TNSN06308A1 - Macrocyclic compounds as inhibitors of viral replication - Google Patents

Macrocyclic compounds as inhibitors of viral replication

Info

Publication number
TNSN06308A1
TNSN06308A1 TNP2006000308A TNSN06308A TNSN06308A1 TN SN06308 A1 TNSN06308 A1 TN SN06308A1 TN P2006000308 A TNP2006000308 A TN P2006000308A TN SN06308 A TNSN06308 A TN SN06308A TN SN06308 A1 TNSN06308 A1 TN SN06308A1
Authority
TN
Tunisia
Prior art keywords
methods
inhibitors
viral replication
macrocyclic compounds
subject compound
Prior art date
Application number
TNP2006000308A
Other languages
French (fr)
Inventor
Steven M Wenglowsky
Steven W Andrews
Kevin R Condroski
Yutong Jiang
April L Kennedy
George A Doherty
John A Josey
Peter J Stengel
Benjamin T Woodard
Machender R Madduru
Lawrence M Blatt
Original Assignee
Intermune Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2005/010494 external-priority patent/WO2005095403A2/en
Application filed by Intermune Inc filed Critical Intermune Inc
Publication of TNSN06308A1 publication Critical patent/TNSN06308A1/en

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The embodiments provide macrocylic compounds, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating flaviviral infection, including hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
TNP2006000308A 2004-03-30 2006-09-27 Macrocyclic compounds as inhibitors of viral replication TNSN06308A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55816104P 2004-03-30 2004-03-30
PCT/US2005/010494 WO2005095403A2 (en) 2004-03-30 2005-03-29 Macrocyclic compounds as inhibitors of viral replication

Publications (1)

Publication Number Publication Date
TNSN06308A1 true TNSN06308A1 (en) 2007-12-03

Family

ID=37955155

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2006000308A TNSN06308A1 (en) 2004-03-30 2006-09-27 Macrocyclic compounds as inhibitors of viral replication

Country Status (5)

Country Link
CN (1) CN1938311A (en)
CU (1) CU20090112A6 (en)
TN (1) TNSN06308A1 (en)
UA (1) UA91677C2 (en)
ZA (1) ZA200608798B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009034055A1 (en) * 2007-09-10 2009-03-19 Novartis Forschungsstiftung, Zweigniederlassung Method for predicting the response of a subject suffering from a viral infection of the liver to an antiviral therapy
CN102224153B (en) 2008-09-22 2014-04-30 阵列生物制药公司 Substituted imidazo[1,2b]pyridazine compounds as TRK kinase inhibitors
KR102037619B1 (en) 2008-10-22 2019-10-28 어레이 바이오파마 인크. SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS
DK2401272T3 (en) * 2009-02-27 2017-02-27 Janssen Pharmaceuticals Inc AMORF SALT OF A MACROCYCLIC INHIBITOR OF HCV
AR077468A1 (en) 2009-07-09 2011-08-31 Array Biopharma Inc PIRAZOLO COMPOUNDS (1,5-A) PYRIMIDINE SUBSTITUTED AS TRK-QUINASA INHIBITORS
KR20120110090A (en) * 2009-09-28 2012-10-09 에프. 호프만-라 로슈 리미티드 Novel macrocyclic inhibitors of hepatitis c virus replication
BR112012018897A2 (en) * 2010-01-27 2017-10-03 Ab Pharma Ltd HIGHLY POTENT POLYHETEROCYCLIC COMPOUNDS AS HCV INHIBITORS
DK2918588T3 (en) 2010-05-20 2017-08-28 Array Biopharma Inc Macrocyclic compounds as TRK kinase inhibitors
GB201116559D0 (en) * 2011-09-26 2011-11-09 Univ Leuven Kath Novel viral replication inhibitors
EP3218380B1 (en) 2014-11-16 2021-03-17 Array Biopharma, Inc. Preparation of a crystalline form of (s)-n-(5-((r)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide hydrogen sulfate
TN2018000138A1 (en) 2015-10-26 2019-10-04 Array Biopharma Inc Point mutations in trk inhibitor-resistant cancer and methods relating to the same
CN107043405B (en) * 2016-02-05 2021-11-19 爱博新药研发(上海)有限公司 Crystal form of polycyclic heterocyclic compound, preparation method, application and composition thereof
PE20181888A1 (en) 2016-04-04 2018-12-11 Loxo Oncology Inc LIQUID FORMULATIONS OF (S) -N- (5 - ((R) -2- (2,5-DIFLUOROPHENYL) -PYRROLIDIN-1-IL) -PYRAZOLE [1,5-A] PYRIMIDIN-3-IL) -3 -HYDROXYPYRROLIDINE-1-CARBOXAMIDE
US10045991B2 (en) 2016-04-04 2018-08-14 Loxo Oncology, Inc. Methods of treating pediatric cancers
AU2017268371B2 (en) 2016-05-18 2020-11-19 Array Biopharma Inc. Preparation of (S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo(1,5-A)pyrimidin-3-y l)-3-hydroxypyrrolidine-1-carboxamide
JOP20190092A1 (en) 2016-10-26 2019-04-25 Array Biopharma Inc PROCESS FOR THE PREPARATION OF PYRAZOLO[1,5-a]PYRIMIDINES AND SALTS THEREOF
JOP20190213A1 (en) 2017-03-16 2019-09-16 Array Biopharma Inc Macrocyclic compounds as ros1 kinase inhibitors

Also Published As

Publication number Publication date
CU20090112A6 (en) 2012-03-15
CN1938311A (en) 2007-03-28
ZA200608798B (en) 2008-06-25
UA91677C2 (en) 2010-08-25

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