TNSN06308A1 - Macrocyclic compounds as inhibitors of viral replication - Google Patents
Macrocyclic compounds as inhibitors of viral replicationInfo
- Publication number
- TNSN06308A1 TNSN06308A1 TNP2006000308A TNSN06308A TNSN06308A1 TN SN06308 A1 TNSN06308 A1 TN SN06308A1 TN P2006000308 A TNP2006000308 A TN P2006000308A TN SN06308 A TNSN06308 A TN SN06308A TN SN06308 A1 TNSN06308 A1 TN SN06308A1
- Authority
- TN
- Tunisia
- Prior art keywords
- methods
- inhibitors
- viral replication
- macrocyclic compounds
- subject compound
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The embodiments provide macrocylic compounds, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating flaviviral infection, including hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US55816104P | 2004-03-30 | 2004-03-30 | |
PCT/US2005/010494 WO2005095403A2 (en) | 2004-03-30 | 2005-03-29 | Macrocyclic compounds as inhibitors of viral replication |
Publications (1)
Publication Number | Publication Date |
---|---|
TNSN06308A1 true TNSN06308A1 (en) | 2007-12-03 |
Family
ID=37955155
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TNP2006000308A TNSN06308A1 (en) | 2004-03-30 | 2006-09-27 | Macrocyclic compounds as inhibitors of viral replication |
Country Status (5)
Country | Link |
---|---|
CN (1) | CN1938311A (en) |
CU (1) | CU20090112A6 (en) |
TN (1) | TNSN06308A1 (en) |
UA (1) | UA91677C2 (en) |
ZA (1) | ZA200608798B (en) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009034055A1 (en) * | 2007-09-10 | 2009-03-19 | Novartis Forschungsstiftung, Zweigniederlassung | Method for predicting the response of a subject suffering from a viral infection of the liver to an antiviral therapy |
CN102224153B (en) | 2008-09-22 | 2014-04-30 | 阵列生物制药公司 | Substituted imidazo[1,2b]pyridazine compounds as TRK kinase inhibitors |
KR102037619B1 (en) | 2008-10-22 | 2019-10-28 | 어레이 바이오파마 인크. | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS |
DK2401272T3 (en) * | 2009-02-27 | 2017-02-27 | Janssen Pharmaceuticals Inc | AMORF SALT OF A MACROCYCLIC INHIBITOR OF HCV |
AR077468A1 (en) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | PIRAZOLO COMPOUNDS (1,5-A) PYRIMIDINE SUBSTITUTED AS TRK-QUINASA INHIBITORS |
KR20120110090A (en) * | 2009-09-28 | 2012-10-09 | 에프. 호프만-라 로슈 리미티드 | Novel macrocyclic inhibitors of hepatitis c virus replication |
BR112012018897A2 (en) * | 2010-01-27 | 2017-10-03 | Ab Pharma Ltd | HIGHLY POTENT POLYHETEROCYCLIC COMPOUNDS AS HCV INHIBITORS |
DK2918588T3 (en) | 2010-05-20 | 2017-08-28 | Array Biopharma Inc | Macrocyclic compounds as TRK kinase inhibitors |
GB201116559D0 (en) * | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
EP3218380B1 (en) | 2014-11-16 | 2021-03-17 | Array Biopharma, Inc. | Preparation of a crystalline form of (s)-n-(5-((r)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide hydrogen sulfate |
TN2018000138A1 (en) | 2015-10-26 | 2019-10-04 | Array Biopharma Inc | Point mutations in trk inhibitor-resistant cancer and methods relating to the same |
CN107043405B (en) * | 2016-02-05 | 2021-11-19 | 爱博新药研发(上海)有限公司 | Crystal form of polycyclic heterocyclic compound, preparation method, application and composition thereof |
PE20181888A1 (en) | 2016-04-04 | 2018-12-11 | Loxo Oncology Inc | LIQUID FORMULATIONS OF (S) -N- (5 - ((R) -2- (2,5-DIFLUOROPHENYL) -PYRROLIDIN-1-IL) -PYRAZOLE [1,5-A] PYRIMIDIN-3-IL) -3 -HYDROXYPYRROLIDINE-1-CARBOXAMIDE |
US10045991B2 (en) | 2016-04-04 | 2018-08-14 | Loxo Oncology, Inc. | Methods of treating pediatric cancers |
AU2017268371B2 (en) | 2016-05-18 | 2020-11-19 | Array Biopharma Inc. | Preparation of (S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo(1,5-A)pyrimidin-3-y l)-3-hydroxypyrrolidine-1-carboxamide |
JOP20190092A1 (en) | 2016-10-26 | 2019-04-25 | Array Biopharma Inc | PROCESS FOR THE PREPARATION OF PYRAZOLO[1,5-a]PYRIMIDINES AND SALTS THEREOF |
JOP20190213A1 (en) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | Macrocyclic compounds as ros1 kinase inhibitors |
-
2005
- 2005-03-29 CN CN 200580010503 patent/CN1938311A/en active Pending
- 2005-03-29 UA UAA200611368A patent/UA91677C2/en unknown
-
2006
- 2006-09-27 TN TNP2006000308A patent/TNSN06308A1/en unknown
- 2006-10-23 ZA ZA200608798A patent/ZA200608798B/en unknown
-
2009
- 2009-06-24 CU CU20090112A patent/CU20090112A6/en unknown
Also Published As
Publication number | Publication date |
---|---|
CU20090112A6 (en) | 2012-03-15 |
CN1938311A (en) | 2007-03-28 |
ZA200608798B (en) | 2008-06-25 |
UA91677C2 (en) | 2010-08-25 |
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