MA33720B1 - Inhibiteurs peptiques cycliques de la replication du virus de l'hépatite c - Google Patents

Inhibiteurs peptiques cycliques de la replication du virus de l'hépatite c

Info

Publication number
MA33720B1
MA33720B1 MA34813A MA34813A MA33720B1 MA 33720 B1 MA33720 B1 MA 33720B1 MA 34813 A MA34813 A MA 34813A MA 34813 A MA34813 A MA 34813A MA 33720 B1 MA33720 B1 MA 33720B1
Authority
MA
Morocco
Prior art keywords
hepatitis
cyclic
methods
virus replication
compounds
Prior art date
Application number
MA34813A
Other languages
Arabic (ar)
English (en)
Inventor
Leonid Beigelman
Vladimir Serebryany
Antitsa Dimitrova Stoycheva
Brad Buckman
John B Nicholas
Timothy Thrailkill
Scott D Seiwert
Original Assignee
Intermune Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intermune Inc filed Critical Intermune Inc
Publication of MA33720B1 publication Critical patent/MA33720B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Les modes de réalisation de l'invention concernent des composés des formules générales i, ia, ii, iii, iv, v, vi-1, vi-2, vii, viii, ix, x, xi et xii, ainsi que des compositions, notamment des compositions pharmaceutiques, contenant un de ces composés. Les modes de réalisation concernent également des méthodes de traitement, notamment des méthodes de traitement d'une infection par le virus de l'hépatite c ainsi que des méthodes de traitement de la fibrose du foie, ces méthodes consistant généralement à administrer une quantité efficace d'un composé ou d'une composition selon l'invention à un individu nécessitant un tel traitement.
MA34813A 2009-09-28 2012-04-26 Inhibiteurs peptiques cycliques de la replication du virus de l'hépatite c MA33720B1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US24646509P 2009-09-28 2009-09-28
US32425110P 2010-04-14 2010-04-14
US34573710P 2010-05-18 2010-05-18
US34623810P 2010-05-19 2010-05-19
PCT/US2010/050298 WO2011038293A1 (fr) 2009-09-28 2010-09-24 Inhibiteurs peptiques cycliques de la réplication du virus de l'hépatite c

Publications (1)

Publication Number Publication Date
MA33720B1 true MA33720B1 (fr) 2012-11-01

Family

ID=43796242

Family Applications (1)

Application Number Title Priority Date Filing Date
MA34813A MA33720B1 (fr) 2009-09-28 2012-04-26 Inhibiteurs peptiques cycliques de la replication du virus de l'hépatite c

Country Status (19)

Country Link
US (1) US20110081315A1 (fr)
EP (1) EP2483290A4 (fr)
JP (1) JP2013505952A (fr)
KR (1) KR20130026410A (fr)
CN (2) CN105001302A (fr)
AR (1) AR078462A1 (fr)
AU (1) AU2010298028A1 (fr)
CA (1) CA2775697A1 (fr)
CO (1) CO6531497A2 (fr)
EA (1) EA201290128A1 (fr)
EC (1) ECSP12011845A (fr)
IL (1) IL218766A0 (fr)
IN (1) IN2012DN02693A (fr)
MA (1) MA33720B1 (fr)
MX (1) MX2012003500A (fr)
PH (1) PH12012500602A1 (fr)
TN (1) TN2012000135A1 (fr)
TW (1) TW201124137A (fr)
WO (1) WO2011038293A1 (fr)

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CN110305018B (zh) * 2019-06-06 2022-07-15 浙江普洛家园药业有限公司 一种3-溴-2-氟硝基苯的制备方法
CN112358447B (zh) * 2020-11-16 2022-04-12 苏州康润医药有限公司 7-氟异喹啉-1-羧酸的合成方法
CN114105800B (zh) * 2021-11-25 2023-09-01 杭州国瑞生物科技有限公司 一种2,3-二氨基苯甲酸甲酯的制备方法
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JP2013505952A (ja) 2013-02-21
AR078462A1 (es) 2011-11-09
ECSP12011845A (es) 2012-06-29
CN102741270A (zh) 2012-10-17
US20110081315A1 (en) 2011-04-07
WO2011038293A1 (fr) 2011-03-31
PH12012500602A1 (en) 2017-08-23
IN2012DN02693A (fr) 2015-09-04
EP2483290A4 (fr) 2013-05-01
IL218766A0 (en) 2012-06-28
MX2012003500A (es) 2012-08-01
TN2012000135A1 (en) 2013-09-19
CA2775697A1 (fr) 2011-03-31
EA201290128A1 (ru) 2013-01-30
AU2010298028A2 (en) 2012-10-04
AU2010298028A1 (en) 2012-04-19
TW201124137A (en) 2011-07-16
CN102741270B (zh) 2015-07-22
EP2483290A1 (fr) 2012-08-08
KR20130026410A (en) 2013-03-13
CO6531497A2 (es) 2012-09-28

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