AR069643A1 - Derivados diazenidiolatos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen - Google Patents
Derivados diazenidiolatos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienenInfo
- Publication number
- AR069643A1 AR069643A1 ARP080105371A ARP080105371A AR069643A1 AR 069643 A1 AR069643 A1 AR 069643A1 AR P080105371 A ARP080105371 A AR P080105371A AR P080105371 A ARP080105371 A AR P080105371A AR 069643 A1 AR069643 A1 AR 069643A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- branched
- linear
- hydrogen atom
- alkyl group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Uso en el tratamiento de la hipertension y enfermedades cardiovasculares. Reivindicacion 1: Compuestos de formula (1), en la que: R1 representa un átomo de hidrogeno o un grupo -COOR en el que R representa un grupo alquilo C1-6 lineal o ramificado o arilalquilo C1-6 lineal o ramificado, R2 representa un grupo G o un grupo alquilo C1-6 lineal o ramificado sustituido con un grupo G, en el que G representa un grupo -(CH2)n-A-(CH2)m-B-(CR4R5)p-(CH2)o-R6 en el que: n vale 0, 1,2 o 3, m vale 0, 1, 2 o 3, p vale 0 o 1; o vale 0, 1 o 2, R4 y R5, idénticos o diferentes, representan cada uno un átomo de hidrogeno o un grupo alquilo C1-6 lineal o ramificado, entendiéndose que uno de los grupos -CH2- o -CR4R5- de la cadena G puede reemplazarse igualmente, si se desea, por un grupo fenileno, -PhC(O)- o -PhC(O)O- (en el que Ph significa fenilo), A y B, idénticos o diferentes, representan cada uno un enlace, un átomo de nitrogeno o un grupo de formulas (2) en los que R7 representa un átomo de hidrogeno o un grupo alquilo C1-6 lineal o ramificado, y R6 representa un grupo de formulas (3) en el que R8, R9 y R10, idénticos o diferentes, representan cada uno un átomo de hidrogeno o un grupo alquilo C1-6 lineal o ramificado no sustituido o sustituido con un grupo amino, o R8 y R9 forman juntos una cadena alquileno C1-6 lineal o ramificada, R3 representa un átomo de hidrogeno, un grupo alquilo C1-6 lineal o ramificado o un grupo NO2, sus enantiomeros y diastereoisomeros así como sus sales de adicion a un ácido o a una base aceptable farmacéuticamente.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0708604A FR2924713B1 (fr) | 2007-12-11 | 2007-12-11 | Nouveaux derives diazeniumdiolates, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR069643A1 true AR069643A1 (es) | 2010-02-10 |
Family
ID=39158541
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080105371A AR069643A1 (es) | 2007-12-11 | 2008-12-11 | Derivados diazenidiolatos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US8288433B2 (es) |
| EP (1) | EP2231598B1 (es) |
| JP (1) | JP5247814B2 (es) |
| KR (1) | KR20100083195A (es) |
| CN (1) | CN101910128B (es) |
| AR (1) | AR069643A1 (es) |
| AT (1) | ATE520658T1 (es) |
| AU (1) | AU2008351147B2 (es) |
| BR (1) | BRPI0822066A2 (es) |
| CA (1) | CA2707853C (es) |
| DK (1) | DK2231598T3 (es) |
| EA (1) | EA201000885A1 (es) |
| ES (1) | ES2371699T3 (es) |
| FR (1) | FR2924713B1 (es) |
| GE (1) | GEP20135733B (es) |
| HR (1) | HRP20110755T1 (es) |
| MA (1) | MA31901B1 (es) |
| MX (1) | MX2010006446A (es) |
| MY (1) | MY147973A (es) |
| NZ (1) | NZ586070A (es) |
| PL (1) | PL2231598T3 (es) |
| PT (1) | PT2231598E (es) |
| RS (1) | RS52001B (es) |
| SI (1) | SI2231598T1 (es) |
| UA (1) | UA97035C2 (es) |
| WO (1) | WO2009103875A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8354394B2 (en) * | 2009-10-29 | 2013-01-15 | Merck Sharp & Dohme Corp. | Diuretics |
| KR20130008523A (ko) | 2010-02-12 | 2013-01-22 | 머크 샤프 앤드 돔 코포레이션 | 디아제늄디올레이트 시클로펜틸 유도체 |
| US8623846B2 (en) | 2010-05-21 | 2014-01-07 | Merck Sharp & Dohme Corp. | Diazeniumdiolate cyclohexyl derivatives |
| MX2013004739A (es) | 2010-10-29 | 2013-07-02 | Merck Sharp & Dohme | Derivados heterociclicos de diazenodiolato. |
| JO3350B1 (ar) * | 2011-03-07 | 2019-03-13 | Merck Sharp & Dohme | مشتقات حلقية غير متجانسة محتوية على مجموعات أمينو أولية ومركبات داي أزينيومديولات |
| EP2704568B1 (en) | 2011-05-02 | 2018-01-24 | Merck Sharp & Dohme Corp. | Diazeniumdiolate cyclohexyl derivatives |
| CN109608371B (zh) * | 2019-01-16 | 2020-12-29 | 泰州学院 | O2-4-(3-(4-胺磺酰基苯基)脲)苯基偶氮鎓二醇盐衍生物、制备方法及用途 |
| CN114805183B (zh) * | 2022-05-07 | 2022-12-27 | 武汉科技大学 | 一类no供体型荜茇酰胺衍生物、制备方法及用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1203691A (en) * | 1968-03-06 | 1970-09-03 | Science Union & Cie | New disubstituted n-amino indoline derivatives and process for preparing them |
| JPH0233030B2 (ja) * | 1982-01-18 | 1990-07-25 | Mitsui Toatsu Chemicals | Surufuamoiruansokukosanjudotaioyobisoreojukoseibuntoshitefukumuchiryoyososeibutsu |
| JPH07118231A (ja) * | 1993-10-22 | 1995-05-09 | Nippon Oil & Fats Co Ltd | スルファモイル安息香酸誘導体 |
| US5958427A (en) * | 1996-11-08 | 1999-09-28 | Salzman; Andrew L. | Nitric oxide donor compounds and pharmaceutical compositions for pulmonary hypertension and other indications |
| AUPS236902A0 (en) * | 2002-05-16 | 2002-06-13 | Northern Sydney Area Health Service | Composition and method for treating hypertension |
| CA2574535A1 (en) * | 2004-11-15 | 2006-05-26 | Nitromed, Inc. | Diuretic compounds comprising heterocyclic nitric oxide donor groups, compositions and methods of use |
| JP2008531579A (ja) * | 2005-02-24 | 2008-08-14 | ニトロメッド インコーポレーティッド | 酸化窒素増強利尿化合物、組成物および使用方法 |
| EP2244575B1 (en) * | 2008-01-24 | 2013-07-17 | Merck Sharp & Dohme Corp. | Angiotensin ii receptor antagonists |
| WO2009099853A2 (en) * | 2008-02-08 | 2009-08-13 | Merck & Co., Inc. | Angiotensin ii receptor antagonists |
-
2007
- 2007-12-11 FR FR0708604A patent/FR2924713B1/fr not_active Expired - Fee Related
-
2008
- 2008-12-10 EP EP08872697A patent/EP2231598B1/fr active Active
- 2008-12-10 MX MX2010006446A patent/MX2010006446A/es active IP Right Grant
- 2008-12-10 AU AU2008351147A patent/AU2008351147B2/en not_active Ceased
- 2008-12-10 KR KR1020107012930A patent/KR20100083195A/ko active IP Right Grant
- 2008-12-10 ES ES08872697T patent/ES2371699T3/es active Active
- 2008-12-10 GE GEAP200811874A patent/GEP20135733B/en unknown
- 2008-12-10 RS RS20110438A patent/RS52001B/en unknown
- 2008-12-10 AT AT08872697T patent/ATE520658T1/de active
- 2008-12-10 EA EA201000885A patent/EA201000885A1/ru unknown
- 2008-12-10 DK DK08872697.1T patent/DK2231598T3/da active
- 2008-12-10 US US12/735,048 patent/US8288433B2/en not_active Expired - Fee Related
- 2008-12-10 NZ NZ586070A patent/NZ586070A/en not_active IP Right Cessation
- 2008-12-10 CN CN2008801229307A patent/CN101910128B/zh not_active Expired - Fee Related
- 2008-12-10 CA CA2707853A patent/CA2707853C/fr not_active Expired - Fee Related
- 2008-12-10 PL PL08872697T patent/PL2231598T3/pl unknown
- 2008-12-10 PT PT08872697T patent/PT2231598E/pt unknown
- 2008-12-10 MY MYPI2010002633A patent/MY147973A/en unknown
- 2008-12-10 SI SI200830404T patent/SI2231598T1/sl unknown
- 2008-12-10 JP JP2010537487A patent/JP5247814B2/ja not_active Expired - Fee Related
- 2008-12-10 BR BRPI0822066A patent/BRPI0822066A2/pt not_active IP Right Cessation
- 2008-12-10 WO PCT/FR2008/001716 patent/WO2009103875A1/fr active Application Filing
- 2008-12-10 UA UAA201008615A patent/UA97035C2/ru unknown
- 2008-12-11 AR ARP080105371A patent/AR069643A1/es not_active Application Discontinuation
-
2010
- 2010-06-07 MA MA32894A patent/MA31901B1/fr unknown
-
2011
- 2011-10-17 HR HR20110755T patent/HRP20110755T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2008351147A1 (en) | 2009-08-27 |
| MX2010006446A (es) | 2010-07-05 |
| ATE520658T1 (de) | 2011-09-15 |
| CN101910128B (zh) | 2013-01-16 |
| ES2371699T3 (es) | 2012-01-09 |
| AU2008351147B2 (en) | 2012-04-12 |
| RS52001B (en) | 2012-04-30 |
| CA2707853C (fr) | 2013-02-05 |
| EA201000885A1 (ru) | 2011-02-28 |
| BRPI0822066A2 (pt) | 2015-09-22 |
| UA97035C2 (ru) | 2011-12-26 |
| SI2231598T1 (sl) | 2011-11-30 |
| PT2231598E (pt) | 2011-10-11 |
| NZ586070A (en) | 2012-06-29 |
| FR2924713A1 (fr) | 2009-06-12 |
| CA2707853A1 (fr) | 2009-08-27 |
| JP2011506408A (ja) | 2011-03-03 |
| JP5247814B2 (ja) | 2013-07-24 |
| DK2231598T3 (da) | 2011-12-05 |
| MA31901B1 (fr) | 2010-12-01 |
| EP2231598B1 (fr) | 2011-08-17 |
| KR20100083195A (ko) | 2010-07-21 |
| MY147973A (en) | 2013-02-28 |
| PL2231598T3 (pl) | 2011-12-30 |
| CN101910128A (zh) | 2010-12-08 |
| HRP20110755T1 (hr) | 2011-11-30 |
| US8288433B2 (en) | 2012-10-16 |
| FR2924713B1 (fr) | 2010-01-29 |
| US20100286225A1 (en) | 2010-11-11 |
| EP2231598A1 (fr) | 2010-09-29 |
| WO2009103875A1 (fr) | 2009-08-27 |
| GEP20135733B (en) | 2013-01-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |