AR063906A1 - Compuestos quimicos derivados del indazol, una composicion farmaceutica y procesos de prpeparacion de los compuestos - Google Patents

Compuestos quimicos derivados del indazol, una composicion farmaceutica y procesos de prpeparacion de los compuestos

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Publication number
AR063906A1
AR063906A1 ARP070105195A ARP070105195A AR063906A1 AR 063906 A1 AR063906 A1 AR 063906A1 AR P070105195 A ARP070105195 A AR P070105195A AR P070105195 A ARP070105195 A AR P070105195A AR 063906 A1 AR063906 A1 AR 063906A1
Authority
AR
Argentina
Prior art keywords
alkyl
4alkyl
haloalkyl
cycloalkyl
aryl
Prior art date
Application number
ARP070105195A
Other languages
English (en)
Inventor
Taflin C
L Bergstrom
Gabos B
Rehwinkel Hartmut
Mckerrecher D
Henriksson
Nilsson S
Hemmerling M
Ivanova C
Dahmen J
M Lepistoe
Bjoern Eriksson
M Berger
Original Assignee
Bayer Schering Pharma Ag
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma Ag, Astrazeneca Ab filed Critical Bayer Schering Pharma Ag
Publication of AR063906A1 publication Critical patent/AR063906A1/es

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    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
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    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Compuestos de fórmula (1) o sales aceptables para uso farmacéutico de los mismos; composiciones que los comprenden, y procesos para preparar dichos compuestos. Estos compuestos son útiles en el tratamiento de un estado patológico inflamatorio. Reivindicación 1: Un compuesto caracterizado porque responde a la fórmula (1) en donde: A es alquilo C1-10, arilo C5-10, aril C5-10-alquiIo C1-6,heteroarilo C5-10, heteroaril C5-10-alquilo C1-6, aril C5-10-alcoxi C1-6, haloalquiIo C1-10, cicloalquilo C3-7, cicloalquil C3-7-alquilo C1-4, alquil C1-6OC(O)aIquiIo C1-6, alquil C1-6C(O)Oalquilo C1-6, ariloxi C5-10-aIquiIo C1-10 o NR5R6alquilo C0-6 en donde el arilo está sustituido optativamente con uno o más sustituyentes seleccionados entre B; R1 y R1a se seleccionan en forma independiente entre hidrógeno, alquilo C1-4, haloalquilo C1-4, hidroxialquilo C1-4 y aIquil C1-4OaIquiIo C1-4; R2 es hidrógeno o alquilo C1-4; R3 es cicloalquilo C3-7 (sustituido optativamente con halógeno o alquilo C1-6), aril C5-10-alquiIo C0-3, aril C5-10Oalquilo C0-3, heteroaril C5-10-alquilo C0-3, alquilo C1-6, alqueniIo C1-6 o alquinilo C1-6 que están sustituidos optativamente con uno o más B; B es hidroxialquilo C0-3, alquilo C1-4, alcoxi C1-4, alquiltio C0-4-alquilo C0-4, cicloalquil C3-6-tioalquilo C0-4, alquil C0-3S(O)nalquilo C0-4, haloalquilo C1-6, haloalcoxi C1-4, halógeno, nitro, ciano, alquiI C1-4Oalquilo C1-6, alquil C0-6OaIquiI C1-4OaIquilo C0-4, aIquil C0-6C(O)alquilo C0-6, alquil C0-4C(O)OaIquilo C0-4, alquiI C0-4OC(O)alquilo C0-4, NR5R6alquiIo C0-4, NR5R6C(O)alquilo C0-4, NR5R6OC(O)alquilo C0-4, NR5R6C(O)Oalquilo C0-4, R6C(O)R5Nalquilo C0-4, alquil C0-4OC(O)alquil C0-4NH, alquil C0-4C(O)Oalquil C0-4NH, alquil C0- 4C(O)alquil C0-4NH o NR5R6S(O)nalquilo C0-4; R4 es hidrógeno, hidroxi, halógeno, alquilo C1-4 o haloalquilo C1-4; W es hidrógeno, cicloalquilo C3-7, alquilo C1-4, fenilo, tienilo, isoxazolilo, pirazolilo, piridinilo o pirimidinilo todos sustituidos optativamente con uno o más sustituyentes seleccionados entre halógeno, hidroxialquilo C0-3, alquilo C1-4, aIcoxi C1-4, alquiltio C0-4-alquilo C0-4, cicloalquil C3-6-tioalquilo C0-4, alquil C0-4S(O)nalquilo C0-4, haloalquilo C1-6, haloalcoxi C1-4, halo, nitro, ciano, alquiI C1-4Oalquilo C1-6, alquil C1-6OaIquiI C1-6OaIquilo C1-6, aIquil C0-6C(O)alquilo C0-6, alquil C0-4C(O)OaIquilo C0-4, alquiI C0-4OC(O)alquilo C0-4, NR5R6alquiIo C0-4, NR5R6C(O)alquilo C0-4, NR5R6C(O)Oalquilo C0-4, NR5R6OC(O)alquilo C0-4, R6C(O)R5Nalquilo C0-4, alquil C0-4OC(O)alquil C0-4NH, alquil C0-4C(O)Oalquil C0-4NH, alquil C0-4C(O)alquil C0-4NH y NR5R6S(O)nalquilo C0-4; X es CH2, O, S, S(O), S(O)2 o NH; Y es hidrógeno, halógeno, alquilo C1-6, alcoxi C1- 4, tioalquilo C1-4, haloalquilo C1-4, alcoxihalo C1-4, nitro, ciano, hidroxi, R5C(O), R5OC(O), R5C(O)O, S(O)nalquilo C1-4, R5R6NS(O)n, benciloxi, imidazolilo, alquil C1-4NHC(O), NR5R6C(O), alquil C1-4C(O)NH o NR5R6; R5 y R6 se seleccionan en forma independiente entre hidrógeno, alquilo C1-4 y cicloalquilo C3-7, o R5 y R6 forman juntos un grupo -(O)aril C5-10C(O)-; y n es 1 o 2, o una sal aceptable para uso farmacéutico del mismo.
ARP070105195A 2006-11-23 2007-11-22 Compuestos quimicos derivados del indazol, una composicion farmaceutica y procesos de prpeparacion de los compuestos AR063906A1 (es)

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Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200829578A (en) 2006-11-23 2008-07-16 Astrazeneca Ab Chemical compounds 537
JO2754B1 (en) * 2006-12-21 2014-03-15 استرازينكا ايه بي Amylendazoleil derivatives for the treatment of glucocorticoid-mediated disorders
IL187245A0 (en) * 2007-11-08 2008-12-29 Hadasit Med Res Service Synthetic sphingolipid analogs
TWI445705B (zh) * 2008-05-20 2014-07-21 Astrazeneca Ab 經苯基及苯并二基取代之吲唑衍生物
WO2009142568A1 (en) * 2008-05-20 2009-11-26 Astrazeneca Ab Combination of (a) glucocorticoid receptor modulator and (b) a b2-agonist
WO2009142589A1 (en) * 2008-05-20 2009-11-26 Astrazeneca Ab Combination of (a) glucocorticoid receptor modulator and (b) a muscarinic antagonist
WO2010008341A1 (en) * 2008-07-16 2010-01-21 Astrazeneca Ab A combination of (a) glucocorticoid receptor modulator and (b) a muscarinic antagonist
US7879873B2 (en) * 2008-09-26 2011-02-01 Boehringer Ingelheim International Gmbh Azaindazole compounds as CCR1 receptor antagonists
WO2011061527A1 (en) * 2009-11-17 2011-05-26 Astrazeneca Ab Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases
US9223209B2 (en) * 2010-02-19 2015-12-29 International Business Machines Corporation Sulfonamide-containing photoresist compositions and methods of use
US9223217B2 (en) * 2010-02-19 2015-12-29 International Business Machines Corporation Sulfonamide-containing topcoat and photoresist additive compositions and methods of use
SG187909A1 (en) * 2010-08-27 2013-03-28 Corcept Therapeutics Inc Pyridyl-amine fused azadecalin modulators
WO2017161518A1 (en) * 2016-03-23 2017-09-28 Astrazeneca Ab New physical form
EP3728219B1 (en) * 2017-12-18 2022-04-13 Grünenthal GmbH Substituted pyrrolidine amides i
TW201927769A (zh) * 2017-12-18 2019-07-16 德商歌林達有限公司 經取代之吡咯啶醯胺ｉｉ

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3992441A (en) * 1972-12-26 1976-11-16 Pfizer Inc. Sulfamylbenzoic acids
DE3000377A1 (de) 1980-01-07 1981-07-09 Boehringer Mannheim Gmbh, 6800 Mannheim Neue sulfonamide, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
DE3514696A1 (de) 1985-04-24 1986-11-06 Bayer Ag, 5090 Leverkusen N-indolylethyl-sulfonsaeureamide, verfahren zu ihrer herstellung und ihre verwendung
DE3535167A1 (de) 1985-10-02 1987-04-09 Boehringer Mannheim Gmbh Neue sulfonyl-phenyl(alkyl)amine, verfahren zu ihrer herstellung sowie arzneimittel
DE3632329A1 (de) 1986-09-24 1988-03-31 Bayer Ag Substituierte phenylsulfonamide
TW224462B (es) 1992-02-24 1994-06-01 Squibb & Sons Inc
NZ247440A (en) 1992-05-06 1995-04-27 Squibb & Sons Inc Phenyl sulphonamide derivatives, preparation and pharmaceutical compositions thereof
CA2114981A1 (en) 1993-02-09 1994-08-10 Kazumi Ogata Quinolonecarboxylic acid derivatives
DE4323916A1 (de) 1993-07-16 1995-01-19 Basf Ag Substituierte 2-Phenylpyridine
ATE225334T1 (de) 1993-07-26 2002-10-15 Eisai Co Ltd Sulfonamide und sulfonsäure-ester mit je einem trizyclischen heteroring
GB9504854D0 (en) 1994-03-31 1995-04-26 Zeneca Ltd Nitrogen derivatives
US5545669A (en) 1994-06-02 1996-08-13 Adams; Jerry L. Anti-inflammatory compounds
GB9417532D0 (en) 1994-08-31 1994-10-19 Zeneca Ltd Aromatic compounds
AU5772296A (en) 1995-05-19 1996-11-29 Chiroscience Limited 3,4-disubstituted-phenylsulphonamides and their therapeutic use
TW523506B (en) 1996-12-18 2003-03-11 Ono Pharmaceutical Co Sulfonamide or carbamide derivatives and drugs containing the same as active ingredients
TW542822B (en) 1997-01-17 2003-07-21 Ajinomoto Kk Benzamidine derivatives
ZA9811898B (en) 1997-12-29 2000-06-28 Ortho Mcneil Pharm Inc Anti-Inflammatory Compounds.
JP4253126B2 (ja) 1998-01-29 2009-04-08 アムジェン インコーポレイテッド Ｐｐａｒ−ガンマ調節剤
DE19856475A1 (de) 1998-11-27 2000-05-31 Schering Ag Nichtsteroidale Entzündungshemmer
KR20020002501A (ko) 1999-05-13 2002-01-09 시오노 요시히코 당뇨병의 예방 또는 치료약
US6569885B1 (en) 1999-12-23 2003-05-27 Icos Corporation Cyclic AMP-specific phosphodiesterase inhibitors
EP1317425B1 (en) 2000-09-11 2004-11-03 Pfizer Products Inc. Resorcinol derivatives
FR2815030A1 (fr) 2000-10-05 2002-04-12 Lipha Derives nitroso de la diphenylamine, compositions pharmaceutiques les contenant et leur utilisation pour la preparation de medicaments
EP1432693A2 (en) 2001-10-01 2004-06-30 Taisho Pharmaceutical Co. Ltd. Mch receptor antagonists
BR0214345A (pt) 2001-11-22 2004-09-14 Ono Pharmaceutical Co Compostos derivados de piperidin-2-ona e composições farmacêuticas contendo estes compostos como ingrediente ativo
PL214279B1 (pl) 2002-03-13 2013-07-31 Janssen Pharmaceutica Nv Pochodna sulfonyloaminowa, sposób jej wytwarzania i zastosowanie oraz kompozycja farmaceutyczna i sposób jej wytwarzania
AU2003221706B2 (en) 2002-04-11 2008-02-28 Merck Sharp & Dohme Corp. 1H-Benzo[F]indazol-5-YL derivatives as selective glucocorticoid receptor modulators
AU2003248549B2 (en) 2002-05-24 2010-04-08 Millennium Pharmaceuticals, Inc. CCR9 inhibitors and methods of use thereof
US20050113450A1 (en) 2002-08-23 2005-05-26 Atli Thorarensen Antibacterial agents
CN1678306A (zh) * 2002-08-29 2005-10-05 贝林格尔·英格海姆药物公司 在炎性、变应性和增生性疾病中用作糖皮质激素模拟物的3－(磺酰氨基乙基)－吲哚衍生物
US6894061B2 (en) 2002-12-04 2005-05-17 Wyeth Substituted dihydrophenanthridinesulfonamides
JP5008025B2 (ja) 2003-02-20 2012-08-22 エンサイシブ・ファーマシューティカルズ・インコーポレイテッド フェニレンジアミンウロテンシン−ｉｉ受容体拮抗薬およびｃｃｒ−９拮抗薬
GB0308466D0 (en) 2003-04-11 2003-05-21 Novartis Ag Organic compounds
US7297709B2 (en) * 2003-05-22 2007-11-20 Abbott Laboratories Indazole, benzisoxazole, and benzisothiazole kinase inhibitors
US20040235892A1 (en) * 2003-05-22 2004-11-25 Yujia Dai Indazole and benzisoxazole kinase inhibitors
WO2004110418A2 (en) 2003-06-10 2004-12-23 Kalypsys, Inc. Carbonyl compounds as inhibitors of histone deacetylase for the treatment of disease
US7393873B2 (en) 2003-07-02 2008-07-01 Merck & Co., Inc. Arylsulfonamide derivatives
CA2549651A1 (en) 2003-12-19 2005-07-07 Pfizer Inc. Benzenesulfonylamino-pyridin-2-yl derivatives and related compounds as inhibitors of 11-beta-hydroxysteroid dehydrogenase type 1 (11-beta-hsd-1) for the treatment of diabetes and obesity
JP2005263787A (ja) 2004-02-17 2005-09-29 Ishihara Sangyo Kaisha Ltd アミド系化合物又はその塩、並びにそれらを含有するサイトカイン産生抑制剤
WO2005082414A2 (en) * 2004-03-02 2005-09-09 Astellas Pharma Inc. Concomitant drugs of a sulfonamide and another therapeutic agent
US20050250820A1 (en) 2004-03-08 2005-11-10 Amgen Inc. Therapeutic modulation of PPARgamma activity
DE102004028862A1 (de) 2004-06-15 2005-12-29 Merck Patent Gmbh 3-Aminoindazole
RS20070076A (en) 2004-10-29 2008-09-29 Astrazeneca Ab., Novel sulphonamide derivatives as glucocorticoid receptor modulators for the treatment of inflammatory diseases
SE0402635D0 (sv) 2004-10-29 2004-10-29 Astrazeneca Ab Chemical compounds
NZ564696A (en) 2005-06-10 2011-05-27 Boehringer Ingelheim Int Glucocorticoid, indazole, mimetics, methods of making them, pharmaceutical compositions, and uses thereof
US7888381B2 (en) 2005-06-14 2011-02-15 Bristol-Myers Squibb Company Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity, and use thereof
TW200815361A (en) 2005-10-20 2008-04-01 Astrazeneca Ab Chemical compounds
GB0522880D0 (en) 2005-11-09 2005-12-21 Glaxo Group Ltd Novel compounds
WO2007114763A1 (en) 2006-03-31 2007-10-11 Astrazeneca Ab Sulphonamide derivates as modulators of the glucocorticoid receptor
TW200811111A (en) * 2006-04-20 2008-03-01 Glaxo Group Ltd Novel compounds
AU2007272504B2 (en) 2006-07-14 2012-06-28 Eli Lilly And Company Glucocorticoid receptor modulator and methods of use
GB0620406D0 (en) 2006-10-13 2006-11-22 Glaxo Group Ltd Novel compounds
GB0620385D0 (en) 2006-10-13 2006-11-22 Glaxo Group Ltd Novel compounds
EA200970401A1 (ru) 2006-10-23 2009-10-30 Мерк Энд Ко., Инк. 2-[1-ФЕНИЛ-5-ГИДРОКСИ ИЛИ МЕТОКСИ-4-АЛЬФА-МЕТИЛГЕКСАГИДРОЦИКЛОПЕНТА[f]ИНДАЗОЛ-5-ИЛ] ЭТИЛФЕНИЛЬНЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ЛИГАНДОВ ГЛЮКОКОРТИКОИДНОГО РЕЦЕПТОРА
CN101573340A (zh) 2006-11-01 2009-11-04 百时美施贵宝公司 糖皮质激素受体AP-1和/或NF-κB活性的调节剂及其用途
US8067447B2 (en) 2006-11-01 2011-11-29 Bristol-Myers Squibb Company Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
TW200829578A (en) 2006-11-23 2008-07-16 Astrazeneca Ab Chemical compounds 537
JP2010512331A (ja) 2006-12-06 2010-04-22 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング グルココルチコイド模倣薬、それらの製造方法、医薬組成物、及びこれらの使用
JO2754B1 (en) 2006-12-21 2014-03-15 استرازينكا ايه بي Amylendazoleil derivatives for the treatment of glucocorticoid-mediated disorders
WO2008079073A1 (en) 2006-12-22 2008-07-03 Astrazeneca Ab Indazolyl sulphonamide derivatives for the treatment of glucocorticoid receptor mediated disorders
EP2136811A1 (en) 2007-04-10 2009-12-30 Boehringer Ingelheim International GmbH Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
CA2683647A1 (en) 2007-04-10 2008-10-16 Boehringer Ingelheim International Gmbh Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
GB0708858D0 (en) 2007-05-08 2007-06-13 Glaxo Group Ltd Novel compounds
GB0720556D0 (en) 2007-10-19 2007-11-28 Glaxo Group Ltd Novel compounds
GB0720546D0 (en) 2007-10-19 2007-11-28 Glaxo Group Ltd Novel compounds
GB0720557D0 (en) 2007-10-19 2007-11-28 Glaxo Group Ltd Novel compounds
GB0720549D0 (en) 2007-10-19 2007-11-28 Glaxo Group Ltd Novel compounds
GB0720544D0 (en) 2007-10-19 2007-11-28 Glaxo Group Ltd Novel compounds
GB0722211D0 (en) 2007-11-12 2007-12-27 Glaxo Group Ltd Novel compounds
GB0724254D0 (en) 2007-12-12 2008-01-23 Glaxo Group Ltd Novel compounds
EP2268630A4 (en) 2008-02-26 2011-03-09 Merck Sharp & Dohme HEXAHYDROCYCLOPENTYLÝF¨INDAZOLE CARBOXAMIDES AND THEIR DERIVATIVES AS SELECTIVE MODULATORS OF THE GLUCOCORTICOID RECEPTOR
JP2011513409A (ja) 2008-03-06 2011-04-28 メルク・シャープ・エンド・ドーム・コーポレイション 選択的グルココルチコイドレセプターモジュレーターとしてのヘキサヒドロシクロペンチル［ｆ］インダゾールスルホンアミドおよびこれらの誘導体

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