EA200971026A1 - Новые макроциклические ингибиторы репликации вируса гепатита с - Google Patents
Новые макроциклические ингибиторы репликации вируса гепатита сInfo
- Publication number
- EA200971026A1 EA200971026A1 EA200971026A EA200971026A EA200971026A1 EA 200971026 A1 EA200971026 A1 EA 200971026A1 EA 200971026 A EA200971026 A EA 200971026A EA 200971026 A EA200971026 A EA 200971026A EA 200971026 A1 EA200971026 A1 EA 200971026A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- hepatitis
- methods
- virus replication
- macrocyclic inhibitors
- new macrocyclic
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Peptides Or Proteins (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Настоящее изобретение раскрывает соединения общей формулы I, также композиции, включающие фармацевтические композиции, содержащие соединение по изобретению. Представленное изобретение раскрывает также способы лечения, включая способы лечения вирусной инфекции гепатита С и способы лечения фиброза печени, способы обычно включают введение пациенту, который нуждается в лечении, эффективного количества соединения или композиции по изобретению.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91589607P | 2007-05-03 | 2007-05-03 | |
US95763007P | 2007-08-23 | 2007-08-23 | |
US1564407P | 2007-12-20 | 2007-12-20 | |
PCT/US2008/062552 WO2008137779A2 (en) | 2007-05-03 | 2008-05-02 | Novel macrocyclic inhibitors of hepatitis c virus replication |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200971026A1 true EA200971026A1 (ru) | 2011-02-28 |
Family
ID=39638815
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200971026A EA200971026A1 (ru) | 2007-05-03 | 2008-05-02 | Новые макроциклические ингибиторы репликации вируса гепатита с |
Country Status (22)
Country | Link |
---|---|
US (1) | US20090155209A1 (ru) |
EP (2) | EP2177523A1 (ru) |
JP (1) | JP2010528987A (ru) |
KR (1) | KR20100024920A (ru) |
CN (1) | CN101784549A (ru) |
AP (1) | AP2009005053A0 (ru) |
AR (1) | AR066448A1 (ru) |
AU (1) | AU2008247509A1 (ru) |
BR (1) | BRPI0811020A2 (ru) |
CA (1) | CA2686138A1 (ru) |
CL (1) | CL2008001274A1 (ru) |
CO (1) | CO6251243A2 (ru) |
EA (1) | EA200971026A1 (ru) |
EC (1) | ECSP099780A (ru) |
IL (1) | IL201757A0 (ru) |
MA (1) | MA31496B1 (ru) |
MX (1) | MX2009011867A (ru) |
NZ (1) | NZ581606A (ru) |
SG (1) | SG174809A1 (ru) |
TN (1) | TN2009000457A1 (ru) |
TW (1) | TW200906830A (ru) |
WO (1) | WO2008137779A2 (ru) |
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-
2008
- 2008-05-02 US US12/114,639 patent/US20090155209A1/en not_active Abandoned
- 2008-05-02 CL CL2008001274A patent/CL2008001274A1/es unknown
- 2008-05-02 EA EA200971026A patent/EA200971026A1/ru unknown
- 2008-05-02 JP JP2010507576A patent/JP2010528987A/ja active Pending
- 2008-05-02 AP AP2009005053A patent/AP2009005053A0/en unknown
- 2008-05-02 WO PCT/US2008/062552 patent/WO2008137779A2/en active Application Filing
- 2008-05-02 SG SG2011065919A patent/SG174809A1/en unknown
- 2008-05-02 EP EP09177761A patent/EP2177523A1/en not_active Withdrawn
- 2008-05-02 KR KR1020097024599A patent/KR20100024920A/ko not_active Application Discontinuation
- 2008-05-02 NZ NZ581606A patent/NZ581606A/xx not_active IP Right Cessation
- 2008-05-02 CA CA002686138A patent/CA2686138A1/en not_active Abandoned
- 2008-05-02 EP EP08755035A patent/EP2160392A2/en not_active Withdrawn
- 2008-05-02 BR BRPI0811020-4A patent/BRPI0811020A2/pt not_active IP Right Cessation
- 2008-05-02 CN CN200880018710A patent/CN101784549A/zh active Pending
- 2008-05-02 MX MX2009011867A patent/MX2009011867A/es not_active Application Discontinuation
- 2008-05-02 AU AU2008247509A patent/AU2008247509A1/en not_active Abandoned
- 2008-05-05 AR ARP080101901A patent/AR066448A1/es unknown
- 2008-05-05 TW TW097116495A patent/TW200906830A/zh unknown
-
2009
- 2009-10-26 IL IL201757A patent/IL201757A0/en unknown
- 2009-10-30 TN TNP2009000457A patent/TN2009000457A1/fr unknown
- 2009-11-26 MA MA32378A patent/MA31496B1/fr unknown
- 2009-11-30 CO CO09136460A patent/CO6251243A2/es not_active Application Discontinuation
- 2009-12-02 EC EC2009009780A patent/ECSP099780A/es unknown
Also Published As
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TN2009000457A1 (en) | 2011-03-31 |
CO6251243A2 (es) | 2011-02-21 |
TW200906830A (en) | 2009-02-16 |
EP2177523A1 (en) | 2010-04-21 |
IL201757A0 (en) | 2010-06-16 |
AU2008247509A1 (en) | 2008-11-13 |
ECSP099780A (es) | 2010-01-29 |
AP2009005053A0 (en) | 2009-12-31 |
AR066448A1 (es) | 2009-08-19 |
JP2010528987A (ja) | 2010-08-26 |
EP2160392A2 (en) | 2010-03-10 |
WO2008137779A3 (en) | 2009-01-08 |
MX2009011867A (es) | 2010-03-22 |
CN101784549A (zh) | 2010-07-21 |
NZ581606A (en) | 2012-06-29 |
CL2008001274A1 (es) | 2008-11-03 |
SG174809A1 (en) | 2011-10-28 |
MA31496B1 (fr) | 2010-07-01 |
WO2008137779A2 (en) | 2008-11-13 |
BRPI0811020A2 (pt) | 2015-07-21 |
CA2686138A1 (en) | 2008-11-13 |
KR20100024920A (ko) | 2010-03-08 |
US20090155209A1 (en) | 2009-06-18 |
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