BR9914814A - Processo para a preparação de luteolina e derivados de luteolina - Google Patents

Processo para a preparação de luteolina e derivados de luteolina

Info

Publication number
BR9914814A
BR9914814A BR9914814-5A BR9914814A BR9914814A BR 9914814 A BR9914814 A BR 9914814A BR 9914814 A BR9914814 A BR 9914814A BR 9914814 A BR9914814 A BR 9914814A
Authority
BR
Brazil
Prior art keywords
luteolin
preparation
derivatives
compounds
poh
Prior art date
Application number
BR9914814-5A
Other languages
English (en)
Inventor
Herwig Buchholz
Ralf Rosskopf
Alice Lichtenberg
Christine Kraus
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1998150283 external-priority patent/DE19850283C2/de
Priority claimed from DE1998150572 external-priority patent/DE19850572A1/de
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BR9914814A publication Critical patent/BR9914814A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/602—Glycosides, e.g. rutin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biotechnology (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Toxicology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Pyrane Compounds (AREA)

Abstract

Patente de Invenção: <B>"PROCESSO PARA A PREPARAçãO DE LUTEOLINA E DERIVADOS DE LUTEOLINA"<D>. é divulgado um método para produzir compostos de fórmula (I), na qual R. representa H ou (CH~ 2~)~ m~OH, R² representa H ou (CH~ 2~)~ n~OH, R³ representa H ou (CH~ 2~)~ p~OH, e m, n e p representam 2 a 8, independentemente um ou outro. Os referidos compostos são particularmente adequados para uso como suplementos alimentícios. Eles são altamente adequados para uso em formulações cosméticas como filtros de UV, por exemplo.
BR9914814-5A 1998-10-30 1999-10-13 Processo para a preparação de luteolina e derivados de luteolina BR9914814A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE1998150283 DE19850283C2 (de) 1998-10-30 1998-10-30 Verfahren zur Herstellung von Luteolin und Luteolin-Derivaten, diese enthaltende Nahrungsmittel und kosmetische Formulierungen sowie Tri(hydroxyalkyl)luteoline
DE1998150572 DE19850572A1 (de) 1998-11-02 1998-11-02 Verfahren zur Herstellung von Luteolin und Luteolin-Derivaten
PCT/EP1999/007687 WO2000026206A1 (de) 1998-10-30 1999-10-13 Verfahren zur herstellung von luteolin und luteolin-derivaten

Publications (1)

Publication Number Publication Date
BR9914814A true BR9914814A (pt) 2001-07-03

Family

ID=26049878

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9914814-5A BR9914814A (pt) 1998-10-30 1999-10-13 Processo para a preparação de luteolina e derivados de luteolina

Country Status (12)

Country Link
US (1) US6538021B1 (pt)
EP (1) EP1124815B1 (pt)
JP (1) JP2002528540A (pt)
KR (1) KR100675999B1 (pt)
CN (1) CN1131224C (pt)
AT (1) ATE267822T1 (pt)
AU (1) AU1036700A (pt)
BR (1) BR9914814A (pt)
CA (1) CA2348392A1 (pt)
DE (1) DE59909616D1 (pt)
ES (1) ES2221453T3 (pt)
WO (1) WO2000026206A1 (pt)

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DE19923715A1 (de) * 1999-05-22 2000-11-23 Beiersdorf Ag Kosmetische oder dermatologische Lichtschutzzubereitungen mit einem Gehalt an Flavonderivaten und/oder Flavanonderivaten, insbesondere von Flavonoiden und s-Triazin sowie die Verwendung von UV-Filtersubstanzen, welche das Strukturmotiv des s-Triazins aufweisen, zur Stabilisierung von Flavonderivaten und/oder Flavanonderivaten, insbesondere von Flavonoiden
DE19923713A1 (de) * 1999-05-22 2000-11-23 Beiersdorf Ag Kosmetische oder dermatologische Lichtschutzzubereitungen mit einem Gehalt an Flavonderivaten und/oder Flavanonderivaten, insbesondere von Flavonoiden und Benzotriazol sowie die Verwendung von UV-Filtersubstanzen, welche das Strukturmotiv des Benzotriazols aufweisen, zur Stabilisierung von Flavonderivaten und/oder Flavanonderivaten, insbesondere von Flavonoiden
WO2001076572A2 (de) * 2000-04-12 2001-10-18 bitop Aktiengesellschaft für biotechnische Optimierung Verwendung von kompatiblen soluten als substanzen mit radikalfangenden eigenschaften
DE10031457C2 (de) * 2000-06-28 2002-12-12 Jean Krutmann Verwendung von O-beta-Hydroxyethylrutosid oder dessen Aglycon zur systemischen Behandlung und Prophylaxe von UV-induzierten Dermatosen und unerwünschten Langzeitfolgen von UV-Bestrahlungen
ES2336545T3 (es) * 2000-08-18 2010-04-14 Bitop Gesellschaft Fur Biotechnische Optimierung Mbh Empleo de fosfatos de alcoholes disacaricos para la proteccion de las celulas cutaneas humanas contra la irradiacion uv y/o ir.
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DE10232595A1 (de) * 2002-07-18 2004-02-05 Merck Patent Gmbh Lichtschutzmittel
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DE10308162A1 (de) * 2003-02-26 2004-09-09 Universitätsklinikum Freiburg Verfahren zur Herstellung von Flavonoid-haltigen Zusammensetzungen und ihre Verwendung
DE10337862A1 (de) * 2003-08-18 2005-03-17 Merck Patent Gmbh Chromen-4-on-Derivate
DE10337863A1 (de) * 2003-08-18 2005-03-17 Merck Patent Gmbh Verwendung von Chromen-4-on-Derivaten
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WO2005074959A1 (en) * 2004-02-05 2005-08-18 Access Business Group International Llc Anti-allergy composition and related method
CN1297552C (zh) * 2004-03-11 2007-01-31 南京莱尔生物化工有限公司 木犀草素的合成方法
CN100355744C (zh) * 2004-05-03 2007-12-19 深圳微芯生物科技有限责任公司 具有治疗前列腺疾病的黄酮类天然产物活性成份的分离、提取和药用制剂的制备
DE102004038728A1 (de) * 2004-08-10 2006-03-02 Merck Patent Gmbh Flavonoid-Komplexe
EP1817023A4 (en) * 2004-11-16 2010-08-18 Limerick Biopharma Inc METHOD AND COMPOSITIONS FOR PAIN TREATMENT
US20070087977A1 (en) * 2004-11-16 2007-04-19 Wendye Robbins Methods and compositions for treating pain
FR2882654B1 (fr) * 2005-03-01 2007-04-27 Servier Lab Utilisation de derives de la diosmetine pour le traitement et la prevention des pathologies thrombotiques
CN1785991B (zh) * 2005-11-09 2011-04-06 四川川大华西药业股份有限公司 一种抗炎解毒木犀草素类衍生物及其制备方法
CN103012345B (zh) * 2007-11-09 2014-11-26 中国医学科学院药物研究所 木犀草素α晶型物质、其制法和其药物组合物与用途
CN102002028B (zh) * 2010-11-03 2012-08-22 西安赛美科医药研发有限公司 一种合成木犀草素的方法
CN103819954B (zh) * 2013-11-12 2016-02-03 北京科技大学 一种聚木犀草素抗菌涂层的制备方法
CN105193782A (zh) * 2014-06-17 2015-12-30 吉林大学 木犀草素的新用途
CN106692127B (zh) * 2016-12-12 2021-01-15 东莞广州中医药大学中医药数理工程研究院 木犀草素在制备防治登革热病毒感染的药物中的应用
CN107880081B (zh) * 2017-12-22 2021-07-06 陕西嘉禾生物科技股份有限公司 一种异槲皮素的合成方法
CN108383821A (zh) * 2018-05-03 2018-08-10 云南大学 甲氧基-7-木犀草素及其制备方法和用途
CN110770218B (zh) * 2018-11-09 2022-08-05 邦泰生物工程(深圳)有限公司 一种制备木犀草素的方法
KR20220045042A (ko) 2019-08-22 2022-04-12 어드밴식스 레진즈 앤드 케미컬즈 엘엘씨 표면-활성 특성을 갖는 아미노산의 실록산 유도체
CN110467592B (zh) * 2019-09-12 2021-07-02 广东药科大学 一种木犀草素的半合成方法
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KR20220116518A (ko) 2019-12-19 2022-08-23 어드밴식스 레진즈 앤드 케미컬즈 엘엘씨 농업용 제품을 위한 계면활성제
CN115087721A (zh) 2019-12-20 2022-09-20 艾德凡斯化学公司 用于清洁产品的表面活性剂
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WO2021138086A1 (en) 2019-12-31 2021-07-08 Advansix Resins & Chemicals Llc Surfactants for oil and gas production
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Also Published As

Publication number Publication date
US6538021B1 (en) 2003-03-25
CN1325393A (zh) 2001-12-05
EP1124815A1 (de) 2001-08-22
KR100675999B1 (ko) 2007-01-29
CN1131224C (zh) 2003-12-17
ATE267822T1 (de) 2004-06-15
EP1124815B1 (de) 2004-05-26
DE59909616D1 (de) 2004-07-01
KR20010085971A (ko) 2001-09-07
WO2000026206A1 (de) 2000-05-11
CA2348392A1 (en) 2000-05-11
AU1036700A (en) 2000-05-22
JP2002528540A (ja) 2002-09-03
ES2221453T3 (es) 2004-12-16

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B15K Others concerning applications: alteration of classification

Ipc: C07D 311/30 (2008.04), A61K 7/42 (00000007), A61K

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: PARA INT. CL: C07D311/30; A61K8/49; A61K31/352; A23L1/30; A61P9/10; A61P29/00; A61P31/04; A61P31/12; A61P35/00; A61P39/06; A61P43/00

Ipc: C07D 311/30 (2010.01), A61K 8/49 (2010.01), A61K 3

B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements
B15K Others concerning applications: alteration of classification

Ipc: C07H 15/26 (2006.01), A61K 8/49 (2006.0