ATE526341T1 - Makrozyklische verbindungen als antivirale mittel - Google Patents

Makrozyklische verbindungen als antivirale mittel

Info

Publication number
ATE526341T1
ATE526341T1 AT07733767T AT07733767T ATE526341T1 AT E526341 T1 ATE526341 T1 AT E526341T1 AT 07733767 T AT07733767 T AT 07733767T AT 07733767 T AT07733767 T AT 07733767T AT E526341 T1 ATE526341 T1 AT E526341T1
Authority
AT
Austria
Prior art keywords
macrocyclic compounds
antiviral agents
macrocyclic
compounds
hepatitis
Prior art date
Application number
AT07733767T
Other languages
English (en)
Inventor
Benedetta Crescenzi
Monica Donghi
Marco Ferrara
Cristina Gardelli
Steven Harper
Uwe Koch
Michael Rowley
Vincenzo Summa
Original Assignee
Angeletti P Ist Richerche Bio
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Angeletti P Ist Richerche Bio filed Critical Angeletti P Ist Richerche Bio
Application granted granted Critical
Publication of ATE526341T1 publication Critical patent/ATE526341T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
AT07733767T 2006-06-23 2007-06-21 Makrozyklische verbindungen als antivirale mittel ATE526341T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0612423.4A GB0612423D0 (en) 2006-06-23 2006-06-23 Therapeutic agents
PCT/GB2007/050346 WO2007148135A1 (en) 2006-06-23 2007-06-21 Macrocyclic compounds as antiviral agents

Publications (1)

Publication Number Publication Date
ATE526341T1 true ATE526341T1 (de) 2011-10-15

Family

ID=36803735

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07733767T ATE526341T1 (de) 2006-06-23 2007-06-21 Makrozyklische verbindungen als antivirale mittel

Country Status (9)

Country Link
US (1) US8314062B2 (de)
EP (1) EP2041159B8 (de)
JP (1) JP5254964B2 (de)
CN (1) CN101501061B (de)
AT (1) ATE526341T1 (de)
AU (1) AU2007262748B2 (de)
CA (1) CA2654884C (de)
GB (1) GB0612423D0 (de)
WO (1) WO2007148135A1 (de)

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EP2041159B1 (de) 2011-09-28
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US20090312241A1 (en) 2009-12-17
GB0612423D0 (en) 2006-08-02
CA2654884A1 (en) 2007-12-27
EP2041159A1 (de) 2009-04-01
EP2041159B8 (de) 2012-02-22
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AU2007262748A1 (en) 2007-12-27

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