IT1215291B - Complessi di flavanolignani con fosfolipidi, loro preparazione e relative composizioni farmaceutiche. - Google Patents

Complessi di flavanolignani con fosfolipidi, loro preparazione e relative composizioni farmaceutiche.

Info

Publication number
IT1215291B
IT1215291B IT8521602A IT2160285A IT1215291B IT 1215291 B IT1215291 B IT 1215291B IT 8521602 A IT8521602 A IT 8521602A IT 2160285 A IT2160285 A IT 2160285A IT 1215291 B IT1215291 B IT 1215291B
Authority
IT
Italy
Prior art keywords
flavanolignani
phospholipids
complexes
preparation
pharmaceutical compositions
Prior art date
Application number
IT8521602A
Other languages
English (en)
Other versions
IT8521602A0 (it
Inventor
Bruno Gabetta
Ezio Bombardelli
Giorgio Pifferi
Original Assignee
Inverni Della Beffa Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11184188&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IT1215291(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Inverni Della Beffa Spa filed Critical Inverni Della Beffa Spa
Priority to IT8521602A priority Critical patent/IT1215291B/it
Publication of IT8521602A0 publication Critical patent/IT8521602A0/it
Priority to CS865455A priority patent/CS257289B2/cs
Priority to FI862850A priority patent/FI82940C/fi
Priority to EP86109257A priority patent/EP0209038B2/en
Priority to US06/882,608 priority patent/US4764508A/en
Priority to DE8686109257T priority patent/DE3665717D1/de
Priority to AT86109257T priority patent/ATE46513T1/de
Priority to HU862864A priority patent/HU197332B/hu
Priority to CA000513497A priority patent/CA1259324A/en
Priority to GR861825A priority patent/GR861825B/el
Priority to PT82988A priority patent/PT82988B/pt
Priority to DK339086A priority patent/DK170804B1/da
Priority to ES8600342A priority patent/ES2002101A6/es
Priority to KR1019860005746A priority patent/KR890002430B1/ko
Priority to JP61167748A priority patent/JPH0692399B2/ja
Priority to AR304532A priority patent/AR241117A1/es
Priority to MX317386A priority patent/MX3173A/es
Priority to YU128086A priority patent/YU45790B/sh
Publication of IT1215291B publication Critical patent/IT1215291B/it
Application granted granted Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C07F9/106—Adducts, complexes, salts of phosphatides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
IT8521602A 1985-07-17 1985-07-17 Complessi di flavanolignani con fosfolipidi, loro preparazione e relative composizioni farmaceutiche. IT1215291B (it)

Priority Applications (18)

Application Number Priority Date Filing Date Title
IT8521602A IT1215291B (it) 1985-07-17 1985-07-17 Complessi di flavanolignani con fosfolipidi, loro preparazione e relative composizioni farmaceutiche.
CS865455A CS257289B2 (en) 1985-07-17 1986-06-17 Preparation method of complex compound of at least one flavanolignane with at least one phospholipide
FI862850A FI82940C (fi) 1985-07-17 1986-07-04 Foerfarande foer framstaellning av som laekemedel anvaendbara komplex av en eller flera flavanolignaner med en eller flera fosfolipider.
EP86109257A EP0209038B2 (en) 1985-07-17 1986-07-07 Complexes of flavanolignanes with phospholipids, preparation thereof and associated pharmaceutical compositions
US06/882,608 US4764508A (en) 1985-07-17 1986-07-07 Complexes of flavanolignans with phospholipids, preparation thereof and associated pharmaceutical compositions
DE8686109257T DE3665717D1 (en) 1985-07-17 1986-07-07 Complexes of flavanolignanes with phospholipids, preparation thereof and associated pharmaceutical compositions
AT86109257T ATE46513T1 (de) 1985-07-17 1986-07-07 Komplexe aus flavanolignanen mit phospholipiden, herstellung davon und verbundene arzneimitteln.
CA000513497A CA1259324A (en) 1985-07-17 1986-07-10 Complexes of flavanolignanes with phospholipids, preparation thereof and associated pharmaceutical compositions
HU862864A HU197332B (en) 1985-07-17 1986-07-10 Process for preparing new complexes of flavanolignanes formed with phospholipids and pharmaceuticals comprising the same as active substance
GR861825A GR861825B (en) 1985-07-17 1986-07-14 Complexes of flavanolignanes with phospholipids preparation thereof and associated pharmaceutical compositions
PT82988A PT82988B (pt) 1985-07-17 1986-07-15 Processo para a preparacao de complexos de flavanolignanos com fosfolipidos e de composicoes farmaceuticas que os contem
DK339086A DK170804B1 (da) 1985-07-17 1986-07-16 Komplekser af en eller flere flavanolignaner med et eller flere phospholipider, fremgangsmåde til fremstilling af komplekserne samt farmaceutiske midler indeholdende komplekserne
ES8600342A ES2002101A6 (es) 1985-07-17 1986-07-16 Un procedimiento para la preparacion de complejos de uno o mas flavanolignanos con uno o mas fosfolipidos
KR1019860005746A KR890002430B1 (ko) 1985-07-17 1986-07-16 플라바놀리그난의 인지질과의 복합체의 제조 방법
JP61167748A JPH0692399B2 (ja) 1985-07-17 1986-07-16 フラバノリグナンとリン脂質との錯体、その製造方法並びに肝臓病治療用薬学的組成物
AR304532A AR241117A1 (es) 1985-07-17 1986-07-17 Procedimiento para la preparacion de complejos de flavanolignanos con fosfolipidos
MX317386A MX3173A (es) 1985-07-17 1986-07-17 Complejos de flavanolignanos/fosfolipidos y procedimiento de obtencion.
YU128086A YU45790B (sh) 1985-07-17 1986-07-17 Postupak za dobijanje kompleksa flavanolignana sa fosfolipidima

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8521602A IT1215291B (it) 1985-07-17 1985-07-17 Complessi di flavanolignani con fosfolipidi, loro preparazione e relative composizioni farmaceutiche.

Publications (2)

Publication Number Publication Date
IT8521602A0 IT8521602A0 (it) 1985-07-17
IT1215291B true IT1215291B (it) 1990-01-31

Family

ID=11184188

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8521602A IT1215291B (it) 1985-07-17 1985-07-17 Complessi di flavanolignani con fosfolipidi, loro preparazione e relative composizioni farmaceutiche.

Country Status (18)

Country Link
US (1) US4764508A (it)
EP (1) EP0209038B2 (it)
JP (1) JPH0692399B2 (it)
KR (1) KR890002430B1 (it)
AR (1) AR241117A1 (it)
AT (1) ATE46513T1 (it)
CA (1) CA1259324A (it)
CS (1) CS257289B2 (it)
DE (1) DE3665717D1 (it)
DK (1) DK170804B1 (it)
ES (1) ES2002101A6 (it)
FI (1) FI82940C (it)
GR (1) GR861825B (it)
HU (1) HU197332B (it)
IT (1) IT1215291B (it)
MX (1) MX3173A (it)
PT (1) PT82988B (it)
YU (1) YU45790B (it)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1201149B (it) * 1987-01-14 1989-01-27 Indena Spa Complessi di bioflavonoidi con fosfolipidi,loro preparazione,uso e composizioni farmaceutici e cosmetiche
IT1201151B (it) * 1987-01-14 1989-01-27 Indena Spa Complessi fosfolipidici con estratti da vitis vinifera,procedimento per la loro preparazione e composizioni che li cntengono
IT1222012B (it) * 1987-07-10 1990-08-31 Indena Spa Composizioni farmaceutiche e cosmetiche contenenti complessi di flavonolignani con fosfolipidi
GB8716918D0 (en) * 1987-07-17 1987-08-26 Inverni Della Beffa Spa Soluble derivatives of silybin
IT1241673B (it) * 1989-10-09 1994-01-27 Istituto Biochimico Italiano Complessi di inclusione di silibinina con ciclodestrina, loro preparazione e composizioni farmaceutiche che li contengono.
IT1238684B (it) * 1990-02-09 1993-09-01 Indena Spa Derivati del bilobalide,loro usi e formulazioni che li contegono
EP0464297B1 (en) * 1990-07-05 1995-05-17 INDENA S.p.A. Complexes of neolignane derivatives with phospholipids, the use thereof and pharmaceutical and cosmetic formulations containing them
JP2672439B2 (ja) * 1991-09-25 1997-11-05 倉敷紡績 株式会社 強化押出成形体
GB9211659D0 (en) * 1992-06-02 1992-07-15 Indena Spa New alkaloid derivatives,their use and pharmaceutical formulations containing them
DE19501266A1 (de) * 1995-01-18 1996-07-25 Madaus Ag Verfahren zur Herstellung von Flavano-Lignan-Zubereitungen mit verbesserter Freisetzung und Resorbierbarkeit danach erhältliche Zubereitungen und deren Verwendung zur Herstellung von Arzneimitteln
IT1274549B (it) * 1995-05-23 1997-07-17 Indena Spa Uso di flavanolignani per la preparazione di medicamenti ad attivita' antiproliferativa nei tumori dell'utero,dell'ovaio e del seno
US6218437B1 (en) 1996-09-30 2001-04-17 The Regents Of The University Of California Treatment and prevention of hepatic disorders
US5922757A (en) * 1996-09-30 1999-07-13 The Regents Of The University Of California Treatment and prevention of hepatic disorders
ITMI20010429A1 (it) * 2001-03-02 2002-09-02 Indena Spa Composizioni farmaceutiche e cosmetiche per la protezione della pelledai danni indotti dalle radiazioni solari
KR100385366B1 (ko) * 2001-03-05 2003-05-27 부광약품 주식회사 생체이용율을 개선한 실리마린 제제 조성물
WO2003011873A2 (en) 2001-07-27 2003-02-13 Neptune Technologies & Bioressources Inc. Natural marine source phospholipids comprising flavonoids, polyunsaturated fatty acids and their applications
WO2003011316A1 (en) * 2001-08-01 2003-02-13 Altana Pharma Ag Combination of selective cox-2 inhibitor and lung surfactant for respiratory syndrome
CZ292832B6 (cs) * 2001-08-30 2003-12-17 Ivax Pharmaceuticals S.R.O. Způsob přípravy silymarinu se zvýšenou rozpustností
ITMI20031388A1 (it) * 2003-07-08 2005-01-09 Indena Spa Formulazioni per il trattamento e la prevenzione di patologie della prostata.
ITMI20051942A1 (it) * 2005-10-14 2007-04-15 S I I T S R L Servizio Interna Composizioni galattogeniche a base di silimarina
RU2319498C2 (ru) * 2005-12-26 2008-03-20 Автономная некоммерческая организация Научно-технический центр "Фармбиопресс" Биокомпозиция, обладающая антитоксическим и антиапоптозным действием, профилактическая биологическая добавка на ее основе
EP1837030A1 (en) 2006-03-09 2007-09-26 INDENA S.p.A. Phospholipid complexes of curcumin having improved bioavailability
EP1844785A1 (en) * 2006-04-13 2007-10-17 Indena S.P.A. Phospholipid complexes of olive fruits or leaves extracts having improved bioavailability
DK2219642T3 (da) 2007-11-15 2011-12-05 Madaus Gmbh Silibininbestandel til behandling af hepatitis
CZ2008407A3 (cs) * 2008-06-26 2009-08-26 Agra Group, A. S. Vodorozpustný prípravek na bázi flavanonol lignanu a zpusob jeho prípravy
US8337835B2 (en) 2009-04-10 2012-12-25 Washington University Use of an endogenous ligand for peroxisome proliferator activated receptor alpha to treat liver disorders
IT1395351B1 (it) 2009-07-09 2012-09-14 Axioma Srl Formulazioni orali ad elevata biodisponibilita' orale costituite da miscele di frazioni lipofile e idrofile ottenute a partire dalla propoli
MX2012004977A (es) 2009-10-29 2012-11-06 Acasti Pharma Inc Composiciones fosfolipídicas terapéuticas concentradas.
ITMI20121317A1 (it) 2012-07-27 2014-01-28 Indena Spa Composizioni per il trattamento della fatica oncologica
ITMI20121784A1 (it) 2012-10-22 2014-04-23 Velleja Res Srl Composizioni galattogeniche a base di fosfatidilserina
ITMI20130425A1 (it) * 2013-03-20 2014-09-21 Istituto Biochimico Italiano Composizione per il trattamento della sindrome metabolica e delle alterazioni metabolico-ossidative nei pazienti con steatoepatite non alcolica (nash)
CN103751785A (zh) * 2014-01-27 2014-04-30 江苏健佳药业有限公司 一种水飞蓟素磷脂复合物及其制备方法
CN104306332B (zh) * 2014-09-24 2017-02-15 东南大学 一种喜树碱类磷脂化合物、其药物组合物及应用
CN105983015B (zh) * 2015-03-23 2022-01-25 天士力医药集团股份有限公司 一种含有水飞蓟宾、ve的药物组合物
CN105983016B (zh) * 2015-03-23 2023-08-11 天士力医药集团股份有限公司 一种含有水飞蓟宾的药物组合
ITUB20155532A1 (it) * 2015-11-12 2017-05-12 St Biochimico Italiano Giovanni Lorenzini Spa Formulazione farmaceutica orale comprendente silibina
IT201600105201A1 (it) 2016-10-19 2018-04-19 Nutrilinea Srl Uso della fosfatidilserina per la prevenzione e il trattamento dei disturbi della prostata e relative composizioni farmaceutiche e nutraceutiche
WO2019070109A1 (es) * 2017-10-03 2019-04-11 Infinite Clinical Research International, S.A. De C.V. Triconjugado para el tratamiento de diabetes mellitus
US11684618B2 (en) 2021-05-18 2023-06-27 Prostasis, Llc Compositions comprising mixtures of compounds and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR5060M (it) * 1965-12-22 1967-05-08
DE1767666C3 (de) * 1968-06-01 1986-07-31 Dr. Madaus & Co, 5000 Koeln Pharmazeutische Zubereitung gegen Lebererkrankungen
DE1963318A1 (de) * 1969-12-17 1971-06-24 Schwabe Willmar Gmbh & Co Silybinhalbester der Bernsteinsaeure und der Phthalsaeure,ihre Salze mit pharmakologisch vertraglichen Basen,Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von Arzneipraeparaten
DE2952115C2 (de) * 1979-12-22 1982-05-06 A. Nattermann & Cie GmbH, 5000 Köln Rosmarinsäure-Phospholipid-Komplex
JPS5958354U (ja) * 1982-10-13 1984-04-16 三菱重工業株式会社 伝熱板
SE442562B (sv) * 1983-01-26 1986-01-13 Asea Ab Sett att innesluta radioaktivt eller annat farligt avfall och en behallare for sadant avfall

Also Published As

Publication number Publication date
EP0209038B1 (en) 1989-09-20
AR241117A2 (es) 1991-11-15
ATE46513T1 (de) 1989-10-15
EP0209038A1 (en) 1987-01-21
FI862850L (fi) 1987-01-18
PT82988B (pt) 1988-07-01
FI82940B (fi) 1991-01-31
GR861825B (en) 1986-11-18
MX3173A (es) 1993-09-01
JPS6222781A (ja) 1987-01-30
YU45790B (sh) 1992-07-20
CS257289B2 (en) 1988-04-15
CA1259324A (en) 1989-09-12
HUT44567A (en) 1988-03-28
DK339086D0 (da) 1986-07-16
EP0209038B2 (en) 1996-03-27
DE3665717D1 (en) 1989-10-26
KR870001188A (ko) 1987-03-12
PT82988A (en) 1986-08-01
JPH0692399B2 (ja) 1994-11-16
HU197332B (en) 1989-03-28
YU128086A (en) 1988-02-29
US4764508A (en) 1988-08-16
IT8521602A0 (it) 1985-07-17
FI82940C (fi) 1991-05-10
DK339086A (da) 1987-01-18
AR241117A1 (es) 1991-11-15
KR890002430B1 (ko) 1989-07-03
DK170804B1 (da) 1996-01-22
ES2002101A6 (es) 1988-07-16
FI862850A0 (fi) 1986-07-04

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Effective date: 19970729