AR063906A1 - Compuestos quimicos derivados del indazol, una composicion farmaceutica y procesos de prpeparacion de los compuestos - Google Patents
Compuestos quimicos derivados del indazol, una composicion farmaceutica y procesos de prpeparacion de los compuestosInfo
- Publication number
- AR063906A1 AR063906A1 ARP070105195A ARP070105195A AR063906A1 AR 063906 A1 AR063906 A1 AR 063906A1 AR P070105195 A ARP070105195 A AR P070105195A AR P070105195 A ARP070105195 A AR P070105195A AR 063906 A1 AR063906 A1 AR 063906A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- 4alkyl
- haloalkyl
- cycloalkyl
- aryl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- BAXOFTOLAUCFNW-UHFFFAOYSA-N 1H-indazole Chemical compound C1=CC=C2C=NNC2=C1 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 title 1
- 239000002131 composite material Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 39
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 9
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 6
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 5
- 229910052736 halogen Inorganic materials 0.000 abstract 5
- 150000002367 halogens Chemical group 0.000 abstract 5
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 4
- -1 C1-4 alkoxyhalo Chemical group 0.000 abstract 4
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 abstract 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 3
- 229910052717 sulfur Inorganic materials 0.000 abstract 3
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000001188 haloalkyl group Chemical group 0.000 abstract 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000004001 thioalkyl group Chemical group 0.000 abstract 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 abstract 1
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000000172 C5-C10 aryl group Chemical group 0.000 abstract 1
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 abstract 1
- 125000005213 alkyl heteroaryl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 125000000842 isoxazolyl group Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000003226 pyrazolyl group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
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Abstract
Compuestos de fórmula (1) o sales aceptables para uso farmacéutico de los mismos; composiciones que los comprenden, y procesos para preparar dichos compuestos. Estos compuestos son útiles en el tratamiento de un estado patológico inflamatorio. Reivindicación 1: Un compuesto caracterizado porque responde a la fórmula (1) en donde: A es alquilo C1-10, arilo C5-10, aril C5-10-alquiIo C1-6,heteroarilo C5-10, heteroaril C5-10-alquilo C1-6, aril C5-10-alcoxi C1-6, haloalquiIo C1-10, cicloalquilo C3-7, cicloalquil C3-7-alquilo C1-4, alquil C1-6OC(O)aIquiIo C1-6, alquil C1-6C(O)Oalquilo C1-6, ariloxi C5-10-aIquiIo C1-10 o NR5R6alquilo C0-6 en donde el arilo está sustituido optativamente con uno o más sustituyentes seleccionados entre B; R1 y R1a se seleccionan en forma independiente entre hidrógeno, alquilo C1-4, haloalquilo C1-4, hidroxialquilo C1-4 y aIquil C1-4OaIquiIo C1-4; R2 es hidrógeno o alquilo C1-4; R3 es cicloalquilo C3-7 (sustituido optativamente con halógeno o alquilo C1-6), aril C5-10-alquiIo C0-3, aril C5-10Oalquilo C0-3, heteroaril C5-10-alquilo C0-3, alquilo C1-6, alqueniIo C1-6 o alquinilo C1-6 que están sustituidos optativamente con uno o más B; B es hidroxialquilo C0-3, alquilo C1-4, alcoxi C1-4, alquiltio C0-4-alquilo C0-4, cicloalquil C3-6-tioalquilo C0-4, alquil C0-3S(O)nalquilo C0-4, haloalquilo C1-6, haloalcoxi C1-4, halógeno, nitro, ciano, alquiI C1-4Oalquilo C1-6, alquil C0-6OaIquiI C1-4OaIquilo C0-4, aIquil C0-6C(O)alquilo C0-6, alquil C0-4C(O)OaIquilo C0-4, alquiI C0-4OC(O)alquilo C0-4, NR5R6alquiIo C0-4, NR5R6C(O)alquilo C0-4, NR5R6OC(O)alquilo C0-4, NR5R6C(O)Oalquilo C0-4, R6C(O)R5Nalquilo C0-4, alquil C0-4OC(O)alquil C0-4NH, alquil C0-4C(O)Oalquil C0-4NH, alquil C0- 4C(O)alquil C0-4NH o NR5R6S(O)nalquilo C0-4; R4 es hidrógeno, hidroxi, halógeno, alquilo C1-4 o haloalquilo C1-4; W es hidrógeno, cicloalquilo C3-7, alquilo C1-4, fenilo, tienilo, isoxazolilo, pirazolilo, piridinilo o pirimidinilo todos sustituidos optativamente con uno o más sustituyentes seleccionados entre halógeno, hidroxialquilo C0-3, alquilo C1-4, aIcoxi C1-4, alquiltio C0-4-alquilo C0-4, cicloalquil C3-6-tioalquilo C0-4, alquil C0-4S(O)nalquilo C0-4, haloalquilo C1-6, haloalcoxi C1-4, halo, nitro, ciano, alquiI C1-4Oalquilo C1-6, alquil C1-6OaIquiI C1-6OaIquilo C1-6, aIquil C0-6C(O)alquilo C0-6, alquil C0-4C(O)OaIquilo C0-4, alquiI C0-4OC(O)alquilo C0-4, NR5R6alquiIo C0-4, NR5R6C(O)alquilo C0-4, NR5R6C(O)Oalquilo C0-4, NR5R6OC(O)alquilo C0-4, R6C(O)R5Nalquilo C0-4, alquil C0-4OC(O)alquil C0-4NH, alquil C0-4C(O)Oalquil C0-4NH, alquil C0-4C(O)alquil C0-4NH y NR5R6S(O)nalquilo C0-4; X es CH2, O, S, S(O), S(O)2 o NH; Y es hidrógeno, halógeno, alquilo C1-6, alcoxi C1- 4, tioalquilo C1-4, haloalquilo C1-4, alcoxihalo C1-4, nitro, ciano, hidroxi, R5C(O), R5OC(O), R5C(O)O, S(O)nalquilo C1-4, R5R6NS(O)n, benciloxi, imidazolilo, alquil C1-4NHC(O), NR5R6C(O), alquil C1-4C(O)NH o NR5R6; R5 y R6 se seleccionan en forma independiente entre hidrógeno, alquilo C1-4 y cicloalquilo C3-7, o R5 y R6 forman juntos un grupo -(O)aril C5-10C(O)-; y n es 1 o 2, o una sal aceptable para uso farmacéutico del mismo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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SE0602501 | 2006-11-23 |
Publications (1)
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AR063906A1 true AR063906A1 (es) | 2009-02-25 |
Family
ID=39429960
Family Applications (1)
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ARP070105195A AR063906A1 (es) | 2006-11-23 | 2007-11-22 | Compuestos quimicos derivados del indazol, una composicion farmaceutica y procesos de prpeparacion de los compuestos |
Country Status (13)
Country | Link |
---|---|
US (1) | US8030340B2 (es) |
EP (1) | EP2097384B1 (es) |
JP (1) | JP2010510985A (es) |
CN (1) | CN101646654B (es) |
AR (1) | AR063906A1 (es) |
CA (1) | CA2677335A1 (es) |
CL (1) | CL2007003356A1 (es) |
ES (1) | ES2393009T3 (es) |
HK (1) | HK1138852A1 (es) |
PE (1) | PE20081227A1 (es) |
TW (1) | TW200829578A (es) |
UY (1) | UY30736A1 (es) |
WO (1) | WO2008063116A1 (es) |
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-
2007
- 2007-11-12 TW TW096142666A patent/TW200829578A/zh unknown
- 2007-11-21 US US11/986,555 patent/US8030340B2/en not_active Expired - Fee Related
- 2007-11-22 AR ARP070105195A patent/AR063906A1/es unknown
- 2007-11-22 EP EP07835228A patent/EP2097384B1/en not_active Not-in-force
- 2007-11-22 UY UY30736A patent/UY30736A1/es not_active Application Discontinuation
- 2007-11-22 ES ES07835228T patent/ES2393009T3/es active Active
- 2007-11-22 CN CN2007800436841A patent/CN101646654B/zh not_active Expired - Fee Related
- 2007-11-22 WO PCT/SE2007/001031 patent/WO2008063116A1/en active Application Filing
- 2007-11-22 JP JP2009538365A patent/JP2010510985A/ja not_active Ceased
- 2007-11-22 CA CA002677335A patent/CA2677335A1/en not_active Abandoned
- 2007-11-22 PE PE2007001623A patent/PE20081227A1/es not_active Application Discontinuation
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HK1138852A1 (en) | 2010-09-03 |
UY30736A1 (es) | 2008-07-03 |
CA2677335A1 (en) | 2008-05-29 |
TW200829578A (en) | 2008-07-16 |
WO2008063116A1 (en) | 2008-05-29 |
CN101646654A (zh) | 2010-02-10 |
CL2007003356A1 (es) | 2008-07-18 |
EP2097384A1 (en) | 2009-09-09 |
EP2097384B1 (en) | 2012-09-12 |
JP2010510985A (ja) | 2010-04-08 |
PE20081227A1 (es) | 2008-11-08 |
ES2393009T3 (es) | 2012-12-17 |
EP2097384A4 (en) | 2009-12-30 |
CN101646654B (zh) | 2012-03-28 |
US20080207721A1 (en) | 2008-08-28 |
US8030340B2 (en) | 2011-10-04 |
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