MX2012003500A - Nuevos inhibidores macrocíclicos de la replicación de virus de la hepatitis c. - Google Patents
Nuevos inhibidores macrocíclicos de la replicación de virus de la hepatitis c.Info
- Publication number
- MX2012003500A MX2012003500A MX2012003500A MX2012003500A MX2012003500A MX 2012003500 A MX2012003500 A MX 2012003500A MX 2012003500 A MX2012003500 A MX 2012003500A MX 2012003500 A MX2012003500 A MX 2012003500A MX 2012003500 A MX2012003500 A MX 2012003500A
- Authority
- MX
- Mexico
- Prior art keywords
- hepatitis
- methods
- cyclic peptide
- virus replication
- peptide inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
Las modalidades proporcionan compuestos de las Fórmulas Generales I, la, II, III, IV, V, VI-1, VI-2, VII, VIII, IX, X, XI, y XII, así como composiciones que incluyen composiciones farmacéuticas que comprenden un compuesto sujeto. Las modalidades además proporcionan métodos de tratamiento que incluyen métodos para tratar la infección por el virus de la Hepatitis C y métodos para tratar la fibrosis hepática, los métodos generalmente comprenden administrar a un individuo que lo necesita una cantidad efectiva de una composición o compuesto sujeto.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24646509P | 2009-09-28 | 2009-09-28 | |
US32425110P | 2010-04-14 | 2010-04-14 | |
US34573710P | 2010-05-18 | 2010-05-18 | |
US34623810P | 2010-05-19 | 2010-05-19 | |
PCT/US2010/050298 WO2011038293A1 (en) | 2009-09-28 | 2010-09-24 | Cyclic peptide inhibitors of hepatitis c virus replication |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2012003500A true MX2012003500A (es) | 2012-08-01 |
Family
ID=43796242
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012003500A MX2012003500A (es) | 2009-09-28 | 2010-09-24 | Nuevos inhibidores macrocíclicos de la replicación de virus de la hepatitis c. |
Country Status (18)
Country | Link |
---|---|
US (1) | US20110081315A1 (es) |
EP (1) | EP2483290A4 (es) |
JP (1) | JP2013505952A (es) |
KR (1) | KR20130026410A (es) |
CN (2) | CN105001302A (es) |
AR (1) | AR078462A1 (es) |
AU (1) | AU2010298028A1 (es) |
CA (1) | CA2775697A1 (es) |
CO (1) | CO6531497A2 (es) |
EA (1) | EA201290128A1 (es) |
EC (1) | ECSP12011845A (es) |
IL (1) | IL218766A0 (es) |
IN (1) | IN2012DN02693A (es) |
MA (1) | MA33720B1 (es) |
MX (1) | MX2012003500A (es) |
TN (1) | TN2012000135A1 (es) |
TW (1) | TW201124137A (es) |
WO (1) | WO2011038293A1 (es) |
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JP6026284B2 (ja) * | 2010-03-03 | 2016-11-16 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤 |
WO2011156337A2 (en) * | 2010-06-07 | 2011-12-15 | Abbott Laboratories | Macrocyclic hepatitis c serine protease inhibitors |
CA2811025C (en) | 2010-09-10 | 2018-07-17 | Shionogi & Co., Ltd. | Hetero ring-fused imidazole derivative having ampk activating effect |
US20120101032A1 (en) * | 2010-10-22 | 2012-04-26 | Intermune, Inc. | Novel macrocyclic inhibitors of hepatitis c virus replication |
US8957203B2 (en) | 2011-05-05 | 2015-02-17 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US8691757B2 (en) | 2011-06-15 | 2014-04-08 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
BR112014006984A2 (pt) * | 2011-09-22 | 2017-04-04 | Janssen Pharmaceuticals Inc | processos e intermediários para a preparação de um inibidor macrocíclico de proteases do hcv |
JP2015525223A (ja) | 2012-06-14 | 2015-09-03 | ビーエーエスエフ ソシエタス・ヨーロピアBasf Se | 動物有害生物を駆除するための置換3−ピリジルチアゾール化合物および誘導体を使用する有害生物防除方法 |
UA119315C2 (uk) | 2012-07-03 | 2019-06-10 | Гіліад Фармассет Елелсі | Інгібітори вірусу гепатиту с |
RS55592B1 (sr) | 2012-10-19 | 2017-06-30 | Bristol Myers Squibb Co | 9-metil supstituisani heksadekahidrociklopropa(e)pirolo(1,2-a)(1,4)diazaciklopentadecinil karbamat derivati kao nestrukturalni 3 (ns3) proteazni inhibitori za lečenje infekcijavirusom hepatitisa c |
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-
2010
- 2010-09-24 EP EP10819571.0A patent/EP2483290A4/en not_active Withdrawn
- 2010-09-24 JP JP2012531086A patent/JP2013505952A/ja not_active Withdrawn
- 2010-09-24 MX MX2012003500A patent/MX2012003500A/es not_active Application Discontinuation
- 2010-09-24 CN CN201510341151.8A patent/CN105001302A/zh active Pending
- 2010-09-24 KR KR1020127010337A patent/KR20130026410A/ko not_active Application Discontinuation
- 2010-09-24 AU AU2010298028A patent/AU2010298028A1/en not_active Abandoned
- 2010-09-24 CN CN201080053601.9A patent/CN102741270B/zh not_active Expired - Fee Related
- 2010-09-24 US US12/890,475 patent/US20110081315A1/en not_active Abandoned
- 2010-09-24 EA EA201290128A patent/EA201290128A1/ru unknown
- 2010-09-24 CA CA2775697A patent/CA2775697A1/en not_active Abandoned
- 2010-09-24 WO PCT/US2010/050298 patent/WO2011038293A1/en active Application Filing
- 2010-09-24 IN IN2693DEN2012 patent/IN2012DN02693A/en unknown
- 2010-09-28 TW TW099132976A patent/TW201124137A/zh unknown
- 2010-09-28 AR ARP100103512A patent/AR078462A1/es unknown
-
2012
- 2012-03-21 IL IL218766A patent/IL218766A0/en unknown
- 2012-03-27 TN TNP2012000135A patent/TN2012000135A1/en unknown
- 2012-04-26 MA MA34813A patent/MA33720B1/fr unknown
- 2012-04-27 EC ECSP12011845 patent/ECSP12011845A/es unknown
- 2012-04-27 CO CO12069712A patent/CO6531497A2/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN105001302A (zh) | 2015-10-28 |
ECSP12011845A (es) | 2012-06-29 |
IL218766A0 (en) | 2012-06-28 |
EP2483290A1 (en) | 2012-08-08 |
AU2010298028A1 (en) | 2012-04-19 |
AR078462A1 (es) | 2011-11-09 |
EA201290128A1 (ru) | 2013-01-30 |
US20110081315A1 (en) | 2011-04-07 |
CA2775697A1 (en) | 2011-03-31 |
EP2483290A4 (en) | 2013-05-01 |
JP2013505952A (ja) | 2013-02-21 |
AU2010298028A2 (en) | 2012-10-04 |
TW201124137A (en) | 2011-07-16 |
IN2012DN02693A (es) | 2015-09-04 |
WO2011038293A1 (en) | 2011-03-31 |
TN2012000135A1 (en) | 2013-09-19 |
CN102741270A (zh) | 2012-10-17 |
MA33720B1 (fr) | 2012-11-01 |
CO6531497A2 (es) | 2012-09-28 |
KR20130026410A (en) | 2013-03-13 |
CN102741270B (zh) | 2015-07-22 |
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