ZA200707472B - Diosmetin derivatives for the treatment and prevention of thrombotic pathologies - Google Patents

Diosmetin derivatives for the treatment and prevention of thrombotic pathologies

Info

Publication number
ZA200707472B
ZA200707472B ZA200707472A ZA200707472A ZA200707472B ZA 200707472 B ZA200707472 B ZA 200707472B ZA 200707472 A ZA200707472 A ZA 200707472A ZA 200707472 A ZA200707472 A ZA 200707472A ZA 200707472 B ZA200707472 B ZA 200707472B
Authority
ZA
South Africa
Prior art keywords
prevention
treatment
thrombotic pathologies
diosmetin
derivatives
Prior art date
Application number
ZA200707472A
Other languages
English (en)
Inventor
Verbeuren Tony
Rupin Alain
Sansilvestri-Morel Patricia
Vallez Marie-Odile
Boussard Marie-Francoise
Wierzbicki Michel
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of ZA200707472B publication Critical patent/ZA200707472B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/32—2,3-Dihydro derivatives, e.g. flavanones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA200707472A 2005-03-01 2006-02-28 Diosmetin derivatives for the treatment and prevention of thrombotic pathologies ZA200707472B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0502044A FR2882654B1 (fr) 2005-03-01 2005-03-01 Utilisation de derives de la diosmetine pour le traitement et la prevention des pathologies thrombotiques

Publications (1)

Publication Number Publication Date
ZA200707472B true ZA200707472B (en) 2008-11-26

Family

ID=35134198

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200707472A ZA200707472B (en) 2005-03-01 2006-02-28 Diosmetin derivatives for the treatment and prevention of thrombotic pathologies

Country Status (18)

Country Link
US (1) US20080176934A1 (es)
EP (1) EP1853253A1 (es)
JP (1) JP2008531660A (es)
KR (2) KR20090128581A (es)
CN (1) CN101132788A (es)
AR (1) AR053149A1 (es)
AU (1) AU2006219853B2 (es)
BR (1) BRPI0607562A2 (es)
CA (1) CA2599658A1 (es)
EA (1) EA013078B1 (es)
FR (1) FR2882654B1 (es)
MA (1) MA29316B1 (es)
MX (1) MX2007010364A (es)
NO (1) NO20074941L (es)
NZ (1) NZ560749A (es)
UA (1) UA91848C2 (es)
WO (1) WO2006092490A1 (es)
ZA (1) ZA200707472B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2002835A1 (en) 2007-06-04 2008-12-17 GenKyo Tex Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
KR101162816B1 (ko) * 2008-04-01 2012-07-09 르 라보레또레 쎄르비에르 디오스메틴 화합물，이의 제조 방법 및 이를 함유하는 약제학적 조성물
FR2929276B1 (fr) 2008-04-01 2010-04-23 Servier Lab Nouveaux derives de diosmetine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP2166010A1 (en) 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
EP2166009A1 (en) 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as nadph oxidase inhibitors
EP2165707A1 (en) 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
WO2010062681A2 (en) * 2008-10-30 2010-06-03 University Of South Florida Luteolin and diosmin/diosmetin as novel stat3 inhibitors for treating autism
EP2305679A1 (en) 2009-09-28 2011-04-06 GenKyoTex SA Pyrazoline dione derivatives as nadph oxidase inhibitors
US9902760B2 (en) * 2011-11-23 2018-02-27 Bioven 3 Limited Recombinant proteins and their therapeutic uses
EP3034500A1 (en) 2014-12-17 2016-06-22 Genkyotex Sa Amido thiazole derivatives as NADPH oxidase inhibitors
BR112018068412A2 (pt) * 2016-03-11 2019-01-22 H. Lee Moffitt Cancer Center And Research Institute, Inc. composto, composição farmacêutica, método de tratamento de síndrome mielodisplásica e método para matar uma célula tumoral
CN108210915A (zh) * 2016-12-15 2018-06-29 深圳瑞健生命科学研究院有限公司 改善心脏病变的药物及其用途
JP7158740B2 (ja) 2016-12-15 2022-10-24 タレンゲン インターナショナル リミテッド 冠状動脈アテローム性硬化症およびその合併症を治療するための方法
WO2018107689A1 (zh) * 2016-12-15 2018-06-21 深圳瑞健生命科学研究院有限公司 一种预防和治疗脂质肾损伤的方法
EP3556379A4 (en) 2016-12-15 2020-08-19 Talengen International Limited METHOD AND DRUG FOR THE PREVENTION AND TREATMENT OF OBESITY
EP3556385A4 (en) * 2016-12-15 2020-12-30 Talengen International Limited PROCESS FOR ALLEGING HEART DISEASE
CN106822087A (zh) * 2017-01-12 2017-06-13 西南大学 香叶木素在制备治疗ⅱ型糖尿病的药物中的应用
CN109280067B (zh) * 2017-07-21 2022-07-05 南京正大天晴制药有限公司 香叶木苷衍生物、其制备方法以及医药用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2701261B1 (fr) * 1993-02-05 1995-03-31 Adir Nouveaux composés glucuronides de la diosmétine, leur procédé de préparation et les compositions pharmaceutiques les renfermant.
FR2726273B1 (fr) * 1994-10-26 1996-12-06 Adir Nouveaux derives de la diosmetine, leur procede de preparation et les compositions pharmaceutiques les contenant
FR2748025B1 (fr) * 1996-04-25 1998-10-30 Adir Nouveaux acides et esters de la diosmetine, et les compositions pharmaceutiques les contenant
EP1124815B1 (de) * 1998-10-30 2004-05-26 MERCK PATENT GmbH Verfahren zur herstellung von luteolin und luteolin-derivaten

Also Published As

Publication number Publication date
EP1853253A1 (fr) 2007-11-14
UA91848C2 (ru) 2010-09-10
NZ560749A (en) 2010-11-26
US20080176934A1 (en) 2008-07-24
EA200701820A1 (ru) 2008-02-28
AU2006219853B2 (en) 2011-06-09
FR2882654B1 (fr) 2007-04-27
JP2008531660A (ja) 2008-08-14
FR2882654A1 (fr) 2006-09-08
MA29316B1 (fr) 2008-03-03
CA2599658A1 (fr) 2006-09-08
KR100971589B1 (ko) 2010-07-20
CN101132788A (zh) 2008-02-27
BRPI0607562A2 (pt) 2009-09-15
KR20090128581A (ko) 2009-12-15
EA013078B1 (ru) 2010-02-26
KR20070110395A (ko) 2007-11-16
NO20074941L (no) 2007-10-01
AU2006219853A1 (en) 2006-09-08
AR053149A1 (es) 2007-04-25
MX2007010364A (es) 2007-09-25
WO2006092490A1 (fr) 2006-09-08

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