AR053149A1 - Uso de compuestos de diosmetina para la obtencion de composiciones farmaceuticas destinadas a la prevencion y/o tratamiento de patologias tromboticas y patologias que conlleven el riesgo de producir trombosis - Google Patents
Uso de compuestos de diosmetina para la obtencion de composiciones farmaceuticas destinadas a la prevencion y/o tratamiento de patologias tromboticas y patologias que conlleven el riesgo de producir trombosisInfo
- Publication number
- AR053149A1 AR053149A1 ARP060100756A ARP060100756A AR053149A1 AR 053149 A1 AR053149 A1 AR 053149A1 AR P060100756 A ARP060100756 A AR P060100756A AR P060100756 A ARP060100756 A AR P060100756A AR 053149 A1 AR053149 A1 AR 053149A1
- Authority
- AR
- Argentina
- Prior art keywords
- radical
- hydrogen atom
- pathologies
- propyl
- allyl
- Prior art date
Links
- MBNGWHIJMBWFHU-UHFFFAOYSA-N diosmetin Chemical class C1=C(O)C(OC)=CC=C1C1=CC(=O)C2=C(O)C=C(O)C=C2O1 MBNGWHIJMBWFHU-UHFFFAOYSA-N 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 230000002265 prevention Effects 0.000 title abstract 3
- 230000001732 thrombotic effect Effects 0.000 title abstract 3
- 208000007536 Thrombosis Diseases 0.000 title abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 10
- -1 2,3-dihydroxypropyl Chemical group 0.000 abstract 8
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 6
- 150000003254 radicals Chemical group 0.000 abstract 4
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 3
- RMRFFCXPLWYOOY-UHFFFAOYSA-N allyl radical Chemical group [CH2]C=C RMRFFCXPLWYOOY-UHFFFAOYSA-N 0.000 abstract 3
- 230000007170 pathology Effects 0.000 abstract 3
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
- C07D311/32—2,3-Dihydro derivatives, e.g. flavanones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Abstract
Uso de compuestos de diosmetina para la obtencion de composiciones farmacéuticas destinadas a la prevencion y/o tratamiento de patologías tromboticas y patologías que conlleven el riesgo de producir trombosis Reivindicacion 1:Utilizacion de compuestos de diosmetina de formula (1) caracterizado porque: R1 representa un átomo de hidrogeno o un radical propilo o alilo; R2 representa un átomo de hidrogeno o un radical propilo, alilo, 2,3-dihidroxipropilo, (2,2-dimetil-1,3-dioxol-4- il)metilo o 3-acetiloxi-2-hidroxipropilo; R3 representa un átomo de hidrogeno o un radical propilo o alilo; R4 representa un átomo de hidrogeno o un radical, metilo, propilo, alilo, 2,3-dihidroxipropilo o (2,2-dimetil-1,3-dioxol-4-il)metilo o un radical de formula -COR'4 donde R'4 representa un radical alquilo (C1-C5) lineal o ramificado o un radical fenilo: -R5 representa un átomo de hidrogeno o un radical propilo o alilo; y R6 representa un átomo de hidrogeno o un radical metilo, propilo, alilo, 2,3-dihidroxipropil o (2,2-dimetil-1,3-dioxol-4-il)metilo, un radical de formula -COR'6 (donde R6 representa un radical alquilo (C1-C5( lineal o ramificado o un radical fenilo) o un radical de formula (I'): proveyéndose que; al menos uno de los grupos R1, R2, R3, R4, R5 y R6 no es un átomo de hidrogeno, y si cada uno de R1, R2 y R3 representa simultáneamente un átomo de hidrogeno, R4 representa también un átomo de hidrogeno, R4 representa también un átomo de hidrogeno, sus diastereoisomeros y enantiomeros, y asimismo sus sales de adicion con un ácido o base farmacéuticamente aceptable en la obtencion de composiciones farmacéuticas destinadas a la prevencion y/o tratamiento de patologías tromboticas.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0502044A FR2882654B1 (fr) | 2005-03-01 | 2005-03-01 | Utilisation de derives de la diosmetine pour le traitement et la prevention des pathologies thrombotiques |
Publications (1)
Publication Number | Publication Date |
---|---|
AR053149A1 true AR053149A1 (es) | 2007-04-25 |
Family
ID=35134198
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP060100756A AR053149A1 (es) | 2005-03-01 | 2006-03-01 | Uso de compuestos de diosmetina para la obtencion de composiciones farmaceuticas destinadas a la prevencion y/o tratamiento de patologias tromboticas y patologias que conlleven el riesgo de producir trombosis |
Country Status (18)
Country | Link |
---|---|
US (1) | US20080176934A1 (es) |
EP (1) | EP1853253A1 (es) |
JP (1) | JP2008531660A (es) |
KR (2) | KR100971589B1 (es) |
CN (1) | CN101132788A (es) |
AR (1) | AR053149A1 (es) |
AU (1) | AU2006219853B2 (es) |
BR (1) | BRPI0607562A2 (es) |
CA (1) | CA2599658A1 (es) |
EA (1) | EA013078B1 (es) |
FR (1) | FR2882654B1 (es) |
MA (1) | MA29316B1 (es) |
MX (1) | MX2007010364A (es) |
NO (1) | NO20074941L (es) |
NZ (1) | NZ560749A (es) |
UA (1) | UA91848C2 (es) |
WO (1) | WO2006092490A1 (es) |
ZA (1) | ZA200707472B (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2002835A1 (en) | 2007-06-04 | 2008-12-17 | GenKyo Tex | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors |
FR2929276B1 (fr) * | 2008-04-01 | 2010-04-23 | Servier Lab | Nouveaux derives de diosmetine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
KR101162816B1 (ko) * | 2008-04-01 | 2012-07-09 | 르 라보레또레 쎄르비에르 | 디오스메틴 화합물,이의 제조 방법 및 이를 함유하는 약제학적 조성물 |
EP2166009A1 (en) | 2008-09-23 | 2010-03-24 | Genkyo Tex Sa | Pyrazolo pyridine derivatives as nadph oxidase inhibitors |
EP2165707A1 (en) | 2008-09-23 | 2010-03-24 | Genkyo Tex Sa | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors |
EP2166010A1 (en) | 2008-09-23 | 2010-03-24 | Genkyo Tex Sa | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors |
WO2010062681A2 (en) * | 2008-10-30 | 2010-06-03 | University Of South Florida | Luteolin and diosmin/diosmetin as novel stat3 inhibitors for treating autism |
EP2305679A1 (en) | 2009-09-28 | 2011-04-06 | GenKyoTex SA | Pyrazoline dione derivatives as nadph oxidase inhibitors |
PL2782598T3 (pl) * | 2011-11-23 | 2021-03-08 | In3Bio Ltd. | Rekombinowane białka i ich zastosowania terapeutyczne |
EP3034500A1 (en) | 2014-12-17 | 2016-06-22 | Genkyotex Sa | Amido thiazole derivatives as NADPH oxidase inhibitors |
EP3426242A4 (en) * | 2016-03-11 | 2020-03-18 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | ICARITINE AND ICARITINE DERIVATIVES |
US11389515B2 (en) | 2016-12-15 | 2022-07-19 | Talengen International Limited | Method for mitigating heart disease |
EP3556379A4 (en) | 2016-12-15 | 2020-08-19 | Talengen International Limited | METHOD AND DRUG FOR THE PREVENTION AND TREATMENT OF OBESITY |
CN108210915A (zh) * | 2016-12-15 | 2018-06-29 | 深圳瑞健生命科学研究院有限公司 | 改善心脏病变的药物及其用途 |
WO2018107689A1 (zh) * | 2016-12-15 | 2018-06-21 | 深圳瑞健生命科学研究院有限公司 | 一种预防和治疗脂质肾损伤的方法 |
WO2018107686A1 (zh) * | 2016-12-15 | 2018-06-21 | 深圳瑞健生命科学研究院有限公司 | 一种治疗动脉粥样硬化及其并发症的方法 |
CN106822087A (zh) * | 2017-01-12 | 2017-06-13 | 西南大学 | 香叶木素在制备治疗ⅱ型糖尿病的药物中的应用 |
CN109280067B (zh) * | 2017-07-21 | 2022-07-05 | 南京正大天晴制药有限公司 | 香叶木苷衍生物、其制备方法以及医药用途 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2701261B1 (fr) * | 1993-02-05 | 1995-03-31 | Adir | Nouveaux composés glucuronides de la diosmétine, leur procédé de préparation et les compositions pharmaceutiques les renfermant. |
FR2726273B1 (fr) * | 1994-10-26 | 1996-12-06 | Adir | Nouveaux derives de la diosmetine, leur procede de preparation et les compositions pharmaceutiques les contenant |
FR2748025B1 (fr) * | 1996-04-25 | 1998-10-30 | Adir | Nouveaux acides et esters de la diosmetine, et les compositions pharmaceutiques les contenant |
BR9914814A (pt) * | 1998-10-30 | 2001-07-03 | Merck Patent Gmbh | Processo para a preparação de luteolina e derivados de luteolina |
-
2005
- 2005-03-01 FR FR0502044A patent/FR2882654B1/fr not_active Expired - Fee Related
-
2006
- 2006-02-28 JP JP2007557534A patent/JP2008531660A/ja not_active Ceased
- 2006-02-28 KR KR1020077022095A patent/KR100971589B1/ko not_active IP Right Cessation
- 2006-02-28 MX MX2007010364A patent/MX2007010364A/es active IP Right Grant
- 2006-02-28 US US11/885,372 patent/US20080176934A1/en not_active Abandoned
- 2006-02-28 CA CA002599658A patent/CA2599658A1/fr not_active Abandoned
- 2006-02-28 EP EP06725989A patent/EP1853253A1/fr not_active Withdrawn
- 2006-02-28 WO PCT/FR2006/000441 patent/WO2006092490A1/fr active Application Filing
- 2006-02-28 UA UAA200710762A patent/UA91848C2/ru unknown
- 2006-02-28 BR BRPI0607562-2A patent/BRPI0607562A2/pt not_active IP Right Cessation
- 2006-02-28 NZ NZ560749A patent/NZ560749A/en not_active IP Right Cessation
- 2006-02-28 EA EA200701820A patent/EA013078B1/ru not_active IP Right Cessation
- 2006-02-28 KR KR1020097025260A patent/KR20090128581A/ko not_active Application Discontinuation
- 2006-02-28 ZA ZA200707472A patent/ZA200707472B/xx unknown
- 2006-02-28 AU AU2006219853A patent/AU2006219853B2/en not_active Ceased
- 2006-02-28 CN CNA200680006765XA patent/CN101132788A/zh active Pending
- 2006-03-01 AR ARP060100756A patent/AR053149A1/es not_active Application Discontinuation
-
2007
- 2007-09-06 MA MA30193A patent/MA29316B1/fr unknown
- 2007-10-01 NO NO20074941A patent/NO20074941L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU2006219853A1 (en) | 2006-09-08 |
AU2006219853B2 (en) | 2011-06-09 |
NZ560749A (en) | 2010-11-26 |
CA2599658A1 (fr) | 2006-09-08 |
CN101132788A (zh) | 2008-02-27 |
JP2008531660A (ja) | 2008-08-14 |
MA29316B1 (fr) | 2008-03-03 |
BRPI0607562A2 (pt) | 2009-09-15 |
EA200701820A1 (ru) | 2008-02-28 |
KR100971589B1 (ko) | 2010-07-20 |
ZA200707472B (en) | 2008-11-26 |
FR2882654A1 (fr) | 2006-09-08 |
EP1853253A1 (fr) | 2007-11-14 |
US20080176934A1 (en) | 2008-07-24 |
KR20070110395A (ko) | 2007-11-16 |
NO20074941L (no) | 2007-10-01 |
UA91848C2 (ru) | 2010-09-10 |
KR20090128581A (ko) | 2009-12-15 |
WO2006092490A1 (fr) | 2006-09-08 |
FR2882654B1 (fr) | 2007-04-27 |
MX2007010364A (es) | 2007-09-25 |
EA013078B1 (ru) | 2010-02-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |