CU20090112A6 - MACROCYCLIC COMPOUNDS AS INHIBITORS OF VIRAL REPLICATION - Google Patents

MACROCYCLIC COMPOUNDS AS INHIBITORS OF VIRAL REPLICATION

Info

Publication number
CU20090112A6
CU20090112A6 CU20090112A CU20090112A CU20090112A6 CU 20090112 A6 CU20090112 A6 CU 20090112A6 CU 20090112 A CU20090112 A CU 20090112A CU 20090112 A CU20090112 A CU 20090112A CU 20090112 A6 CU20090112 A6 CU 20090112A6
Authority
CU
Cuba
Prior art keywords
methods
inhibitors
viral replication
macrocyclic compounds
compound
Prior art date
Application number
CU20090112A
Other languages
Spanish (es)
Inventor
Yutong Jaing
Benjamin Woodard
George Andrew Doherty
Peter John Stengel
John Anthony Josey
Kevin Ronald Condroski
April Layne Kennedy
Steven Wade Andrews
Steven Mark Wenglowsky
Lawrence M Blatt
Original Assignee
Intermune Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intermune Inc filed Critical Intermune Inc
Publication of CU20090112A6 publication Critical patent/CU20090112A6/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

En diversas realizaciones se proveen compuestos de las fórmulas generales I-XIX, así como composiciones, entre las que se incluyen composiciones farmacéuticas, que comprenden un compuestos de la invención. Las realizaciones proveen además métodos de tratamiento, que incluyen métodos de tratamiento de infecciones flavivirales, que incluyen la infección por el virus de hepatitis C y métodos de tratar la fibrosis hepática. Los métodos consisten en general en la administración a un individuo que lo necesita, una cantidad eficaz de un compuesto o composición de la invención.In various embodiments, compounds of the general formulas I-XIX are provided, as well as compositions, including pharmaceutical compositions, comprising a compound of the invention. The embodiments further provide treatment methods, which include methods of treating flaviviral infections, which include hepatitis C virus infection and methods of treating liver fibrosis. The methods generally consist of administering to an individual in need, an effective amount of a compound or composition of the invention.

CU20090112A 2004-03-30 2009-06-24 MACROCYCLIC COMPOUNDS AS INHIBITORS OF VIRAL REPLICATION CU20090112A6 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US55816104P 2004-03-30 2004-03-30

Publications (1)

Publication Number Publication Date
CU20090112A6 true CU20090112A6 (en) 2012-03-15

Family

ID=37955155

Family Applications (1)

Application Number Title Priority Date Filing Date
CU20090112A CU20090112A6 (en) 2004-03-30 2009-06-24 MACROCYCLIC COMPOUNDS AS INHIBITORS OF VIRAL REPLICATION

Country Status (5)

Country Link
CN (1) CN1938311A (en)
CU (1) CU20090112A6 (en)
TN (1) TNSN06308A1 (en)
UA (1) UA91677C2 (en)
ZA (1) ZA200608798B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2191274A1 (en) * 2007-09-10 2010-06-02 Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute for Biomedical Research Method for predicting the response of a subject suffering from a viral infection of the liver to an antiviral therapy
CN103965200B (en) 2008-09-22 2016-06-08 阵列生物制药公司 As imidazo [1,2-B] pyridazine compound of the replacement of TRK kinase inhibitor
LT3372605T (en) 2008-10-22 2022-02-10 Array Biopharma, Inc. Substituted pyrazolo[1,5-a]pyrimidine compounds as trk kinase inhibitors
CA2898529C (en) 2009-02-27 2017-10-17 Peter Jozef Maria Van Remoortere Amorphous sodium salt of tmc435 inhibitor of hcv
AR077468A1 (en) 2009-07-09 2011-08-31 Array Biopharma Inc PIRAZOLO COMPOUNDS (1,5-A) PYRIMIDINE SUBSTITUTED AS TRK-QUINASA INHIBITORS
US20110129444A1 (en) * 2009-09-28 2011-06-02 Intermune, Inc Novel macrocyclic inhibitors of hepatitis c virus replication
US8653025B2 (en) * 2010-01-27 2014-02-18 AB Pharma Ltd. Polyheterocyclic compounds highly potent as HCV inhibitors
KR102132405B1 (en) 2010-05-20 2020-07-09 어레이 바이오파마 인크. Macrocyclic compounds as trk kinase inhibitors
GB201116559D0 (en) * 2011-09-26 2011-11-09 Univ Leuven Kath Novel viral replication inhibitors
RS64122B1 (en) 2014-11-16 2023-05-31 Array Biopharma Inc Crystalline form of (s)-n-(5-((r)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide hydrogen sulfate
BR112018008357A2 (en) 2015-10-26 2018-11-27 Array Biopharma Inc dot mutations in trk inhibitor resistant cancer and related methods
CN107043405B (en) * 2016-02-05 2021-11-19 爱博新药研发(上海)有限公司 Crystal form of polycyclic heterocyclic compound, preparation method, application and composition thereof
US10045991B2 (en) 2016-04-04 2018-08-14 Loxo Oncology, Inc. Methods of treating pediatric cancers
AU2017246554B2 (en) 2016-04-04 2022-08-18 Loxo Oncology, Inc. Liquid formulations of (S)-N-(5-((R)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo(1,5-a)pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide
HRP20230704T1 (en) 2016-05-18 2023-10-27 Loxo Oncology, Inc. Preparation of (s)-n-(5-((r)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide
JOP20190092A1 (en) 2016-10-26 2019-04-25 Array Biopharma Inc PROCESS FOR THE PREPARATION OF PYRAZOLO[1,5-a]PYRIMIDINES AND SALTS THEREOF
JOP20190213A1 (en) 2017-03-16 2019-09-16 Array Biopharma Inc Macrocyclic compounds as ros1 kinase inhibitors

Also Published As

Publication number Publication date
ZA200608798B (en) 2008-06-25
CN1938311A (en) 2007-03-28
TNSN06308A1 (en) 2007-12-03
UA91677C2 (en) 2010-08-25

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