MX2010005356A - Derivados de indol 3-heterociclico sustituidos y metodos de uso de los mismos. - Google Patents
Derivados de indol 3-heterociclico sustituidos y metodos de uso de los mismos.Info
- Publication number
- MX2010005356A MX2010005356A MX2010005356A MX2010005356A MX2010005356A MX 2010005356 A MX2010005356 A MX 2010005356A MX 2010005356 A MX2010005356 A MX 2010005356A MX 2010005356 A MX2010005356 A MX 2010005356A MX 2010005356 A MX2010005356 A MX 2010005356A
- Authority
- MX
- Mexico
- Prior art keywords
- substituted indole
- heterocyclic substituted
- methods
- indole derivatives
- heterocyclic
- Prior art date
Links
- 150000002475 indoles Chemical class 0.000 title abstract 4
- 229940054051 antipsychotic indole derivative Drugs 0.000 title abstract 3
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000000203 mixture Chemical class 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Abstract
La presente invención se refiere a derivados de indol 3- heterocíclico sustituidos, composiciones que comprenden por lo menos un derivado de indol 3-heterocíclico sustituido, y métodos de uso de los derivados de indol 3-heterocíclico sustituidos para tratar o prevenir una infección viral o un trastorno relacionado con virus en un paciente.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US98852807P | 2007-11-16 | 2007-11-16 | |
PCT/US2008/083351 WO2009064848A1 (en) | 2007-11-16 | 2008-11-13 | 3-heterocyclic substituted indole derivatives and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2010005356A true MX2010005356A (es) | 2010-05-27 |
Family
ID=40344906
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2010005356A MX2010005356A (es) | 2007-11-16 | 2008-11-13 | Derivados de indol 3-heterociclico sustituidos y metodos de uso de los mismos. |
Country Status (7)
Country | Link |
---|---|
US (1) | US8765757B2 (es) |
EP (1) | EP2222660B1 (es) |
JP (1) | JP5249344B2 (es) |
CN (1) | CN102099351A (es) |
CA (1) | CA2705586A1 (es) |
MX (1) | MX2010005356A (es) |
WO (1) | WO2009064848A1 (es) |
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CN101821252A (zh) * | 2007-08-29 | 2010-09-01 | 先灵公司 | 取代的吲哚衍生物及其使用方法 |
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JP5249344B2 (ja) | 2007-11-16 | 2013-07-31 | メルク・シャープ・アンド・ドーム・コーポレーション | ヘテロ環の3位が置換されたインドール誘導体およびその使用 |
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BR112019025801A2 (pt) | 2017-06-08 | 2020-07-07 | Vertex Pharmaceuticals Incorporated | métodos de tratamento para fibrose cística |
AU2018304168B2 (en) | 2017-07-17 | 2023-05-04 | Vertex Pharmaceuticals Incorporated | Methods of treatment for cystic fibrosis |
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MX2020002191A (es) | 2017-08-28 | 2020-10-05 | Enanta Pharm Inc | Agentes antivirales contra la hepatitis b. |
US10988454B2 (en) * | 2017-09-14 | 2021-04-27 | Abbvie Overseas S.À.R.L. | Modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use |
WO2019079760A1 (en) | 2017-10-19 | 2019-04-25 | Vertex Pharmaceuticals Incorporated | CRYSTALLINE FORMS AND COMPOSITIONS OF CFTR MODULATORS |
US10428070B2 (en) | 2017-12-06 | 2019-10-01 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
US10723733B2 (en) | 2017-12-06 | 2020-07-28 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
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US11058678B2 (en) | 2018-01-22 | 2021-07-13 | Enanta Pharmaceuticals, Inc. | Substituted heterocycles as antiviral agents |
TWI810243B (zh) | 2018-02-05 | 2023-08-01 | 美商維泰克斯製藥公司 | 用於治療囊腫纖化症之醫藥組合物 |
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CN112028815A (zh) * | 2019-06-03 | 2020-12-04 | 中国药科大学 | 吲哚类衍生物及其医药用途 |
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US11738019B2 (en) | 2019-07-11 | 2023-08-29 | Enanta Pharmaceuticals, Inc. | Substituted heterocycles as antiviral agents |
US11236108B2 (en) | 2019-09-17 | 2022-02-01 | Enanta Pharmaceuticals, Inc. | Functionalized heterocycles as antiviral agents |
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CA2705587A1 (en) | 2007-11-16 | 2009-05-22 | Schering Corporation | 3-aminosulfonyl substituted indole derivatives and methods of use thereof |
-
2008
- 2008-11-13 JP JP2010534158A patent/JP5249344B2/ja not_active Expired - Fee Related
- 2008-11-13 EP EP08848587.5A patent/EP2222660B1/en active Active
- 2008-11-13 WO PCT/US2008/083351 patent/WO2009064848A1/en active Application Filing
- 2008-11-13 CN CN2008801249688A patent/CN102099351A/zh active Pending
- 2008-11-13 US US12/743,016 patent/US8765757B2/en active Active
- 2008-11-13 CA CA2705586A patent/CA2705586A1/en not_active Abandoned
- 2008-11-13 MX MX2010005356A patent/MX2010005356A/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JP2011503195A (ja) | 2011-01-27 |
CA2705586A1 (en) | 2009-05-22 |
JP5249344B2 (ja) | 2013-07-31 |
US8765757B2 (en) | 2014-07-01 |
WO2009064848A1 (en) | 2009-05-22 |
US20110165118A1 (en) | 2011-07-07 |
CN102099351A (zh) | 2011-06-15 |
EP2222660B1 (en) | 2014-03-26 |
EP2222660A1 (en) | 2010-09-01 |
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