CU20090112A6 - MACROCYCLIC COMPOUNDS AS INHIBITORS OF VIRAL REPLICATION - Google Patents
MACROCYCLIC COMPOUNDS AS INHIBITORS OF VIRAL REPLICATIONInfo
- Publication number
- CU20090112A6 CU20090112A6 CU20090112A CU20090112A CU20090112A6 CU 20090112 A6 CU20090112 A6 CU 20090112A6 CU 20090112 A CU20090112 A CU 20090112A CU 20090112 A CU20090112 A CU 20090112A CU 20090112 A6 CU20090112 A6 CU 20090112A6
- Authority
- CU
- Cuba
- Prior art keywords
- methods
- inhibitors
- viral replication
- macrocyclic compounds
- compound
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
En diversas realizaciones se proveen compuestos de las fórmulas generales I-XIX, así como composiciones, entre las que se incluyen composiciones farmacéuticas, que comprenden un compuestos de la invención. Las realizaciones proveen además métodos de tratamiento, que incluyen métodos de tratamiento de infecciones flavivirales, que incluyen la infección por el virus de hepatitis C y métodos de tratar la fibrosis hepática. Los métodos consisten en general en la administración a un individuo que lo necesita, una cantidad eficaz de un compuesto o composición de la invención.In various embodiments, compounds of the general formulas I-XIX are provided, as well as compositions, including pharmaceutical compositions, comprising a compound of the invention. The embodiments further provide treatment methods, which include methods of treating flaviviral infections, which include hepatitis C virus infection and methods of treating liver fibrosis. The methods generally consist of administering to an individual in need, an effective amount of a compound or composition of the invention.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US55816104P | 2004-03-30 | 2004-03-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
CU20090112A6 true CU20090112A6 (en) | 2012-03-15 |
Family
ID=37955155
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CU20090112A CU20090112A6 (en) | 2004-03-30 | 2009-06-24 | MACROCYCLIC COMPOUNDS AS INHIBITORS OF VIRAL REPLICATION |
Country Status (5)
Country | Link |
---|---|
CN (1) | CN1938311A (en) |
CU (1) | CU20090112A6 (en) |
TN (1) | TNSN06308A1 (en) |
UA (1) | UA91677C2 (en) |
ZA (1) | ZA200608798B (en) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2191274A1 (en) * | 2007-09-10 | 2010-06-02 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute for Biomedical Research | Method for predicting the response of a subject suffering from a viral infection of the liver to an antiviral therapy |
CN103965200B (en) | 2008-09-22 | 2016-06-08 | 阵列生物制药公司 | As imidazo [1,2-B] pyridazine compound of the replacement of TRK kinase inhibitor |
LT3372605T (en) | 2008-10-22 | 2022-02-10 | Array Biopharma, Inc. | Substituted pyrazolo[1,5-a]pyrimidine compounds as trk kinase inhibitors |
CA2898529C (en) | 2009-02-27 | 2017-10-17 | Peter Jozef Maria Van Remoortere | Amorphous sodium salt of tmc435 inhibitor of hcv |
AR077468A1 (en) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | PIRAZOLO COMPOUNDS (1,5-A) PYRIMIDINE SUBSTITUTED AS TRK-QUINASA INHIBITORS |
US20110129444A1 (en) * | 2009-09-28 | 2011-06-02 | Intermune, Inc | Novel macrocyclic inhibitors of hepatitis c virus replication |
US8653025B2 (en) * | 2010-01-27 | 2014-02-18 | AB Pharma Ltd. | Polyheterocyclic compounds highly potent as HCV inhibitors |
KR102132405B1 (en) | 2010-05-20 | 2020-07-09 | 어레이 바이오파마 인크. | Macrocyclic compounds as trk kinase inhibitors |
GB201116559D0 (en) * | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
RS64122B1 (en) | 2014-11-16 | 2023-05-31 | Array Biopharma Inc | Crystalline form of (s)-n-(5-((r)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide hydrogen sulfate |
BR112018008357A2 (en) | 2015-10-26 | 2018-11-27 | Array Biopharma Inc | dot mutations in trk inhibitor resistant cancer and related methods |
CN107043405B (en) * | 2016-02-05 | 2021-11-19 | 爱博新药研发(上海)有限公司 | Crystal form of polycyclic heterocyclic compound, preparation method, application and composition thereof |
US10045991B2 (en) | 2016-04-04 | 2018-08-14 | Loxo Oncology, Inc. | Methods of treating pediatric cancers |
AU2017246554B2 (en) | 2016-04-04 | 2022-08-18 | Loxo Oncology, Inc. | Liquid formulations of (S)-N-(5-((R)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo(1,5-a)pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide |
HRP20230704T1 (en) | 2016-05-18 | 2023-10-27 | Loxo Oncology, Inc. | Preparation of (s)-n-(5-((r)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide |
JOP20190092A1 (en) | 2016-10-26 | 2019-04-25 | Array Biopharma Inc | PROCESS FOR THE PREPARATION OF PYRAZOLO[1,5-a]PYRIMIDINES AND SALTS THEREOF |
JOP20190213A1 (en) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | Macrocyclic compounds as ros1 kinase inhibitors |
-
2005
- 2005-03-29 UA UAA200611368A patent/UA91677C2/en unknown
- 2005-03-29 CN CN 200580010503 patent/CN1938311A/en active Pending
-
2006
- 2006-09-27 TN TNP2006000308A patent/TNSN06308A1/en unknown
- 2006-10-23 ZA ZA200608798A patent/ZA200608798B/en unknown
-
2009
- 2009-06-24 CU CU20090112A patent/CU20090112A6/en unknown
Also Published As
Publication number | Publication date |
---|---|
ZA200608798B (en) | 2008-06-25 |
CN1938311A (en) | 2007-03-28 |
TNSN06308A1 (en) | 2007-12-03 |
UA91677C2 (en) | 2010-08-25 |
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