ATE378328T1 - Pyrrolo-indol- und pyrrolo-chinolin-derivate als prodrugs zur tumorbehandlung - Google Patents
Pyrrolo-indol- und pyrrolo-chinolin-derivate als prodrugs zur tumorbehandlungInfo
- Publication number
- ATE378328T1 ATE378328T1 AT02712114T AT02712114T ATE378328T1 AT E378328 T1 ATE378328 T1 AT E378328T1 AT 02712114 T AT02712114 T AT 02712114T AT 02712114 T AT02712114 T AT 02712114T AT E378328 T1 ATE378328 T1 AT E378328T1
- Authority
- AT
- Austria
- Prior art keywords
- pyrrolo
- prodrugs
- indole
- tumor treatment
- quinoline derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01301636 | 2001-02-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE378328T1 true ATE378328T1 (de) | 2007-11-15 |
Family
ID=8181737
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02712114T ATE378328T1 (de) | 2001-02-22 | 2002-02-22 | Pyrrolo-indol- und pyrrolo-chinolin-derivate als prodrugs zur tumorbehandlung |
Country Status (7)
Country | Link |
---|---|
US (1) | US7626026B2 (de) |
EP (1) | EP1409480B1 (de) |
JP (1) | JP2004529887A (de) |
AT (1) | ATE378328T1 (de) |
DE (1) | DE60223544T2 (de) |
ES (1) | ES2299560T3 (de) |
WO (1) | WO2002068412A1 (de) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1408960B1 (de) * | 2001-02-22 | 2006-05-31 | School Of Pharmacy, University Of London | Benz-indol- und benzo-chinolin-derivate als prodrugs zur tumorbehandlung |
GB0302094D0 (en) | 2003-01-29 | 2003-02-26 | Pharmagene Lab Ltd | EP4 receptor antagonists |
GB0324269D0 (en) | 2003-10-16 | 2003-11-19 | Pharmagene Lab Ltd | EP4 receptor antagonists |
GB0505644D0 (en) | 2005-03-18 | 2005-04-27 | Univ London Pharmacy | Analogues of the azinomycins as anti-tumour agents and as prodrugs |
CA2674831A1 (en) | 2006-12-22 | 2008-11-13 | Schering Corporation | 5,6-ring annulated indole derivatives and methods of use thereof |
US8546420B2 (en) * | 2006-12-22 | 2013-10-01 | Merck Sharp & Dohme Corp. | 4, 5-ring annulated indole derivatives for treating or preventing of HCV and related viral infections |
US8557848B2 (en) * | 2006-12-22 | 2013-10-15 | Merck Sharp & Dohme Corp. | 4,5-ring annulated indole derivatives for treating or preventing of HCV and related viral infections |
US9901567B2 (en) | 2007-08-01 | 2018-02-27 | Syntarga B.V. | Substituted CC-1065 analogs and their conjugates |
WO2009032125A1 (en) | 2007-08-29 | 2009-03-12 | Schering Corporation | 2,3-substituted azaindole derivatives for treating viral infections |
KR20100049667A (ko) | 2007-08-29 | 2010-05-12 | 쉐링 코포레이션 | 바이러스 감염 치료용 2,3-치환된 인돌 유도체 |
BRPI0815811A2 (pt) | 2007-08-29 | 2015-02-18 | Schering Corp | Derivados de indol substituído e métodos de uso dos mesmos |
WO2009064852A1 (en) | 2007-11-16 | 2009-05-22 | Schering Corporation | 3-aminosulfonyl substituted indole derivatives and methods of use thereof |
CA2705586A1 (en) | 2007-11-16 | 2009-05-22 | Schering Corporation | 3-heterocyclic substituted indole derivatives and methods of use thereof |
AR072088A1 (es) | 2008-06-13 | 2010-08-04 | Schering Corp | Derivados de indol triciclicos y sus metodos de uso |
ES2647317T3 (es) | 2008-11-03 | 2017-12-20 | Syntarga B.V. | Análogos de CC-1065 y sus conjugados |
EP3108886B1 (de) | 2010-04-21 | 2020-06-17 | Syntarga B.V. | Konjugate von cc-1065 analogen und bifunktionelle linker |
US8496218B2 (en) * | 2011-06-08 | 2013-07-30 | Alcon Research, Ltd. | Display monitor guide |
DK3092010T3 (en) | 2014-01-10 | 2018-08-27 | Synthon Biopharmaceuticals Bv | Process for purification of Cys-linked antibody-drug conjugates |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4413132A (en) | 1980-11-18 | 1983-11-01 | The Upjohn Company | Antibiotic CC-1065 indoline intermediates |
GB2190724B (en) | 1986-04-16 | 1990-08-08 | Courtaulds Plc | Composite element |
FI85403C (fi) | 1989-12-22 | 1992-04-10 | Neste Oy | Foerfarande foer framstaellning av en plastkompositbalk eller -pelare med staolfoerstaerkningen. |
ES2149768T3 (es) | 1992-03-25 | 2000-11-16 | Immunogen Inc | Conjugados de agentes enlazantes de celulas derivados de cc-1065. |
FR2700805B1 (fr) | 1993-01-27 | 1995-04-07 | Ind Entreprise | Procédé de renforcement d'une poutre détériorée, et poutre ainsi obtenue. |
US5448869A (en) | 1994-02-17 | 1995-09-12 | Marvin Lumber And Cedar Co. | Composite framing member and window or door assembly incorporating a composite framing member |
US5720143A (en) | 1994-03-01 | 1998-02-24 | The United States Of America As Represented By The Secretary Of Agriculture | Localized notch reinforcement for wooden beams |
US5501054A (en) | 1994-03-01 | 1996-03-26 | The United States Of America As Represented By The Secretary Of Agriculture | Bolted wood connections |
US5679432A (en) | 1994-05-09 | 1997-10-21 | Benchmark Foam, Inc. | Multi-layer laminate structure |
US5688426A (en) | 1995-06-07 | 1997-11-18 | The Boeing Company | Hybrid metal webbed composite beam |
US5657595A (en) | 1995-06-29 | 1997-08-19 | Hexcel-Fyfe Co., L.L.C. | Fabric reinforced beam and column connections |
GB9519490D0 (en) | 1995-09-25 | 1995-11-29 | Melvin William T | Use of a cytochrome P450 enzyme in tumour cells as a marker and target |
JP2000506168A (ja) | 1996-03-08 | 2000-05-23 | ザ スクリップス リサーチ インスティテュート | Cc―1065及びデュオカマイシンのmcbi類似体 |
US5843937A (en) | 1996-05-23 | 1998-12-01 | Panorama Research, Inc. | DNA-binding indole derivatives, their prodrugs and immunoconjugates as anticancer agents |
US6060608A (en) | 1996-05-31 | 2000-05-09 | The Scripps Research Institute | Analogs of CC-1065 and the duocarmycins |
US5794402A (en) | 1996-09-30 | 1998-08-18 | Martin Marietta Materials, Inc. | Modular polymer matrix composite support structure and methods of constructing same |
AU754083B2 (en) * | 1997-05-22 | 2002-11-07 | Scripps Research Institute, The | Analogs of duocarmycin and CC-1065 |
ES2226332T3 (es) | 1998-02-06 | 2005-03-16 | De Montfort University | Profarmacos activados mediante hidroxilacion. |
-
2002
- 2002-02-22 WO PCT/GB2002/000796 patent/WO2002068412A1/en active IP Right Grant
- 2002-02-22 JP JP2002567925A patent/JP2004529887A/ja active Pending
- 2002-02-22 AT AT02712114T patent/ATE378328T1/de not_active IP Right Cessation
- 2002-02-22 ES ES02712114T patent/ES2299560T3/es not_active Expired - Lifetime
- 2002-02-22 US US10/468,741 patent/US7626026B2/en not_active Expired - Fee Related
- 2002-02-22 DE DE60223544T patent/DE60223544T2/de not_active Expired - Lifetime
- 2002-02-22 EP EP02712114A patent/EP1409480B1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE60223544D1 (de) | 2007-12-27 |
ES2299560T3 (es) | 2008-06-01 |
US20040157873A1 (en) | 2004-08-12 |
DE60223544T2 (de) | 2008-09-25 |
JP2004529887A (ja) | 2004-09-30 |
EP1409480A1 (de) | 2004-04-21 |
WO2002068412A1 (en) | 2002-09-06 |
US7626026B2 (en) | 2009-12-01 |
EP1409480B1 (de) | 2007-11-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |