BRPI0907122B8 - compostos de piridoindóis (1-azinona) substituídos, composição farmacêutica compreendendo os referidos compostos, e usos dos mesmos - Google Patents

compostos de piridoindóis (1-azinona) substituídos, composição farmacêutica compreendendo os referidos compostos, e usos dos mesmos

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Publication number
BRPI0907122B8
BRPI0907122B8 BRPI0907122A BRPI0907122A BRPI0907122B8 BR PI0907122 B8 BRPI0907122 B8 BR PI0907122B8 BR PI0907122 A BRPI0907122 A BR PI0907122A BR PI0907122 A BRPI0907122 A BR PI0907122A BR PI0907122 B8 BRPI0907122 B8 BR PI0907122B8
Authority
BR
Brazil
Prior art keywords
compounds
optionally substituted
alkyl
azinone
pharmaceutical composition
Prior art date
Application number
BRPI0907122A
Other languages
English (en)
Inventor
John Henderson Alan
Grabowski James
Hadden Mark
David Surman Matthew
Xiaowu Jiang May
Guzzo Peter
Original Assignee
Albany Molecular Res Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Albany Molecular Res Inc filed Critical Albany Molecular Res Inc
Publication of BRPI0907122A2 publication Critical patent/BRPI0907122A2/pt
Publication of BRPI0907122B1 publication Critical patent/BRPI0907122B1/pt
Publication of BRPI0907122B8 publication Critical patent/BRPI0907122B8/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D521/00—Heterocyclic compounds containing unspecified hetero rings

Abstract

compostos de piridoindóis (1-azinona) substituídos, composição farmacêutica compreendendo os referidos compostos, e usos dos mesmos. a presente invenção refere-se à piridoindóis substituídos para a incorporação em composições farmacêuticas empregadas no tratamento de várias doenças correspondem à fórmula (i) caracterizado pelo fato de que r1 é h ou alquila opcionalmente substituída; r2 , r3 , r4 são cada independentemente selecionados de h, -0-alquila, -s-alquila, alquila, halo, -cf3, e -cn; g é -cr12r13-nr5 - ou -nr5-cr12r13; r5 é h, alquila opcionalmente substituída, heterociclo opcionalmente substituído, -c(=o)-r6 , -c(=0)-0-r7 , ou -c(=o)-nr19r20 ; r6 e r7 são cada alquila opcionalmente substituída ou heterociclo opcionalmente substituído; r8 , r9 , r10 , r11 , r12 , r13 , r19 e r20 são cada independentemente selecionados de h ou alquila opcionalmente substituída; r14 e r15 são cada independentemente h ou halogênio; l é -ch2-0-, -ch2ch2-, ch=ch- ou uma ligação; e 8 é arila ou heteroarila ou cicloalquila; com a condição de que, quando l for uma ligação direta, 8 não pode ser heteroarila não substituída ou heteroarila monossubstituída por flúor.
BRPI0907122A 2008-01-11 2009-01-09 compostos de piridoindóis (1-azinona) substituídos, composição farmacêutica compreendendo os referidos compostos, e usos dos mesmos BRPI0907122B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US2053008P 2008-01-11 2008-01-11
US61/020,530 2008-01-11
US4867708P 2008-04-29 2008-04-29
US61/048,677 2008-04-29
PCT/US2009/030646 WO2009089482A1 (en) 2008-01-11 2009-01-09 (1-azinone) -substituted pyridoindoles as mch antagonists

Publications (3)

Publication Number Publication Date
BRPI0907122A2 BRPI0907122A2 (pt) 2015-07-14
BRPI0907122B1 BRPI0907122B1 (pt) 2019-04-16
BRPI0907122B8 true BRPI0907122B8 (pt) 2021-05-25

Family

ID=40429805

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0907122A BRPI0907122B8 (pt) 2008-01-11 2009-01-09 compostos de piridoindóis (1-azinona) substituídos, composição farmacêutica compreendendo os referidos compostos, e usos dos mesmos

Country Status (13)

Country Link
US (4) US8716308B2 (pt)
EP (2) EP2240481A1 (pt)
JP (2) JP5501251B2 (pt)
KR (1) KR101614723B1 (pt)
CN (1) CN101945872B (pt)
AU (1) AU2009204048B2 (pt)
BR (1) BRPI0907122B8 (pt)
CA (1) CA2727055C (pt)
ES (1) ES2523580T3 (pt)
IL (1) IL206594A (pt)
MX (1) MX2010007430A (pt)
NZ (1) NZ586120A (pt)
WO (1) WO2009089482A1 (pt)

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HU230880B1 (hu) 2015-04-15 2018-11-29 Richter Gedeon Nyrt Indol származékok
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WO2020186027A1 (en) * 2019-03-13 2020-09-17 Daisuke Tomita Inhibitors of cgas for treating autoinflammatory diseases and cancer metastasis
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