AR094537A1 - COMPUESTOS DE PIRIDILO SUSTITUIDOS CON ALQUILAMIDA ÚTILES COMO MODULADORES DE LAS RESPUESTAS DE IL-12, IL-23 Y/O IFNa - Google Patents
COMPUESTOS DE PIRIDILO SUSTITUIDOS CON ALQUILAMIDA ÚTILES COMO MODULADORES DE LAS RESPUESTAS DE IL-12, IL-23 Y/O IFNaInfo
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- AR094537A1 AR094537A1 ARP130104090A ARP130104090A AR094537A1 AR 094537 A1 AR094537 A1 AR 094537A1 AR P130104090 A ARP130104090 A AR P130104090A AR P130104090 A ARP130104090 A AR P130104090A AR 094537 A1 AR094537 A1 AR 094537A1
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- carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
Abstract
Son útiles para la modulación de IL-12, IL-23 y/o lFNa que actúan en Tyk-2 para generar la inhibición de la transducción de señal. Reivindicación 1: Un compuesto caracterizado porque tiene la fórmula (1), o un estereoisómero o una sal de aquel aceptable desde el punto de vista farmacéutico, en donde R¹ es alquilo C₁₋₃ opcionalmente sustituido con 0 - 7 R¹ᵃ; R¹ᵃ es, en cada caso, independientemente hidrógeno, deuterio, F, CI, Br, CF₃ o CN; R² es alquilo C₁₋₆ sustituido con 0 - 4 R²ᵃ, cicloalquilo C₃₋₆ sustituido con 0 - 4 R²ᵃ, arilo C₆₋₁₀ sustituido con 0 - 4 R²ᵃ, un heterociclo de 5 - 14 miembros que contiene 1 - 4 heteroátomos seleccionados de N, O y S, sustituido con 0 - 4 R²ᵃ, NR⁶R⁶ u ORᵇ; R²ᵃ es, en cada caso, independientemente hidrógeno, =O, halo, OCF₃, CN, NO₂, -(CH₂)ʳORᵇ, -(CH₂)ʳSRᵇ, -(CH₂)ʳC(O)Rᵇ, -(CH₂)ʳC(O)ORᵇ, -(CH₂)ʳOC(O)Rᵇ, -(CH₂)ʳNR¹¹R¹¹, -(CH₂)ʳC(O)NR¹¹R¹¹, -(CH₂)ʳNRᵇC(O)Rᶜ, -(CH₂)ʳNRᵇC(O)ORᶜ, -NRᵇC(O)NR¹¹R¹¹, -S(O)ₚNR¹¹R¹¹, -NRᵇS(O)ₚRᶜ, -S(O)ₚRᶜ, alquilo C₁₋₆ sustituido con 0 - 3 Rᵃ, haloalquilo C₁₋₆, -(CH₂)ʳ-carbociclo de 3 - 14 miembros sustituido con 0 - 1 Rᵃ o -(CH₂)ʳ-heterociclo de 5 - 7 miembros que comprende átomos de carbono o 1 - 4 heteroátomos seleccionados de N, O y S(O)ₚ sustituido con 0 - 2 Rᵃ; o un R²ᵃ y otro R²ᵃ, junto con los átomos a los que están unidos, se combinan para formar un anillo fusionado de 5 - 6 miembros, en donde el anillo fusionado se puede sustituir con 0 - 2 Rᵃ; R³ es -(CH₂)ʳ-carbociclo de 3 - 14 miembros sustituido 0 - 5 R³ᵃ; R³ᵃ es, en cada caso, independientemente hidrógeno, =O, halo (F), OCF₃, CF₃, CHF₂, CN, NO₂, -(CH₂)ʳORᵇ, -(CH₂)ʳSRᵇ, -(CH₂)ʳC(O)Rᵇ, -(CH₂)ʳC(O)ORᵇ, -(CH₂)ʳOC(O)Rᵇ, -(CH₂)ʳNR¹¹R¹¹, -(CH₂)ʳC(O)NR¹¹R¹¹, -(CH₂)ʳNRᵇC(O)Rᶜ, -(CH₂)ʳNRᵇC(O)ORᶜ, -NRᵇC(O)NR¹¹R¹¹, -S(O)ₚNR¹¹R¹¹, -NRᵇS(O)ₚRᶜ, -S(O)ₚRᶜ, alquilo C₁₋₆ sustituido con 0 - 3 Rᵃ, haloalquilo C₁₋₆, -(CH₂)ʳ-carbociclo de 3 - 14 miembros sustituido con 0 - 3 Rᵃ o -(CH₂)ʳ-heterociclo de 5 - 10 miembros que comprende átomos de carbono y 1 - 4 heteroátomos seleccionados de N, O y S(O)ₚ sustituido con 0 - 3 Rᵃ; o dos R³ᵃ, junto con los átomos a los que están unidos, se combinan para formar un anillo fusionado, en donde el anillo se selecciona de fenilo y un heterociclo de 5 - 7 miembros que comprende átomos de carbono y 1 - 4 heteroátomos seleccionados de N, S u O, y ese anillo fenilo fusionado también se puede sustituir con Rᵃ; R⁴ y R⁵ son independientemente hidrógeno, alquilo C₁₋₄ sustituido con 0 - 1 Rᶠ, (CH₂)ʳ-fenilo sustituido con 0 - 3 Rᵈ o -(CH₂)-heterociclo de 5 - 7 miembros que comprende átomos de carbono y 1 - 4 heteroátomos seleccionados de N, O y S(O)ₚ; R⁶ y R¹¹ son, en cada caso, independientemente hidrógeno, alquilo C₁₋₄ sustituido con 0 - 3 Rᶠ, CF₃, cicloalquilo C₃₋₁₀ sustituido con 0 - 1 Rᶠ, (CH)ʳ-fenilo sustituido con 0 - 3 Rᵈ o (CH₂)ʳ-heterociclo de 5 - 7 miembros que comprende átomos de carbono y 1 - 4 heteroátomos seleccionados de N, O y S(O)ₚ sustituido con 0 - 3 Rᵈ; Rᵃ es, en cada caso, hidrógeno, F, CI, Br, OCF₃, CF₃, CHF₂, CN, NO₂, -(CH₂)ʳORᵇ, -(CH₂)ʳSRᵇ, -(CH₂)ʳC(O)Rᵇ, -(CH₂)ʳC(O)ORᵇ, -(CH₂)ʳOC(O)Rᵇ, -(CH₂)ʳNR¹¹R¹¹, -(CH₂)ʳC(O)NR¹¹R¹¹, -(CH₂)ʳNRᵇC(O)Rᶜ, -(CH₂)ʳNRᵇC(O)ORᶜ, -NRᵇC(O)NR¹¹R¹¹, -S(O)ₚNR¹¹R¹¹, -NRᵇS(O)Rᶜ, -S(O)Rᶜ, -S(O)₂Rᶜ, alquilo C₁₋₆ sustituido con 0 - 3 Rᶠ, haloalquilo C₁₋₆, -(CH₂)ʳ-carbociclo de 3 - 14 miembros o -(CH₂)ʳ-heterociclo de 5 - 7 miembros que comprende átomos de carbono y 1 - 4 heteroátomos seleccionados de N, O y S(O)ₚ sustituido con 0 - 3 Rᶠ; Rᵇ es, en cada caso, hidrógeno, alquilo C₁₋₆ sustituido con 0 - 3 Rᵈ, haloalquilo C₁₋₆, cicloalquilo C₃₋₆ sustituido con 0 - 2 Rᵈ, o -(CH₂)ʳ-heterociclo de 5 - 7 miembros que comprende átomos de carbono y 1 - 4 heteroátomos seleccionados de N, O y S(O)ₚ sustituido con 0 - 3 Rᶠ o (CH₂)ʳ-fenilo sustituido con 0 - 3 Rᵈ; Rᶜ es alquilo C₁₋₆ sustituido con 0 - 3 Rᶠ, (CH₂)ʳ-cicloalquilo C₃₋₆ sustituido con 0 - 3 Rᶠ o (CH₂)ʳ-fenilo sustituido con 0 - 3 Rᶠ; Rᵈ es, en cada caso, independientemente hidrógeno, F, CI, Br, OCF₃, CF₃, CN, NO₂, -ORᵉ, -(CH₂)ʳ-C(O)Rᶜ, -NRᵉRᵉ, -NRᵉC(O)ORᶜ, alquilo C₁₋₆ o (CH₂)ʳ-fenilo sustituido con 0 - 3 Rᶠ; Rᵉ se selecciona, independientemente en cada caso, de hidrógeno, alquilo C₁₋₆, cicloalquilo C₃₋₆ y (CH₂)ʳ-fenilo sustituido con 0 - 3 Rᶠ; Rᶠ es, en cada caso, independientemente hidrógeno, halo, CN, NH₂, OH, cicloalquilo C₃₋₆, CF₃, O(alquilo C₁₋₆) o -(CH₂)ʳ-heteroarilo de 5 - 7 miembros que comprende átomos de carbono y 1 - 4 heteroátomos seleccionados de N, O y S(O)ₚ; p es 0, 1 ó 2; y r es 0, 1, 2, 3 ó 4.
Priority Applications (34)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ARP130104090A AR094537A1 (es) | 2013-11-07 | 2013-11-07 | COMPUESTOS DE PIRIDILO SUSTITUIDOS CON ALQUILAMIDA ÚTILES COMO MODULADORES DE LAS RESPUESTAS DE IL-12, IL-23 Y/O IFNa |
TW102140574A TWI582077B (zh) | 2013-11-07 | 2013-11-07 | 作爲IL-12、IL-23及/或IFNα反應調節劑之經烷基-醯胺取代之吡啶化合物 |
LTEP14702707.2T LT3066078T (lt) | 2013-11-07 | 2014-01-16 | Alkilamidu-pakeisti piridilo junginiai, naudingi kaip il-12, il-23 ir (arba) ifn-alfa atsako moduliatoriai |
RS20191041A RS59125B1 (sr) | 2013-11-07 | 2014-01-16 | Alkil-amid-supstituisana piridil jedinjenja korisna kao modulatori il-12, il-23 i/ili ifnalfa odgovora |
EA201690865A EA033272B1 (ru) | 2013-11-07 | 2014-01-16 | АЛКИЛАМИД-ЗАМЕЩЕННЫЕ ПИРИДИЛЬНЫЕ СОЕДИНЕНИЯ, ПРИМЕНИМЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ ОТВЕТОВ IL-12, IL-23 И/ИЛИ IFNα |
MYPI2016701601A MY174453A (en) | 2013-11-07 | 2014-01-16 | Alkyl-amide-substituted pyridyl compounds useful as modulators of il-12, il-23 and/or ifnalpha responses |
KR1020167014612A KR102186633B1 (ko) | 2013-11-07 | 2014-01-16 | Il-12, il-23 및/또는 ifn알파 반응의 조정제로서 유용한 알킬-아미드-치환된 피리딜 화합물 |
ES14702707T ES2738826T3 (es) | 2013-11-07 | 2014-01-16 | Compuestos de piridilo sustituidos con alquilamida útiles como moduladores de respuestas de IL-12, IL-23 y/o IFNalfa |
DK14702707.2T DK3066078T3 (da) | 2013-11-07 | 2014-01-16 | Alkyl-amid-substituerede pyridylforbindelser, der er anvendelige som modulatorer af il-12-, il-23- og/eller ifn-alpha-responser |
JP2016528221A JP6312823B2 (ja) | 2013-11-07 | 2014-01-16 | Il−12、il−23および/またはifnアルファ応答の調節因子として有用なアルキル−アミド−置換ピリジル化合物 |
EP14702707.2A EP3066078B1 (en) | 2013-11-07 | 2014-01-16 | Alkyl-amide-substituted pyridyl compounds useful as modulators of il-12, il-23 and/or ifnalpha responses |
AU2014347275A AU2014347275B2 (en) | 2013-11-07 | 2014-01-16 | Alkyl-amide-substituted pyridyl compounds useful as modulators of IL-12, IL-23 and/or IFNalpha responses |
CA2930060A CA2930060C (en) | 2013-11-07 | 2014-01-16 | Alkyl-amide-substituted pyridyl compounds useful as modulators of il-12, il-23 and/or ifnalpha responses |
SI201431231T SI3066078T1 (sl) | 2013-11-07 | 2014-01-16 | Alkil-amid-substituirane spojine piridila uporabne kot modulatorji IL-12, IL-23 in/ali IFN-ALFA odgovorov |
EP19173861.6A EP3590926A1 (en) | 2013-11-07 | 2014-01-16 | Alkyl-amide-substituted pyridyl compounds useful as modulators of il-12, il-23 and/or ifnalpha responses |
PCT/US2014/011769 WO2015069310A1 (en) | 2013-11-07 | 2014-01-16 | Alkyl-amide-substituted pyridyl compounds useful as modulators of il-12, il-23 and/or ifnalpha responses |
MA39001A MA39001A1 (fr) | 2013-11-07 | 2014-01-16 | Composés pyridyle substitués par alkyl-amide, utiles comme modulateurs d'il-12, il-23 et/ou de réponses à l'ifn? |
BR112016010172-3A BR112016010172B1 (pt) | 2013-11-07 | 2014-01-16 | Compostos de piridila substituída por alquil- amida úteis no tratamento de uma doença inflamatória ou autoimune e composição farmacêutica que os compreende |
CN201480072423.2A CN106660960B (zh) | 2013-11-07 | 2014-01-16 | 用作IL-12、IL-23和/或IFNα响应的调节剂的烷基-酰胺-取代的吡啶化合物 |
PE2016000603A PE20160961A1 (es) | 2013-11-07 | 2014-01-16 | Compuestos de piridilo sustituidos con alquilamida utiles como moduladores de respuestas de citocinas heterodimericas interleucina 12 y 23 (il-12 e il-23) y/o interferon alfa (ifnalfa) |
PT14702707T PT3066078T (pt) | 2013-11-07 | 2014-01-16 | Compostos de piridilo substitoidos com alqoil-amida uteis como modoladores de respostas de il-12, il-23 e/00 ifn-alfa |
MX2016005853A MX369394B (es) | 2013-11-07 | 2014-01-16 | Compuestos de piridilo sustituidos con alquilamida utiles como muduladores de respuestas de citocinas heterodimericas interleucina 12 y 23 (il-12 e il-23) y/o interferon alfa (ifnalfa). |
TN2016000153A TN2016000153A1 (en) | 2013-11-07 | 2014-01-16 | Alkyl-amide-substituted pyridyl compounds useful as modulators of il-12, il-23 and/or ifnalpha responses. |
US15/034,915 US9663467B2 (en) | 2013-11-07 | 2014-01-16 | Alkyl-amide-substituted pyridyl compounds useful as modulators of IL-12, IL-23 and/or IFNα responses |
NZ720710A NZ720710A (en) | 2013-11-07 | 2014-01-16 | Alkyl-amide-substituted pyridyl compounds useful as modulators of il-12, il-23 and/or ifnalpha responses |
PL14702707T PL3066078T3 (pl) | 2013-11-07 | 2014-01-16 | Związki pirydylowe podstawione alkilo-amidami przydatne jako modulatory odpowiedzi il-12, il-23 i/lub ifn-alfa |
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CL2016001101A CL2016001101A1 (es) | 2013-11-07 | 2016-05-06 | Compuestos de piridilo sustituidos con alquilamida útiles como moduladores de respuestas de il-12 e il-23 y/o ifnalfa |
HK16114678A HK1226400A1 (zh) | 2013-11-07 | 2016-12-23 | 作為il-12,il-23調節劑的烷基醯胺取代的吡啶基化合物 |
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CY20191100878T CY1122065T1 (el) | 2013-11-07 | 2019-08-14 | Ενωσεις αλκυλ-αμιδο-υποκατεστημενου πυριδυλιου χρησιμες ως διαμορφωτες των αποκρισεων il-12, il-23 και/η ιfναλφα |
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TW102140574A TWI582077B (zh) | 2013-11-07 | 2013-11-07 | 作爲IL-12、IL-23及/或IFNα反應調節劑之經烷基-醯胺取代之吡啶化合物 |
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