AR241117A2 - Procedimiento para la preparacion de complejos de flavanolignanos con fosfolipidos - Google Patents
Procedimiento para la preparacion de complejos de flavanolignanos con fosfolipidosInfo
- Publication number
- AR241117A2 AR241117A2 AR30453286A AR30453286A AR241117A2 AR 241117 A2 AR241117 A2 AR 241117A2 AR 30453286 A AR30453286 A AR 30453286A AR 30453286 A AR30453286 A AR 30453286A AR 241117 A2 AR241117 A2 AR 241117A2
- Authority
- AR
- Argentina
- Prior art keywords
- complexes
- flavanolignanes
- phospholipids
- preparation
- formula
- Prior art date
Links
- 150000003904 phospholipids Chemical class 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- QOLIPNRNLBQTAU-UHFFFAOYSA-N flavan Chemical compound C1CC2=CC=CC=C2OC1C1=CC=CC=C1 QOLIPNRNLBQTAU-UHFFFAOYSA-N 0.000 abstract 1
- 238000004108 freeze drying Methods 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 238000001291 vacuum drying Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/10—Phosphatides, e.g. lecithin
- C07F9/106—Adducts, complexes, salts of phosphatides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
UN PROCEDIMIENTO PARA LA PREPARACION DE COMPLEJOS DE UNO O MAS FLAVANOLIGNANOS CON UNO O MAS FOSFOLIPIDOS, DE FORMULA (I) DONDE R Y R1, IGUALES O DIFERENTES ENTRE SI, REPRESENTAN EL RESTO ACILICO DE LOS ACIDOS PALMITICO, ESTEARICO, OLEICO, LINOLEICO O LINOLENICO; R+ REPRESENTA UNO DE LOS RESTOS -CH2-CH2-N+(CH3), -CH2-CH2-NH3, -CH2CH(COOH)-NH3; R3 REPRESENTA UNO DE LOS RESTOS (A), (B), Y (C). EL METODO CONSISTE EN HACER REACCIONAR UN FOSFOLIPIDO DE LA FORMULA (II) CON UN FLAVANO DE LA FORMULA (III) (DONDE R, R1, R2 Y R3 TIENEN LOS SIGNIFICADOS DESCRIPTOS ANTERIORMENTE), EN UNA RELACION MOLAR DE FLAVANOLIGNANO A FOSFOLIPIDO COMPRENDIDA ENTRE 1:0,3 Y 1:2 Y AISLAR LOS COMPLEJOS FORMADOS MEDIANTE PRECIPITACION CON NO DISOLVENTES, LIOFILIZACION O SECADO A VACIO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT8521602A IT1215291B (it) | 1985-07-17 | 1985-07-17 | Complessi di flavanolignani con fosfolipidi, loro preparazione e relative composizioni farmaceutiche. |
Publications (2)
Publication Number | Publication Date |
---|---|
AR241117A1 AR241117A1 (es) | 1991-11-15 |
AR241117A2 true AR241117A2 (es) | 1991-11-15 |
Family
ID=11184188
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AR304532A AR241117A1 (es) | 1985-07-17 | 1986-07-17 | Procedimiento para la preparacion de complejos de flavanolignanos con fosfolipidos |
Country Status (18)
Country | Link |
---|---|
US (1) | US4764508A (es) |
EP (1) | EP0209038B2 (es) |
JP (1) | JPH0692399B2 (es) |
KR (1) | KR890002430B1 (es) |
AR (1) | AR241117A1 (es) |
AT (1) | ATE46513T1 (es) |
CA (1) | CA1259324A (es) |
CS (1) | CS257289B2 (es) |
DE (1) | DE3665717D1 (es) |
DK (1) | DK170804B1 (es) |
ES (1) | ES2002101A6 (es) |
FI (1) | FI82940C (es) |
GR (1) | GR861825B (es) |
HU (1) | HU197332B (es) |
IT (1) | IT1215291B (es) |
MX (1) | MX3173A (es) |
PT (1) | PT82988B (es) |
YU (1) | YU45790B (es) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1201149B (it) * | 1987-01-14 | 1989-01-27 | Indena Spa | Complessi di bioflavonoidi con fosfolipidi,loro preparazione,uso e composizioni farmaceutici e cosmetiche |
IT1201151B (it) * | 1987-01-14 | 1989-01-27 | Indena Spa | Complessi fosfolipidici con estratti da vitis vinifera,procedimento per la loro preparazione e composizioni che li cntengono |
IT1222012B (it) * | 1987-07-10 | 1990-08-31 | Indena Spa | Composizioni farmaceutiche e cosmetiche contenenti complessi di flavonolignani con fosfolipidi |
GB8716918D0 (en) * | 1987-07-17 | 1987-08-26 | Inverni Della Beffa Spa | Soluble derivatives of silybin |
IT1241673B (it) * | 1989-10-09 | 1994-01-27 | Istituto Biochimico Italiano | Complessi di inclusione di silibinina con ciclodestrina, loro preparazione e composizioni farmaceutiche che li contengono. |
IT1238684B (it) * | 1990-02-09 | 1993-09-01 | Indena Spa | Derivati del bilobalide,loro usi e formulazioni che li contegono |
ES2072416T3 (es) * | 1990-07-05 | 1995-07-16 | Indena Spa | Complejos de derivados de neolignano con fosfolipidos, su uso y formulaciones farmaceuticas y cosmeticas que los contienen. |
JP2672439B2 (ja) * | 1991-09-25 | 1997-11-05 | 倉敷紡績 株式会社 | 強化押出成形体 |
GB9211659D0 (en) * | 1992-06-02 | 1992-07-15 | Indena Spa | New alkaloid derivatives,their use and pharmaceutical formulations containing them |
DE19501266A1 (de) * | 1995-01-18 | 1996-07-25 | Madaus Ag | Verfahren zur Herstellung von Flavano-Lignan-Zubereitungen mit verbesserter Freisetzung und Resorbierbarkeit danach erhältliche Zubereitungen und deren Verwendung zur Herstellung von Arzneimitteln |
US5922757A (en) * | 1996-09-30 | 1999-07-13 | The Regents Of The University Of California | Treatment and prevention of hepatic disorders |
US6218437B1 (en) | 1996-09-30 | 2001-04-17 | The Regents Of The University Of California | Treatment and prevention of hepatic disorders |
ITMI20010429A1 (it) * | 2001-03-02 | 2002-09-02 | Indena Spa | Composizioni farmaceutiche e cosmetiche per la protezione della pelledai danni indotti dalle radiazioni solari |
KR100385366B1 (ko) * | 2001-03-05 | 2003-05-27 | 부광약품 주식회사 | 생체이용율을 개선한 실리마린 제제 조성물 |
DE60220415T2 (de) | 2001-07-27 | 2008-02-14 | Neptune Technologies & Bioressources Inc., Laval | Flavonoide und mehrfach ungesättigte fettsäuren enthaltende natürliche phospholipide maritimen ursprungs sowie deren anwendungen |
JP2005500349A (ja) * | 2001-08-01 | 2005-01-06 | アルタナ ファルマ アクチエンゲゼルシャフト | 呼吸症候群のための選択的cox−2インヒビターと肺表面活性物質の組合せ物 |
CZ292832B6 (cs) * | 2001-08-30 | 2003-12-17 | Ivax Pharmaceuticals S.R.O. | Způsob přípravy silymarinu se zvýšenou rozpustností |
ITMI20031388A1 (it) * | 2003-07-08 | 2005-01-09 | Indena Spa | Formulazioni per il trattamento e la prevenzione di patologie della prostata. |
ITMI20051942A1 (it) * | 2005-10-14 | 2007-04-15 | S I I T S R L Servizio Interna | Composizioni galattogeniche a base di silimarina |
EP1837030A1 (en) | 2006-03-09 | 2007-09-26 | INDENA S.p.A. | Phospholipid complexes of curcumin having improved bioavailability |
EP1844785A1 (en) * | 2006-04-13 | 2007-10-17 | Indena S.P.A. | Phospholipid complexes of olive fruits or leaves extracts having improved bioavailability |
JP5349486B2 (ja) * | 2007-11-15 | 2013-11-20 | マダウス ゲーエムベーハー | 肝炎の治療のためのシリビニン成分 |
CZ2008407A3 (cs) * | 2008-06-26 | 2009-08-26 | Agra Group, A. S. | Vodorozpustný prípravek na bázi flavanonol lignanu a zpusob jeho prípravy |
US8337835B2 (en) | 2009-04-10 | 2012-12-25 | Washington University | Use of an endogenous ligand for peroxisome proliferator activated receptor alpha to treat liver disorders |
IT1395351B1 (it) | 2009-07-09 | 2012-09-14 | Axioma Srl | Formulazioni orali ad elevata biodisponibilita' orale costituite da miscele di frazioni lipofile e idrofile ottenute a partire dalla propoli |
PT2493478T (pt) | 2009-10-29 | 2018-04-03 | Acasti Pharma Inc | Composições terapêuticas concentradas de fosfolípidos |
ITMI20121317A1 (it) | 2012-07-27 | 2014-01-28 | Indena Spa | Composizioni per il trattamento della fatica oncologica |
ITMI20121784A1 (it) | 2012-10-22 | 2014-04-23 | Velleja Res Srl | Composizioni galattogeniche a base di fosfatidilserina |
ITMI20130425A1 (it) * | 2013-03-20 | 2014-09-21 | Istituto Biochimico Italiano | Composizione per il trattamento della sindrome metabolica e delle alterazioni metabolico-ossidative nei pazienti con steatoepatite non alcolica (nash) |
CN103751785A (zh) * | 2014-01-27 | 2014-04-30 | 江苏健佳药业有限公司 | 一种水飞蓟素磷脂复合物及其制备方法 |
CN104306332B (zh) * | 2014-09-24 | 2017-02-15 | 东南大学 | 一种喜树碱类磷脂化合物、其药物组合物及应用 |
CN105983015B (zh) * | 2015-03-23 | 2022-01-25 | 天士力医药集团股份有限公司 | 一种含有水飞蓟宾、ve的药物组合物 |
CN105983016B (zh) * | 2015-03-23 | 2023-08-11 | 天士力医药集团股份有限公司 | 一种含有水飞蓟宾的药物组合 |
ITUB20155532A1 (it) * | 2015-11-12 | 2017-05-12 | St Biochimico Italiano Giovanni Lorenzini Spa | Formulazione farmaceutica orale comprendente silibina |
IT201600105201A1 (it) | 2016-10-19 | 2018-04-19 | Nutrilinea Srl | Uso della fosfatidilserina per la prevenzione e il trattamento dei disturbi della prostata e relative composizioni farmaceutiche e nutraceutiche |
WO2019070109A1 (es) * | 2017-10-03 | 2019-04-11 | Infinite Clinical Research International, S.A. De C.V. | Triconjugado para el tratamiento de diabetes mellitus |
AU2022277553A1 (en) | 2021-05-18 | 2023-11-09 | Prostasis, Llc | Compositions comprising mixtures of compounds and uses thereof |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR5060M (es) * | 1965-12-22 | 1967-05-08 | ||
DE1767666C3 (de) * | 1968-06-01 | 1986-07-31 | Dr. Madaus & Co, 5000 Koeln | Pharmazeutische Zubereitung gegen Lebererkrankungen |
DE1963318A1 (de) * | 1969-12-17 | 1971-06-24 | Schwabe Willmar Gmbh & Co | Silybinhalbester der Bernsteinsaeure und der Phthalsaeure,ihre Salze mit pharmakologisch vertraglichen Basen,Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von Arzneipraeparaten |
DE2952115C2 (de) * | 1979-12-22 | 1982-05-06 | A. Nattermann & Cie GmbH, 5000 Köln | Rosmarinsäure-Phospholipid-Komplex |
JPS5958354U (ja) * | 1982-10-13 | 1984-04-16 | 三菱重工業株式会社 | 伝熱板 |
SE442562B (sv) * | 1983-01-26 | 1986-01-13 | Asea Ab | Sett att innesluta radioaktivt eller annat farligt avfall och en behallare for sadant avfall |
-
1985
- 1985-07-17 IT IT8521602A patent/IT1215291B/it active
-
1986
- 1986-06-17 CS CS865455A patent/CS257289B2/cs not_active IP Right Cessation
- 1986-07-04 FI FI862850A patent/FI82940C/fi not_active IP Right Cessation
- 1986-07-07 EP EP86109257A patent/EP0209038B2/en not_active Expired - Lifetime
- 1986-07-07 DE DE8686109257T patent/DE3665717D1/de not_active Expired
- 1986-07-07 US US06/882,608 patent/US4764508A/en not_active Expired - Lifetime
- 1986-07-07 AT AT86109257T patent/ATE46513T1/de not_active IP Right Cessation
- 1986-07-10 CA CA000513497A patent/CA1259324A/en not_active Expired
- 1986-07-10 HU HU862864A patent/HU197332B/hu not_active IP Right Cessation
- 1986-07-14 GR GR861825A patent/GR861825B/el unknown
- 1986-07-15 PT PT82988A patent/PT82988B/pt unknown
- 1986-07-16 ES ES8600342A patent/ES2002101A6/es not_active Expired
- 1986-07-16 JP JP61167748A patent/JPH0692399B2/ja not_active Expired - Lifetime
- 1986-07-16 DK DK339086A patent/DK170804B1/da not_active IP Right Cessation
- 1986-07-16 KR KR1019860005746A patent/KR890002430B1/ko not_active IP Right Cessation
- 1986-07-17 AR AR304532A patent/AR241117A1/es active
- 1986-07-17 YU YU128086A patent/YU45790B/sh unknown
- 1986-07-17 MX MX317386A patent/MX3173A/es unknown
Also Published As
Publication number | Publication date |
---|---|
EP0209038B1 (en) | 1989-09-20 |
AR241117A1 (es) | 1991-11-15 |
MX3173A (es) | 1993-09-01 |
PT82988A (en) | 1986-08-01 |
DK170804B1 (da) | 1996-01-22 |
DE3665717D1 (en) | 1989-10-26 |
FI82940C (fi) | 1991-05-10 |
DK339086D0 (da) | 1986-07-16 |
DK339086A (da) | 1987-01-18 |
ES2002101A6 (es) | 1988-07-16 |
JPS6222781A (ja) | 1987-01-30 |
KR870001188A (ko) | 1987-03-12 |
YU128086A (en) | 1988-02-29 |
KR890002430B1 (ko) | 1989-07-03 |
FI862850A0 (fi) | 1986-07-04 |
HUT44567A (en) | 1988-03-28 |
JPH0692399B2 (ja) | 1994-11-16 |
CS257289B2 (en) | 1988-04-15 |
US4764508A (en) | 1988-08-16 |
EP0209038B2 (en) | 1996-03-27 |
HU197332B (en) | 1989-03-28 |
FI82940B (fi) | 1991-01-31 |
IT1215291B (it) | 1990-01-31 |
CA1259324A (en) | 1989-09-12 |
FI862850A (fi) | 1987-01-18 |
ATE46513T1 (de) | 1989-10-15 |
EP0209038A1 (en) | 1987-01-21 |
IT8521602A0 (it) | 1985-07-17 |
PT82988B (pt) | 1988-07-01 |
GR861825B (en) | 1986-11-18 |
YU45790B (sh) | 1992-07-20 |
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