PE20080992A1 - Quinoxalinil macrociclicos inhibidores de serina proteasa del virus de la hepatitis c - Google Patents
Quinoxalinil macrociclicos inhibidores de serina proteasa del virus de la hepatitis cInfo
- Publication number
- PE20080992A1 PE20080992A1 PE2007000815A PE2007000815A PE20080992A1 PE 20080992 A1 PE20080992 A1 PE 20080992A1 PE 2007000815 A PE2007000815 A PE 2007000815A PE 2007000815 A PE2007000815 A PE 2007000815A PE 20080992 A1 PE20080992 A1 PE 20080992A1
- Authority
- PE
- Peru
- Prior art keywords
- heteroaryl
- aryl
- hepatitis
- virus
- serine protease
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
- C07D245/04—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/215—IFN-beta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
SE REFIERE A COMPUESTOS QUINOXALINIL MACROCICLICOS DE FORMULA (I), EN DONDE A ES H, -(C=O)-O-R1, -(C=O)-R2, -(C=O)-NH-R2, -S(O)2R1-, -S(O)2NHR2; R1 ES ARILO, HETEROARILO, ALQUILO(C1-C8), ENTRE OTROS; G ES -NHS(O)2-R3 O -NH(SO2)NR4R5; CADA R3 ES ARILO, HETEROARILO, ALQUILO, ALQUENILO(C1-C8), ENTRE OTROS; L ES -CH2-, -O-, -S- o -S(O)2-; X E Y TOMADOS JUNTO CON LOS CARBONO A LOS CUALES ESTAN UNIDOS FORMAN: ARILO, HETEROARILO, OPCIONALMENTE SUSTITUIDOS; W ESTA AUSENTE O ES -O-,-S-,-NH-, ALQUILENO(2-C4), ENTRE OTROS; Z ES H, -CN, -N3, HETEROARILO, ARILO, OPCIONALMENTE SUSTITUIDOS ENTRE OTROS; j ES DE 0 A 4; k ES DE 1 A 3; m ES DE 0 A 2. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y UN PROCESO DE PREPARACION. ESTOS COMPUESTOS SON INHIBIDORES DE LA ACTIVIDAD DE SERINA PROTEASA, EN PARTICULAR LA PROTEASA NS3-NS4A DEL VIRUS DE LA HEPATITIS C (HCV), SIENDO UTILES EN EL TRATAMIENTO DE UNA INFECCION POR HCV
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87244206P | 2006-06-26 | 2006-06-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20080992A1 true PE20080992A1 (es) | 2008-08-06 |
Family
ID=38846474
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2007000815A PE20080992A1 (es) | 2006-06-26 | 2007-06-25 | Quinoxalinil macrociclicos inhibidores de serina proteasa del virus de la hepatitis c |
Country Status (18)
Country | Link |
---|---|
US (2) | US8501681B2 (es) |
EP (1) | EP2066326A4 (es) |
JP (1) | JP5520046B2 (es) |
KR (1) | KR101505056B1 (es) |
CN (1) | CN101478970B (es) |
AR (1) | AR061629A1 (es) |
AU (1) | AU2007265157B2 (es) |
BR (1) | BRPI0714074A2 (es) |
CA (1) | CA2654945C (es) |
IL (1) | IL195512A (es) |
MX (1) | MX2008016528A (es) |
NZ (1) | NZ573275A (es) |
PE (1) | PE20080992A1 (es) |
RU (1) | RU2475494C2 (es) |
TW (1) | TWI454264B (es) |
UY (1) | UY30437A1 (es) |
WO (1) | WO2008002924A2 (es) |
ZA (1) | ZA200810519B (es) |
Families Citing this family (51)
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JP2003007697A (ja) * | 2001-06-21 | 2003-01-10 | Hitachi Kokusai Electric Inc | 半導体装置の製造方法、基板処理方法および基板処理装置 |
MY140680A (en) | 2002-05-20 | 2010-01-15 | Bristol Myers Squibb Co | Hepatitis c virus inhibitors |
AU2006276246B2 (en) | 2005-07-25 | 2012-09-27 | Intermune, Inc. | Novel macrocyclic inhibitors of hepatitis C virus replication |
UA93990C2 (ru) | 2005-10-11 | 2011-03-25 | Интермюн, Инк. | Соединения и способ ингибирования репликации вируса гепатита c |
KR20090024834A (ko) | 2006-07-05 | 2009-03-09 | 인터뮨, 인크. | C형 간염 바이러스 복제의 신규 억제제 |
JP5268927B2 (ja) | 2006-10-27 | 2013-08-21 | メルク・シャープ・アンド・ドーム・コーポレーション | Hcvns3プロテアーゼ阻害剤 |
EA200971041A1 (ru) | 2007-05-10 | 2010-08-30 | Интермьюн, Инк. | Новые пептидные ингибиторы репликации вируса гепатита с |
US20090005387A1 (en) * | 2007-06-26 | 2009-01-01 | Deqiang Niu | Quinoxalinyl macrocyclic hepatitis c virus serine protease inhibitors |
WO2009005690A2 (en) * | 2007-06-29 | 2009-01-08 | Gilead Sciences, Inc. | Antiviral compounds |
CL2008003384A1 (es) | 2007-11-14 | 2009-12-11 | Enanta Pharm Inc | Compuestos derivados de quinoxalina macrocíclica, inhibidores de serina proteasa; composicion farmaceutica que los comprende; y su uso en el tratamiento de la hepatitis c. |
US8962551B2 (en) | 2007-12-05 | 2015-02-24 | Enanta Pharmaceuticals, Inc. | Quinoxalinyl derivatives |
WO2009073713A1 (en) * | 2007-12-05 | 2009-06-11 | Enanta Pharmaceuticals, Inc. | Oximyl macrocyclic derivatives |
EP2224920A4 (en) * | 2007-12-06 | 2012-05-09 | Enanta Pharm Inc | PROCESS FOR THE PREPARATION OF MACROCYCLIC OXIMYL HEPATITIS C PROTEASE INHIBITORS |
CN102036966A (zh) * | 2008-01-24 | 2011-04-27 | 益安药业 | 作为hcv丝氨酸蛋白酶抑制剂的二氟化三肽 |
US8003659B2 (en) | 2008-02-04 | 2011-08-23 | Indenix Pharmaceuticals, Inc. | Macrocyclic serine protease inhibitors |
CA2705300A1 (fr) * | 2008-02-15 | 2009-06-04 | Xeda International | Macrocyclic inhibitors of hepatitis c protease |
US8372802B2 (en) * | 2008-03-20 | 2013-02-12 | Enanta Pharmaceuticals, Inc. | Fluorinated macrocyclic compounds as hepatitis C virus inhibitors |
KR20110005869A (ko) | 2008-04-15 | 2011-01-19 | 인터뮨, 인크. | C형 간염 바이러스 복제의 신규한 마크로사이클릭 억제제 |
ES2491090T3 (es) | 2008-07-22 | 2014-09-05 | Merck Sharp & Dohme Corp. | Combinaciones de un compuesto de quinoxalina macrocíclica que es un inhibidor de la proteasa NS3 del VHC con otros agentes del VHC |
US8207341B2 (en) | 2008-09-04 | 2012-06-26 | Bristol-Myers Squibb Company | Process or synthesizing substituted isoquinolines |
UY32099A (es) * | 2008-09-11 | 2010-04-30 | Enanta Pharm Inc | Inhibidores macrocíclicos de serina proteasas de hepatitis c |
AR075584A1 (es) | 2009-02-27 | 2011-04-20 | Intermune Inc | COMPOSICIONES TERAPEUTICAS QUE COMPRENDEN beta-D-2'-DESOXI-2'-FLUORO-2'-C-METILCITIDINA Y UN DERIVADO DE ACIDO ISOINDOL CARBOXILICO Y SUS USOS. COMPUESTO. |
TW201040181A (en) | 2009-04-08 | 2010-11-16 | Idenix Pharmaceuticals Inc | Macrocyclic serine protease inhibitors |
US8936781B2 (en) | 2009-05-13 | 2015-01-20 | Enanta Pharmaceuticals, Inc. | Macrocyclic compounds as hepatitis C virus inhibitors |
US8232246B2 (en) * | 2009-06-30 | 2012-07-31 | Abbott Laboratories | Anti-viral compounds |
WO2011017389A1 (en) | 2009-08-05 | 2011-02-10 | Idenix Pharmaceuticals, Inc. | Macrocyclic serine protease inhibitors useful against viral infections, particularly hcv |
HUE030402T2 (en) * | 2009-09-15 | 2017-05-29 | Taigen Biotechnology Co Ltd | HCV protease inhibitors |
WO2011049908A2 (en) * | 2009-10-19 | 2011-04-28 | Enanta Pharmaceuticals, Inc. | Bismacrokyclic compounds as hepatitis c virus inhibitors |
JP2013511562A (ja) * | 2009-11-24 | 2013-04-04 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | C型肝炎阻害化合物 |
MY156888A (en) * | 2010-03-10 | 2016-04-15 | Abbvie Bahamas Ltd | Solid Compositions |
WO2011150156A2 (en) * | 2010-05-26 | 2011-12-01 | Sunovion Pharmaceuticals Inc. | Heteroaryl compounds and methods of use thereof |
CN103025736B (zh) * | 2010-06-07 | 2016-07-06 | Abbvie公司 | 大环的丙型肝炎丝氨酸蛋白酶抑制剂 |
NZ608720A (en) | 2010-09-21 | 2015-03-27 | Enanta Pharm Inc | Macrocyclic proline derived hcv serine protease inhibitors |
US20120101032A1 (en) * | 2010-10-22 | 2012-04-26 | Intermune, Inc. | Novel macrocyclic inhibitors of hepatitis c virus replication |
CN103534256B (zh) * | 2010-12-30 | 2016-08-10 | 益安药业 | 大环丙型肝炎丝氨酸蛋白酶抑制剂 |
JP2014506255A (ja) * | 2010-12-30 | 2014-03-13 | エナンタ ファーマシューティカルズ インコーポレイテッド | フェナントリジン大環状c型肝炎セリンプロテアーゼ阻害剤 |
US9353100B2 (en) | 2011-02-10 | 2016-05-31 | Idenix Pharmaceuticals Llc | Macrocyclic serine protease inhibitors, pharmaceutical compositions thereof, and their use for treating HCV infections |
US8957203B2 (en) | 2011-05-05 | 2015-02-17 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
US8691757B2 (en) | 2011-06-15 | 2014-04-08 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
CN104136453B (zh) | 2012-01-11 | 2018-01-12 | 艾伯维公司 | 用于制备hcv蛋白酶抑制剂的方法 |
AU2013329514A1 (en) | 2012-10-08 | 2015-04-30 | Abbvie Inc. | Compounds useful for making HCV protease inhibitors |
ES2613766T3 (es) | 2012-10-19 | 2017-05-25 | Bristol-Myers Squibb Company | Derivados de carbamato de hexadecahidrociclopropa(e)pirrolo(1,2-a)(1,4)diazaciclopentadecinilo sustituidos con 9-metilo como inhibidores de la proteasa no estructural 3 (NS3) para el tratamiento de infecciones del virus de la hepatitis C |
EP2914598B1 (en) | 2012-11-02 | 2017-10-18 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
US9643999B2 (en) | 2012-11-02 | 2017-05-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US9598433B2 (en) | 2012-11-02 | 2017-03-21 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US9409943B2 (en) | 2012-11-05 | 2016-08-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
JP6342922B2 (ja) | 2013-03-07 | 2018-06-13 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | C型肝炎ウイルス阻害剤 |
US11484534B2 (en) | 2013-03-14 | 2022-11-01 | Abbvie Inc. | Methods for treating HCV |
EP3089757A1 (en) | 2014-01-03 | 2016-11-09 | AbbVie Inc. | Solid antiviral dosage forms |
CN111689951A (zh) * | 2020-06-11 | 2020-09-22 | 西北师范大学 | 一种1-苄基-3-烷基喹喔啉-2(1h)-酮的合成方法 |
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US6323180B1 (en) * | 1998-08-10 | 2001-11-27 | Boehringer Ingelheim (Canada) Ltd | Hepatitis C inhibitor tri-peptides |
UA74546C2 (en) * | 1999-04-06 | 2006-01-16 | Boehringer Ingelheim Ca Ltd | Macrocyclic peptides having activity relative to hepatitis c virus, a pharmaceutical composition and use of the pharmaceutical composition |
US6608027B1 (en) | 1999-04-06 | 2003-08-19 | Boehringer Ingelheim (Canada) Ltd | Macrocyclic peptides active against the hepatitis C virus |
JP4352594B2 (ja) * | 2000-03-15 | 2009-10-28 | 三菱マテリアル株式会社 | 酸化物イオン伝導体及びその製造方法並びにこれを用いた燃料電池 |
MY140680A (en) * | 2002-05-20 | 2010-01-15 | Bristol Myers Squibb Co | Hepatitis c virus inhibitors |
US20050075279A1 (en) | 2002-10-25 | 2005-04-07 | Boehringer Ingelheim International Gmbh | Macrocyclic peptides active against the hepatitis C virus |
EP1590442A4 (en) * | 2003-02-07 | 2007-07-18 | Enanta Pharm Inc | MACROCYCLIC HEPATITIS C SERIN PROTEASE INHIBITORS |
WO2004094452A2 (en) | 2003-04-16 | 2004-11-04 | Bristol-Myers Squibb Company | Macrocyclic isoquinoline peptide inhibitors of hepatitis c virus |
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US7176208B2 (en) | 2003-04-18 | 2007-02-13 | Enanta Pharmaceuticals, Inc. | Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors |
PE20050431A1 (es) * | 2003-09-22 | 2005-07-19 | Boehringer Ingelheim Int | Peptidos macrociclicos activos contra el virus de la hepatitis c |
JP4525982B2 (ja) * | 2003-09-26 | 2010-08-18 | シェーリング コーポレイション | C型肝炎ウイルスのns3セリンプロテアーゼの大環状インヒビター |
US7132504B2 (en) | 2003-11-12 | 2006-11-07 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
JP2007532479A (ja) * | 2003-11-20 | 2007-11-15 | シェーリング コーポレイション | C型肝炎ウイルスns3プロテアーゼの脱ペプチド化インヒビター |
CA2549167A1 (en) * | 2003-12-11 | 2005-06-30 | Schering Corporation | Inhibitors of hepatitis c virus ns3/ns4a serine protease |
DE602005025855D1 (de) | 2004-01-21 | 2011-02-24 | Boehringer Ingelheim Pharma | Makrocyclische peptide mit wirkung gegen das hepatitis-c-virus |
CN101273038A (zh) | 2005-07-29 | 2008-09-24 | 美迪维尔公司 | 丙型肝炎病毒的大环化合物抑制剂 |
US7741281B2 (en) | 2005-11-03 | 2010-06-22 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
-
2007
- 2007-06-25 UY UY30437A patent/UY30437A1/es not_active Application Discontinuation
- 2007-06-25 AR ARP070102807A patent/AR061629A1/es unknown
- 2007-06-25 TW TW096122888A patent/TWI454264B/zh not_active IP Right Cessation
- 2007-06-25 PE PE2007000815A patent/PE20080992A1/es active IP Right Grant
- 2007-06-26 RU RU2009102252/04A patent/RU2475494C2/ru active
- 2007-06-26 EP EP07784548A patent/EP2066326A4/en not_active Withdrawn
- 2007-06-26 CN CN200780024107.8A patent/CN101478970B/zh active Active
- 2007-06-26 AU AU2007265157A patent/AU2007265157B2/en active Active
- 2007-06-26 US US11/768,712 patent/US8501681B2/en not_active Expired - Fee Related
- 2007-06-26 MX MX2008016528A patent/MX2008016528A/es active IP Right Grant
- 2007-06-26 BR BRPI0714074-6A patent/BRPI0714074A2/pt not_active Application Discontinuation
- 2007-06-26 NZ NZ573275A patent/NZ573275A/en unknown
- 2007-06-26 US US11/768,723 patent/US8809264B2/en not_active Expired - Fee Related
- 2007-06-26 JP JP2009518517A patent/JP5520046B2/ja active Active
- 2007-06-26 WO PCT/US2007/072140 patent/WO2008002924A2/en active Application Filing
- 2007-06-26 CA CA2654945A patent/CA2654945C/en not_active Expired - Fee Related
- 2007-06-26 KR KR1020097001503A patent/KR101505056B1/ko not_active IP Right Cessation
-
2008
- 2008-11-25 IL IL195512A patent/IL195512A/en active IP Right Grant
- 2008-12-11 ZA ZA200810519A patent/ZA200810519B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
US8501681B2 (en) | 2013-08-06 |
JP2009541491A (ja) | 2009-11-26 |
WO2008002924A3 (en) | 2008-04-03 |
EP2066326A2 (en) | 2009-06-10 |
TWI454264B (zh) | 2014-10-01 |
TW200810777A (en) | 2008-03-01 |
JP5520046B2 (ja) | 2014-06-11 |
US8809264B2 (en) | 2014-08-19 |
IL195512A0 (en) | 2009-09-01 |
ZA200810519B (en) | 2009-08-26 |
MX2008016528A (es) | 2009-03-31 |
AU2007265157B2 (en) | 2013-06-27 |
CN101478970B (zh) | 2014-07-02 |
KR101505056B1 (ko) | 2015-03-23 |
BRPI0714074A2 (pt) | 2012-12-18 |
NZ573275A (en) | 2011-12-22 |
CA2654945A1 (en) | 2008-01-03 |
EP2066326A4 (en) | 2010-09-29 |
AU2007265157A1 (en) | 2008-01-03 |
AR061629A1 (es) | 2008-09-10 |
US20080008681A1 (en) | 2008-01-10 |
CN101478970A (zh) | 2009-07-08 |
UY30437A1 (es) | 2008-01-31 |
RU2475494C2 (ru) | 2013-02-20 |
KR20090023732A (ko) | 2009-03-05 |
US20070299078A1 (en) | 2007-12-27 |
CA2654945C (en) | 2013-08-06 |
WO2008002924A2 (en) | 2008-01-03 |
IL195512A (en) | 2014-05-28 |
RU2009102252A (ru) | 2010-08-10 |
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