AR054121A1 - Compuestos de fenilpiridilpiperazina, procedimiento de preparacion, composiciones farmaceuticas que los contienen, y usos farmacologicos como antagonistas de receptores histaminergicos h3 - Google Patents
Compuestos de fenilpiridilpiperazina, procedimiento de preparacion, composiciones farmaceuticas que los contienen, y usos farmacologicos como antagonistas de receptores histaminergicos h3Info
- Publication number
- AR054121A1 AR054121A1 ARP060101889A ARP060101889A AR054121A1 AR 054121 A1 AR054121 A1 AR 054121A1 AR P060101889 A ARP060101889 A AR P060101889A AR P060101889 A ARP060101889 A AR P060101889A AR 054121 A1 AR054121 A1 AR 054121A1
- Authority
- AR
- Argentina
- Prior art keywords
- branched
- linear
- group
- alkyl
- groups
- Prior art date
Links
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical class C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 230000000742 histaminergic effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 230000000144 pharmacologic effect Effects 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 8
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- -1 carboxy, hydroxy Chemical group 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000006684 polyhaloalkyl group Polymers 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000006621 (C3-C8) cycloalkyl-(C1-C6) alkyl group Chemical group 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000006267 biphenyl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Psychology (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
Abstract
Reivindicacion 1: Compuestos de formula (1), en la cual: X representa un grupo C(O) o SO2; R1 representa: un grupo arilo; o un grupo NR3R4 en el cual: R3 y R4, que pueden ser idénticos o diferentes, representan cada uno un átomo de hidrogeno o un grupo alquilo C1-6 lineal o ramificado, un grupo cicloalquilo C3-8 o un grupo cicloalquilC3-8-alquiloC1-6 en el que la parte alquilo es lineal o ramificada; o R3 y R4 forman junto con el átomo de nitrogeno que los lleva un anillo que comprende de 5 a 8 miembros en el cual uno de los átomos de carbono puede ser reemplazado por un átomo de nitrogeno, oxígeno o azufre o por un grupo SO o SO2, y dicho anillo puede ser, opcionalmente, puenteado por un grupo alquilo C1-6 lineal o ramificado y/o puede ser opcionalmente sustituido por uno o más grupos, idénticos o diferentes, seleccionados entre halogeno, alquilo C1-6 lineal o ramificado, cicloalquilo C3-8, alcoxi C1-6 lineal o ramificado, polihaloalquilo C1-6 lineal o ramificado, carboxi, hidroxi, ciano, nitro y amino (opcionalmente sustituido por uno o más grupos alquilo C1-6 lineal o ramificado); R2 representa un grupo alquilo C1-6 lineal o ramificado, un grupo cicloalquilo C3-8 o un grupo cicloalquiloC3-8-alquiloC1-6 en el cual la parte alquilo puede ser lineal o ramificada; y se entiende que: un grupo arilo, comprende los grupos fenilo, naftilo y bifenilo, y esos grupos pueden ser opcionalmente sustituidos por uno o más grupos, idénticos o diferentes, seleccionados entre halogeno, alquilo C1-6 lineal o ramificado, alcoxi C1-6 lineal o ramificado, polihaloalquilo C1-6 lineal o ramificado, carboxi, hidroxi, ciano, nitro y amino (opcionalmente sustituido por uno o más grupos alquilo C1-6 lineal o ramificado); sus enantiomeros y diastereoisomeros, así como sus sales de adicion con un ácido o con una base farmacéuticamente aceptable.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0504758A FR2885616B1 (fr) | 2005-05-12 | 2005-05-12 | Nouveaux derives de phenylpyridinylpiperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
Publication Number | Publication Date |
---|---|
AR054121A1 true AR054121A1 (es) | 2007-06-06 |
Family
ID=35668833
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP060101889A AR054121A1 (es) | 2005-05-12 | 2006-05-11 | Compuestos de fenilpiridilpiperazina, procedimiento de preparacion, composiciones farmaceuticas que los contienen, y usos farmacologicos como antagonistas de receptores histaminergicos h3 |
Country Status (25)
Country | Link |
---|---|
US (1) | US7494994B2 (es) |
EP (1) | EP1721897A1 (es) |
JP (1) | JP2006316061A (es) |
KR (1) | KR100807481B1 (es) |
CN (1) | CN100569767C (es) |
AP (1) | AP2007004223A0 (es) |
AR (1) | AR054121A1 (es) |
AU (1) | AU2006201994A1 (es) |
BR (1) | BRPI0601773A (es) |
CA (1) | CA2546392A1 (es) |
CR (1) | CR9499A (es) |
EA (1) | EA011155B1 (es) |
FR (1) | FR2885616B1 (es) |
GE (1) | GEP20084470B (es) |
GT (1) | GT200700097A (es) |
IL (1) | IL186862A0 (es) |
MA (1) | MA28326A1 (es) |
MY (1) | MY141784A (es) |
NO (1) | NO20062083L (es) |
NZ (1) | NZ547122A (es) |
SG (1) | SG127801A1 (es) |
TN (1) | TNSN07395A1 (es) |
UA (1) | UA87284C2 (es) |
WO (1) | WO2006120349A1 (es) |
ZA (1) | ZA200603810B (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030236259A1 (en) * | 2002-02-05 | 2003-12-25 | Rolf Hohlweg | Novel aryl- and heteroarylpiperazines |
ES2375929T3 (es) | 2005-07-04 | 2012-03-07 | High Point Pharmaceuticals, Llc | Antagonistas del receptor histamina h3. |
SG163547A1 (en) | 2006-05-29 | 2010-08-30 | High Point Pharmaceuticals Llc | 3- (1, 3-benz0di0x0l-5-yl) -6- (4-cyclopropylpiperazin-1-yl) -pyridazine, its salts and solvates and its use as histamine h3 receptor antagonist |
CA2672661C (en) * | 2006-12-14 | 2015-04-28 | Janssen Pharmaceutica N.V. | Process for the preparation of piperazinyl and diazepanyl benzamide derivatives |
EP2014656A3 (en) * | 2007-06-11 | 2011-08-24 | High Point Pharmaceuticals, LLC | New heteocyclic h3 antagonists |
ES2594409T3 (es) | 2011-02-23 | 2016-12-20 | Lupin Limited | Derivados de heteroarilo como moduladores del nAChR á7 |
IN2014MN01756A (es) | 2012-03-06 | 2015-07-03 | Lupin Ltd | |
EP3373935B1 (en) * | 2015-11-12 | 2021-09-01 | Merck Sharp & Dohme Corp. | Cyanopyridine derivatives as liver x receptor beta agonists, compositions, and their use |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0361489A3 (en) * | 1988-09-30 | 1991-06-12 | Chugai Seiyaku Kabushiki Kaisha | Novel 3,4-diaminoquinoline and pyridine compounds |
CA2089728A1 (en) * | 1990-09-13 | 1992-03-14 | James S. Frazee | Pyridylthio or pyridyloxy alkanoic acids |
CA2267835A1 (en) * | 1996-10-04 | 1998-04-16 | Novo Nordisk A/S | 1,4-disubstituted piperazines |
EP1020445B1 (en) * | 1997-10-02 | 2008-08-13 | Eisai R&D Management Co., Ltd. | Fused pyridine derivatives |
DE69826883T2 (de) * | 1997-10-27 | 2005-02-03 | Neurosearch A/S | Heteroaryl diazacycloalkane als cholinergische ligande für nikotin-acetylcholin-rezeptoren |
GB9919776D0 (en) * | 1998-08-31 | 1999-10-27 | Zeneca Ltd | Compoujnds |
US20030236259A1 (en) * | 2002-02-05 | 2003-12-25 | Rolf Hohlweg | Novel aryl- and heteroarylpiperazines |
-
2005
- 2005-05-12 FR FR0504758A patent/FR2885616B1/fr not_active Expired - Fee Related
-
2006
- 2006-05-02 MA MA28997A patent/MA28326A1/fr unknown
- 2006-05-05 SG SG200603045A patent/SG127801A1/en unknown
- 2006-05-09 NO NO20062083A patent/NO20062083L/no not_active Application Discontinuation
- 2006-05-10 MY MYPI20062154A patent/MY141784A/en unknown
- 2006-05-11 NZ NZ547122A patent/NZ547122A/en unknown
- 2006-05-11 GE GEAP20069393A patent/GEP20084470B/en unknown
- 2006-05-11 WO PCT/FR2006/001050 patent/WO2006120349A1/fr active Application Filing
- 2006-05-11 US US11/432,250 patent/US7494994B2/en not_active Expired - Fee Related
- 2006-05-11 AP AP2007004223A patent/AP2007004223A0/xx unknown
- 2006-05-11 EP EP06290758A patent/EP1721897A1/fr not_active Withdrawn
- 2006-05-11 AR ARP060101889A patent/AR054121A1/es unknown
- 2006-05-11 UA UAA200605182A patent/UA87284C2/ru unknown
- 2006-05-12 JP JP2006133322A patent/JP2006316061A/ja active Pending
- 2006-05-12 CN CNB2006101263989A patent/CN100569767C/zh not_active Expired - Fee Related
- 2006-05-12 BR BRPI0601773-8A patent/BRPI0601773A/pt not_active IP Right Cessation
- 2006-05-12 AU AU2006201994A patent/AU2006201994A1/en not_active Abandoned
- 2006-05-12 ZA ZA200603810A patent/ZA200603810B/xx unknown
- 2006-05-12 EA EA200600760A patent/EA011155B1/ru not_active IP Right Cessation
- 2006-05-12 CA CA002546392A patent/CA2546392A1/fr not_active Abandoned
- 2006-05-12 KR KR1020060042839A patent/KR100807481B1/ko not_active IP Right Cessation
-
2007
- 2007-10-23 IL IL186862A patent/IL186862A0/en unknown
- 2007-10-24 TN TNP2007000395A patent/TNSN07395A1/en unknown
- 2007-11-05 CR CR9499A patent/CR9499A/es not_active Application Discontinuation
- 2007-11-07 GT GT200700097A patent/GT200700097A/es unknown
Also Published As
Publication number | Publication date |
---|---|
FR2885616B1 (fr) | 2007-06-22 |
BRPI0601773A (pt) | 2007-05-15 |
GEP20084470B (en) | 2008-08-25 |
UA87284C2 (ru) | 2009-07-10 |
GT200700097A (es) | 2009-06-04 |
KR100807481B1 (ko) | 2008-02-25 |
NZ547122A (en) | 2007-05-31 |
CN1896073A (zh) | 2007-01-17 |
CR9499A (es) | 2008-02-20 |
JP2006316061A (ja) | 2006-11-24 |
FR2885616A1 (fr) | 2006-11-17 |
EP1721897A1 (fr) | 2006-11-15 |
MY141784A (en) | 2010-06-30 |
ZA200603810B (en) | 2007-08-29 |
US20060258670A1 (en) | 2006-11-16 |
WO2006120349A1 (fr) | 2006-11-16 |
AP2007004223A0 (en) | 2007-10-31 |
CN100569767C (zh) | 2009-12-16 |
CA2546392A1 (fr) | 2006-11-12 |
AU2006201994A1 (en) | 2006-11-30 |
SG127801A1 (en) | 2006-12-29 |
MA28326A1 (fr) | 2006-12-01 |
EA200600760A1 (ru) | 2006-12-29 |
EA011155B1 (ru) | 2009-02-27 |
US7494994B2 (en) | 2009-02-24 |
NO20062083L (no) | 2006-11-13 |
TNSN07395A1 (en) | 2009-03-17 |
IL186862A0 (en) | 2008-02-09 |
KR20060117263A (ko) | 2006-11-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR054121A1 (es) | Compuestos de fenilpiridilpiperazina, procedimiento de preparacion, composiciones farmaceuticas que los contienen, y usos farmacologicos como antagonistas de receptores histaminergicos h3 | |
AR062677A1 (es) | Derivados de biaril-sulfonamida, procesos de produccion y composiciones farmaceuticas que los comprenden | |
AR061739A1 (es) | Nuevos derivados naftalenicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen | |
AR061835A1 (es) | Derivados tetraciclicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen | |
AR089774A1 (es) | Derivados de indolizina, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen | |
CO5680403A2 (es) | Antagonistas de mchr1r | |
AR038723A1 (es) | Cumarinas utiles como biomarcadores | |
AR056560A1 (es) | Pirrolopiridinonas como moduladores cb1 | |
AR063988A1 (es) | Derivados heterociclicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen | |
AR039413A1 (es) | Derivados de n-(fenil(piperidin-2-il)metil)benzamida, su preparacion y su aplicacion en terapeutica | |
AR065795A1 (es) | Derivados de aza-piridopirimidinona,metodo de preparacion,medicamentos que los contienen y usos como agentes antitromboticos, antihiperlipidemicos y antidiabeticos,entre otros. | |
AR033379A1 (es) | Compuestos de difenilurea, procedimiento para su preparacion y composiciones farmaceuticas que los contienen | |
PA8795301A1 (es) | Derivados de 1,2,4,5-tetrahidro-3h-benzazepinas, su procedimiento de preparacion y las composiciones farmaceuticas que las contienen | |
AR049770A1 (es) | Derivados de piperidina como moduladores de la actividad de quimioquinas | |
AR051392A1 (es) | Antagonistas no peptidicos de bradiquinina y composiciones farmaceuticas de los mismos | |
AR060267A1 (es) | Tiazolil- dihidro -ciclopentapirazoles | |
AR061377A1 (es) | Derivados diazeniodiolatos, procedimiento de preparacion, composiciones farmaceuticas que los contienen y usos en patologias cardiovasculares. | |
AR066457A1 (es) | Derivados de imidazol, procesos de obtencion, composiciones farmaceuticas y usos. | |
SV2006002126A (es) | Derivados de tetrahidroisoquinolilsulfonamidas, su preparacion y su utilizacion en terapeutica | |
AR060268A1 (es) | Tiazolil - dihidro - indazoles | |
PE20061362A1 (es) | Derivados de tetrahidronaftalina, procedimientos para su preparacion y su uso como inhibidor de la inflamacion | |
PE20140968A1 (es) | Derivados de benzamida sustituida | |
AR069643A1 (es) | Derivados diazenidiolatos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen | |
AR054120A1 (es) | Compuestos de fenilpiridilpiperazina, procedimiento de preparacion, composiciones farmaceuticas que los contienen, y usos farmacologicos como antagonistas de receptores histaminergicos h3 | |
AR042362A1 (es) | Derivados de 3h-quinazolin-4-ona, proceso de obtencion y composiciones farmaceuticas que los contienen |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |