MA33720B1 - Inhibiteurs peptiques cycliques de la replication du virus de l'hépatite c - Google Patents
Inhibiteurs peptiques cycliques de la replication du virus de l'hépatite cInfo
- Publication number
- MA33720B1 MA33720B1 MA34813A MA34813A MA33720B1 MA 33720 B1 MA33720 B1 MA 33720B1 MA 34813 A MA34813 A MA 34813A MA 34813 A MA34813 A MA 34813A MA 33720 B1 MA33720 B1 MA 33720B1
- Authority
- MA
- Morocco
- Prior art keywords
- hepatitis
- cyclic
- methods
- virus replication
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Les modes de réalisation de l'invention concernent des composés des formules générales i, ia, ii, iii, iv, v, vi-1, vi-2, vii, viii, ix, x, xi et xii, ainsi que des compositions, notamment des compositions pharmaceutiques, contenant un de ces composés. Les modes de réalisation concernent également des méthodes de traitement, notamment des méthodes de traitement d'une infection par le virus de l'hépatite c ainsi que des méthodes de traitement de la fibrose du foie, ces méthodes consistant généralement à administrer une quantité efficace d'un composé ou d'une composition selon l'invention à un individu nécessitant un tel traitement.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24646509P | 2009-09-28 | 2009-09-28 | |
US32425110P | 2010-04-14 | 2010-04-14 | |
US34573710P | 2010-05-18 | 2010-05-18 | |
US34623810P | 2010-05-19 | 2010-05-19 | |
PCT/US2010/050298 WO2011038293A1 (fr) | 2009-09-28 | 2010-09-24 | Inhibiteurs peptiques cycliques de la réplication du virus de l'hépatite c |
Publications (1)
Publication Number | Publication Date |
---|---|
MA33720B1 true MA33720B1 (fr) | 2012-11-01 |
Family
ID=43796242
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA34813A MA33720B1 (fr) | 2009-09-28 | 2012-04-26 | Inhibiteurs peptiques cycliques de la replication du virus de l'hépatite c |
Country Status (18)
Country | Link |
---|---|
US (1) | US20110081315A1 (fr) |
EP (1) | EP2483290A4 (fr) |
JP (1) | JP2013505952A (fr) |
KR (1) | KR20130026410A (fr) |
CN (2) | CN105001302A (fr) |
AR (1) | AR078462A1 (fr) |
AU (1) | AU2010298028A1 (fr) |
CA (1) | CA2775697A1 (fr) |
CO (1) | CO6531497A2 (fr) |
EA (1) | EA201290128A1 (fr) |
EC (1) | ECSP12011845A (fr) |
IL (1) | IL218766A0 (fr) |
IN (1) | IN2012DN02693A (fr) |
MA (1) | MA33720B1 (fr) |
MX (1) | MX2012003500A (fr) |
TN (1) | TN2012000135A1 (fr) |
TW (1) | TW201124137A (fr) |
WO (1) | WO2011038293A1 (fr) |
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JP5249028B2 (ja) | 2005-07-25 | 2013-07-31 | インターミューン・インコーポレーテッド | C型肝炎ウイルス複製の新規大環状阻害剤 |
DE602006019323D1 (de) * | 2005-10-11 | 2011-02-10 | Intermune Inc | Verbindungen und verfahren zur inhibierung der replikation des hepatitis-c-virus |
CN102046622A (zh) * | 2008-04-15 | 2011-05-04 | 因特蒙公司 | 丙型肝炎病毒复制的新颖大环抑制剂 |
JP2012505897A (ja) * | 2008-10-15 | 2012-03-08 | インターミューン・インコーポレーテッド | 治療用抗ウイルス性ペプチド |
TW201116540A (en) * | 2009-10-01 | 2011-05-16 | Intermune Inc | Therapeutic antiviral peptides |
ES2586231T3 (es) * | 2010-03-03 | 2016-10-13 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
TW201211046A (en) * | 2010-06-07 | 2012-03-16 | Enanta Pharm Inc | Macrocyclic hepatitis C serine protease inhibitors |
CN103209981B (zh) | 2010-09-10 | 2016-12-28 | 盐野义制药株式会社 | 具有ampk活化作用的杂环稠合咪唑衍生物 |
US20120101032A1 (en) * | 2010-10-22 | 2012-04-26 | Intermune, Inc. | Novel macrocyclic inhibitors of hepatitis c virus replication |
US8957203B2 (en) | 2011-05-05 | 2015-02-17 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US8691757B2 (en) | 2011-06-15 | 2014-04-08 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
TWI565704B (zh) * | 2011-09-22 | 2017-01-11 | 健生醫藥公司 | 用於製備hcv巨環蛋白酶抑制劑之方法及中間物 |
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UA119315C2 (uk) | 2012-07-03 | 2019-06-10 | Гіліад Фармассет Елелсі | Інгібітори вірусу гепатиту с |
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US9598433B2 (en) | 2012-11-02 | 2017-03-21 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US9334279B2 (en) | 2012-11-02 | 2016-05-10 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
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KR20150127085A (ko) | 2013-03-15 | 2015-11-16 | 신젠타 파티서페이션즈 아게 | 살균 활성인 이미다조피리딘 유도체 |
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CN108314648A (zh) * | 2018-04-12 | 2018-07-24 | 苏州康润医药有限公司 | 4-溴-7-氟异喹啉的合成方法 |
CN110305018B (zh) * | 2019-06-06 | 2022-07-15 | 浙江普洛家园药业有限公司 | 一种3-溴-2-氟硝基苯的制备方法 |
CN112358447B (zh) * | 2020-11-16 | 2022-04-12 | 苏州康润医药有限公司 | 7-氟异喹啉-1-羧酸的合成方法 |
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-
2010
- 2010-09-24 EA EA201290128A patent/EA201290128A1/ru unknown
- 2010-09-24 CA CA2775697A patent/CA2775697A1/fr not_active Abandoned
- 2010-09-24 KR KR1020127010337A patent/KR20130026410A/ko not_active Application Discontinuation
- 2010-09-24 IN IN2693DEN2012 patent/IN2012DN02693A/en unknown
- 2010-09-24 WO PCT/US2010/050298 patent/WO2011038293A1/fr active Application Filing
- 2010-09-24 MX MX2012003500A patent/MX2012003500A/es not_active Application Discontinuation
- 2010-09-24 CN CN201510341151.8A patent/CN105001302A/zh active Pending
- 2010-09-24 US US12/890,475 patent/US20110081315A1/en not_active Abandoned
- 2010-09-24 JP JP2012531086A patent/JP2013505952A/ja not_active Withdrawn
- 2010-09-24 AU AU2010298028A patent/AU2010298028A1/en not_active Abandoned
- 2010-09-24 EP EP10819571.0A patent/EP2483290A4/fr not_active Withdrawn
- 2010-09-24 CN CN201080053601.9A patent/CN102741270B/zh not_active Expired - Fee Related
- 2010-09-28 TW TW099132976A patent/TW201124137A/zh unknown
- 2010-09-28 AR ARP100103512A patent/AR078462A1/es unknown
-
2012
- 2012-03-21 IL IL218766A patent/IL218766A0/en unknown
- 2012-03-27 TN TNP2012000135A patent/TN2012000135A1/en unknown
- 2012-04-26 MA MA34813A patent/MA33720B1/fr unknown
- 2012-04-27 CO CO12069712A patent/CO6531497A2/es not_active Application Discontinuation
- 2012-04-27 EC ECSP12011845 patent/ECSP12011845A/es unknown
Also Published As
Publication number | Publication date |
---|---|
JP2013505952A (ja) | 2013-02-21 |
MX2012003500A (es) | 2012-08-01 |
WO2011038293A1 (fr) | 2011-03-31 |
EA201290128A1 (ru) | 2013-01-30 |
CN102741270B (zh) | 2015-07-22 |
CN105001302A (zh) | 2015-10-28 |
EP2483290A1 (fr) | 2012-08-08 |
AR078462A1 (es) | 2011-11-09 |
IN2012DN02693A (fr) | 2015-09-04 |
IL218766A0 (en) | 2012-06-28 |
AU2010298028A2 (en) | 2012-10-04 |
US20110081315A1 (en) | 2011-04-07 |
CA2775697A1 (fr) | 2011-03-31 |
KR20130026410A (en) | 2013-03-13 |
EP2483290A4 (fr) | 2013-05-01 |
AU2010298028A1 (en) | 2012-04-19 |
TW201124137A (en) | 2011-07-16 |
ECSP12011845A (es) | 2012-06-29 |
CN102741270A (zh) | 2012-10-17 |
CO6531497A2 (es) | 2012-09-28 |
TN2012000135A1 (en) | 2013-09-19 |
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