-31 2010-08-17 Celgene Corporation Methods for the treatment and management of macular degeneration using cyclopropyl-N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-3-oxoisoindoline-4-yl}carboxamide
JP2006507324A (ja) * 2002-11-06 2006-03-02 セルジーン・コーポレーション 骨髄増殖性疾患を治療および管理するための選択的サイトカイン阻害薬を含む組成物およびその使用法
NZ540547A (en) * 2002-11-18 2008-03-28 Celgene Corp Use of compositions comprising (+)-3-(3,4-dimethoxy-phenyl)-3-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionamide for inhibiting TNF-alpha production
WO2004054501A2 (en) * 2002-11-18 2004-07-01 Celgene Corporation Methods of usig and compositions comprising (-)-3-(3,4-dimethoxy-phenyl)-3-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionamide
CN100402023C (zh) * 2003-06-21 2008-07-16 山东绿叶天然药物研究开发有限公司 一种水飞蓟素软胶囊及其制备方法
US20080027113A1 (en) * 2003-09-23 2008-01-31 Zeldis Jerome B Methods of Using and Compositions Comprising Immunomodulatory Compounds for Treatment and Management of Macular Degeneration
KR100577514B1 (ko) * 2003-10-21 2006-05-10 한미약품 주식회사 비페닐디메틸디카복실레이트, 및 카르두스 마리아누스추출물 또는 이로부터 정제된 실리빈을 함유하는 경구용마이크로에멀젼 조성물
US20050142104A1 (en) * 2003-11-06 2005-06-30 Zeldis Jerome B. Methods of using and compositions comprising PDE4 modulators for the treatment and management of asbestos-related diseases and disorders
US20060084704A1 (en) * 2004-01-28 2006-04-20 Charles Shih Methods and compositions for enhancing degradation of nuclear receptor transcription factors and uses thereof
NZ548670A (en) * 2004-01-28 2010-05-28 Androscience Corp Enhancement of anti-androgenic activity by a combination of inhibitors targeting different steps of a steroid-dependent gene activation pathway and uses thereof
EP1744748A4 (de) * 2004-04-14 2009-08-12 Celgene Corp Verfahren zur verwendung von selektiven zytokin-hemmenden arzneimitteln und diese enthaltende zusammensetzungen zur behandlung und versorgung von myelodysplastischen syndromen
AU2005234783A1 (en) * 2004-04-23 2005-11-03 Celgene Corporation Methods of using and compositions comprising PDE4 modulators for the treatment and management of pulmonary hypertension
ES2434946T3 (es) 2005-08-31 2013-12-18 Celgene Corporation Compuestos de isoindol imida y composiciones que los comprenden y métodos para usarlo
US8877780B2 (en) 2006-08-30 2014-11-04 Celgene Corporation 5-substituted isoindoline compounds
ATE555104T1 (de) 2006-09-26 2012-05-15 Celgene Corp 5-substituierte chinazolinon-derivate als antitumorverbindungen
CN101573360A (zh) 2006-10-19 2009-11-04 西格诺药品有限公司 杂芳基化合物、其组合物以及它们作为蛋白激酶抑制剂的用途
AU2008205312B2 (en) 2007-01-08 2013-11-21 Annji Pharmaceutical Co., Ltd. Compounds with (substituted phenyl)-propenal moiety, their derivatives, biological activity, and uses thereof
US8710272B2 (en) 2007-01-08 2014-04-29 Androscience Corporation Compounds with (1 E, 6E)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstituted-hepta-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof
US9000222B2 (en) 2007-01-08 2015-04-07 Androscience Corporation Compounds with (1E, 6E)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstituted-hepta-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof
US7907654B2 (en) * 2007-04-27 2011-03-15 Hewlett-Packard Development Company, L.P. Laser diode with a grating layer
MX2010001125A (es) 2007-07-31 2010-09-30 Androscience Corp Composiciones incluyendo receptor androgeno de degradacion (ard) ponteciadores y metodos de tratamiento profilactico o terapeutico de trastornos de la piel y la caida de cabello.
MY157495A (en) 2007-09-26 2016-06-15 Celgene Corp 6-,7-, or 8-substituted quinazolinone derivatives and compositions comprising and methods of using the same
US20090298882A1 (en) * 2008-05-13 2009-12-03 Muller George W Thioxoisoindoline compounds and compositions comprising and methods of using the same
CZ2008407A3 (cs) * 2008-06-26 2009-08-26 Agra Group, A. S. Vodorozpustný prípravek na bázi flavanonol lignanu a zpusob jeho prípravy
US8110578B2 (en) 2008-10-27 2012-02-07 Signal Pharmaceuticals, Llc Pyrazino[2,3-b]pyrazine mTOR kinase inhibitors for oncology indications and diseases associated with the mTOR/PI3K/Akt pathway
JP5603876B2 (ja) 2008-10-29 2014-10-08 セルジーン コーポレイション 癌の治療に使用するためのイソインドリン化合物
WO2010093434A1 (en) 2009-02-11 2010-08-19 Celgene Corporation Isotopologues of lenalidomide
AU2010249615B2 (en) 2009-05-19 2013-07-18 Celgene Corporation Formulations of 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione
US8716252B2 (en) 2009-12-22 2014-05-06 Celgene Corporation (Methylsulfonyl) ethyl benzene isoindoline derivatives and their pharmaceutical uses
NZ601289A (en) 2010-02-11 2014-10-31 Celgene Corp Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same
US8603527B2 (en) 2010-10-25 2013-12-10 Signal Pharmaceuticals, Llc Pharmaceutical formulations of a substituted diaminopurine
WO2012096884A1 (en) 2011-01-10 2012-07-19 Celgene Corporation Phenethylsulfone isoindoline derivatives as inhibitors of pde 4 and/or cytokines
US9045417B2 (en) 2011-01-14 2015-06-02 Celgene Corporation Isotopologues of isoindole derivatives
RU2611007C2 (ru) 2011-03-11 2017-02-17 Селджин Корпорейшн Твердые формы 3-(5-амино-2-метил-4-оксо-4н-хиназолин-3-ил)пиперидин-2, 6-диона и их фармацевтические композиции и применение
US20140221427A1 (en) 2011-06-22 2014-08-07 Celgene Corporation Isotopologues of pomalidomide
KR20140063808A (ko) 2011-09-14 2014-05-27 셀진 코포레이션 시클로프로판카르복실 산{2-[(1s)-1-(3-에톡시-4-메톡시-페닐)-2-메탄술포닐-에틸]-3-옥소-2,3-디하이드로-1h-이소인돌-4-일}-아마이드의 제제
AU2012362562B2 (en) 2011-12-27 2017-11-02 Amgen (Europe) GmbH Formulations of (+)-2-[1-(3-ethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethyl]-4-acetyl aminoisoindoline-1,3-dione
EP3524598B1 (de) 2012-08-09 2021-07-07 Celgene Corporation Eine feste form des (s)3-(4-((4-morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidin-2,6-dion hydrochlorids
EP2752201A1 (de) * 2013-01-04 2014-07-09 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. C-terminale HSP90-Hemmer zur Behandlung von Hypophysenadenomen
EP2943201B2 (de) 2013-01-14 2020-07-29 Deuterx, LLC 3-(5-substituierte 4-oxochinazolin-3(4h) -yl)-3-deutero-piperidin-2,6-dionderivate
EP2764866A1 (de) 2013-02-07 2014-08-13 IP Gesellschaft für Management mbH Hemmer der nedd8-aktivierenden Enzyme
US9132117B2 (en) 2013-06-17 2015-09-15 Kgk Synergize, Inc Compositions and methods for glycemic control of subjects with impaired fasting glucose
UA117141C2 (uk) 2013-10-08 2018-06-25 Селджин Корпорейшн Склади (s)-3-(4-((4-(морфолінометил)бензил)оксі)-1-оксоізоіндолін-2-іл)піперидин-2,6-діону
TWI546722B (zh) * 2013-12-11 2016-08-21 新益先創科技股份有限公司 控制點感測面板及控制點感測面板設計方法
TW201540323A (zh) 2014-01-15 2015-11-01 Celgene Corp 3-(5-胺基-2-甲基-4-側氧基-4h-喹唑啉-3-基)-哌啶-2,6-二酮之調配物
US20170172921A1 (en) * 2016-12-14 2017-06-22 Mahmoud Reza Jaafari Polyphenolic compounds encapsualated in long circulating liposomes and use thereof
CN110183431B (zh) * 2018-06-09 2023-04-11 江苏新元素医药科技有限公司 一类用于肝病治疗或预防的化合物
CN109432084A (zh) * 2018-12-26 2019-03-08 温州医科大学 一种抗癌组合物及其在药物制备中的应用
CN112494479B (zh) * 2020-12-28 2022-06-21 华中科技大学同济医学院附属同济医院 茶黄素在制备卵巢功能保护药物方面的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2261434A (en) * 1991-11-15 1993-05-19 Inverni Della Beffa Spa New radical scavenging and antipoperoxidant flavanolignans their preparation and formulations for therapeutic use
CN1047944C (zh) * 1993-06-26 2000-01-05 曾庆通 一种治疗慢性肝炎的中药胶囊

Also Published As

Publication number Publication date
PL182064B1 (pl) 2001-10-31
RU2161488C2 (ru) 2001-01-10
SI0828500T1 (en) 2004-10-31
EP0828500A1 (de) 1998-03-18
WO1996037209A1 (en) 1996-11-28
HU220627B1 (hu) 2002-03-28
FI974268A (fi) 1997-12-02
CA2221753C (en) 2001-07-24
ATE268183T1 (de) 2004-06-15
AU709802B2 (en) 1999-09-09
PL323450A1 (en) 1998-03-30
DK0828500T3 (da) 2004-08-16
ITMI951047A0 (it) 1995-05-23
ITMI951047A1 (it) 1996-11-23
NO975334D0 (no) 1997-11-20
AU3805195A (en) 1996-12-11
NO317153B1 (no) 2004-08-30
DE69533112D1 (de) 2004-07-08
ES2222466T3 (es) 2005-02-01
HUT77966A (hu) 1998-12-28
KR19990014941A (ko) 1999-02-25
JPH10511685A (ja) 1998-11-10
HK1006222A1 (en) 1999-02-19
JP3178844B2 (ja) 2001-06-25
CA2221753A1 (en) 1996-11-28
IT1274549B (it) 1997-07-17
EP0828500B1 (de) 2004-06-02
CN1185112A (zh) 1998-06-17
PT828500E (pt) 2004-08-31
US6218369B1 (en) 2001-04-17
KR100290030B1 (ko) 2001-05-15
US5912265A (en) 1999-06-15
FI974268A0 (fi) 1997-11-18
FI119100B (fi) 2008-07-31
NO975334L (no) 1997-11-20
CN1148181C (zh) 2004-05-05

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8328 Change in the person/name/address of the agent

Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN

8328 Change in the person/name/address of the agent

Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC