UA91677C2 - Macrocyclic compounds as inhibitors of hcv replication - Google Patents

Macrocyclic compounds as inhibitors of hcv replication

Info

Publication number
UA91677C2
UA91677C2 UAA200611368A UAA200611368A UA91677C2 UA 91677 C2 UA91677 C2 UA 91677C2 UA A200611368 A UAA200611368 A UA A200611368A UA A200611368 A UAA200611368 A UA A200611368A UA 91677 C2 UA91677 C2 UA 91677C2
Authority
UA
Ukraine
Prior art keywords
methods
inhibitors
hcv replication
macrocyclic compounds
subject compound
Prior art date
Application number
UAA200611368A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Лоренс М. Блетт
Стивен М. Венгловски
Стивен В. Эндрюс
Кевин Р. Кондроски
Ютонг Джианг
Эйприл Л. Кеннеди
Джордж Э. Догерти
Джон Э. Джоси
Питер Д. Стенджел
Вуддард Бенджамин Т., (умерший)
Мачендер Р. Маддуру
Original Assignee
Интермюн, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Интермюн, Инк. filed Critical Интермюн, Инк.
Priority claimed from PCT/US2005/010494 external-priority patent/WO2005095403A2/en
Publication of UA91677C2 publication Critical patent/UA91677C2/en

Links

Abstract

The embodiments provide compounds of the general formulas I-XIX, as well as compositions, including pharmaceutical compositions, comprising a subject compound The embodiments further provide treatment methods, including methods of treating flaviviral infection, including hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
UAA200611368A 2004-03-30 2005-03-29 Macrocyclic compounds as inhibitors of hcv replication UA91677C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55816104P 2004-03-30 2004-03-30
PCT/US2005/010494 WO2005095403A2 (en) 2004-03-30 2005-03-29 Macrocyclic compounds as inhibitors of viral replication

Publications (1)

Publication Number Publication Date
UA91677C2 true UA91677C2 (en) 2010-08-25

Family

ID=37955155

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200611368A UA91677C2 (en) 2004-03-30 2005-03-29 Macrocyclic compounds as inhibitors of hcv replication

Country Status (5)

Country Link
CN (1) CN1938311A (en)
CU (1) CU20090112A6 (en)
TN (1) TNSN06308A1 (en)
UA (1) UA91677C2 (en)
ZA (1) ZA200608798B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009034055A1 (en) * 2007-09-10 2009-03-19 Novartis Forschungsstiftung, Zweigniederlassung Method for predicting the response of a subject suffering from a viral infection of the liver to an antiviral therapy
PT2350075E (en) 2008-09-22 2014-06-09 Array Biopharma Inc Substituted imidazo[1,2b]pyridazine compounds as trk kinase inhibitors
SG10201914059WA (en) 2008-10-22 2020-03-30 Array Biopharma Inc Substituted pyrazolo[1,5-a]pyrimidine compounds as trk kinase inhibitors
SG173772A1 (en) * 2009-02-27 2011-09-29 Ortho Mcneil Janssen Pharm Amorphous salt of a macrocyclic inhibitor of hcv
AR077468A1 (en) 2009-07-09 2011-08-31 Array Biopharma Inc PIRAZOLO COMPOUNDS (1,5-A) PYRIMIDINE SUBSTITUTED AS TRK-QUINASA INHIBITORS
KR20120110090A (en) * 2009-09-28 2012-10-09 에프. 호프만-라 로슈 리미티드 Novel macrocyclic inhibitors of hepatitis c virus replication
JP5833022B2 (en) * 2010-01-27 2015-12-16 エービー・ファーマ・リミテッド Polyheterocyclic compounds as hepatitis C virus inhibitors
MX365251B (en) 2010-05-20 2019-05-28 Array Biopharma Inc Macrocyclic compounds as trk kinase inhibitors.
GB201116559D0 (en) * 2011-09-26 2011-11-09 Univ Leuven Kath Novel viral replication inhibitors
CN113354649A (en) 2014-11-16 2021-09-07 阵列生物制药公司 Novel crystal form
CA3003153A1 (en) 2015-10-26 2017-05-04 Loxo Oncology, Inc. Point mutations in trk inhibitor-resistant cancer and methods relating to the same
CN107043405B (en) * 2016-02-05 2021-11-19 爱博新药研发(上海)有限公司 Crystal form of polycyclic heterocyclic compound, preparation method, application and composition thereof
PE20181888A1 (en) 2016-04-04 2018-12-11 Loxo Oncology Inc LIQUID FORMULATIONS OF (S) -N- (5 - ((R) -2- (2,5-DIFLUOROPHENYL) -PYRROLIDIN-1-IL) -PYRAZOLE [1,5-A] PYRIMIDIN-3-IL) -3 -HYDROXYPYRROLIDINE-1-CARBOXAMIDE
US10045991B2 (en) 2016-04-04 2018-08-14 Loxo Oncology, Inc. Methods of treating pediatric cancers
RU2745953C2 (en) 2016-05-18 2021-04-05 Локсо Онколоджи, Инк. Method for making (s)-n-(5-((r)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrolidine-1-carboxamide and its salts
JOP20190092A1 (en) 2016-10-26 2019-04-25 Array Biopharma Inc PROCESS FOR THE PREPARATION OF PYRAZOLO[1,5-a]PYRIMIDINES AND SALTS THEREOF
JOP20190213A1 (en) 2017-03-16 2019-09-16 Array Biopharma Inc Macrocyclic compounds as ros1 kinase inhibitors

Also Published As

Publication number Publication date
ZA200608798B (en) 2008-06-25
CU20090112A6 (en) 2012-03-15
TNSN06308A1 (en) 2007-12-03
CN1938311A (en) 2007-03-28

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