CL2020001338A1 - Compuestos de heteroarilo sustituidos con alquilamida de piridinsulfona. - Google Patents

Compuestos de heteroarilo sustituidos con alquilamida de piridinsulfona.

Info

Publication number
CL2020001338A1
CL2020001338A1 CL2020001338A CL2020001338A CL2020001338A1 CL 2020001338 A1 CL2020001338 A1 CL 2020001338A1 CL 2020001338 A CL2020001338 A CL 2020001338A CL 2020001338 A CL2020001338 A CL 2020001338A CL 2020001338 A1 CL2020001338 A1 CL 2020001338A1
Authority
CL
Chile
Prior art keywords
pyridinesulfone
alkylamide
compounds substituted
heteroaryl compounds
heteroaryl
Prior art date
Application number
CL2020001338A
Other languages
English (en)
Inventor
Chunjian Liu
Michael G Yang
Zili Xiao
Ling Chen
Ryan M Moslin
John S Tokarski
David S Weinstein
Stephen T Wrobleski
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of CL2020001338A1 publication Critical patent/CL2020001338A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Compuestos que tienen la siguiente Fórmula I, o un estereoisómero o una sal de aquellos aceptable desde el punto de vista farmacéutico, en donde R1, R2, R3, R4 y R5 son como se definen en la presente, son útiles para la modulación de IL-12, IL-23 y/o IFNa que actúan en Tyk-2 para generar la inhibición de la transducción de señal.
CL2020001338A 2017-11-21 2020-05-20 Compuestos de heteroarilo sustituidos con alquilamida de piridinsulfona. CL2020001338A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762589165P 2017-11-21 2017-11-21

Publications (1)

Publication Number Publication Date
CL2020001338A1 true CL2020001338A1 (es) 2020-09-25

Family

ID=65036887

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2020001338A CL2020001338A1 (es) 2017-11-21 2020-05-20 Compuestos de heteroarilo sustituidos con alquilamida de piridinsulfona.

Country Status (19)

Country Link
US (3) US11021462B2 (es)
EP (1) EP3713930A1 (es)
JP (2) JP7258903B2 (es)
KR (1) KR102702228B1 (es)
CN (1) CN111315737B (es)
AR (1) AR113895A1 (es)
AU (3) AU2018371010C1 (es)
BR (1) BR112020009606A2 (es)
CA (1) CA3083122A1 (es)
CL (1) CL2020001338A1 (es)
CO (1) CO2020006139A2 (es)
EA (1) EA202091269A1 (es)
IL (1) IL274816B2 (es)
MX (1) MX2020005210A (es)
PE (1) PE20211461A1 (es)
SG (1) SG11202004592TA (es)
TW (1) TWI776994B (es)
WO (1) WO2019103952A1 (es)
ZA (1) ZA202003717B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20211461A1 (es) * 2017-11-21 2021-08-05 Bristol Myers Squibb Co Compuestos de heteroarilo sustituidos con alquilamida de piridinsulfona
CN111484480B (zh) * 2019-01-29 2023-08-11 上海翰森生物医药科技有限公司 一种多环类衍生物抑制剂、其制备方法和应用
CN114728949A (zh) * 2019-08-01 2022-07-08 整体生物科学私人有限公司 作为激酶抑制剂的杂环化合物及其用途
US20240140929A1 (en) * 2020-12-22 2024-05-02 InventisBio Co., Ltd. Heteroaryl compounds, preparation methods and uses thereof
MX2023009682A (es) 2021-02-19 2023-10-30 Sudo Biosciences Ltd Inhibidores de tyk2 y sus usos.
WO2022175752A1 (en) 2021-02-19 2022-08-25 Sudo Biosciences Limited Tyk2 inhibitors and uses thereof
CN117177960A (zh) * 2021-03-30 2023-12-05 浙江文达医药科技有限公司 作为tyk2假激酶结构域抑制剂的杂环化合物及合成方法和用途
EP4337650A1 (en) * 2021-05-14 2024-03-20 Bristol-Myers Squibb Company Substituted heterocyclic compounds
CN116693449A (zh) 2022-03-04 2023-09-05 上海致根医药科技有限公司 用作tyk2抑制剂的化合物、其制备方法及其在医药上的应用
WO2024125651A1 (zh) * 2022-12-16 2024-06-20 津药生物科技（天津）有限公司 新型含杂环取代的丙烯酸衍生物及其用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2860547A1 (en) 2012-01-10 2013-07-18 Johannes Cornelius Hermann Pyridazine amide compounds and their use as syk inhibitors
EP2909174A1 (en) 2012-10-19 2015-08-26 F. Hoffmann-La Roche AG Inhibitors of syk
MA38072A1 (fr) * 2012-11-08 2016-07-29 Bristol Myers Squibb Co Composés hétérocycliques substitués par amide, utiles comme modulateurs d'il-12, il-23 et/ou de réponses à l'ifn?
AU2013341185B2 (en) * 2012-11-08 2017-07-13 Bristol-Myers Squibb Company Alkyl-amide-substituted pyridyl compounds useful as modulators of IL-12, IL-23 and/or IFNalpha responses
TWI582077B (zh) 2013-11-07 2017-05-11 必治妥美雅史谷比公司 作爲ＩＬ－１２、ＩＬ－２３及／或ＩＦＮα反應調節劑之經烷基－醯胺取代之吡啶化合物
CN105960404B (zh) 2013-12-05 2019-09-03 药品循环有限责任公司 布鲁顿氏酪氨酸激酶的抑制剂
WO2018111787A1 (en) 2016-12-13 2018-06-21 Bristol-Myers Squibb Company Phosphine oxide alkyl amide substituted heteroaryl compounds as modulators of il-12, il-23, and/or ifn alpha responses
PE20211461A1 (es) * 2017-11-21 2021-08-05 Bristol Myers Squibb Co Compuestos de heteroarilo sustituidos con alquilamida de piridinsulfona

Also Published As

Publication number Publication date
JP2021504443A (ja) 2021-02-15
IL274816B2 (en) 2023-12-01
CN111315737A (zh) 2020-06-19
IL274816B1 (en) 2023-08-01
US11787779B2 (en) 2023-10-17
WO2019103952A1 (en) 2019-05-31
CA3083122A1 (en) 2019-05-31
TWI776994B (zh) 2022-09-11
US11021462B2 (en) 2021-06-01
KR20200089706A (ko) 2020-07-27
JP2023098942A (ja) 2023-07-11
CO2020006139A2 (es) 2020-05-29
JP7258903B2 (ja) 2023-04-17
AU2018371010A1 (en) 2020-07-02
IL274816A (en) 2020-07-30
BR112020009606A2 (pt) 2020-11-03
EP3713930A1 (en) 2020-09-30
SG11202004592TA (en) 2020-06-29
US20190152948A1 (en) 2019-05-23
US20210253554A1 (en) 2021-08-19
TW201925187A (zh) 2019-07-01
AR113895A1 (es) 2020-06-24
CN111315737B (zh) 2024-06-18
PE20211461A1 (es) 2021-08-05
MX2020005210A (es) 2020-08-20
EA202091269A1 (ru) 2020-08-07
ZA202003717B (en) 2022-01-26
KR102702228B1 (ko) 2024-09-02
AU2018371010B2 (en) 2022-06-09
JP7490107B2 (ja) 2024-05-24
AU2022228101B2 (en) 2023-08-03
US20240002364A1 (en) 2024-01-04
AU2023255024A1 (en) 2023-11-16
AU2022228101A1 (en) 2022-09-29
AU2018371010C1 (en) 2024-09-26

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