MX2010002317A - Derivados de indol sustituidos y metodos para su utilizacion. - Google Patents
Derivados de indol sustituidos y metodos para su utilizacion.Info
- Publication number
- MX2010002317A MX2010002317A MX2010002317A MX2010002317A MX2010002317A MX 2010002317 A MX2010002317 A MX 2010002317A MX 2010002317 A MX2010002317 A MX 2010002317A MX 2010002317 A MX2010002317 A MX 2010002317A MX 2010002317 A MX2010002317 A MX 2010002317A
- Authority
- MX
- Mexico
- Prior art keywords
- substituted indole
- methods
- indole derivatives
- derivatives
- substituted
- Prior art date
Links
- 150000002475 indoles Chemical class 0.000 title abstract 4
- 229940054051 antipsychotic indole derivative Drugs 0.000 title abstract 3
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000000203 mixture Chemical class 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
La presente invención se refiere a derivados de indol sustituidos, composiciones que comprenden por lo menos un derivado de indol sustituido, y métodos para utilizar los derivados de indol sustituidos para tratar o prevenir una infección viral o un trastorno relacionado con un virus en un paciente.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US96869807P | 2007-08-29 | 2007-08-29 | |
PCT/US2008/010148 WO2009032124A1 (en) | 2007-08-29 | 2008-08-27 | Substituted indole derivatives and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2010002317A true MX2010002317A (es) | 2010-03-22 |
Family
ID=39968138
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2010002317A MX2010002317A (es) | 2007-08-29 | 2008-08-27 | Derivados de indol sustituidos y metodos para su utilizacion. |
Country Status (17)
Country | Link |
---|---|
US (1) | US8614229B2 (es) |
EP (1) | EP2408761B1 (es) |
JP (2) | JP5272008B2 (es) |
KR (1) | KR20100067652A (es) |
CN (1) | CN101821252A (es) |
AR (1) | AR068106A1 (es) |
AU (1) | AU2008295484B2 (es) |
BR (1) | BRPI0815811A2 (es) |
CA (1) | CA2697454C (es) |
CL (1) | CL2008002539A1 (es) |
EC (1) | ECSP10010004A (es) |
ES (1) | ES2447543T3 (es) |
MX (1) | MX2010002317A (es) |
PE (1) | PE20090630A1 (es) |
RU (1) | RU2010111551A (es) |
TW (1) | TW200924780A (es) |
WO (1) | WO2009032124A1 (es) |
Families Citing this family (41)
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US20110104109A1 (en) * | 2005-07-13 | 2011-05-05 | Frank Bennett | Tetracyclic indole derivatives and their use for treating or preventing viral infections |
CN101631773A (zh) | 2006-12-22 | 2010-01-20 | 先灵公司 | 治疗或预防hcv和相关病毒感染的4,5-环化吲哚衍生物 |
AU2007339386B8 (en) | 2006-12-22 | 2013-12-05 | Merck Sharp & Dohme Corp. | 4, 5-ring annulated indole derivatives for treating or preventing of HCV and related viral infections |
WO2008136815A2 (en) | 2006-12-22 | 2008-11-13 | Schering Corporation | 5, 6-ring annulated indole derivatives and use thereof |
TW200911807A (en) * | 2007-08-29 | 2009-03-16 | Schering Corp | 2,3-substituted azaindole derivatives and methods of use thereof |
CN101821252A (zh) | 2007-08-29 | 2010-09-01 | 先灵公司 | 取代的吲哚衍生物及其使用方法 |
JP5249344B2 (ja) * | 2007-11-16 | 2013-07-31 | メルク・シャープ・アンド・ドーム・コーポレーション | ヘテロ環の3位が置換されたインドール誘導体およびその使用 |
CA2705587A1 (en) * | 2007-11-16 | 2009-05-22 | Schering Corporation | 3-aminosulfonyl substituted indole derivatives and methods of use thereof |
EP2303893B1 (en) * | 2008-06-13 | 2016-12-07 | Merck Sharp & Dohme Corp. | Tricyclic indole derivatives |
WO2010138791A1 (en) | 2009-05-29 | 2010-12-02 | Schering Corporation | Antiviral compounds composed of three linked aryl moieties to treat diseases such as hepatitis c |
EP2491033A4 (en) * | 2009-10-20 | 2013-03-13 | Eiger Biopharmaceuticals Inc | AZAINDAZOLES FOR THE TREATMENT OF FLAVIVIRIDAE VIRUS INFECTION |
WO2011061243A1 (en) * | 2009-11-21 | 2011-05-26 | F. Hoffmann-La Roche Ag | Heterocyclic antiviral compounds |
US20120276047A1 (en) | 2009-11-25 | 2012-11-01 | Rosenblum Stuart B | Fused tricyclic compounds and derivatives thereof useful for the treatment of viral diseases |
US20130156731A1 (en) | 2009-12-22 | 2013-06-20 | Kevin X. Chen | Fused tricyclic compounds and methods of use thereof for the treatment of viral diseas |
PE20130062A1 (es) | 2010-03-09 | 2013-02-28 | Merck Sharp & Dohme | Compuestos de sililo triciclicos fusionados para el tratamiento de enfermedades virales |
RU2572558C2 (ru) * | 2010-07-07 | 2016-01-20 | Ф. Хоффманн-Ля Рош Аг | Противовирусные гетероциклические соединения |
CA2805440A1 (en) | 2010-07-26 | 2012-02-09 | Merck Sharp & Dohme Corp. | Substituted biphenylene compounds and methods of use thereof for the treatment of viral diseases |
WO2012050848A1 (en) | 2010-09-29 | 2012-04-19 | Schering Corporation | Fused tetracycle derivatives and methods of use thereof for the treatment of viral diseases |
CN103269586B (zh) | 2010-10-26 | 2015-07-15 | 普雷西迪奥制药公司 | 丙型肝炎病毒抑制剂 |
MX2013006467A (es) | 2010-12-09 | 2013-10-01 | Amgen Inc | Compuestos biciclicos como inhibidores pim. |
JP2014510105A (ja) | 2011-03-22 | 2014-04-24 | アムジエン・インコーポレーテツド | Pim阻害剤としてのアゾール化合物 |
JP2014515023A (ja) | 2011-04-13 | 2014-06-26 | メルク・シャープ・アンド・ドーム・コーポレーション | 2’−置換ヌクレオシド誘導体およびウイルス疾患の処置のためのその使用方法 |
EP2697242B1 (en) | 2011-04-13 | 2018-10-03 | Merck Sharp & Dohme Corp. | 2'-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
WO2013033901A1 (en) | 2011-09-08 | 2013-03-14 | Merck Sharp & Dohme Corp. | Heterocyclic-substituted benzofuran derivatives and methods of use thereof for the treatment of viral diseases |
WO2013033899A1 (en) | 2011-09-08 | 2013-03-14 | Merck Sharp & Dohme Corp. | Substituted benzofuran compounds and methods of use thereof for the treatment of viral diseases |
WO2013033900A1 (en) | 2011-09-08 | 2013-03-14 | Merck Sharp & Dohme Corp. | Tetracyclic heterocycle compounds and methods of use thereof for the treatment of viral diseases |
WO2013039876A1 (en) | 2011-09-14 | 2013-03-21 | Merck Sharp & Dohme Corp. | Silyl-containing heterocyclic compounds and methods of use thereof for the treatment of viral diseases |
US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
WO2014059902A1 (en) | 2012-10-17 | 2014-04-24 | Merck Sharp & Dohme Corp. | 2'-disubstituted substituted nucleoside derivatives and methods of use thereof for treatment of viral diseases |
US9242988B2 (en) | 2012-10-17 | 2016-01-26 | Merck Sharp & Dohme Corp. | 2′-cyano substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
AR092959A1 (es) | 2012-10-17 | 2015-05-06 | Merck Sharp & Dohme | Derivados de nucleosidos 2-metil sustituidos y metodos de uso de los mismos para el tratamiento de enfermedades virales |
JP2016501200A (ja) | 2012-11-19 | 2016-01-18 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | ウイルス性疾患を処置するための2−アルキニル置換ヌクレオシド誘導体 |
US9394285B2 (en) | 2013-03-15 | 2016-07-19 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
US9765107B2 (en) | 2013-06-18 | 2017-09-19 | Merck Sharp & Dohme Corp. | Cyclic phosphonate substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
WO2014205592A1 (en) | 2013-06-24 | 2014-12-31 | Merck Sharp & Dohme Corp. | Heterocyclic compounds and methods of use thereof for treatment of hepatitis c |
WO2014205593A1 (en) | 2013-06-24 | 2014-12-31 | Merck Sharp & Dohme Corp. | Substituted benzofuran compounds and methods of use thereof for treatment of viral diseases |
US10167298B2 (en) | 2013-10-30 | 2019-01-01 | Merck Sharp & Dohme Corp. | Pseudopolymorphs of an HCV NS5A inhibitor and uses thereof |
EP3313836B1 (en) | 2015-06-26 | 2020-11-11 | Takeda Pharmaceutical Company Limited | 2,3-dihydro-4h-1,3-benzoxazin-4-one derivatives as modulators of cholinergic muscarinic m1 receptor |
US10548899B2 (en) | 2015-10-20 | 2020-02-04 | Takeda Pharmaceutical Company Limited | Quinazolinone and benzotriazinone compounds with cholinergic muscarinin M1 receptor positive allosteric modulator activity |
EP3471737A4 (en) | 2016-06-20 | 2019-12-25 | Merck Sharp & Dohme Corp. | CYCLIC PHOSPHONATE-SUBSTITUTED NUCLEOSIDE COMPOUND AND METHOD FOR USE THEREOF FOR TREATING VIRUS DISEASES |
US20220281824A1 (en) * | 2019-07-30 | 2022-09-08 | Oregon State University | Aryl hydrocarbon receptor activators |
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CN101631773A (zh) * | 2006-12-22 | 2010-01-20 | 先灵公司 | 治疗或预防hcv和相关病毒感染的4,5-环化吲哚衍生物 |
WO2008136815A2 (en) * | 2006-12-22 | 2008-11-13 | Schering Corporation | 5, 6-ring annulated indole derivatives and use thereof |
AU2007339386B8 (en) * | 2006-12-22 | 2013-12-05 | Merck Sharp & Dohme Corp. | 4, 5-ring annulated indole derivatives for treating or preventing of HCV and related viral infections |
CN101821252A (zh) | 2007-08-29 | 2010-09-01 | 先灵公司 | 取代的吲哚衍生物及其使用方法 |
TW200911807A (en) * | 2007-08-29 | 2009-03-16 | Schering Corp | 2,3-substituted azaindole derivatives and methods of use thereof |
BRPI0816116A2 (pt) * | 2007-08-29 | 2015-03-03 | Schering Corp | Derivados de indol 2,3-substituídos para o tratamento de infecções virais. |
JP4737166B2 (ja) | 2007-09-07 | 2011-07-27 | 株式会社デンソー | 目詰まり検出装置 |
JP5249344B2 (ja) * | 2007-11-16 | 2013-07-31 | メルク・シャープ・アンド・ドーム・コーポレーション | ヘテロ環の3位が置換されたインドール誘導体およびその使用 |
CA2705587A1 (en) * | 2007-11-16 | 2009-05-22 | Schering Corporation | 3-aminosulfonyl substituted indole derivatives and methods of use thereof |
-
2008
- 2008-08-27 CN CN200880110744A patent/CN101821252A/zh active Pending
- 2008-08-27 PE PE2008001453A patent/PE20090630A1/es not_active Application Discontinuation
- 2008-08-27 BR BRPI0815811-8A2A patent/BRPI0815811A2/pt not_active Application Discontinuation
- 2008-08-27 AR ARP080103715A patent/AR068106A1/es not_active Application Discontinuation
- 2008-08-27 KR KR1020107006433A patent/KR20100067652A/ko not_active Application Discontinuation
- 2008-08-27 CA CA2697454A patent/CA2697454C/en active Active
- 2008-08-27 WO PCT/US2008/010148 patent/WO2009032124A1/en active Application Filing
- 2008-08-27 MX MX2010002317A patent/MX2010002317A/es not_active Application Discontinuation
- 2008-08-27 US US12/675,891 patent/US8614229B2/en active Active
- 2008-08-27 ES ES08795629.8T patent/ES2447543T3/es active Active
- 2008-08-27 RU RU2010111551/04A patent/RU2010111551A/ru unknown
- 2008-08-27 JP JP2010522934A patent/JP5272008B2/ja not_active Expired - Fee Related
- 2008-08-27 AU AU2008295484A patent/AU2008295484B2/en not_active Ceased
- 2008-08-27 EP EP08795629.8A patent/EP2408761B1/en active Active
- 2008-08-27 TW TW097132796A patent/TW200924780A/zh unknown
- 2008-08-28 CL CL2008002539A patent/CL2008002539A1/es unknown
-
2010
- 2010-02-26 EC EC2010010004A patent/ECSP10010004A/es unknown
-
2013
- 2013-03-05 JP JP2013042524A patent/JP2013100375A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
AR068106A1 (es) | 2009-11-04 |
AU2008295484B2 (en) | 2013-09-26 |
JP2010537981A (ja) | 2010-12-09 |
KR20100067652A (ko) | 2010-06-21 |
TW200924780A (en) | 2009-06-16 |
BRPI0815811A2 (pt) | 2015-02-18 |
JP5272008B2 (ja) | 2013-08-28 |
CA2697454C (en) | 2015-11-03 |
CN101821252A (zh) | 2010-09-01 |
CL2008002539A1 (es) | 2009-07-17 |
JP2013100375A (ja) | 2013-05-23 |
CA2697454A1 (en) | 2009-03-12 |
US8614229B2 (en) | 2013-12-24 |
EP2408761A1 (en) | 2012-01-25 |
RU2010111551A (ru) | 2011-10-10 |
ES2447543T3 (es) | 2014-03-12 |
PE20090630A1 (es) | 2009-05-16 |
EP2408761B1 (en) | 2014-01-01 |
WO2009032124A1 (en) | 2009-03-12 |
US20110104110A1 (en) | 2011-05-05 |
AU2008295484A1 (en) | 2009-03-12 |
ECSP10010004A (es) | 2010-03-31 |
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