CO6321236A2 - Derivados indolicos 2,3 sustituidos y metodos de uso de los mismos - Google Patents

Derivados indolicos 2,3 sustituidos y metodos de uso de los mismos

Info

Publication number
CO6321236A2
CO6321236A2 CO10035485A CO10035485A CO6321236A2 CO 6321236 A2 CO6321236 A2 CO 6321236A2 CO 10035485 A CO10035485 A CO 10035485A CO 10035485 A CO10035485 A CO 10035485A CO 6321236 A2 CO6321236 A2 CO 6321236A2
Authority
CO
Colombia
Prior art keywords
alkyl
substitutes
methods
same
so2n
Prior art date
Application number
CO10035485A
Other languages
English (en)
Inventor
Gopinadhan Anilkumar
Frank Bennett
Boris Feld
Yuhua Huang
Weiying Yang
Wanli Wu
Bancha Vibulbhan
Oleg B Selyutin
Haiyan Pu
Patrick A Pinto
Yueheng Jiang
Stephen J Gavalas
Neng-Yang Shih
Stuart Rosenblum
George Njoroge
Joseph A Kozlowski
Charles A Lesburg
Jose S Duca
Qingbei Zeng
Srikanth Venkatraman
Francisco Velasquez
Mousumi Sannigrahi
Kevin X Chen
Tin-Yau Chan
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of CO6321236A2 publication Critical patent/CO6321236A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

1.- Un compuesto que tiene la fórmula:o una de sus sales, solvatos, ésteres o prodrogas aceptables desde el punto de vista farmacéutico,en los cuales:R1 es un enlace, -[C(R12)2]r, -[C(R12)2]r-O-[C(R12)2]q-[C(R12)2]q-CH=CH-[C(R12)2]q-, -[C(R12)2]q-C=C-[C(R12)2]q-, o -[C(R12)2]q-SO2-[C(R12)2]q-, R2 es -[C(R12)2]q-C(O)N(R9)SOR11, -[C(R12)2]q-C(O)N(R9)SO2R11, -[C(R12)2]q-C(O)N(R9)SO2N(R9)2,R3 es: R4, R5, R6 y R7 son cada uno, en forma independiente, H, alquilo, alquenilo, alquinilo, arilo, -[C(R12)2]q-cicloalquilo, -[C(R12)2]q-cicloalquenilo, -[C(R12)2]q-heterocicloalquilo, -[C(R12)2]q-heterocicloalquenilo, -[C(R12)2]q-heteroarilo, -[C(R12)2]q-haloalquilo, -[C(R12)2]q-hidroxialquilo, halo, -OH, -OR9, -CN, -[C(R12)2]q--C(O)R8, -[C(R12)2]q-C(O)OR9, -[C(R12)2]q-C(O)N(R9)2, -[C(R12)2]q-OR9, -[C(R12)2]q-N(R9)2, -[C(R12)2]q-NHC(O)R8, -[C(R12)2]q-NR8C(O)N(R9)2, -[C(R12)2]q-NHSO2R11, -[C(R12)2]q-S(O)pR11, -[C(R12)2]q-SO2N(R9)2 o -SO2N(R9)C(O)N(R9)2;cada vez que ocurre R8 es en forma independiente H, alquilo, alquenilo, alquinilo, -[C(R12)2]q-arilo, -[C(R12)2]q-cicloalquilo, -[C(R12)2]q-cicloalquenilo,-[C(R12)2]q-heterocicloalquilo, -[C(R12)2]q-heterocicloalquenilo, -[C(R12)2]q-heteroarilo, haloalquilo o hidroxialquilo;cada vez que ocurre R9 es en forma independiente H, alquilo, alquenilo, alquinilo, -[C(R12)2]q-O-alquilo, -[C(R12)2]q-N(alquil)2, -[C(R12)2]q-arilo, -[C(R12)2]q-cicloalquilo, -[C(R12)2]q-cicloalquenilo, -[C(R12)2]q-heterocicloalquilo, -[C(R12)2]q-heterocicloalquenilo, ...
CO10035485A 2007-08-29 2010-03-25 Derivados indolicos 2,3 sustituidos y metodos de uso de los mismos CO6321236A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US96874507P 2007-08-29 2007-08-29

Publications (1)

Publication Number Publication Date
CO6321236A2 true CO6321236A2 (es) 2011-09-20

Family

ID=40220015

Family Applications (1)

Application Number Title Priority Date Filing Date
CO10035485A CO6321236A2 (es) 2007-08-29 2010-03-25 Derivados indolicos 2,3 sustituidos y metodos de uso de los mismos

Country Status (18)

Country Link
US (1) US8143305B2 (es)
EP (1) EP2197842B1 (es)
JP (1) JP5272007B2 (es)
KR (1) KR20100049667A (es)
CN (1) CN101842353A (es)
AR (1) AR068107A1 (es)
AU (1) AU2008295476B2 (es)
BR (1) BRPI0816116A2 (es)
CA (1) CA2697375A1 (es)
CL (1) CL2008002538A1 (es)
CO (1) CO6321236A2 (es)
EC (1) ECSP10010002A (es)
MX (1) MX2010002319A (es)
PE (1) PE20090995A1 (es)
RU (1) RU2010111550A (es)
TW (1) TW200924751A (es)
WO (1) WO2009032116A1 (es)
ZA (1) ZA201001335B (es)

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TW200924751A (en) 2009-06-16
US8143305B2 (en) 2012-03-27
AR068107A1 (es) 2009-11-04
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US20110033417A1 (en) 2011-02-10
EP2197842A1 (en) 2010-06-23
RU2010111550A (ru) 2011-10-10
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EP2197842B1 (en) 2012-05-23
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CL2008002538A1 (es) 2009-07-17
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