UA97035C2 - Соединения диазенийдиолата, способ их получения и фармацевтическая композиция, которая их содержит - Google Patents

Соединения диазенийдиолата, способ их получения и фармацевтическая композиция, которая их содержит

Info

Publication number
UA97035C2
UA97035C2 UAA201008615A UAA201008615A UA97035C2 UA 97035 C2 UA97035 C2 UA 97035C2 UA A201008615 A UAA201008615 A UA A201008615A UA A201008615 A UAA201008615 A UA A201008615A UA 97035 C2 UA97035 C2 UA 97035C2
Authority
UA
Ukraine
Prior art keywords
same
pharmaceutical compositions
compositions containing
group
preparing
Prior art date
Application number
UAA201008615A
Other languages
English (en)
Ukrainian (uk)
Inventor
Алексис Корди
Лор Аберкорн
Тони Вербюрен
Кристин Курше
Серж Симоне
Original Assignee
Ле Лаборатуар Сервье
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ле Лаборатуар Сервье filed Critical Ле Лаборатуар Сервье
Publication of UA97035C2 publication Critical patent/UA97035C2/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Соединение формулы (I):, (I)где:Rпредставляет собой атом водорода или -COOR группу,Rпредставляет собой группу G или линейную или разветвленную (С-С)алкильную группу, замещенную группой G, в которой G представляет собой (CH)-A-(CH)-B-(CRR)-(CH)-Rгруппу, как определено выше в описании,Rпредставляет собой атом водорода, алкильную группу или NOгруппу.Лекарственные средства.
UAA201008615A 2007-12-11 2008-12-10 Соединения диазенийдиолата, способ их получения и фармацевтическая композиция, которая их содержит UA97035C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0708604A FR2924713B1 (fr) 2007-12-11 2007-12-11 Nouveaux derives diazeniumdiolates, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
UA97035C2 true UA97035C2 (ru) 2011-12-26

Family

ID=39158541

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201008615A UA97035C2 (ru) 2007-12-11 2008-12-10 Соединения диазенийдиолата, способ их получения и фармацевтическая композиция, которая их содержит

Country Status (26)

Country Link
US (1) US8288433B2 (ru)
EP (1) EP2231598B1 (ru)
JP (1) JP5247814B2 (ru)
KR (1) KR20100083195A (ru)
CN (1) CN101910128B (ru)
AR (1) AR069643A1 (ru)
AT (1) ATE520658T1 (ru)
AU (1) AU2008351147B2 (ru)
BR (1) BRPI0822066A2 (ru)
CA (1) CA2707853C (ru)
DK (1) DK2231598T3 (ru)
EA (1) EA201000885A1 (ru)
ES (1) ES2371699T3 (ru)
FR (1) FR2924713B1 (ru)
GE (1) GEP20135733B (ru)
HR (1) HRP20110755T1 (ru)
MA (1) MA31901B1 (ru)
MX (1) MX2010006446A (ru)
MY (1) MY147973A (ru)
NZ (1) NZ586070A (ru)
PL (1) PL2231598T3 (ru)
PT (1) PT2231598E (ru)
RS (1) RS52001B (ru)
SI (1) SI2231598T1 (ru)
UA (1) UA97035C2 (ru)
WO (1) WO2009103875A1 (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011053519A1 (en) * 2009-10-29 2011-05-05 Merck Sharp & Dohme Corp. Diuretics
EP2533644B1 (en) 2010-02-12 2017-01-18 Merck Sharp & Dohme Corp. Diazeniumdiolate cyclopentyl derivatives
EP2571351B1 (en) * 2010-05-21 2016-09-14 Merck Sharp & Dohme Corp. Diazeniumdiolate cyclohexyl derivatives
CN103347385A (zh) 2010-10-29 2013-10-09 默沙东公司 二醇二氮烯鎓类杂环衍生物
JO3350B1 (ar) * 2011-03-07 2019-03-13 Merck Sharp & Dohme مشتقات حلقية غير متجانسة محتوية على مجموعات أمينو أولية ومركبات داي أزينيومديولات
WO2012151114A1 (en) 2011-05-02 2012-11-08 Merck Sharp & Dohme Corp. Diazeniumdiolate cyclohexyl derivatives
CN109608371B (zh) * 2019-01-16 2020-12-29 泰州学院 O2-4-(3-(4-胺磺酰基苯基)脲)苯基偶氮鎓二醇盐衍生物、制备方法及用途
CN114805183B (zh) * 2022-05-07 2022-12-27 武汉科技大学 一类no供体型荜茇酰胺衍生物、制备方法及用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1203691A (en) * 1968-03-06 1970-09-03 Science Union & Cie New disubstituted n-amino indoline derivatives and process for preparing them
JPH0233030B2 (ja) * 1982-01-18 1990-07-25 Mitsui Toatsu Chemicals Surufuamoiruansokukosanjudotaioyobisoreojukoseibuntoshitefukumuchiryoyososeibutsu
JPH07118231A (ja) * 1993-10-22 1995-05-09 Nippon Oil & Fats Co Ltd スルファモイル安息香酸誘導体
US5958427A (en) * 1996-11-08 1999-09-28 Salzman; Andrew L. Nitric oxide donor compounds and pharmaceutical compositions for pulmonary hypertension and other indications
AUPS236902A0 (en) * 2002-05-16 2002-06-13 Northern Sydney Area Health Service Composition and method for treating hypertension
JP2008520578A (ja) * 2004-11-15 2008-06-19 ニトロメッド インコーポレーティッド 複素環式の酸化窒素供与体基を含む利尿化合物、組成物および使用方法
CA2597460A1 (en) * 2005-02-24 2006-08-31 Nitromed, Inc. Nitric oxide enhancing diuretic compounds, compositions and methods of use
CA2711134A1 (en) * 2008-01-24 2009-07-30 Merck Sharp & Dohme Corp. Angiotensin ii receptor antagonists
JP2011511079A (ja) * 2008-02-08 2011-04-07 メルク・シャープ・エンド・ドーム・コーポレイション アンジオテンシンｉｉ受容体アンタゴニスト

Also Published As

Publication number Publication date
JP2011506408A (ja) 2011-03-03
GEP20135733B (en) 2013-01-25
ES2371699T3 (es) 2012-01-09
RS52001B (en) 2012-04-30
JP5247814B2 (ja) 2013-07-24
US8288433B2 (en) 2012-10-16
CA2707853C (fr) 2013-02-05
HRP20110755T1 (hr) 2011-11-30
PT2231598E (pt) 2011-10-11
WO2009103875A1 (fr) 2009-08-27
AU2008351147A1 (en) 2009-08-27
CN101910128B (zh) 2013-01-16
NZ586070A (en) 2012-06-29
DK2231598T3 (da) 2011-12-05
FR2924713A1 (fr) 2009-06-12
SI2231598T1 (sl) 2011-11-30
EP2231598A1 (fr) 2010-09-29
ATE520658T1 (de) 2011-09-15
MY147973A (en) 2013-02-28
PL2231598T3 (pl) 2011-12-30
EP2231598B1 (fr) 2011-08-17
EA201000885A1 (ru) 2011-02-28
MX2010006446A (es) 2010-07-05
AU2008351147B2 (en) 2012-04-12
MA31901B1 (fr) 2010-12-01
US20100286225A1 (en) 2010-11-11
FR2924713B1 (fr) 2010-01-29
KR20100083195A (ko) 2010-07-21
AR069643A1 (es) 2010-02-10
CA2707853A1 (fr) 2009-08-27
BRPI0822066A2 (pt) 2015-09-22
CN101910128A (zh) 2010-12-08

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