AR113895A1 - Compuestos de heteroarilo sustituidos con alquilamida de piridinsulfona - Google Patents

Compuestos de heteroarilo sustituidos con alquilamida de piridinsulfona

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Publication number
AR113895A1
AR113895A1 ARP180103395A ARP180103395A AR113895A1 AR 113895 A1 AR113895 A1 AR 113895A1 AR P180103395 A ARP180103395 A AR P180103395A AR P180103395 A ARP180103395 A AR P180103395A AR 113895 A1 AR113895 A1 AR 113895A1
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AR
Argentina
Prior art keywords
substituted
alkyl
membered
hydrogen
cycloalkyl
Prior art date
Application number
ARP180103395A
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English (en)
Inventor
David S Weinstein
John S Tokarski
Ryan M Moslin
Ling Chen
Zili Xiao
Michael G Yang
Chunjian Liu
Original Assignee
Bristol Myers Squibb Co
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Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AR113895A1 publication Critical patent/AR113895A1/es

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/501Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Una composición farmacéutica que los comprende y su uso en el tratamiento de enfermedades inflamatorias autoinmunes. Reivindicación 1: Un compuesto caracterizado porque tiene la fórmula (1), en donde Y es N o CR⁶; R¹ es H, CD₃ o C₁₋₃ alquilo; R² es -C(O)R²ᵃ; o C₁₋₆ alquilo, -(CH₂)ʳ-carbociclo de 3 - 14 miembros sustituido con 0 - 1 R²ᵃ o un heterociclo de 5 - 14 miembros que contiene 1 - 4 heteroátomos seleccionados de N, O, y S, sustituido con 0 - 4 R²ᵃ; R²ᵃ, en cada caso, es independientemente hidrógeno, OH, halo, OCF₃, CN, NO₂, -(CH₂)ʳORᵇ, -(CH₂)ʳSRᵇ, -(CH₂)ʳC(O)Rᵇ, -(CH₂)ʳC(O)ORᵇ, -(CH₂)ʳOC(O)Rᵇ, -(CH₂)ʳNR¹¹R¹¹, -(CH₂)ʳC(O)NR¹¹R¹¹, -(CH₂)ʳNRᵇC(O)Rᶜ, -(CH₂)ʳNRᵇC(O)ORᶜ, -NRᵇC(O)NR¹¹R¹¹, -S(O)ₚNR¹¹R¹¹, -NRᵇS(O)ₚRᶜ, -S(O)ₚRᶜ, C₁₋₆ alquilo sustituido con 0 - 3 Rᵃ, C₁₋₆ haloalquilo, C₂₋₆ alquenilo sustituido con 0 - 3 Rᵃ, -(CH₂)ʳ-carbociclo de 3 - 14 miembros sustituido con 0 - 1 Rᵃ o un -(CH₂)ʳ-heterociclo de 5 - 7 miembros que contiene 1 - 4 heteroátomos seleccionados de N, O y S(O)ₚ sustituido con 0 - 2 Rᵃ; R³ es un compuesto de fórmula (2); X está ausente, es O ó NH; R⁴ y R⁵ son independientemente hidrógeno, C₁₋₄ alquilo sustituido con 0 - 1 Rᶠ, (CH₂)ʳ-fenilo sustituido con 0 - 3 Rᵈ o un -(CH₂)-heterociclo de 5 - 7 miembros que contiene 1 - 4 heteroátomos seleccionados de N, O y S(O)ₚ; R⁶ es hidrógeno, halo, C₁₋₄ alquilo, C₁₋₄ alquiloxi, C₁₋₄ haloalquilo, C₁₋₄ haloalcoxi, C₃₋₆ cicloalquilo, CN, NO₂ u OH; R¹¹, en cada caso, es independientemente hidrógeno, C₁₋₄ alquilo sustituido con 0 - 3 Rᶠ, CF₃, C₃₋₁₀ cicloalquilo sustituido con 0 - 1 Rᶠ, (CH₂)ʳ-fenilo sustituido con 0 - 3 Rᵈ o -(CH₂)ʳ-heterociclo de 5 - 7 miembros que contiene 1 - 4 heteroátomos seleccionados de N, O y S(O)ₚ sustituido con 0 - 3 Rᵈ; Rᵃ y Rᵃ¹, en cada caso, son independientemente hidrógeno, F, Cl, Br, OCF₃, CF₃, CHF₂, CN, NO₂, -(CH₂)ʳORᵇ, -(CH₂)ʳSRᵇ, -(CH₂)ʳC(O)Rᵇ, -(CH₂)ʳC(O)ORᵇ, -(CH₂)ʳOC(O)Rᵇ, -(CH₂)ʳNR¹¹R¹¹, -(CH₂)ʳC(O)NR¹¹R¹¹, -(CH₂)ʳNRᵇC(O)Rᶜ, -(CH₂)ʳNRᵇC(O)ORᶜ, -NRᵇC(O)NR¹¹R¹¹, -S(O)ₚNR¹¹R¹¹, -NRᵇS(O)ₚRᶜ, -S(O)Rᶜ, -S(O)₂Rᶜ, C₁₋₆ alquilo sustituido con 0 - 3 Rᶠ, C₁₋₆ haloalquilo, C₂₋₆ alquenilo sustituido con 0 - 3 Rᵃ, C₂₋₆ alquinilo sustituido con 0 - 3 Rᵃ, -(CH₂)ʳ-carbociclo de 3 - 14 miembros o -(CH₂)ʳ-heterociclo de 5 - 7 miembros que contiene 1 - 4 heteroátomos seleccionados de N, O y S(O)ₚ sustituido con 0 - 3 Rᶠ; Rᵇ es hidrógeno, C₁₋₆ alquilo sustituido con 0 - 3 Rᵈ, C₁₋₆ haloalquilo, C₃₋₆ cicloalquilo sustituido con 0 - 2 Rᵈ o -(CH₂)ʳ-heterociclo de 5 - 7 miembros que contiene 1 - 4 heteroátomos seleccionados de N, O y S(O)ₚ sustituido con 0 - 3 Rᶠ, o (CH₂)ʳ-fenilo sustituido con 0 - 3 Rᵈ; Rᶜ es C₁₋₆ alquilo sustituido con 0 - 3 Rᶠ, (CH₂)ʳ-C₃₋₆ cicloalquilo sustituido con 0 - 3 Rᶠ o (CH₂)ʳ-fenilo sustituido con 0 - 3 Rᶠ; Rᵈ es independientemente, en cada caso, hidrógeno, F, Cl, Br, OCF₃, CF₃, CN, NO₂, -ORᵉ, -(CH₂)ʳC(O)Rᶜ, -NRᵉRᵉ, -NRᵉC(O)ORᶜ, C₁₋₆, alquilo o (CH₂)ʳ-fenilo sustituido con 0 - 3 Rᶠ; Rᵉ es independientemente, en cada caso, hidrógeno, C₁₋₆ alquilo, C₃₋₆ cicloalquilo o (CH₂)ʳ-fenilo sustituido con 0 - 3 Rᶠ; Rᶠ es independientemente, en cada caso, hidrógeno, halo, CN, NH₂, OH, C₃₋₆ cicloalquilo, CF₃, O(C₁₋₆ alquilo) o un -(CH₂)ʳ-heterociclo de 5 - 7 miembros que contiene 1 - 4 heteroátomos seleccionados de N, O y S(O)ₚ; p es 0, 1 ó 2; r es 0, 1, 2, 3 ó 4; o un estereoisómero o una sal de aquel aceptable desde el punto de vista farmacéutico.
ARP180103395A 2017-11-21 2018-11-20 Compuestos de heteroarilo sustituidos con alquilamida de piridinsulfona AR113895A1 (es)

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US201762589165P 2017-11-21 2017-11-21

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US (3) US11021462B2 (es)
EP (1) EP3713930A1 (es)
JP (2) JP7258903B2 (es)
KR (1) KR102702228B1 (es)
CN (1) CN111315737B (es)
AR (1) AR113895A1 (es)
AU (3) AU2018371010C1 (es)
BR (1) BR112020009606A2 (es)
CA (1) CA3083122A1 (es)
CL (1) CL2020001338A1 (es)
CO (1) CO2020006139A2 (es)
EA (1) EA202091269A1 (es)
IL (1) IL274816B2 (es)
MX (1) MX2020005210A (es)
PE (1) PE20211461A1 (es)
SG (1) SG11202004592TA (es)
TW (1) TWI776994B (es)
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ZA (1) ZA202003717B (es)

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AU2018371010C1 (en) * 2017-11-21 2024-09-26 Bristol-Myers Squibb Company Sulfone pyridine alkyl amide-substituted heteroaryl compounds
CN111484480B (zh) * 2019-01-29 2023-08-11 上海翰森生物医药科技有限公司 一种多环类衍生物抑制剂、其制备方法和应用
JP2022542704A (ja) * 2019-08-01 2022-10-06 インテグラル バイオサイエンシーズ プライベート リミテッド キナーゼインヒビターとしての複素環式化合物およびその使用
CN115160297B (zh) * 2020-12-22 2023-03-31 益方生物科技(上海)股份有限公司 杂芳基化合物及其制备方法和用途
BR112023016614A2 (pt) 2021-02-19 2023-11-07 Sudo Biosciences Ltd Inibidores de tyk2 e usos dos mesmos
EP4294807A1 (en) 2021-02-19 2023-12-27 Sudo Biosciences Limited Tyk2 inhibitors and uses thereof
US20240182429A1 (en) * 2021-03-30 2024-06-06 Zhejiang Wenda Pharma Technology Ltd. Heterocyclic compound as tyk2 pseudokinase domain inhibitor, synthetic method, and use
JP2024518792A (ja) * 2021-05-14 2024-05-02 ブリストル-マイヤーズ スクイブ カンパニー 置換ヘテロ環化合物
CN116693449A (zh) 2022-03-04 2023-09-05 上海致根医药科技有限公司 用作tyk2抑制剂的化合物、其制备方法及其在医药上的应用
WO2024125651A1 (zh) * 2022-12-16 2024-06-20 津药生物科技(天津)有限公司 新型含杂环取代的丙烯酸衍生物及其用途

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KR20140108594A (ko) 2012-01-10 2014-09-11 에프. 호프만-라 로슈 아게 피리다진 아미드 화합물 및 syk 저해제로서의 이의 용도
WO2014060371A1 (en) 2012-10-19 2014-04-24 F. Hoffmann-La Roche Ag Inhibitors of syk
AU2013341185B2 (en) * 2012-11-08 2017-07-13 Bristol-Myers Squibb Company Alkyl-amide-substituted pyridyl compounds useful as modulators of IL-12, IL-23 and/or IFNalpha responses
RS63328B1 (sr) * 2012-11-08 2022-07-29 Bristol Myers Squibb Co Amidom-supstituisana heterociklična jedinjenja korisna kao modulatori il-12, il-23 i/ili ifn alfa odgovora
AR094537A1 (es) * 2013-11-07 2015-08-12 Bristol Myers Squibb Co COMPUESTOS DE PIRIDILO SUSTITUIDOS CON ALQUILAMIDA ÚTILES COMO MODULADORES DE LAS RESPUESTAS DE IL-12, IL-23 Y/O IFNa
JP6345786B2 (ja) 2013-12-05 2018-06-20 ファーマサイクリックス エルエルシー ブルトン型チロシンキナーゼの阻害剤
TW201827423A (zh) 2016-12-13 2018-08-01 美商必治妥美雅史谷比公司 做為IL-12, IL-23及/或IFNα反應調節劑之經烷基醯胺取代之雜芳基化合物氧化膦
AU2018371010C1 (en) * 2017-11-21 2024-09-26 Bristol-Myers Squibb Company Sulfone pyridine alkyl amide-substituted heteroaryl compounds

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AU2022228101B2 (en) 2023-08-03
US20210253554A1 (en) 2021-08-19
AU2022228101A1 (en) 2022-09-29
CA3083122A1 (en) 2019-05-31
BR112020009606A2 (pt) 2020-11-03
IL274816B2 (en) 2023-12-01
IL274816B1 (en) 2023-08-01
EA202091269A1 (ru) 2020-08-07
AU2018371010B2 (en) 2022-06-09
US20190152948A1 (en) 2019-05-23
ZA202003717B (en) 2022-01-26
JP7490107B2 (ja) 2024-05-24
AU2018371010C1 (en) 2024-09-26
US11021462B2 (en) 2021-06-01
KR102702228B1 (ko) 2024-09-02
US20240002364A1 (en) 2024-01-04
IL274816A (en) 2020-07-30
JP2023098942A (ja) 2023-07-11
SG11202004592TA (en) 2020-06-29
MX2020005210A (es) 2020-08-20
TWI776994B (zh) 2022-09-11
CO2020006139A2 (es) 2020-05-29
TW201925187A (zh) 2019-07-01
PE20211461A1 (es) 2021-08-05
AU2018371010A1 (en) 2020-07-02
AU2023255024A1 (en) 2023-11-16
US11787779B2 (en) 2023-10-17
CN111315737A (zh) 2020-06-19
CL2020001338A1 (es) 2020-09-25
KR20200089706A (ko) 2020-07-27
WO2019103952A1 (en) 2019-05-31
JP2021504443A (ja) 2021-02-15
JP7258903B2 (ja) 2023-04-17
EP3713930A1 (en) 2020-09-30
CN111315737B (zh) 2024-06-18

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